allo-20260420

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

Filed by the Registrant ☒ Filed by a party other than the Registrant ☐

Check the appropriate box:


☒			Preliminary Proxy Statement

☐			Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☐			Definitive Proxy Statement

☐			Definitive Additional Materials

☐			Soliciting Material Pursuant to § 240.14a-12

ALLOGENE THERAPEUTICS, INC.

(Name of Registrant as Specified In Its Charter)

N/A

(Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply)



☒			No fee required.

☐			Fee paid previously with preliminary materials.

☐			Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

PRELIMINARY PROXY STATEMENT

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held on June 18, 2026

Dear Stockholder:

You are cordially invited to attend the 2026 Annual Meeting of Stockholders ("Annual Meeting") of Allogene Therapeutics, Inc., a Delaware corporation (the "Company"). The meeting will be held on June 18, 2026 at 8:00 a.m., Pacific Time. The Annual Meeting will be a completely virtual meeting of stockholders. You can attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/ALLO2026 where you will be able to listen to the meeting live, submit questions and vote online. We are holding the Annual Meeting for the following purposes, as more fully described in the accompanying Proxy Statement:

1.To elect the Board of Directors’ three nominees for director named herein to hold office until the 2029 Annual Meeting of Stockholders.

2.To approve, on an advisory basis, the compensation of the Company’s named executive officers, as disclosed in the Proxy Statement accompanying this notice.

3.To approve, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers.

4.To approve an amendment to our Certificate of Incorporation to increase the number of authorized shares of common stock from 400,000,000 shares to 800,000,000 shares.

5.To ratify the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2026.

6.To conduct any other business properly brought before the meeting.

These items of business are more fully described in the Proxy Statement accompanying this notice.

The record date for the Annual Meeting is April 20, 2026. Only stockholders of record at the close of business on that date may vote at the meeting or any adjournment thereof.

BY ORDER OF THE BOARD OF DIRECTORS

Earl Douglas

Senior Vice President, General Counsel and Corporate Secretary

South San Francisco, California

April , 2026



YOUR VOTE IS IMPORTANT. You are cordially invited to attend the meeting online. Whether or not you plan to attend the Annual Meeting, we urge you to submit your vote via the Internet, telephone or mail as soon as possible to ensure your shares are represented. For additional instructions on voting by telephone or the Internet, please refer to your Notice of Internet Availability of Proxy Materials or proxy card that may be mailed to you. Returning the proxy does not deprive you of your right to attend the Annual Meeting and to vote your shares at the Annual Meeting.

Table of Contents


Page
Questions and Answers about These Proxy Materials and Voting			1

Proposal 1 - Election of Directors			9
Our Board of Directors			10
Nominees for Election at the Annual Meeting			10
Directors Continuing in Office Until the 2027 Annual Meeting			11
Directors Continuing in Office Until the 2028 Annual Meeting			14

Information Regarding the Board of Directors and Corporate Governance			16
General			16
Corporate Governance Guidelines			16
Independence of the Board of Directors			17
Board Leadership Structure			17
Distinctive Role of the Executive Chair			18
Classified Board Structure			19

Board Qualifications			20
Board Self-Evaluation Process			20
Role of the Board in Risk Oversight			21
Meetings of The Board of Directors			21
Information Regarding Committees of the Board of Directors			22
Audit Committee			22
Compensation Committee			23
Nominating and Corporate Governance Committee			25
International and Business Development Oversight Committee			26
Research and Development Committee			27
Stockholder Communications with the Board of Directors			27
Stockholder Engagement			27
Code of Ethics			28
Environmental, Social & Governance (ESG) Practices			28


Proposal 2 - Advisory Vote on Executive Compensation			30
Executive Officers			31

Executive Compensation			32
Discussion of Named Executive Officer Compensation			32
Overview			32


Page
Corporate Highlights for 2025			33
Compensation Highlights for 2025			34
Executive Compensation Governance Practices			35
Response to Advisory Vote on Executive Compensation			36
Executive Compensation Philosophy and Overview			36
2025 Summary Compensation Table			37
Narrative to Summary Compensation Table			37
Executive Compensation Program and Compensation Decisions for the Named Executive Officers			39
Agreements with our Named Executive Officers			44
Potential Payments and Benefits Upon Termination or Change in Control			45
Stock Ownership Guidelines			46
Insider Trading Policy; Prohibition on Hedging, Pledging, and Speculative Trading			46
Clawback Policy			47
2025 Outstanding Equity Awards at Fiscal Year-End Table			47
Securities Authorized for Issuance under Equity Compensation Plans			48
Pay Versus Performance			49
Risk Assessment Concerning Compensation Practices and Policies			53
Policies and Practices Related to the Grant of Certain Equity Awards Close in Time to the Release of Material Nonpublic Information			53

Director Compensation			55
Executive Chair Compensation			56
Non-Employee Director Compensation Policy			58

Security Ownership or Certain Beneficial Owners and Management			60

Transactions with Related Persons			63

Proposal 3 - Say-On-Pay Vote Frequency			67

Proposal 4 - Amendment to Amended and Restated Certificate of Incorporation To Increase the Number of Authorized Shares			68

Proposal 5 - Ratification of Selection of Independent Registered Public Accounting Firm			70
Report of the Audit Committee of the Board of Directors			72

Other Matters			74

ALLOGENE THERAPEUTICS, INC.

210 East Grand Avenue

South San Francisco, California 94080

PRELIMINARY PROXY STATEMENT FOR THE

2026 ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON

June 18, 2026

Annual Meeting

Proposal

Matter to be voted on

Board recommendation

at a glance

Date

Election of three directors

FOR

June 18, 2026

Time

Advisory approval of executive compensation

FOR

8:00 a.m. Pacific Time

Format

Advisory vote on say-on-pay frequency

ONE YEAR

Completely virtual

Record date

Increase authorized common stock to 800,000,000 shares

FOR

April 20, 2026

Webcast

Ratification of Ernst & Young LLP

FOR

www.virtualshareholdermeeting.com/ALLO2026

2025 Highlights


Cema-cel and ALPHA3 •Advanced the pivotal Phase 2 ALPHA3 trial with over 60 sites activated in the US and Canada •Expanded the strategic MRD collaboration with Foresight Diagnostics (now part of Natera) •Strengthened the cema-cel legal and territorial foundation			ALLO-316 •Showcased updated Phase 1 TRAVERSE clinical data at ASCO 2025 •Highlighted a 31% confirmed response rate in patients with CD70 TPS ≥50% •Advanced regulatory-path planning for a pivotal/registration trial
ALLO-329 autoimmune program •Secured FDA IND clearance for ALLO-329 •Received three FDA Fast Track designations •Initiated the Phase 1 RESOLUTION trial and progressed to active enrollment •Advanced Dagger® technology into autoimmune disease development			Infrastructure and operations •Continued to leverage Cell Forge 1 ("CF1") to manufacture product candidates for clinical trials •Executed operational and cost realignment initiatives during 2025 •Maintained sufficient inventory to support ALPHA3, RESOLUTION and TRAVERSE near-term clinical needs

ALLOGENE THERAPEUTICS, INC.

210 East Grand Avenue

South San Francisco, California 94080

PRELIMINARY PROXY STATEMENT FOR THE

2026 ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON

June 18, 2026

Questions and Answers about These Proxy Materials and Voting

Why did I receive a notice regarding the availability of proxy materials on the internet?

Pursuant to rules adopted by the Securities and Exchange Commission (the "SEC"), we have elected to provide access to our proxy materials over the internet. Accordingly, we have sent you a Notice of Internet Availability of Proxy Materials (the "Notice") because the Board of Directors (sometimes referred to as the “Board”) of Allogene Therapeutics, Inc. (sometimes referred to as "we," "us," "our," the "Company" or "Allogene") is soliciting your proxy to vote at the 2026 Annual Meeting of Stockholders ("Annual Meeting"), including at any adjournments or postponements of the meeting. The Annual Meeting will be held virtually on June 18, 2026 at 8:00 a.m., Pacific Time. You can attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/ALLO2026, where you will be able to listen to the meeting live, submit questions and vote online. All stockholders will have the ability to access the proxy materials on the website referred to in the Notice or request to receive a printed set of the proxy materials. Instructions on how to access the proxy materials over the internet or to request a printed copy may be found in the Notice.

We intend to mail the Notice on April 30, 2026 to all stockholders of record entitled to vote at the Annual Meeting.

Will I receive any other proxy materials by mail?

We may send you a proxy card, along with a second Notice, on or after the tenth day following the Notice mailing date.

Why are we holding a virtual Annual Meeting?

This year we will have a virtual format for our Annual Meeting, which will be conducted via live audio webcast and online stockholder tools. We believe a virtual format helps to facilitate stockholder attendance and participation by enabling stockholders to participate fully, and equally, from any location around the world at no cost (other than any costs associated with your Internet access, such as usage charges from Internet access providers and telephone companies). A virtual Annual Meeting makes it possible for more stockholders (regardless of size, resources or physical location) to have direct access to information more quickly, while saving the Company and our stockholders time and money. We also believe that the online tools we have selected will increase stockholder communication. For example, the virtual format allows stockholders to communicate with us in advance of, and during, the Annual Meeting so they can ask questions of our Board of Directors, management, or independent public accounting firm. During the Annual Meeting, we may answer questions submitted during the Annual Meeting and address those asked in advance, to the extent relevant to the business of the Annual Meeting, as time permits. We do not intend to post questions received during the Annual Meeting on our website.

What do I need to do to attend the Annual Meeting?

You will be able to attend the Annual Meeting online, submit your questions during the meeting and vote your shares electronically at the meeting by visiting www.virtualshareholdermeeting.com/ALLO2026. To participate in the Annual Meeting, you will need the control number included on your Notice or proxy card. The Annual Meeting webcast will begin promptly at 8:00 a.m. Pacific Time on June 18, 2026. We encourage you to access the meeting prior to the start time. Online check-in will begin at 7:45 a.m. Pacific Time, and you should allow ample time for the check-in procedures.

Who can vote at the Annual Meeting?

Only stockholders of record at the close of business on April 20, 2026 will be entitled to vote at the Annual Meeting. On this record date, there were [ ] shares of common stock outstanding and entitled to vote. A list of our stockholders of record will be open for examination by any stockholder beginning ten days prior to the Annual Meeting at our headquarters located at 210 East Grand Avenue, South San Francisco, California 94080. If you would like to view the list, please contact our Corporate Secretary to schedule an appointment by calling (650) 457-2700 or writing to him at the Company’s address above.

Stockholder of Record: Shares Registered in Your Name

If on April 20, 2026 your shares were registered directly in your name with Allogene’s transfer agent, Equiniti Trust Company, LLC, then you are a stockholder of record. As a stockholder of record, you may vote live online at the meeting or vote by proxy. Whether or not you plan to attend the meeting, we urge you to fill out and return the proxy card that may be mailed to you or vote by proxy over the telephone or on the internet as instructed below to ensure your vote is counted.

Beneficial Owner: Shares Registered in the Name of a Broker or Bank

If on April 20, 2026 your shares were held, not in your name, but rather in an account at a brokerage firm, bank, dealer or other similar organization, then you are the beneficial owner of shares held in “street name” and the Notice is being forwarded to you by that organization. The organization holding your account is considered to be the stockholder of record for purposes of voting at the Annual Meeting. As a beneficial owner, you have the right to direct your broker or other agent regarding how to vote the shares in your account. You must follow the instructions provided by your brokerage firm, bank, dealer or other similar organization for your bank, broker, dealer or other stockholder of record to vote your shares per your instructions. You are also invited to attend the Annual Meeting. However, since you are not the stockholder of record, you may not vote your shares live at the Annual Meeting unless you request and obtain a valid proxy from your broker or other agent.

What am I voting on?

There are five matters scheduled for a vote:

•Proposal 1: Election of the Board’s three nominees for director named herein to hold office until the 2029 Annual Meeting of Stockholders;

•Proposal 2: Advisory approval of the compensation of the Company’s named executive officers, as disclosed in this Proxy Statement in accordance with SEC rules;

•Proposal 3: Advisory vote on the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers;

•Proposal 4: Approval of an amendment to our Certificate of Incorporation to increase the number of authorized shares of common stock from 400,000,000 shares to 800,000,000 shares (the "Authorized Shares Amendment"); and

•Proposal 5: Ratification of the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2026.

What if another matter is properly brought before the meeting?

The Board of Directors knows of no other matters that will be presented for consideration at the Annual Meeting. If any other matters are properly brought before the meeting, it is the intention of the persons named in the accompanying proxy to vote on those matters in accordance with their best judgment. Discretionary authority for them to do so is provided for in the proxy card.

How do I vote?

You may either vote “For” all the nominees to the Board of Directors or you may “Withhold” your vote for any nominee you specify. For each of Proposals 2, 4 and 5, you may vote “For” or “Against” or abstain from voting. For Proposal 3, you may vote for "1 Year," "2 Years," "3 Years" or abstain from voting.

The procedures for voting are fairly simple:

Stockholder of Record: Shares Registered in Your Name

If you are a stockholder of record, you may vote live online at the Annual Meeting, vote by proxy over the telephone, vote by proxy through the internet or vote by proxy using a proxy card that you may request or that we may elect to deliver at a later time. Whether or not you plan to attend the meeting, we urge you to vote by proxy to ensure your vote is counted. You may still attend the meeting and vote live online even if you have already voted by proxy.

•To vote live at the Annual Meeting, attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/ALLO2026, where stockholders may vote and submit questions during the meeting (have your Notice or proxy card in hand when you visit the website).

•To vote using the proxy card that may be delivered to you, simply complete, sign and date the proxy card and return it promptly in the envelope provided. If you return your signed proxy card to us before the Annual Meeting, we will vote your shares as you direct.

•To vote over the telephone, dial toll-free 1-800-690-6903 and follow the recorded instructions. You will be asked to provide the company number and control number from the Notice. Your telephone vote must be received by 11:59 p.m., Eastern Time, on June 17, 2026 to be counted.

•To vote through the internet, go to www.proxyvote.com and follow the on-screen instructions to complete an electronic proxy card or scan the QR code on your Notice with your smartphone. You will be asked to provide the company number and control number from the Notice. Your internet vote must be received by 11:59 p.m., Eastern Time, on June 17, 2026 to be counted.

Beneficial Owner: Shares Registered in the Name of Broker or Bank

If you are a beneficial owner of shares registered in the name of your broker, bank, or other agent, you should have received a Notice containing voting instructions from that organization rather than from Allogene. Simply follow the voting instructions in the Notice to ensure that your vote is counted. To vote live online at the Annual Meeting, you must obtain a valid proxy from your broker, bank or other agent. Follow the instructions from your broker or bank included with these proxy materials, or contact your broker or bank to request a proxy form.


Internet proxy voting is being provided to allow you to vote your shares online, with procedures designed to ensure the authenticity and correctness of your proxy vote instructions. However, please be aware that you must bear any costs associated with your internet access, such as usage charges from internet access providers and telephone companies.

How many votes do I have?

On each matter to be voted upon, you have one vote for each share of common stock you owned as of the close of business on April 20, 2026.

What happens if I do not vote?

Stockholder of Record: Shares Registered in Your Name

If you are a stockholder of record and do not vote by completing your proxy card, by telephone, through the internet or live online at the Annual Meeting, your shares will not be voted.

Beneficial Owner: Shares Registered in the Name of Broker or Bank

If you are a beneficial owner and do not instruct your broker, bank, or other agent how to vote your shares, the question of whether your broker or nominee will still be able to vote your shares depends on whether the New York Stock Exchange (NYSE) deems the particular proposal to be a “routine” matter. Brokers and nominees can use their discretion to vote “uninstructed” shares with respect to matters that are considered to be “routine,” but not with respect to “non-routine” matters. Under the rules and interpretations of the NYSE, “non-routine” matters are matters that may substantially affect the rights or privileges of stockholders, such as mergers, stockholder proposals, elections of directors (even if not contested), executive compensation (including any advisory stockholder votes on executive compensation and on the frequency of stockholder votes on executive compensation), and certain corporate governance proposals, even if management-supported. Proposals 1, 2, 3 and 4 are considered "non-routine" proposals and accordingly your broker or nominee may not vote your shares on these proposals without your instructions. We have been advised by the NYSE that Proposal 4 is considered "non-routine" because we do not currently have sufficient authorized and available shares for all of our current share reserves. Proposal 5 is considered a "routine" matter and accordingly your broker or nominee may vote your shares on Proposal 5 even in the absence of your instruction.

If you are a beneficial owner of shares held in street name, in order to ensure your shares are voted in the way you would prefer, you must provide voting instructions to your broker, bank or other agent by the deadline provided in the materials you receive from your broker, bank or other agent.

What if I return a proxy card or otherwise vote but do not make specific choices?

If you return a signed and dated proxy card or otherwise vote without marking voting selections, your shares will be voted, as applicable, (i) “For” the election of the Board's three nominees for director, (ii) “For” the advisory approval of the compensation of the Company's named executive officers, (iii) “1 Year” as the preferred frequency of advisory votes to approve the compensation of the Company's named executive officers, (iv) “For” the approval of the Authorized Shares Amendment, and (v) “For” the ratification of the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2026. If any other matter is properly presented at the meeting, your proxyholder (one of the individuals named on your proxy card) will vote your shares using their best judgment.

Who is paying for this proxy solicitation?

We will pay for the entire cost of soliciting proxies. In addition to these proxy materials, our directors and employees may also solicit proxies in person, by telephone, or by other means of communication. Directors and employees will not be paid any additional compensation for soliciting proxies. We may also reimburse brokerage firms, banks and other agents for the cost of forwarding proxy materials to beneficial owners.

What does it mean if I receive more than one Notice?

If you receive more than one Notice, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on each of the Notices to ensure that all of your shares are voted.

Can I change my vote after submitting my proxy?

Stockholder of Record: Shares Registered in Your Name

Yes. You can revoke your proxy at any time before the final vote at the meeting. If you are the record holder of your shares, you may revoke your proxy in any one of the following ways:

•You may submit another properly completed proxy card with a later date.

•You may grant a subsequent proxy by telephone or through the internet.

•You may send a timely written notice that you are revoking your proxy to the Company’s Corporate Secretary at 210 East Grand Avenue, South San Francisco, California 94080. Your revocation will be considered timely if it is received by our Corporate Secretary prior to the Annual Meeting.

•You may attend and vote online at the Annual Meeting (although attendance at the Annual Meeting will not, by itself, revoke a proxy).

Your most current proxy card or telephone or internet proxy is the one that is counted.

Beneficial Owner: Shares Registered in the Name of Broker or Bank

If your shares are held by your broker or bank as a nominee or agent, you should follow the instructions provided by your broker or bank.

When are stockholder proposals and director nominations due for next year’s annual meeting?

To be considered for inclusion in next year’s proxy materials, your proposal must be submitted in writing by December 31, 2026, to Attn: Corporate Secretary, 210 East Grand Avenue, South San Francisco, California 94080. If you wish to submit a proposal (including a director nomination) at the meeting that is not to be included in next year’s proxy materials, you must do so between February 18, 2027 and March 20, 2027. You are also advised to review the Company’s Bylaws, which contain additional requirements relating to advance notice of stockholder proposals and director nominations.

In addition, stockholders who intend to solicit proxies in support of director nominees other than our nominees must provide in their notice any additional information required by Rule 14a-19(b) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”).

How are votes counted?

Votes will be counted by the inspector of election appointed for the meeting, who will separately count, for the proposal to elect directors, votes “For,” “Withhold” and broker non-votes; with respect to Proposal 2 regarding advisory approval of the compensation of the Company’s named executive officers, votes “For,” “Against,” abstentions and broker non-votes; with respect to Proposal 3 regarding the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers, votes cast for each of “1 Year,” “2 Years,” “3 Years,” as well as abstentions and broker non-votes; with respect to Proposal 4 regarding the Authorized Shares Amendment, votes “For,” “Against,” abstentions and broker non-votes; and for Proposal 5 regarding the ratification of the Audit Committee’s selection of Ernst & Young LLP as our independent registered public accounting firm, votes “For,” “Against” and abstentions. Only "For" votes will affect the outcome of Proposal 1. For Proposals 2 and 5, abstentions will have the same effect as “Against” votes on those proposals. For Proposal 3, abstentions will have the same effect as votes “Against” each of the proposed voting frequencies. Abstentions will have no effect on Proposal 4. Broker non-votes will be counted toward the presence of a quorum but will not be counted toward the vote total for any proposal.

What are “broker non-votes”?

As discussed above, when a beneficial owner of shares held in “street name” does not give instructions to the broker or nominee holding the shares as to how to vote on matters deemed by the NYSE to be “non-routine,” the broker or nominee cannot vote the shares. These unvoted shares are counted as “broker non-votes.” Broker non-votes will have no effect on any proposal. Proposal 5 is considered a “routine” matter and therefore there cannot be any broker non-votes on this proposal.

How many votes are needed to approve each proposal?

For the election of directors, the three nominees receiving the most “For” votes from the holders of shares present or represented by proxy and entitled to vote on the election of directors will be elected. Only votes “For” will affect the outcome. However, for uncontested elections, it is the Company’s policy that if a director is elected by a plurality but not a majority of the votes cast for such director, such director must submit his or her resignation to the Board of Directors, which will be subject to review by the Nominating and Corporate Governance Committee of the Board of Directors. The Nominating and Corporate Governance Committee will then make a recommendation to the Board of Directors as to whether to accept or reject the director’s resignation. The Board will consider and act upon the Nominating and Corporate Governance Committee’s recommendation within 30 days of certification of the vote at the Annual Meeting. Promptly following the Board’s decision, the Company will disclose that decision and an explanation of such decision in a filing with the Securities and Exchange Commission and a press release.

To be approved, Proposal 2, advisory approval for the compensation of the Company’s named executive officers, must receive “For” votes from the holders of a majority of shares present at the Annual Meeting or represented by proxy and entitled to vote on the matter. If you “Abstain” from voting, it will have the same effect as an “Against” vote. Broker non-votes will have no effect.

To be approved, Proposal 3, regarding the preferred frequency of stockholder advisory votes on the compensation of the Company’s named executive officers, a frequency must receive “For” votes from the holders of a majority of shares present at the Annual Meeting or represented by proxy and entitled to vote on the matter. If you “Abstain” from voting, it will have the same effect as a vote “Against” each of the proposed voting frequencies. In the event none of the proposed frequencies receives “For” votes from the holders of a majority of shares present at the Annual Meeting or represented by proxy and entitled to vote on the matter, we will consider the frequency receiving the highest number of affirmative votes to be the frequency preferred by our stockholders. Broker non-votes will have no effect. Because this vote is advisory, it will not be binding on us, our Compensation Committee or our Board of Directors. However, we value our stockholders’ input and will take the vote into consideration when determining the frequency of stockholder advisory votes on the compensation of the Company’s named executive officers.

To be approved, Proposal 4, the Authorized Shares Amendment, the proposal must receive “For” votes from a majority of the votes cast for such proposal. If you “Abstain” from voting, it will have no effect. Broker non-votes will have no effect.

To be approved, Proposal 5, ratification of the selection of Ernst & Young LLP as the Company’s independent registered public accounting firm for its fiscal year ending December 31, 2026, must receive “For” votes from the holders of a majority of shares present at the Annual Meeting or represented by proxy and entitled to vote on the matter. If you “Abstain” from voting, it will have the same effect as an “Against” vote. There cannot be any broker non-votes for this proposal.

What is the quorum requirement?

A quorum of stockholders is necessary to hold a valid meeting. A quorum will be present if stockholders holding at least a majority of the outstanding shares entitled to vote are present at the meeting or represented by proxy. On the record date, there were [ ] shares outstanding and entitled to vote. Thus, the holders of [ ] shares must be present at the meeting or represented by proxy at the meeting to have a quorum.

Your shares will be counted toward the quorum only if you submit a valid proxy (or one is submitted on your behalf by your broker, bank or other nominee) or if you vote live online at the meeting. Abstentions and broker non-votes will be counted toward the quorum requirement. If there is no quorum, either the Chairman of the meeting or the holders of a majority of shares present at the meeting or represented by proxy may adjourn the meeting to another date.

How can I find out the results of the voting at the Annual Meeting?

Preliminary voting results will be announced at the Annual Meeting. In addition, final voting results will be published in a current report on Form 8-K that we expect to file within four business days after the Annual Meeting. If final voting results are not available to us in time to file a Form 8-K within four business days after the meeting, we intend to file a Form 8-K

to publish preliminary results and, within four business days after the final results are known to us, file an additional Form 8-K to publish the final results.

FORWARD-LOOKING STATEMENTS

This Proxy Statement contains “forward-looking statements” as that term is defined in the Private Securities Litigation Reform Act of 1995. In some cases, you can identify these statements by terms such as “anticipate,” “believe,” “could,” “estimate,” “expects,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” or the negative of those terms, and similar expressions that convey uncertainty of future events or outcomes. These statements are based on management’s current expectations and involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements. The forward-looking statements may include statements of the Company’s plans and future commitments with respect to corporate governance initiatives and the composition of its board of directors; the Company’s plans and expectations regarding executive compensation; the potential impact of the Authorized Shares Amendment and our plans if such Authorized Shares Amendment is approved; the Company's development plans and business strategy; the potential of the Company’s product candidates and the extent to which such product candidates may or may not require lymphodepletion in order to be effective; the Company’s ongoing and planned clinical trials; the timing of any potential commercialization of the Company’s product candidates; the data from the interim futility analysis in the Company's ALPHA3 trial; and the potential market opportunity of the Company’s product candidates and competitive landscape. No forward-looking statement can be guaranteed and actual results may differ materially from those projected. Allogene undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements should be evaluated together with the many uncertainties that affect Allogene’s business, particularly those mentioned in the risk factors and cautionary statements in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025, and in its periodic reports on Form 10-Q and current reports on Form 8-K, if any.


Proposal 1 Election of Directors

Recommendation:

The Board recommends the vote “FOR” the election of each of Deborah Messemer, Vicki Sato, Ph.D., and Owen Witte, M.D. as a director.

Our Board of Directors currently consists of eleven members and is divided into three classes. Each class consists, as nearly as possible, of one-third of the total number of directors, and each class has a three-year term. There are four directors in Class II, whose term of office expires at the Annual Meeting: Ms. Deborah Messemer, Dr. Vicki Sato, Mr. Todd Sisitsky, and Dr. Owen Witte. The Board, acting on the recommendation of our Nominating and Corporate Governance Committee, has nominated Deborah Messemer, Vicki Sato, Ph.D., and Owen Witte, M.D. for election at the Annual Meeting for a term of three years to serve as Class II directors until the 2029 Annual Meeting of Stockholders, and until their respective successors are duly elected and qualified, or until their earlier death, resignation or removal. Following discussions with Mr. Sisitsky and in consideration of his expanding responsibilities in his current role with TPG, and in alignment with the Board’s long-term succession planning, the Board did not nominate Mr. Sisitsky to stand for re-election at the Annual Meeting. The Board thanks Mr. Sisitsky for his years of service, dedication to the Board, and his many contributions to the Company.

Proxies cannot be voted for a greater number of persons than the number of nominees named in this proxy statement (three nominees). In April 2026, our Board of Directors approved a reduction in the size of the Board of Directors to ten members, effective as of the Annual Meeting. As a result, after the Annual Meeting, our Board of Directors will be composed of ten directors. Our Board has determined that it will not nominate a new director to replace Mr. Sisitsky in connection with the upcoming Annual Meeting. Rather than making an immediate appointment, consistent with the Board’s deliberate and strategic approach to Board composition, the Board intends to thoughtfully assess the specific skills, experience, and expertise that will be most valuable as the Company progresses toward potential commercialization. This includes evaluating capabilities in areas such as commercial execution, market access, manufacturing scale-up, and global launch strategy, among others. The Board will also consider the appropriate timing for adding such expertise to maximize its impact.

If any nominee becomes unavailable for election as a result of an unexpected occurrence, shares that would have been voted for that nominee will instead be voted “For” the election of a substitute nominee designated by our Board of Directors, or alternatively, the Board may leave a vacancy on the Board or reduce the size of the Board. Each nominee has agreed to serve as a director if elected and we have no reason to believe that any nominee will be unable to serve.

It is our policy to invite directors and nominees for director to attend the Annual Meeting. All of our directors attended our 2025 Annual Meeting of Stockholders.

Our Board of Directors

In addition to our Class II directors, our Board includes three Class I directors, Elizabeth Barrett, Arie Belldegrun, M.D., and David Chang, M.D., Ph.D., and four Class III directors, John DeYoung, Franz Humer, Ph.D., Joshua Kazam and Stephen Mayo, Ph.D. These directors will serve until our Annual Meetings of Stockholders to be held in 2028 and 2027, respectively, and until their respective successors have been elected and qualified, or until their earlier death, resignation or removal.

The Board believes that its current members collectively possess the experience and perspectives necessary to effectively oversee the Company’s strategy and operations at this time. The Board remains committed to ongoing refreshment and will continue to evaluate opportunities to enhance its composition as the Company’s needs evolve.

The Nominating and Corporate Governance Committee seeks to assemble a Board of Directors that, as a whole, possesses the appropriate balance of professional and industry knowledge, financial expertise and high-level management experience necessary to oversee and direct the Company’s business. The Nominating and Corporate Governance Committee also seeks to attain a balance among directors of thought, viewpoints, and backgrounds. To those ends, the Nominating and Corporate Governance Committee has identified and evaluated nominees in the broader context of the Board of Directors’ overall composition, with the goal of recruiting members who complement and strengthen the skills of other members and who also exhibit integrity, collegiality, sound business judgment and other qualities that the Nominating and Corporate Governance Committee views as critical to effective functioning of the Board of Directors. We discuss our approach to evaluating nominees in this Proxy Statement under “Information Regarding the Board of Directors and Corporate Governance—Nominating and Corporate Governance Committee.” The brief biographies below include information, as of the date of this proxy statement, regarding the specific and particular experience, qualifications, attributes or skills of each director/nominee that led the Nominating and Corporate Governance Committee to believe that that nominee should continue to serve on the Board. However, each of the members of the Nominating and Corporate Governance Committee may have a variety of reasons why they believe a particular person would be an appropriate nominee for the Board of Directors, and these views may differ from the views of other members.

Nominees for Election at the Annual Meeting

The following is a brief biography of each nominee.

Deborah Messemer has served as a member of our Board since September 2018. Ms. Messemer has served as a director of TPG Inc. since January 2022 and PayPal Holdings, Inc. since January 2019. Ms. Messemer is a certified public accountant and joined KPMG LLP ("KPMG"), the U.S. member firm of KPMG International, in 1982 and was admitted into the partnership in 1995. Most recently, she served as the Managing Partner of KPMG’s Bay Area and Northwest region until her retirement in September 2018. Ms. Messemer spent the majority of her career in KPMG’s audit practice as an audit engagement partner serving public and private clients in a variety of industry sectors. In addition to her operational and audit signing responsibilities, she has significant experience in SEC filings, due diligence, initial public offerings, mergers and acquisitions, and internal controls over financial reporting. Ms. Messemer received a bachelor’s degree in accounting from the University of Texas at Arlington.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe Ms. Messemer’s expertise in the accounting and finance industry, her experience advising public companies, her experience as a director of other companies, and her education provide her with the qualifications and skills to serve on our Board of Directors.

Vicki Sato, Ph.D. has served as a member of our Board since July 2021. She was a professor of management practice at Harvard Business School from September 2006 to July 2017 and was a professor in the Department of Molecular and Cell Biology at Harvard University from July 2005 until October 2015. Previously, she served as President of Vertex Pharmaceuticals, Inc. (Vertex), a publicly traded biotechnology company, which she joined in 1992. Prior to becoming President of Vertex, she was the Chief Scientific Officer and Senior Vice President of Research and Development. Prior to joining Vertex, Dr. Sato served as Vice President of Research at Biogen Inc. Dr. Sato currently serves on the board of directors of Vir Biotechnology, Inc., a publicly traded company. She also serves on the boards of Encoded Therapeutics, Inc. and Aera Therapeutics, Inc., each a private biotechnology company, and is a venture partner at ClavysBio Pte Ltd and ARCH Venture Partners. Dr. Sato previously served on the boards of directors of Denali Therapeutics, Inc. (2015-2025), Bristol-Myers Squibb Company (2006-2021), BorgWarner Inc. (2014-2021), and Akouos, Inc. (2020-2022). Dr. Sato received her A.B. in Biology from Radcliffe College and her A.M. and Ph.D. in Biology from Harvard University. She conducted her postdoctoral work at both the University of California, Berkeley and Stanford Medical Center.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe that Dr. Sato’s expertise and experience in life sciences, her experience as a director of other companies and her educational background provide her with the qualifications and skills to serve on our Board of Directors.

Owen Witte, M.D. has served as a member of our Board since April 2018. Dr. Witte previously served as a member of the board of directors of Kite from March 2017 until October 2017. Dr. Witte joined the UCLA faculty in 1980, where he is presently a University Professor of microbiology, immunology and molecular genetics, the UCLA David Saxon Presidential Chair in Developmental Immunology and previously served as the director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. Dr. Witte was appointed a University Professor by the University of California Board of Regents, an honor reserved for scholars of the highest international distinction. Dr. Witte is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the National Academy of Medicine. Dr. Witte currently serves on several editorial and advisory boards. He previously served on the board of directors for the American Association for Cancer Research. He was appointed by President Obama to the President’s Cancer Panel. Dr. Witte holds a bachelor’s degree from Cornell University and an M.D. from Stanford University. He completed postdoctoral research at the Massachusetts Institute of Technology.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe Dr. Witte’s expertise and experience in cancer research, his experience in academia and his educational background provide him with the qualifications and skills to serve on our Board of Directors.

Directors Continuing in Office Until the 2027 Annual Meeting

The following is a brief biography of each director whose term will continue after the Annual Meeting and until the 2027 Annual Meeting.

John DeYoung has served as a member of our Board since April 2018. Mr. DeYoung serves as a member of the Compensation Committee and the International and Business Development Oversight Committee. Mr. DeYoung is Vice President of Worldwide Business Development for Pfizer’s Oncology Business Unit. He is a member of Pfizer’s Oncology Leadership Team and its Worldwide Business Development Leadership Team. Mr. DeYoung joined Pfizer in 1991 and has held leadership positions in Finance, Marketing, Commercial Development and Business Development. Mr. DeYoung received his bachelor’s degree in business from Michigan State University in 1985 and his MBA from the University of Chicago in 1990.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe Mr. DeYoung’s expertise and experience in the life sciences and his financial background provide him with the qualifications and skills to serve on our Board of Directors.

Franz Humer, Ph.D. has served as a member of our Board since April 2018. Dr. Humer currently serves on the board of directors of LetterOne Holdings S.A. and as Chair of the board of directors of Kallyope, Inc. In addition, Dr. Humer serves on the board of directors of the International Centre for Missing and Exploited Children and is Chair of the Humer Foundation. Dr. Humer previously served as Chair of the board of directors of Neogene Therapeutics, Inc., a private research-stage biotechnology company, from October 2020 until January 2023 and as a member of the board of directors of Kite from September 2015 until October 2017. He also served as an independent director of Citigroup Inc. from 2012 until 2018, Chugai Pharmaceuticals Ltd. (Japan) from 2002 until 2014, and Arix Bioscience plc from April 2016 to December 2019. He served as Chair of Diageo plc from 2005 to 2017. He served as a member of the board of directors of WISeKey SA, a publicly traded global cybersecurity company, from May 2016 to December 2017. In addition, Dr. Humer served as Head of Pharmaceuticals and then as Chief Operating Officer of F. Hoffmann-La Roche Ltd. from 1996 to 1998, prior to serving as Chief Executive Officer of Roche Group from 1998 to 2001 and later as Chair and Chief Executive Officer from 2001 to 2008. His tenure as Chair of Roche Holding Ltd. extended from 2008 to 2014. Before joining Roche Group, he served on the board of Glaxo Holdings plc and was responsible for research, business development, manufacturing, commercial strategy, and all non-US operations for 13 years. In 1973, Dr. Humer joined Schering Plough Corporation where he held various General Management positions in Latin America and Europe. Dr. Humer attended the University of Innsbruck, where he obtained a Ph.D. in Law, and INSEAD in Fontainebleau, where he obtained an MBA.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe that Dr. Humer’s expertise and experience in life sciences, his experience as a director of other companies and his educational background provide him with the qualifications and skills to serve on our Board of Directors.

Joshua Kazam has served as a member of our Board since November 2017. Mr. Kazam served as our President from November 2017 until June 2018. He was a founder of Kite and served as a member of Kite’s board of directors from Kite’s inception in June 2009 until October 2017. In June 2009, Mr. Kazam co-founded Two River, LLC, a life-science company incubation and investment firm. Mr. Kazam is a co-founder and Director of Vida Ventures, and an advisor to Symbiotic Capital. Mr. Kazam has served on the board of Kronos Bio, Inc. since June 2017. He also serves on the boards of the following private companies: Vision Path, Inc. (d/b/a Hubble Contacts) since May 2016, ByHeart, Inc. since November 2016, Breakthrough Properties LLC and Breakthrough Services LLC since April 2019, and Baby Generation since January 2018. Mr. Kazam has also served on the boards of several blank check companies formed for the purpose of effecting a business combination with one or more businesses: Screaming Eagle Acquisition Corp. from January 2022 until May 2024, Tishman Speyer Innovation Corp. II since February 2021 until December 2022, TS Innovation Acquisitions Corp. from November 2020 until June 2021, Soaring Eagle Acquisition Corp. from February 2021 to September 2021, Flying Eagle Acquisition Corp. from February 2020 until December 2020, Diamond Eagle Acquisition Corp. from January 2019 until April 2020, and Platinum Eagle Acquisition Corp. from January 2018 to March 2019. Mr. Kazam has served as the President of Desert Flower Foundation since June 2016. Mr. Kazam received his bachelor’s degree in Entrepreneurial Management from the Wharton School of the University of Pennsylvania and is a Member of the Wharton School’s Undergraduate Executive Board, and is a Penn Medicine Trustee.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe Mr. Kazam’s expertise and experience in the life sciences and venture capital industries and his educational background provide him with the qualifications and skills to serve on our Board of Directors.

Stephen Mayo, Ph.D. has served as a member of our Board since July 2022. Since 2021, he has served as a member of the board of directors and as a member of the research and development and audit committees of Sarepta Therapeutics, Inc., and as a member of the board of directors and on the audit and research committees of Merck & Co., Inc., each a publicly-traded company. In addition, he serves on the scientific advisory board of Vida Ventures. He co- founded Molecular Simulations Inc. (now Biovia), Protabit LLC and Xencor, Inc., a public antibody engineering company. Dr. Mayo is currently the Bren Professor of Biology and Chemistry and Merkin Institute Professor at California Institute of Technology (Caltech). He joined the Caltech faculty in 1992, was a Caltech- based Howard Hughes Medical Institute Investigator from 1994 to 2007, served as Vice Provost for Research from 2007 to 2010 and served as Chair of the Division of Biology and Biological Engineering from 2010 to 2020. Dr. Mayo was elected to the National Academy of Sciences in 2004 for his pioneering contributions in the field of protein design. He served as an elected board member for the American Association for the Advancement of Science from 2010 to 2014 and as a presidential appointee on the National Science Foundation’s National Science Board from 2013 to 2018. Dr. Mayo holds a B.S. in Chemistry from Pennsylvania State University and a Ph.D. in Chemistry from Caltech. He completed postdoctoral work at both UC Berkeley and Stanford University School of Medicine in chemistry and biochemistry, respectively.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe Dr. Mayo's expertise and experience in cancer research, his experience in academia, his experience as a director of other companies and his educational background provide him with the qualifications and skills to serve on our Board of Directors.

Directors Continuing in Office Until the 2028 Annual Meeting

The following is a brief biography of each director whose term will continue after the Annual Meeting and until the 2028 Annual Meeting.

Elizabeth Barrett has served as a member of our Board since July 2021. Ms. Barrett is a director and President and Chief Executive Officer of UroGen Pharma Ltd. ("UroGen"), a biotechnology company dedicated to developing and commercializing innovative solutions that treat urothelial and specialty cancers. At UroGen, Ms. Barrett spearheaded the 2020 approval of Jelmyto® for the treatment of low-grade upper tract urothelial carcinoma. Before joining UroGen, Ms. Barrett served as the Chief Executive Officer of Novartis Oncology, where she managed the development and launch of the autologous CAR T therapy Kymriah®, and as a member of the Executive Committee of Novartis Oncology from February 2018 to December 2018. Prior to that, Ms. Barrett served at Pfizer in various capacities, most recently as the Global President of Oncology, and before that as Pfizer’s Regional President of US Oncology Business Unit since March 2009. Prior to Pfizer, she was Vice President and General Manager of the Oncology Business Unit at Cephalon Inc. Ms. Barrett has served as a director of Sage Therapeutics, Inc., a publicly traded biotechnology company focused on brain health medicines, since February 2019. Ms. Barrett received a Bachelor of Science in Business Administration from the University of Louisiana and a Master’s in Business Administration-Marketing from St. Joseph’s University.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe that Ms. Barrett’s expertise and experience in life sciences, her experience as a chief executive and director of a biotechnology company, and her educational background provide her with the qualifications and skills to serve on our Board of Directors.

Arie Belldegrun, M.D. is a co-founder of Allogene and has served as Executive Chair of our Board since November 2017. From March 2014 until October 2017, Dr. Belldegrun served as the President and Chief Executive Officer of Kite Pharma, Inc. ("Kite") and as a director from June 2009 until October 2017. Dr. Belldegrun has served as Chair of UroGen since December 2012, and previously served as Chair of Kronos Bio, Inc., from June 2017 to June 2025. He was a director of Ginkgo Bioworks, Inc., from September 2021 to November 2024. Dr. Belldegrun has also served on the boards of several private companies, including Breakthrough Properties LLC and Breakthrough Services LLC, since April 2019, ByHeart, Inc., since October 2019, and as Co-Chairman of Symbiotic Capital since June 2023. Dr. Belldegrun has also served as Chairman of Bellco Capital LLC since 2004, as Chair and Partner of Two River Group since June 2009, and as Senior Managing Director of Vida Ventures, LLC since November 2017. He is certified by the American Board of Urology and is a Fellow of the American Association of Genitourinary Surgeons. Dr. Belldegrun is Research Professor, holds the Roy and Carol Doumani Chair in Urologic Oncology, and is Founder and Director of the Institute of Urologic Oncology at the David

Geffen School of Medicine at the University of California, Los Angeles (UCLA). Prior to joining UCLA in October 1988, he was a research fellow at NCI/NIH in surgical oncology and immunotherapy from July 1985 to August 1988 under Dr. Steven Rosenberg. Dr. Belldegrun received his M.D. from the Hebrew University Hadassah Medical School in Jerusalem before completing his postgraduate studies in Immunology at the Weizmann Institute of Science and his residency in Urologic Surgery at Harvard Medical School.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe Dr. Belldegrun’s expertise, experience, and track record in forming successful companies in immuno-oncology as well as his expertise as a urological oncologist provide him with the qualifications and skills to serve on our Board of Directors.

David Chang, M.D., Ph.D. is a co-founder of Allogene and has served as our President and Chief Executive Officer and as a member of our Board since June 2018. Dr. Chang has served on the boards of two private companies as Chair of the Board of Directors of IconOVir Bio, Inc., from June 2020 to 2025, and director of 1200 Pharma LLC since June 2021. Dr. Chang served on the Board of Directors of Notch Therapeutics, Inc. (Notch), a private research-stage biotechnology company, from November 2019 to March 2022. Prior to joining us, Dr. Chang served as the Chief Medical Officer and Executive Vice President, Research and Development of Kite from June 2014 until March 2018. Dr. Chang previously held senior positions at Amgen Inc. ("Amgen"), a biopharmaceutical company. Prior to that, he was an Associate Professor at the UCLA School of Medicine. He has also served as a Venture Partner of Vida Ventures, LLC since November 2017, and Two River, LLC since October 2017. In addition, he serves as a member of the Caltech Andrew and Peggy Cheng Medical Engineering Advisory Council and of the MIT Corporation Biology Visiting Committee. Dr. Chang obtained a B.S. in Biology from the Massachusetts Institute of Technology and an M.D. and Ph.D. from Stanford University.

Skills and Qualifications: Our Nominating and Corporate Governance Committee and Board of Directors believe Dr. Chang’s expertise and experience in life sciences, including his work in immuno-oncology and his educational background, provide him with the qualifications and skills to serve on our Board of Directors.


Information Regarding the Board of Directors and Corporate Governance

General

We believe that good corporate governance is important to ensure that Allogene is managed for the long-term benefit of our stockholders. This section describes key corporate governance practices that we have adopted. We have adopted a Code of Business Conduct and Ethics, which applies to all of our officers, directors and employees, Corporate Governance Guidelines and Charters for our Audit Committee, our Compensation Committee, our Nominating and Corporate Governance Committee, our International and Business Development Oversight Committee, and our Research and Development Committee. We continuously review these policies and practices and compare them to those of our peer group and those suggested by various authorities in corporate governance to ensure we adopt best industry practices. We have posted copies of our Code of Business Conduct and Ethics and Corporate Governance Guidelines, as well as each of our committee Charters, on the “Investors—Corporate Governance—Documents and Charters” section of our website, www.allogene.com, which you can access free of charge. Information contained on, or accessible through, our website is not incorporated by reference in, or considered part of, this Proxy Statement. We will also provide copies of these documents, as well as our other corporate governance documents, free of charge, to any stockholder upon written request to Allogene Therapeutics, Inc., 210 E. Grand Ave, South San Francisco, CA 94080 Attn: Corporate Secretary.

Corporate Governance Guidelines

Our Board of Directors has adopted Corporate Governance Guidelines to support the effective execution of its fiduciary duties and promote the long-term interests of Allogene and its stockholders. These Guidelines establish a clear framework for the governance of the Company and reinforce our commitment to transparency, accountability, independent oversight, and responsible leadership.

Key principles outlined in the Guidelines include:

•the Board’s fundamental role is to provide strategic guidance and independent oversight of management in support of Allogene’s mission and objectives;

•a majority of the Board shall consist of independent directors in accordance with Nasdaq listing standards;

•the independent directors meet no less than two times per year in executive session, without management present, to ensure open dialogue and objective decision-making;

•directors are granted access to management and independent advisors as needed to fulfill their duties; and

•the Board and each of its committees conduct annual self-evaluations to assess performance and enhance effectiveness.

The adoption of these Corporate Governance Guidelines reflects our Board’s commitment to continuous improvement and the ongoing enhancement of our governance practices. By codifying these principles, our Board seeks to ensure rigorous oversight, thoughtful stewardship, and alignment with stockholder expectations.

Independence of the Board of Directors

As required under our Corporate Governance Guidelines and the Nasdaq Stock Market (Nasdaq) listing standards, a majority of the members of our Board of Directors must qualify as “independent.” The Board of Directors is responsible for affirmatively determining director independence, consulting with the Company’s legal counsel to ensure compliance with relevant securities laws, regulations, and Nasdaq listing standards, as updated from time to time. To assist in making these determinations, the Board evaluates each director’s independence against Nasdaq’s categorical standards, which include various objective tests and criteria.

Moreover, the Nasdaq rules mandate that each audit and compensation committee member must meet additional independence criteria specified by the Exchange Act. Specifically, audit committee members must comply with Rule 10A-3 under the Exchange Act, prohibiting them from accepting consulting or other compensatory fees, apart from board-related service, or being an affiliated person of the Company. Compensation committee members must adhere to Rule 10C-1 under the Exchange Act, where the Board must assess factors relevant to independence, including sources of compensation and affiliations.

After a comprehensive review of all relevant transactions, relationships, and circumstances concerning each director and their family members, including beneficial stock ownership, the Board affirmatively determined that all current directors are independent, except Dr. Belldegrun, Dr. Chang, and Mr. Kazam. Dr. Chang lacks independence due to his role as president and chief executive officer. Dr. Belldegrun is deemed non-independent due to his consulting relationship with the Company through Bellco Capital LLC. Mr. Kazam was determined to be non-independent based on the Company’s previous contractual relationship with Two River, terminated in December 2023, within the past three years.

In addition, our Board of Directors determined that Ms. Barrett, Dr. Mayo and Ms. Messemer, who currently comprise our Audit Committee, Ms. Barrett, Mr. DeYoung and Dr. Humer, who currently comprise our Compensation Committee, and Ms. Messemer, Mr. Sisitsky and Dr. Witte, who currently comprise our Nominating and Corporate Governance Committee, satisfy the independence standards for such committees established by the SEC and the Nasdaq Listing Rules, as applicable. In making such determinations, our Board of Directors considered the relationships that each such non-employee director has with our Company, including any relevant transactions described below in “Certain Relationships and Related Party Transactions” and the beneficial ownership of our capital stock by each non-employee director, as well as all other facts and circumstances our Board of Directors deemed relevant in determining independence. Independent directors regularly conduct executive sessions without management presence, led by Dr. Franz Humer, who serves as Lead Independent Director.

The Board has concluded that the current composition of its committees meets all applicable Nasdaq independence requirements and SEC regulations. For additional details, see the sections entitled “Information Regarding the Board of Directors and Corporate Governance—Information Regarding Committees of the Board of Directors” and “Transactions with Related Persons.”

Board Leadership Structure

Our Board is currently chaired by Dr. Belldegrun. Because the Company maintains a consulting agreement with Bellco, which is owned by Dr. Belldegrun (see more information below under the heading “Executive Chair Compensation”), Dr. Belldegrun is designated as a non-independent director. Our Board leadership structure features a Lead Independent Director, Dr. Franz Humer, who provides a strong independent oversight counterbalance to our Executive Chair. Dr. Humer presides over executive sessions of independent directors, facilitates communication between the independent directors and management, and ensures the effective functioning of the Board and its committees, thereby enhancing our corporate governance structure.

The Company believes that the role of the Lead Independent Director, in addition to the separation of the positions of Executive Chair and Chief Executive Officer ("CEO"), provides the Company with a governance structure that best advances the objectives of the Company while providing proper checks and balances on senior management, fostering open communication and reinforcing Board independence in its oversight of our business and affairs. In addition, we have a separate chair for each committee of our Board, and each of those positions is held by an independent director.

Distinctive Role of the Executive Chair

Dr. Belldegrun accepts no compensation under our Non-Employee Director Compensation Policy, which is described below. Instead, in view of his more expansive role, Dr. Belldegrun is compensated through the Company’s consulting agreement with Bellco. The compensation provided under the Bellco consulting agreement (as amended, the "Bellco Consulting Agreement") is determined on an annual basis by our Compensation Committee in connection with their annual review and is informed by peer data and analysis provided by the Compensation Committee’s independent compensation consultant.

Dr. Belldegrun’s responsibilities under the Bellco Consulting Agreement extend well beyond typical board chair duties, encompassing comprehensive operational and strategic involvement. Through his consulting relationship, Dr. Belldegrun serves in a highly engaged role that includes substantial involvement in management, strategy, and operations, working closely with the Chief Executive Officer and senior leadership. The following is a summary of Dr. Belldegrun’s activities under the Bellco Consulting Agreement:

1. Operational and Strategic Involvement:

•Works in close coordination with the Chief Executive Officer and senior management in the development and execution of corporate strategy and key operational initiatives.

•Regularly attends executive management meetings, including bi-weekly Executive Committee meetings, senior leadership meetings, operational reviews, and strategy sessions.

•Actively engaged in executive recruitment, retention, and talent development.

•Engages directly in advancing the Company’s clinical trials and strategic initiatives.

2. Greater Time Commitment:

•Devotes a level of time and engagement that exceeds that of a typical non-executive board chair.

•Maintains a continuous and active involvement in Company matters through frequent participation in non-board-related meetings, calls, and ongoing interactions with management and external stakeholders.

3. Scientific and Strategic Expertise:

•Provides expertise in CAR T therapy and oncology, contributing to clinical development strategy, trial design, innovation, and related business decisions.

•Participates in our Scientific Advisory Board, contributing scientific and medical perspectives relevant to product development.

•Assigns to the Company any intellectual property arising from services provided under the consulting agreement.

4. Project-Specific Responsibilities:

•Participates in discussions/negotiations with third parties relating to business development, including strategic transactions and collaborations.

•Engages with clinical investigators and trial sites in support of clinical development activities, including patient enrollment.

5. External Engagement:

•Represents the Company in interactions with investors, partners and other stakeholders, including participation in investor meetings and industry conferences.

•Participates in the development and maintenance of relationships with strategic partners and collaborators.

6. Industry Relationships and Networks:

•Provides access to industry relationships and networks that support the Company's business development and strategic objectives.

•Actively cultivates and leverages high-level industry contacts to advance the Company’s strategic objectives and market position.

These activities, and Dr. Belldegrun’s time commitment under the Bellco Consulting Agreement extend far beyond traditional board oversight. For more information on Dr. Belldegrun’s compensation under the Bellco Consulting Agreement, and the Board’s processes for evaluating and setting his compensation, see the section below under the heading “Director Compensation—Executive Chair Compensation.”

Classified Board Structure

As noted above, our Board of Directors is divided into three classes with each class having a three-year term. The Board of Directors continues to believe that a classified board remains appropriate at this time. Our classified board structure is thoughtfully designed to align with the unique demands and long-term strategies inherent in the biotechnology industry. We believe this view is shared among our peers as evidenced by the fact that among our executive compensation peers, 90% have a classified board structure. In assessing the continued appropriateness of our classified board structure, our Board also considered the following factors:

•Preserve Specialized and Stable Leadership - In biotech, sustained success depends heavily on deep scientific expertise, specialized technical understanding, and comprehensive regulatory knowledge. Our staggered board structure is specifically designed to retain directors who possess extensive and evolving insights into our proprietary CAR T technologies, clinical protocols, regulatory processes, funding strategies, and overall business operations. By mitigating the risk of abrupt changes in board composition, our structure ensures stable, informed oversight and decision-making continuity, essential for driving forward our complex and long-term therapeutic development initiatives.

•Enhance Negotiation Leverage in M&A or Strategic Partnerships - Given the significant value potential embedded in our pipeline, the classified board structure strategically positions us to optimize outcomes in critical negotiations, whether related to acquisitions, mergers, or strategic partnerships. By preventing a swift or wholesale change in board composition, this governance arrangement strengthens our negotiating position, reducing the risk of being pressured into premature or undervalued transactions that could otherwise jeopardize future stockholder value.

•Align with the Capital-Intensive Nature of Biotech - As a development-stage biotech company, we regularly undertake capital-intensive clinical trials, necessitating ongoing strategic equity raises to finance these critical endeavors. A classified board provides our long-term investors with a robust assurance that our governance and strategic direction remain stable, particularly during periods of financial vulnerability and evolution. This governance structure is highly attractive to sophisticated biotech investors, reinforcing confidence that strategic oversight remains consistent and insulated from short-term volatility.

•Protect Against Activist Investors with Misaligned Objectives - Activist investors or special interest groups may advocate short-term measures, such as premature asset divestitures or rapid exits, that could undermine our carefully planned, long-term strategy crucial for realizing the full potential of our innovative therapies. Our classified board acts as a prudent safeguard, ensuring that any significant shifts in corporate control or strategy occur through thoughtful deliberation rather than reactive decision-making, thereby protecting long-term stockholder interests and the continuity of our research programs.

After careful consideration, including consideration of the factors noted above, both the Nominating and Corporate Governance Committee and the full Board remain confident that maintaining our classified board structure optimally supports the achievement of our long-term strategic goals, facilitates informed and sophisticated oversight, and significantly enhances our ability to deliver sustained value to stockholders.

Our Board recognizes ongoing stockholder interest in board declassification and the benefits of annual director elections. We remain committed to an annual formal review of our classified structure. The Board will actively consider proposing a phased board declassification when these protections are no longer deemed appropriate to safeguard stockholder interests.

Board Qualifications

Experience and Expertise: Our Board is responsible for overseeing our business consistent with their fiduciary duties. This significant responsibility requires highly skilled individuals with various qualities, attributes, and professional experience. We believe the Board is well-rounded, with a balance of relevant perspectives and experience, as illustrated in the chart below.

Our Board believes that a diverse mix of backgrounds, perspectives, and experiences enhances its effectiveness and the quality of its decision-making. In identifying and evaluating candidates for service on the Board, the Nominating and Corporate Governance Committee considers a wide range of attributes, including professional experience, industry knowledge, leadership skills, and geographic background, among other characteristics that support sound governance and align with the Company’s long-term strategy.

We strive to build a Board with a broad range of perspectives relevant to our business, patients, investors, and other stakeholders. As part of both the annual nomination process and any new director search, the Committee seeks individuals who will contribute to the Board’s collective strength and effectiveness.

Experience/Skill

Barrett

Belldegrun

Chang

DeYoung

Humer

Kazam

Mayo

Messemer

Sato

Sisitsky

Witte

Biopharmaceutical Industry

●

Financial/Audit & Risk

●

Strategic Planning & Vision

●

Risk Management

●

Business Development & Strategic Transactions

●

Scientific Research & Drug Development

●

Public Policy/ Government Affairs/

Regulatory

●

Global/International Operations

●

Governance/Compliance

●

Mergers & Acquisitions (M&A)

●

Executive Leadership

●

Human Capital and Talent Development

●

Technology & Innovation

●

Capital Markets

●

Commercialization, Marketing & Branding

●

Operations, Manufacturing & Supply Chain

●

Investor Relations

●

Crisis Management

●

Character: Board members should possess the personal attributes necessary to be an effective director, including unquestioned integrity, sound judgment, a collaborative spirit, and commitment to the Company, our stockholders, and other constituencies.

Board Self-Evaluation Process

Our Board is committed to continuous improvement and conducts a robust annual self-assessment process designed to enhance Board effectiveness and governance practices by evaluating overall Board performance as well as individual director performance. The Nominating and Corporate Governance Committee oversees this evaluation process, including reviewing and approving the self-assessment questionnaire and the methodology used, consistent with our Corporate Governance Guidelines.

In 2026, the Board evaluation was facilitated through an extensive, structured questionnaire addressing key areas such as Board composition, information flow, operational efficiency, Board engagement and interaction, accountability, individual director contributions, and performance related to strategic decision-making.

All continuing directors participated fully in the evaluation, providing comprehensive, anonymous and candid feedback. An independent third-party advisor is used to collect, analyze, and summarize the directors' responses to preserve anonymity and objectivity, further enhancing the integrity of the assessment. The advisor will present detailed findings to each respective committee, and collectively to the full Board, fostering in-depth discussions focused on identified strengths and specific opportunities for improvement.

Key topics covered in the evaluation include:

•The effectiveness of our current Board leadership structure and independence.

•Quality, timeliness, and relevance of information provided to directors.

•Efficiency and effectiveness of Board and committee meetings.

•Board’s strategic oversight and response to evolving business challenges.

•Assessment of risk oversight processes and management accountability.

•Individual and collective director contributions and areas for skill enhancement.

Following the evaluation, the Board and each committee identifies actionable steps to address feedback, improve governance processes, and enhance Board and committee performance. This iterative process underscores the Board’s proactive approach to governance, promoting transparency, accountability, and long-term value creation for our stockholders.

Role of the Board in Risk Oversight

One of the key functions of our Board of Directors is informed oversight of our risk management process. The Board does not have a standing risk management committee, but rather administers this oversight function directly through the Board of Directors as a whole, as well as through the Audit Committee and the Compensation Committee. The Audit Committee and the Compensation Committee receive reports from management periodically regarding our assessment of risks. In addition, the Audit Committee and the Compensation Committee report regularly to our Board of Directors, which also considers our risk profile. Our Board of Directors, and its committees, focus on the most significant risks we face and our general risk management strategies. For instance, the Audit Committee plays a critical role in overseeing the Company’s comprehensive risk management program, including detailed reviews of financial, operational, regulatory, compliance, and cybersecurity risks. In addition, the Compensation Committee periodically reviews risks associated with our compensation policies and programs. While our Board of Directors oversees our risk management, management is responsible for day-to-day risk management processes. Our Board of Directors expects management to consider risk and risk management in each business decision, to proactively develop and monitor risk management strategies and processes for day-to-day activities and to effectively implement risk management strategies adopted by the Audit Committee, the Compensation Committee and our Board of Directors. We believe this division of responsibilities is the most effective approach for addressing the risks we face and that our Board of Directors’ leadership structure, which also emphasizes the independence of our Board of Directors in its oversight of its business and affairs, supports this approach.

Meetings of the Board of Directors

The Board of Directors met five times during the last fiscal year. Each current Board member attended at least 75% of the aggregate number of meetings of the Board and of the committees on which they served, held during the portion of the last fiscal year for which they were a director or committee member.

Information Regarding Committees of the Board of Directors

The Board maintains an Audit Committee, a Compensation Committee, a Nominating and Corporate Governance Committee, an International and Business Development Oversight Committee, and a Research and Development Committee. The following table provides membership information for each of the foregoing Board committees:

Directors

Age

Director Since

Audit

Compensation

Nominating and Corporate Governance

International and Business Development Oversight

Research and Development

Elizabeth Barrett ✓

2021

●

Arie Belldegrun, M.D. (EC)

2017

David Chang, M.D., Ph.D.

2018

John DeYoung ✓

2018

●

Franz Humer, Ph.D. (LID) ✓

2018

Joshua Kazam

2017

●

Stephen Mayo, Ph.D. ✓

2022

●

Deborah Messemer ✓

2018

●

Vicki Sato, Ph.D. ✓

2021

●

Todd Sisitsky ✓

2018

●

Owen Witte, M.D. ✓

2018

“EC” Executive Chair

“C” Committee Chair

“LID” Lead Independent Director

✓ Independent Director

Below is a description of each committee of the Board of Directors. The Board of Directors has determined that each member of each committee, other than Mr. Kazam on the International and Business Development Oversight Committee (a committee that is not required under Nasdaq rules), meets the applicable Nasdaq rules and regulations regarding “independence” and each member is free of any relationship that would impair his or her individual exercise of independent judgment with regard to the Company.

Audit Committee

The Audit Committee of the Board of Directors was established by the Board in accordance with Section 3(a)(58)(A) of the Exchange Act, to oversee the Company’s corporate accounting and financial reporting processes and audits of its financial statements. The Audit Committee is composed of three directors: Ms. Barrett, Dr. Mayo, and Ms. Messemer. Ms. Messemer serves as the chair of our Audit Committee.

The Board of Directors reviews the Nasdaq listing standards definition of independence for Audit Committee members on an annual basis and has determined that all members of the Company’s Audit Committee are independent (as independence is currently defined in Rule 5605(c)(2)(A)(i) and (ii) of the Nasdaq listing standards), are financially literate and offer significant expertise in financial reporting, audit procedures, and biotechnology best practices.

The Board of Directors has also determined that Ms. Messemer qualifies as an “audit committee financial expert,” as defined in applicable SEC rules. The Board made a qualitative assessment of Ms. Messemer’s level of knowledge and experience based on a number of factors, including her formal education and experience in financial and executive roles.

The functions of the Audit Committee include, among other things:

•evaluating the performance, independence and qualifications of our independent registered public accounting firm and determining whether to retain our existing independent registered public accounting firm or engage a new independent registered public accounting firm;

•reviewing and approving or pre-approving the engagement of the independent registered public accounting firm to perform audit services and any permissible non-audit services;

•monitoring the rotation of partners of the independent registered public accounting firm on our engagement team as required by law;

•prior to engagement of any independent registered public accounting firm, and at least annually thereafter, reviewing relationships that may reasonably be thought to bear on their independence, and assessing and otherwise taking the appropriate action to oversee the independence of our independent registered public accounting firm;

•reviewing our annual and quarterly financial statements and reports, including the disclosures contained under the caption “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” and discussing the statements and reports with our independent registered public accounting firm and management;

•reviewing, with our independent registered public accounting firm and management, significant issues that arise regarding accounting principles and financial statement presentation and matters concerning the scope, adequacy and effectiveness of our financial controls;

•reviewing with management and our independent registered public accounting firm any earnings announcements and other public announcements regarding material developments;

•establishing procedures for the receipt, retention and treatment of complaints received by us regarding financial controls, accounting or auditing matters and other matters;

•approving the report that the SEC requires in our annual proxy statement;

•reviewing, approving or ratifying and providing oversight of any related-person transactions in accordance with our related person transaction policy and reviewing management’s efforts to monitor compliance with legal and regulatory responsibilities, including our Code of Business Conduct and Ethics;

•reviewing our major financial risk exposures, including the guidelines and policies to govern the process by which risk assessment and risk management are implemented;

•reviewing on a periodic basis our investment policy, related person transaction policy and our Code of Business Conduct and Ethics;

•reviewing and evaluating on an annual basis the performance of the Audit Committee and the Audit Committee charter; and

•periodically reviewing our cybersecurity and other information technology risks, controls and procedures, including plans to mitigate cybersecurity risks, plans to respond to data breaches and any specific cybersecurity issues that could affect the adequacy of our internal controls.

Typically, the Audit Committee meets at least quarterly and with greater frequency, if necessary. Our Audit Committee met five times during 2025. The Board has adopted a written Audit Committee Charter that is available to stockholders on the Company’s website at www.allogene.com.

Compensation Committee

The Compensation Committee is composed of three directors: Ms. Barrett, Mr. DeYoung and Dr. Humer. Dr. Humer serves as the chair of the Compensation Committee. Our Board has determined that all members of the Compensation Committee are independent (as independence is currently defined in Rule 5605(d)(2) of the Nasdaq listing standards). The Board has adopted a written Compensation Committee charter that is available to stockholders on the Company’s website at www.allogene.com.

The functions of the Compensation Committee include, among other things:

•reviewing, modifying and approving (or if it deems appropriate, making recommendations to the full Board regarding):

• our overall compensation strategy and policies;

•the compensation and other terms of employment of our executive officers, including the terms of any employment agreements, severance arrangements, change in control protections and any other compensatory arrangements for our executive officers;

•performance goals and objectives relevant to the compensation of our executive officers and assessing their performance against these goals and objectives; and

•policies with respect to equity compensation arrangements, including implementing, modifying, or terminating equity incentive plans and programs;

•evaluating risks associated with our compensation policies and practices and assessing whether risks arising from our compensation policies and practices for our employees are reasonably likely to have a material adverse effect on us;

•overseeing the human capital management;

•reviewing and making recommendations to the full Board regarding the type and amount of compensation to be paid or awarded to our non-employee board members;

•establishing policies with respect to votes by our stockholders to approve named executive officer compensation as required by Section 14A of the Exchange Act and determining our recommendations regarding the frequency of advisory votes on named executive officer compensation, to the extent required by law;

•reviewing and assessing the independence of compensation consultants, legal counsel and other advisors as required by Section 10C of the Exchange Act;

•administering our equity incentive plans;

•reviewing the competitiveness of our executive compensation program and evaluating the effectiveness of our compensation policy and strategy in achieving expected benefits to us;

•adopting and administering clawback policies and approving clawback provisions for incentive-based compensation arrangements applicable to senior executives,and reviewing the facts and circumstances regarding whether to exercise any clawback right on behalf of the Company;

•reviewing with management and approving our disclosures under the caption “Compensation Discussion and Analysis” in our periodic reports or proxy statements to be filed with the SEC, to the extent such caption is included in any such report or proxy statement;

•preparing the report from the Compensation Committee to be included in our annual proxy statement (if any), in accordance with the applicable SEC rules and regulations; and

•reviewing and assessing on an annual basis the performance of the Compensation Committee and the Compensation Committee charter.

Compensation Committee Processes and Procedures

Typically, the Compensation Committee meets at least quarterly and with greater frequency if necessary. Our Compensation Committee met five times during 2025. The agenda for each meeting is usually developed in consultation with the Chair of the Compensation Committee, the Executive Chair, Chief Executive Officer, Chief People Officer, General Counsel, and Compensia, Inc. ("Compensia"), the Compensation Committee’s independent compensation consultant. The Compensation Committee meets regularly in executive session. However, from time to time, various members of management and other employees as well as outside advisors or consultants may be invited by the Compensation Committee to make presentations, to provide financial or other background information or advice or to otherwise participate in Compensation Committee meetings. The Chief Executive Officer may not participate in, or be present during, any deliberations or determinations of the Compensation Committee regarding his compensation or individual performance objectives. The charter of the Compensation Committee grants the Compensation Committee full access to all books, records, facilities and personnel of the Company. In addition, under the charter, the Compensation Committee has the authority to obtain, at the expense of the Company, advice and assistance from compensation consultants and internal and external legal, accounting or other advisors and other external resources that the

Compensation Committee considers necessary or appropriate in the performance of its duties. The Compensation Committee has direct responsibility for the oversight of the work of any consultants or advisers engaged for the purpose of advising the Committee. In particular, the Compensation Committee has the sole authority to retain, in its sole discretion, compensation consultants to assist in its evaluation of executive and director compensation, including the authority to approve the consultant’s reasonable fees and other retention terms. Under the charter, the Compensation Committee may select, or receive advice from, a compensation consultant, legal counsel or other adviser to the Compensation Committee, other than in-house legal counsel and certain other types of advisers, only after taking into consideration six factors, prescribed by the SEC and Nasdaq, that bear upon the adviser’s independence; however, there is no requirement that any adviser be independent.

During the past fiscal year, after taking into consideration the six factors prescribed by the SEC and Nasdaq that did not raise a conflict of interest, the Compensation Committee engaged Compensia as a compensation consultant. The Compensation Committee requested that Compensia develop a comparative group of companies for purposes of reviewing industry-wide compensation practices and trends and assessing the competitiveness of our executive and non-employee director compensation programs and compensation levels. Compensia also meets with certain members of management and human resources to learn more about the Company’s business operations and strategy, key performance metrics and strategic goals, as well as the labor markets in which the Company competes. Compensia ultimately developed guidance primarily pertaining to our peer group, equity compensation strategy and executive and non-employee director compensation determinations that were presented to and actively discussed with the Compensation Committee and the Board for their consideration and approvals.

Nominating and Corporate Governance Committee

The Nominating and Corporate Governance Committee is composed of three directors: Ms. Messemer, Mr. Sisitsky and Dr. Witte. Effective on the date of the Annual Meeting, the Nominating and Corporate Governance Committee will be comprised of Ms. Messemer and Dr. Witte. Our Board has determined that each of the members of this committee is independent (as independence is currently defined in Rule 5605(a)(2) of the Nasdaq listing standards). Dr. Witte serves as the chair of our Nominating and Corporate Governance Committee. The Board has adopted a written Nominating and Corporate Governance Committee charter that is available to stockholders on the Company’s website at www.allogene.com.

The Nominating and Corporate Governance Committee of the Board of Directors is responsible for:

•identifying, reviewing, evaluating, nominating and recommending candidates to serve on our Board of Directors consistent with criteria approved by our Board;

•determining the minimum qualifications for service on our Board of Directors;

•evaluating director performance on the board and applicable committees of the board and determining whether continued service on our board is appropriate;

•evaluating nominations by stockholders of candidates for election to our Board of Directors;

•considering and assessing the independence of members of our Board of Directors;

•overseeing the Board's committee structure and operations;

•developing a set of corporate governance policies and principles, periodically reviewing and assessing these policies and principles and their application and recommending to our Board of Directors any changes to such policies and principles;

•reviewing environmental, social and governance (ESG) matters, policies and initiatives;

•considering questions of possible conflicts of interest of directors as such questions arise; and

•reviewing and evaluating on an annual basis the performance of the Nominating and Corporate Governance Committee and the Nominating and Corporate Governance Committee charter.

Typically, the Nominating and Corporate Governance Committee meets at least three times a year, and with greater frequency if necessary. Our Nominating and Corporate Governance Committee met three times during 2025.

Director Nominee Qualifications and Nomination Process

The Nominating and Corporate Governance Committee believes that the candidates for director, both individually and collectively, have the integrity, experience, judgment, commitment (including having sufficient time to devote to us and level of participation), skills and expertise appropriate for us. In assessing the directors, both individually and collectively, the Nominating and Corporate Governance Committee considers our current needs, and the needs of the Board of Directors, to maintain a balance of knowledge, experience, capability, geography, thought, viewpoints, backgrounds, skills, and expertise. However, the Nominating and Corporate Governance Committee retains the right to modify these qualifications from time to time.

The Nominating and Corporate Governance Committee uses its and the Company’s network of contacts to compile a list of potential candidates, but may also engage, if it deems appropriate, a professional search firm. Candidates for director nominees are reviewed in the context of the current composition of the Board of Directors, our operating requirements and the long-term interests of stockholders. In conducting this assessment, the Nominating and Corporate Governance Committee typically considers geography, thought, viewpoints, backgrounds, skills and such other factors as it deems appropriate given our current needs and the needs of the Board of Directors, to maintain a balance of knowledge, experience and capability. In the case of incumbent directors whose terms of office are set to expire, the Nominating and Corporate Governance Committee reviews these directors’ overall service to us during their terms, including the number of meetings attended, level of participation, quality of performance and any other relationships and transactions that might impair the directors’ independence. In the case of new director candidates, the Nominating and Corporate Governance Committee also determines whether the nominee is independent for Nasdaq purposes, which determination is based upon applicable Nasdaq listing standards, applicable SEC rules and regulations and the advice of counsel, if necessary. To the extent any search firm is retained to assist the Nominating and Corporate Governance Committee in seeking candidates for the Board, the search firm will be instructed to seek to include a mixture of candidates in terms of geography, thought, viewpoints, backgrounds, skills, experience, and expertise from, among other areas, professional and academic areas relevant to the Company’s areas of focus. In addition, the Nominating and Corporate Governance Committee conducts any appropriate and necessary inquiries into the backgrounds and qualifications of possible candidates after considering the function and needs of the Board of Directors. The Nominating and Corporate Governance Committee meets to discuss and consider the candidates’ qualifications and then selects a nominee for recommendation to the Board of Directors by majority vote.

The Nominating and Corporate Governance Committee will consider director candidates recommended by stockholders. The Nominating and Corporate Governance Committee does not intend to alter the manner in which it evaluates candidates, including the minimum criteria set forth above, based on whether or not the candidate was recommended by a stockholder. Stockholders who wish to recommend individuals for consideration by the Nominating and Corporate Governance Committee to become nominees for election to the Board of Directors may do so by delivering a written recommendation to the Nominating and Corporate Governance Committee at the following address: 210 East Grand Avenue, South San Francisco, California 94080, Attn: Corporate Secretary, no later than the 90th day and no earlier than the 120th day prior to the one-year anniversary of the preceding year’s annual meeting of stockholders. Submissions must include, among other things, (1) the name and address of the stockholder on whose behalf the submission is made; (2) number of our shares that are owned beneficially by such stockholder as of the date of the submission; (3) the full name of the proposed candidate; (4) description of the proposed candidate’s business experience for at least the previous five years; (5) complete biographical information for the proposed candidate; (6) a description of the proposed candidate’s qualifications as a director and (7) any other information required by our Amended and Restated Bylaws. We may require any proposed nominee to furnish such other information as we may reasonably require to determine the eligibility of such proposed nominee to serve as our independent director or that could be material to a reasonable stockholder’s understanding of the independence, or lack thereof, of such proposed nominee.

International and Business Development Oversight Committee

Our International and Business Development Oversight Committee consists of Dr. Humer, as chair, and Mr. DeYoung, Mr. Kazam and Dr. Sato. Typically, the International and Business Development Oversight Committee meets at least three times a year, and with greater frequency if necessary. Our International and Business Development Oversight Committee met three times during 2025. The purpose of the International and Business Development Oversight Committee is to

assist our Board of Directors in fulfilling our Board of Directors’ responsibilities to (1) oversee our international and business development strategic planning, and (2) review and evaluate any of our specific strategic initiatives, including the risks and opportunities relating to such initiatives. The International and Business Development Oversight Committee charter can be found on our website at www.allogene.com.

Research and Development Committee

Our Research and Development Committee consists of Dr. Mayo, Dr. Sato, and Dr. Witte, who serves as chair of the committee. The Research and Development Committee met twice during 2025. The purpose of the Research and Development Committee is to review and provide advice for the Company’s research and development programs on behalf of the Board, including (i) to assist the Board in its oversight of the Company’s research and development, (ii) to assist in discussing significant emerging trends and issues in science and technology and consider the potential impact of such on the Company’s research and development, and (iii) to provide advice to the Company’s management and to the Board in connection with the allocation, deployment, utilization of, and investment of resources in the Company’s research and development. The Research and Development Committee charter can be found on our website at www.allogene.com.

Stockholder Communications with the Board of Directors

The Company’s Board has adopted a formal process by which stockholders may communicate with the Board or any of its directors. Stockholders who wish to communicate with the Board may do so by sending written communications addressed to: Allogene Therapeutics, Inc., Attn: Corporate Secretary, 210 East Grand Avenue, South San Francisco, California 94080. These communications will be reviewed by the Corporate Secretary, who will determine whether the communication is appropriate for presentation to the Board or the relevant director. The purpose of this screening is to allow the Board to avoid having to consider irrelevant or inappropriate communications (such as advertisements, solicitations and hostile communications).

Stockholder Engagement

We recognize the importance of maintaining a robust, proactive, and year-round stockholder engagement program. Through regular and constructive dialogue with existing and prospective investors, we seek to clearly communicate our business strategy, share perspectives, and solicit feedback on topics including corporate governance, executive compensation, and other matters relevant to our business.

Our Investor Relations function leads these efforts, with active participation from senior management, including our Chief Executive Officer, Chief Financial Officer, Chief Medical Officer, and Chief Corporate Affairs and Brand Strategy Officer. Throughout the year, management engages with investors through a variety of forums, including one-on-one meetings, investor conferences, analyst calls, and non-deal roadshows, conducted both virtually and in person.

We engage with investors both responsively, by addressing inbound inquiries, and proactively, through targeted outreach to institutional investors, including portfolio managers, analysts, and stewardship professionals, regardless of ownership size or analyst coverage. We also engage with prospective investors and respond to inquiries from individual stockholders. Feedback and insights from these interactions are periodically shared with our Board of Directors and relevant committees.

Consistent with our prior practice, we evaluated opportunities for targeted outreach in 2025, including engagement on executive compensation and corporate governance matters. In connection with this evaluation, we conducted outreach to certain stockholders to solicit feedback on these topics; however, those stockholders declined or did not pursue meetings focused on executive compensation. During this period, our stockholder base continued to evolve, and we adapted our engagement efforts accordingly, focusing on maintaining open lines of communication with both existing and prospective investors.

At our 2025 annual meeting of stockholders, we received strong support across our governance and compensation proposals, including approximately 90.77% support for our say-on-pay proposal (excluding abstentions and broker non-votes), and each director nominee was elected with between approximately 84% and 98% of votes cast in favor. These results, together with ongoing investor dialogue, continue to inform our engagement approach.

We remain committed to constructive and transparent engagement with our stockholders and will continue to tailor our outreach efforts to reflect our evolving ownership base and investor interest. In addition, our Board of Directors and management remain focused on continuous improvement in our governance and compensation practices, including regular review of our board structure, voting standards, and compensation and equity programs.

Code of Ethics

The Company has adopted the Code of Business Conduct and Ethics that applies to all officers, directors and employees, which was amended in March 2026 as part of our annual review of our governance policies and our ongoing goal to enhance our corporate governance practices. The Code of Business Conduct and Ethics is available on the Company’s website at www.allogene.com. We intend to promptly disclose on our website, to the extent required by the rules and regulations of the SEC, (i) the nature of any amendment to the Code of Business Conduct and Ethics that applies to our principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions, and (ii) the nature of any waiver, including an implicit waiver, from a provision of the Code of Business Conduct and Ethics that is granted to one of these specified individuals, the name of such person who is granted the waiver and the date of the waiver.

Environmental, Social & Governance (ESG) Practices

We remain committed to responsible and sustainable business practices, aligning our ESG initiatives with our core mission and long-term strategic objectives. Recognizing that our stockholders hold a variety of diverse perspectives, we prioritize transparency, accountability, and value creation in all ESG-related activities. Our Nominating and Corporate Governance Committee continues to oversee and advise our Board of Directors on ESG matters, including strategic initiatives, potential risks, opportunities, and performance metrics, as detailed in its charter. The Committee regularly updates the full Board on ESG progress and stakeholder feedback.

Belonging, Fairness and Representation

We are committed to cultivating a workplace environment characterized by belonging, fairness, and representation. We foster a supportive, respectful, and collaborative atmosphere, encouraging open communication and valuing distinct perspectives, experiences, and backgrounds. Our approach emphasizes equitable treatment and opportunities for all employees based on merit and qualifications.

Our talent acquisition strategies are designed to attract the best available candidates from a diverse and qualified talent pool. We utilize reputable recruitment platforms, provide training to interviewers and hiring managers to mitigate unconscious bias, and regularly review these processes for fairness and effectiveness. We are committed to ensuring that hiring decisions are driven solely by qualifications and job-related factors.

Our initiatives support our broader culture of responsibility, empowerment, and psychological safety, ensuring all employees feel valued, engaged, and committed to our mission. Key practices include:

•Promoting respectful, open and transparent communication and cooperation between all employees.

•Encouraging constructive employee feedback and active participation.

•Supporting teamwork and collaboration across departments and roles.

•Engaging positively and constructively with the communities we serve.

We will continue seeking varied viewpoints and constructive input from employees and stockholders alike, adapting our strategies to support both sustainable business growth and the varied interests of our stakeholders. For more information regarding the profile of our employees, please see our EEO-1 report that can be found on the “Investors—Corporate Governance—Documents and Charters” section of our website, www.allogene.com.

Competitive Pay & Benefits and Pay Equity

We are committed to fair and equitable compensation practices. Our compensation structure is informed by market-driven benchmarks and data-driven analysis, regularly reviewed to maintain pay equity. Annual compensation reviews confirm

our ongoing commitment to fair pay, based on role requirements, market comparisons, individual and organizational performance, and internal equity.

We strive to provide competitive and robust compensation and benefits programs that help meet the varying needs of our employees. Our total compensation package includes competitive pay, comprehensive healthcare benefits package for employees, family medical leave and flexible work schedules. In addition, we offer every full-time employee, both exempt and non-exempt, the benefit of equity ownership in the company through stock option grants, restricted stock unit grants, and our employee stock purchase plan. In addition, we provide a Section 401(k) plan to our employees, including our Named Executive Officers, as discussed in the section below entitled “—Section 401(k) Plan.”

Employee Development, Training and Retention

The competition for talent in our industry and in the San Francisco Bay Area where our headquarters and manufacturing facility are located is significant. As a result, our commitment to investing in human capital is of critical importance to ensure our ability to attract, develop and retain key talent to support the growth of our business. We focus on providing training opportunities and promotional opportunities. Learning and development, training and other resources are an integral part of retaining our employees and creating a culture of learning and leadership within Allogene. We also train relevant members of our team on important environmental health and safety topics to help ensure we protect our people and our environment as we operate our business. We encourage our employees to participate and take advantage of a variety of learning and development resources, including online business skills courses, professional development events, and external training programs based on individual needs. We also actively review employee performance and business needs every six months that lead to promotional opportunities for employees across departments and levels.

Environment

We are committed to sustainable business practices that minimize employee and environmental risks as well as implementing processes that reduce our overall carbon footprint and reduce water consumption. We aim to reduce our environmental footprint and impact through corporate initiatives and in compliance with applicable laws and regulations. The objectives of our approach to minimize our environmental impact are to:

•be an environmentally responsible corporate citizen;

•monitor consumption of resources used by Allogene in our operations;

•educate our employees and provide channels for employees to create environmental awareness and contribute to our efforts; and

•monitor and continually improve our measures to use resources more efficiently and minimize adverse environmental effects.

Most of our environmental initiatives have focused on our state-of-the-art manufacturing facility, Cell Forge 1 ("CF1"), in Newark, California. Our 136,000 square foot facility was designed and constructed from the ground-up to optimize energy performance and efficiency. This includes the use of low-emitting materials, segregation and recycling of construction waste, and selection of energy-efficient utility equipment. With construction completed in 2020, it is a high-profile example of our commitment to environmental sustainability.


Proposal 2 Advisory Vote on Executive Compensation

At our 2020 Annual Meeting of Stockholders, the stockholders indicated their preference that we solicit a non-binding advisory vote on the compensation of our named executive officers, commonly referred to as a “say-on-pay vote,” every year. The Board has adopted a policy that is consistent with that preference. In accordance with that policy, this year, we are again asking the stockholders to approve, on an advisory basis, the compensation of our named executive officers as disclosed in this proxy statement in accordance with SEC rules.

Recommendation

The Board recommends the vote “FOR” approval of, on an advisory basis, the compensation of our named executive officers.

This vote is not intended to address any specific item of compensation, but rather the overall compensation of the Company’s named executive officers and the philosophy, policies and practices described in this Proxy Statement. Our executive compensation program for our executive officers is designed to attract, motivate, and retain individuals of superior ability and managerial talent who can successfully perform and succeed in our environment. Our named executive officers are rewarded for the achievement of our near-term and longer-term financial and strategic goals and for driving corporate performance. This program contains elements of cash and equity-based compensation designed to align the interests of our executives with those of our stockholders as well as have the appropriate incentive to achieve key strategic and financial performance measures by linking compensation opportunities and actual compensation earned through our pay-for-performance compensation program to the achievement of corporate goals. We also make equity grants designed to align our named executive officers’ compensation to the long-term performance of Allogene in addition to creating an ownership culture that helps unify the interests of our executives and stockholders.

Our Board and the Compensation Committee regularly review the compensation programs for our named executive officers and undertake a comprehensive annual review to ensure that our compensation policies and programs align with current market practices and the interests of our stockholders. The “Discussion of Named Executive Officer Compensation” section of this Proxy Statement, the compensation tables, and the related narrative disclosure contained in this Proxy Statement describes in detail our executive compensation program and the decisions made by the Compensation Committee with respect to the fiscal year ended December 31, 2025.

In light of our performance in 2025, we believe that the compensation paid to our named executive officers was appropriate. Accordingly, the Board is asking the stockholders to indicate their support for the compensation of the Company’s named executive officers as described in this Proxy Statement by casting a non-binding advisory vote “FOR” the following resolution:

“RESOLVED, that the compensation paid to the Company’s named executive officers, as disclosed pursuant to Item 402 of Regulation S-K, including the compensation tables and narrative discussion is hereby APPROVED.”

Because the vote is advisory, it is not binding on the Board or the Company. Nevertheless, the views expressed by the stockholders, whether through this vote or otherwise, are important to management and the Board and, accordingly, the Board and the Compensation Committee intend to consider the results of this vote in making determinations in the future regarding executive compensation arrangements.

Unless the Board decides to modify its policy regarding the frequency of soliciting advisory votes on the compensation of the Company’s named executive officers, and in particular, after consideration of the outcome of the say-on-pay frequency proposal included in this Proxy Statement, the next scheduled say-on-pay vote will be at the 2027 Annual Meeting of Stockholders.

Executive Officers

Executive officers are chosen by and serve at the discretion of the Board of Directors. Set forth below is biographical information for each of our executive officers as of the date of this Proxy Statement, other than Dr. Chang, whose biographical information is set forth above.

Ben Beneski, 49, has served as our Senior Vice President and Chief Technical Officer since March 2025. Mr. Beneski joined Allogene in 2019 as our Executive Director and Plant Manager, where he played a pivotal role in the design, construction, and successful startup of Cell Forge 1, our state-of-the-art cell therapy manufacturing facility. Since then, Mr. Beneski has advanced through a series of increasingly senior roles, including Vice President of Manufacturing and Vice President of Product Development and Manufacturing where he led the development of next-generation platforms, effectively managed internal and external manufacturing networks, and drove key initiatives to support IND submissions and ensure commercial readiness. Prior to joining Allogene, Mr. Beneski held senior manufacturing roles at various biotechnology companies, including Vir Biotechnology and Amgen. He earned B.S. in chemical engineering from Stevens Institute of Technology and an MBA from Northeastern University.

Earl Douglas, 63, has served as the Company’s Senior Vice President, General Counsel and Compliance Officer since August 2023 and as our Corporate Secretary since January 2024. Before joining Allogene, Mr. Douglas served as Executive Vice President, General Counsel of Applied Molecular Transport. Prior to that role, he served in the same capacity for Kiverdi, Inc. He has also served as Vice President, General Counsel at BioMimetic Therapeutics, Spinal Dynamics, and OPX Biotechnologies. He previously served as Counsel with Wilson Sonsini Goodrich & Rosati, and earlier in his career practiced as an Associate with Weil, Gotshal & Manges. In addition, Mr. Douglas currently serves as a member of the board of directors of Lynch Regenerative Medicine, LLC. He earned his B.S. in chemical engineering from the Massachusetts Institute of Technology ("MIT") and his J.D. from Columbia University School of Law.

Geoffrey Parker, 61, has served as our Executive Vice President, Chief Financial Officer since October 2023. Prior to joining us, Mr. Parker served as Chief Operating Officer, Chief Financial Officer and Executive Vice President of Tricida, Inc. Prior to joining Tricida, Mr. Parker served as Chief Financial Officer of Anacor Pharmaceuticals, and served as a Partner and Managing Director at Goldman Sachs, where he led the West Coast Healthcare Investment Banking group. In addition, Mr. Parker currently serves as a member of the board of directors of Perrigo Company plc. He earned a B.A. with a double major in Economics and Engineering Sciences from Dartmouth College and an MBA from the Stanford Graduate School of Business.

Zachary Roberts, M.D., Ph.D., 48, has served as our Chief Medical Officer since April 2023 and as our Executive Vice President, Research and Development since January 2023. Previously, Dr. Roberts served as Chief Medical Officer for Instil Bio, Inc. ("Instil") from March 2020 to November 2022. Prior to joining Instil, he served in various roles for Kite, during his four-year tenure, with his last position as Vice President, Clinical Development from February 2018 to May 2019. Prior to joining Kite, Dr. Roberts served in various roles in Amgen, with his last position as Clinical Research Medical Director for Amgen Oncology from January 2015 to July 2015. Dr. Roberts completed his training in internal medicine and hematology/oncology at the Massachusetts General Hospital and Dana Farber Cancer Institute. He earned his B.S. in microbiology and immunology from the University of Maryland, College Park and both his Ph.D. in immunology and his M.D. from the University of Maryland, Baltimore.


Executive Compensation

Discussion of Named Executive Officer Compensation

We are a smaller reporting company under the applicable rules and regulations of the Securities and Exchange Commission, and thus are not required to include a Compensation Discussion and Analysis in this Proxy Statement. However, we believe providing additional disclosure regarding our compensation philosophy, policies and principles underlying our executive compensation decisions constitutes good corporate governance and provides our stockholders with valuable information regarding our executive compensation practices. In particular, this Discussion of Named Executive Officer Compensation is designed to provide you with a better understanding of our compensation philosophy and how our Compensation Committee makes decisions regarding compensation for our named executive officers listed below.

Overview

This Discussion of Named Executive Officer Compensation discusses the compensation philosophy, policies and principles underlying our executive compensation decisions for 2025. It provides qualitative information on the factors relevant to these decisions and the manner in which compensation is awarded to our named executive officers (our "Named Executive Officers" or "NEOs") for the fiscal year ended December 31, 2025, which consist of our principal executive officer and the Company’s two other most highly compensated executive officers during 2025. Our Named Executive Officers for 2025 were:

•David Chang, M.D., Ph.D., our President and Chief Executive Officer;

•Zachary Roberts, M.D., Ph.D., our Executive Vice President, Research and Development and Chief Medical Officer; and

•Geoffrey Parker, our Executive Vice President and Chief Financial Officer.

Corporate Highlights for 2025

We are a clinical-stage biotechnology company pioneering the development of allogeneic CAR T cell products for cancer and autoimmune disease. Our Compensation Committee determined that in 2025 the Company continued to advance its vision of pioneering allogeneic CAR T cell therapy, achieving several significant milestones:

Cemacabtagene Ansegedleucel (cema-cel) and ALPHA3 Program:

•Advanced the pivotal Phase 2 ALPHA3 trial evaluating cemacabtagene ansegedleucel ("cema-cel") as a first-line (1L) MRD-guided consolidation strategy in large B-cell lymphoma ("LBCL"), expanding activation to over 60 community and academic sites in the United States and Canada, and continuing international expansion planning.

•Expanded the strategic MRD collaboration with Foresight Diagnostics via an amended and restated collaboration agreement, thereby providing the framework for supporting development of the MRD assay outside the U.S. (EU, UK, Canada, Australia) for ALPHA3 and the broader cema-cel development strategy.

•Engaged the hematology/oncology community through major medical meetings, including public disclosures supporting Trial-in-Progress presentations for ALPHA3 at the American Society of Clinical Oncology and American Society of Hematology 2025 annual meetings.

•Strengthened the cema-cel legal and territorial foundation through a favorable Cellectis/Servier arbitration outcome related to cema-cel, which reconfirmed our development and commercial control for cema-cel in the U.S., EU Member States, and UK, clarified key license-related issues, and resulted in the return to us of 20M € from escrow.

ALLO-316 Development for Renal Cell Carcinoma (RCC):

•Showcased updated Phase 1 TRAVERSE clinical data for ALLO-316 at ASCO 2025, highlighting antitumor activity in advanced/metastatic RCC, including a 31% confirmed response rate in patients with CD70 TPS ≥50% and ongoing durability among responders, supported by reported robust expansion/persistence with standard lymphodepletion.

•Advanced regulatory-path planning for ALLO‑316, including alignment discussions with the FDA on the design of a pivotal/registration trial to support next-step development and potential strategic partnering initiatives.

Autoimmune Disease Program Execution:

•Secured FDA IND clearance for ALLO‑329 (CD19/CD70 dual-targeted allogeneic CAR T) and subsequently received three FDA Fast Track designations for ALLO‑329 across lupus, myositis, and scleroderma indications, underscoring the program’s potential to address unmet need.

•Initiated the Phase 1 RESOLUTION trial in rheumatology during 2025 and progressed to active enrollment, using a design that evaluates two approaches intended to broaden patient accessibility: cyclophosphamide-only lymphodepletion and no lymphodepletion.

•Advanced Allogene’s Dagger® technology into autoimmune disease development, with ALLO‑329 incorporating Dagger to potentially reduce or eliminate lymphodepletion while targeting both CD19+ B cells and CD70+ activated T cells implicated in autoimmune pathology.

Infrastructure and Operating Execution:

•Continued to leverage our internal proprietary state-of-the-art Cell Forge 1 ("CF1") cGMP manufacturing facility in Newark, California to exclusively manufacture product candidates for clinical trials.

•Executed operational and cost realignment initiatives during 2025, including a workforce reduction and reduced manufacturing operations, while maintaining sufficient inventory to support ALPHA3, RESOLUTION and TRAVERSE near-term clinical needs.

These 2025 milestones reflect Allogene’s continued effort to evolve allogeneic CAR T therapy toward broader real-world adoption, including advancing MRD-guided earlier-line oncology development, extending the platform into autoimmune disease with reduced-intensity or lymphodepletion-free clinical regimens, and supporting scalable execution through integrated manufacturing and disciplined operations.

Compensation Highlights for 2025

The Compensation Committee, in consultation with the Board, is responsible for establishing, implementing, and overseeing our overall compensation strategy and policies, including our executive compensation program, in a manner that supports our business objectives, taking into consideration best practices and emerging trends, stockholder input as well as data and feedback provided by its independent executive compensation consultant, Compensia. In the past year, we continued to align our compensation program with stockholder interests including the following actions:

•Maintained all NEO base salaries at 2024 levels, with no increase for 2025, which was the fourth consecutive year that Dr. Chang’s base salary was not increased.

•In 2025, our Chief Executive Officer’s base salary represented approximately 11.8% of his total compensation. Excluding our Chief Executive Officer, base salaries comprised approximately 22.4% of our other Named Executive Officers' total compensation, on average.

•A substantial majority of our Named Executive Officers’ compensation continued to be delivered in long-term incentives, which are inherently performance-based and aligned with stockholder value creation. Approximately 81.5% of our Chief Executive Officer’s total compensation for 2025 was in the form of long-term incentives. For our other Named Executive Officers, on average, approximately 68.4% of their total compensation for 2025 was represented by long-term incentives.

•For 2025 annual long-term incentives, the Compensation Committee reintroduced performance stock units ("PSUs") into the executive equity program. The Committee utilized a mix of restricted stock units ("RSUs"), PSUs and stock options to provide a target long-term incentive ("LTI") award opportunity that was heavily weighted towards performance-based vehicles, consisting of approximately 20% PSUs, 55% stock options and 25% RSUs. The Compensation Committee continues to view stock options as strongly performance-based and aligned with long-term stockholder interests given our pre-commercial stage of maturity.

The Compensation Committee determined that 2025 annual cash incentive payouts were based strictly on corporate performance, with the final corporate score set at 85% of target based on achievement of approximately 85% of our pre-established annual goals. This approach is consistent with our “One Allogene” culture, and reflects our belief that our leadership team should be unified in its pursuit of strategic execution and should share equally in the Company’s successes and shortfalls. No discretionary payments or upward adjustments were made for any Named Executive Officer. A detailed description of the 2025 milestones in support of the Company’s business strategy and the Compensation Committee's assessment of performance against these milestones are described below under the heading “2025 Annual Performance-Based Cash Incentive.”


Dr. Chang’s Actual 2025 Direct Total Compensation			Other NEOs Actual 2025 Direct Total Compensation

The graphs above display the base salary, cash incentive, long-term incentives (stock option, RSU and PSU grant date fair values) of our Chief Executive Officer, Dr. Chang (left chart) and other NEOs (Dr. Roberts and Mr. Parker) (right chart). The equity values reflected in the graphs above and the compensation tables below reflect the grant date fair values.

Executive Compensation Governance Practices

Below we summarize certain executive compensation related governance practices that we follow and that we believe serve our stockholders’ long-term interests.


WHAT WE DO
✓			DO maintain an executive compensation program designed to align pay with performance
✓			DO conduct an annual say-on-pay advisory vote
✓			DO align pay and performance with the significant majority of total compensation linked either to the achievement of Company operational, strategic goals established at the beginning of the performance period or to sustained stock price appreciation
✓			DO maintain a Compensation Committee comprised solely of independent directors
✓			DO have double trigger on executive change in control severance arrangements
✓			DO prohibit speculative trading of company stock (short sales, put or call options, hedging transactions, etc.)
✓			DO prohibit pledging or the use of common stock to secure a margin or other loan
✓			DO retain an independent compensation consultant
✓			DO maintain stock ownership guidelines for executives and directors
✓			DO maintain an executive officer recoupment (claw back) policy
✓			DO conduct an annual comprehensive compensation program risk assessment
✓			DO evaluate officer compensation levels against a peer group of similarly situated companies
✓			DO conduct an annual comprehensive review of compensation of our senior vice presidents and above, including our NEOs
✓			DO require equity awards granted to our executive officers vest over multi-year periods or based on the achievement of key strategic goals


WHAT WE DO NOT DO
✘			NO incentives that may motivate excessive risk-taking or present a windfall risk
✘			NO pay decisions that circumvent pay-for-performance, such as options backdating or waiving performance requirements for performance stock units
✘			NO repricing or replacing of underwater stock options/SARs without prior shareholder approval (including cash buyouts and voluntary surrender of underwater options)
✘			NO agreements providing for tax gross-ups for any employee or director (except for HSR fee reimbursement from time to time)
✘			NO material perquisites
✘			NO excessive termination or CIC severance payments (2 years or less)
✘			NO executive single-trigger change in control benefits
✘			NO severance payments or benefits for executives who voluntarily terminate their employment
✘			NO guaranteed compensation and all executives are employed “at will”
✘			NO guaranteed annual bonus payouts
✘			NO benefits for our executives not generally available for all employees
✘			NO granting of in-the-money stock options

Response to Advisory Vote on Executive Compensation

At our 2025 Annual Meeting of Stockholders, our say-on-pay advisory vote received the support of approximately 91% of the votes cast (excluding abstentions and broker non-votes). The Compensation Committee reviewed these results and considers this high level of support to be a strong endorsement of our executive compensation philosophy and programs.

As a result of this significant stockholder consensus, the Committee determined that no substantial changes to our compensation program were necessary specifically in response to the vote. We continue to engage in regular dialogue with our major stockholders to ensure our pay practices remain aligned with their interests and continue to drive long-term value creation. Our Compensation Committee expects to continue to consider the outcome of our say-on-pay votes and our stockholders’ views when making future compensation decisions for our NEOs.

Executive Compensation Philosophy and Overview

We operate in a very technical, highly regulated, and extremely competitive industry where our long-term success is highly dependent on the specialized skills, talent, and dedication of our executive officers. Our Compensation Committee believes that a well-designed compensation program should align executive interests with the drivers of growth and stockholder return, while enabling us to attract and retain employees whose talents, expertise, leadership, and contributions are critical to building and sustaining growth in long-term stockholder value. As a result, we calibrate total compensation levels relative to our peers with whom we compete for talent and utilize a strong pay-for-performance compensation philosophy that ties executives’ pay opportunities to the achievement of corporate goals, individual performance and sustained stock price appreciation.

Our executive compensation program is intended to meet five principal objectives:

•enable us to attract, retain and motivate superior talent;

•link rewards to the achievement of critical strategic priorities;

•create incentives for our executive officers to further our long-term strategic plan to create long-term stockholder value;

•provide appropriate levels of risk and reward relative to an executive officer’s position with us; and

•differentiate compensation based on individual performance.

Based on this philosophy, our performance-driven compensation program primarily consists of three components: base salary, annual cash incentive opportunity, and long-term incentive compensation in the form of equity awards. The Compensation Committee has determined that these three components, with the vast majority of target total direct compensation allocated to “at-risk” performance-based incentives through the use of short-term and long-term incentive compensation, best align the interests of our executive officers with those of our stockholders. While it does not have any formal policies for allocating compensation among the three components, the Compensation Committee reviews relevant competitive market data and uses its judgment to determine the appropriate level and mix of compensation on an annual basis to ensure that compensation levels and opportunities are competitive and that we are able to attract and retain capable executive officers to work for our long-term prosperity and stockholder value, without taking unnecessary or excessive risks.

2025 Summary Compensation Table

The following table sets forth all of the compensation awarded to, earned by or paid to our Named Executive Officers during the fiscal years ended December 31, 2025, and December 31, 2024.


Name and principal position	Year	Salary ($)	Bonus ($)		RSU awards ($)(1)	PSU awards ($)(2)	Option awards ($)(3)	Non-equity incentive plan compensation ($)(4)	All other compensation ($)(5)	Total ($)
David Chang, M.D., Ph.D.	2025	724,000	—	1,071,218		1,338,319	2,588,329	400,010	14,218	6,136,094
President and Chief Executive Officer	2024	724,000	—	1,016,960			2,401,683	329,420	10,145	4,482,208
Zachary J. Roberts M.D., Ph.D.	2025	530,207	—	337,391		421,740	815,222	202,804	17,750	2,325,114
Chief Medical Officer and Executive Vice President of Research and Development	2024	530,207	—	448,000			1,058,010	167,015	17,525	2,220,757
Geoffrey Parker Executive Vice President and Chief Financial Officer	2025	500,000	—	337,391		421,740	815,222	191,250	15,750	2,281,353

(1) The dollar amounts in this column reflect the aggregate grant date fair value of RSUs granted during the indicated year and computed in accordance with FASB ASC 718. The grant date fair values of the 2025 and 2024 RSUs are based on the closing market price of the Company’s common stock on the date of grant.

(2) The dollar amount in this column reflects the aggregate grant date fair value of PSUs granted in 2025. The amount reflects a maximum possible payout of 150%. The grant date fair value is based on the closing market price of the Company’s common stock on the date of grant.

(3) The dollar amounts in this column represent the aggregate grant date fair value of stock option awards granted during the indicated year. These amounts have been computed in accordance with FASB ASC Topic 718, using the Black-Scholes option pricing model. For a discussion of valuation assumptions, see Note 9 “Stock-based Compensation” to our financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2025. These amounts do not reflect the actual economic value that will be realized by the Named Executive Officer upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stock options.

(4) The dollar amounts in this column represent annual performance-based incentive earned for the indicated year. For more information, see above under “2025 Annual Performance-Based Cash Incentive.”

(5) The dollar amounts in this column represent Section 401(k) contributions. For Dr. Chang and Dr. Roberts, the dollar amount in this column includes health savings account benefits.

Narrative to Summary Compensation Table

Process for Setting Executive Compensation

We seek to foster a performance-oriented culture, where individual performance is aligned with organizational objectives. To achieve this, we evaluate and reward our executive officers based on their contributions to the achievement of annual goals and objectives set early in the year. Performance is reviewed at least annually through processes discussed further below, with a focus on our research, clinical, regulatory, financial and operational performance, and in view of economic

and financial conditions affecting the performance period. We also evaluate and adjust executive compensation in response to our say-on-pay results from our annual stockholder meetings.

Role of the Compensation Committee

The Compensation Committee reviews and approves our executive compensation philosophy, objectives and methods, evaluates our performance and the performance of our executive officers, and either approves executive compensation or makes recommendations for ratification by our Board members. Please see “Information Regarding Committees of the Board of Directors—Compensation Committee—Compensation Committee Processes and Procedures” for additional information.

Awards of performance-based compensation for the previous year are typically made at the last-scheduled Compensation Committee meeting of the year or first-scheduled meeting of the following year. Adjustments to the base salaries of our Named Executive Officers, if any, are also typically made at the last-scheduled Compensation Committee meeting of the year or first-scheduled meeting of the following year. The Compensation Committee typically reviews annual equity awards in the first quarter of the year.

Role of Management

In making compensation decisions, the Compensation Committee considers the recommendations of our Chief Executive Officer, with input from our Executive Chair, Chief People Officer and General Counsel. Our Chief Executive Officer, Dr. Chang, makes recommendations to the Compensation Committee with respect to our executive officers, but is not present and does not participate in the deliberations or determination of his own compensation. The Compensation Committee may review and approve the corporate objectives and goals pursuant to the powers delegated under its charter. Dr. Chang annually leads the development of our corporate objectives and goals, which are typically reviewed and approved by the Compensation Committee and then our Board. Dr. Chang provided our business and operations perspective for the Compensation Committee’s final review of progress made on the goals set for 2025. Other than as described above, no other executive officers participate in the determination or recommendation of the amount or form of executive officer compensation.

Role of Independent Compensation Consultant

The Compensation Committee is authorized to engage a compensation consultant or other advisors to review our executive officers’ compensation, including preparing an analysis against the compensation of executive officers at comparable companies, to ensure that our compensation is market competitive, with the goal of retaining and adequately motivating our senior management. During 2025, the Compensation Committee engaged Compensia to make recommendations for updating our compensation peer group, and to review and make recommendations regarding our equity plan and executive and director compensation for 2025. Compensia was invited to attend Compensation Committee meetings where they presented and discussed their analysis and findings. For 2025, with the assistance of Compensia, the Compensation Committee updated our compensation peer group, described below in the section entitled “Peer Companies and Market Compensation Data.”

On an annual basis since 2018 and most recently in March 2026, the Compensation Committee analyzed whether the work of Compensia as a compensation consultant has raised any conflict of interest, taking into consideration the following factors: (i) the provision of other services to the Company by Compensia; (ii) the amount of fees from the Company paid to Compensia as a percentage of the firm’s total revenue; (iii) Compensia’s policies and procedures that are designed to prevent conflicts of interest; (iv) any business or personal relationship of Compensia or the individual compensation advisors employed by the firm with an executive officer of the Company; (v) any business or personal relationship of the individual compensation advisors with any member of the Compensation Committee; and (vi) any stock of the Company owned by the individual compensation advisors employed by Compensia. The Compensation Committee determined, based on its analysis of the above factors, that the work of Compensia and the individual compensation advisors employed by Compensia has not raised any conflict of interest and the Compensation Committee is satisfied with the independence of Compensia.

Peer Group and Market Compensation Data

Each year the Compensation Committee, with the assistance of Compensia, reviews, updates and approves a group of publicly-traded peer companies against which the Company benchmarks its executive compensation program. The Compensation Committee reviews the information provided by Compensia and management to select our peer group from a pool of comparable companies. For the compensation peer group approved for 2025, the Compensation Committee considered the following criteria when selecting peer companies:

•Primary Criteria

•Industry: Biotechnology or pharmaceutical companies.

•Market Capitalization: Targeted 30-day average market capitalization of approximately .25x to 4.0x of Allogene’s 30-day average market capitalization (approximately $560 million at time of peer group review, corresponding to an approximate range of $140 million to $2.2 billion).

•Stage of Lead Drug: Companies must be in clinical development or early-stage commercial (approved and/or marketed product with less than $500 million in revenue for the last four quarters).

•Additional Refinement Criteria

•Indication: Preference for companies with cell therapy focus, gene therapy focus, and/or an oncology pipeline representing more than 33% of the portfolio.

Based on these criteria, in September 2024 the Compensation Committee selected the companies to be included in the peer group referenced for 2025 executive compensation decisions. The peer group was comprised of the following companies:


Agios Pharmaceuticals, Inc.	Editas Medicine, Inc.	Nurix Therapeutics, Inc.
Beam Therapeutics Inc.	Fate Therapeutics, Inc.	Precigen, Inc.
C4 Therapeutics, Inc.	Foghorn Therapeutics Inc.	Replimune Group, Inc.
Cabaletta Bio, Inc.	IGM Biosciences, Inc.	Sana Biotechnology, Inc.
CARGO Therapeutics, Inc.	iTeos Therapeutics, Inc.	Vir Biotechnology, Inc.
Caribou Biosciences, Inc.	Lyell Immunopharma, Inc.	Xencor, Inc.
Cullinan Therapeutics, Inc.	Nkarta, Inc.

In updating the compensation peer group for 2025, the Compensation Committee removed Mirati Therapeutics because it had been acquired by Bristol Myers Squibb, removed Celldex Therapeutics, ImmunityBio, Iovance Biotherapeutics, SpringWorks Therapeutics and Ultragenyx Pharmaceutical because they exceeded the applicable market capitalization parameters, and removed AlloVir because it fell below the applicable market capitalization parameters. The Compensation Committee added C4 Therapeutics, CARGO Therapeutics, Cullinan Therapeutics, iTeos Therapeutics, Nkarta, Precigen, Replimune Group and Vir Biotechnology due to their overall fit relative to the peer selection criteria. At the time our 2025 compensation peer group was analyzed by Compensia, our market capitalization was at the 47th percentile of the peer group based on 30-day average market capitalization and at the 49th percentile based on grant-date market capitalization.

The Compensation Committee intends to continue reviewing and revising the peer group annually to ensure that it continues to reflect publicly traded companies comparable to Allogene.

Executive Compensation Program and Compensation Decisions for the Named Executive Officers

Our executive compensation program in 2025 primarily consisted of base salary, annual performance-based cash incentive plan, and long-term incentive program, each of which plays an important role in our pay-for-performance philosophy and in achieving our compensation program objectives. For each element of compensation, we target an overall executive compensation program that is competitive with market data.

2025 Annual Base Salaries

The base salary is designed to provide a fixed and predictable level of compensation for our executive officers and to compensate executive officers competitively at levels necessary to attract and retain qualified executives in the life sciences industry. The Compensation Committee believes base salaries should be competitive with the base salaries provided by companies in our peer group. In January 2025, the Compensation Committee performed its annual analysis of base salaries for our executive management team, including our Named Executive Officers, using the peer group market data provided by Compensia. Based on this analysis, the Compensation Committee recommended no changes to Dr. Chang’s, Dr. Roberts' and Mr. Parker’s 2024 annual base salaries, and based on that recommendation, the Board did not approve any changes.

The 2025 annual base salaries for our Named Executive Officers (including a comparison with the 2024 base salaries) were as follows:


	Base Salary		Base Salary Change
Name and Position	2024	2025
David Chang, M.D., Ph.D. President and Chief Executive Officer	$724,000	$724,000	0%
Zachary Roberts, M.D., Ph.D. Executive Vice President, Research and Development and Chief Medical Officer	$530,207	$530,207	0%
Geoffrey Parker Executive Vice President, Chief Financial Officer	$500,000	$500,000	0%

2025 Annual Performance-Based Cash Incentive

Our Named Executive Officers are eligible to receive annual performance-based cash incentives, which are designed to provide appropriate incentives to our executive officers to achieve pre-established annual corporate goals and to reward them for individual performance towards these goals. The annual performance-based cash incentive each Named Executive Officer is eligible to receive is generally based on the extent to which we achieve the corporate goals that our Board establishes at the start of each year. At the end of the year, our Board and the Compensation Committee review our performance and approve the extent to which we achieved each of these annual corporate goals. Although our Board and the Compensation Committee, as applicable, will assess each Named Executive Officer’s individual contributions towards reaching our annual corporate goals, annual performance-based cash incentive awards for all Named Executive Officers are typically based only on the level of achievement of the annual corporate goals, and the Board and the Compensation Committee do not typically establish specific individual goals for our Named Executive Officers. This approach is consistent with our "One Allogene" culture, and reflects our belief that our leadership team should be unified in its pursuit of strategic execution and should share equally in the Company's successes and shortfalls. Any adjustments to such awards based on individual performance are discretionary, and such discretion was not exercised in 2025.

For 2025, the target annual performance-based cash incentive percentages were unchanged from 2024 and were as follows:


Position						2025 Target Incentive % of Base Salary
Chief Executive Officer						65%
Other Named Executive Officers						45%

Our Board and the Compensation Committee may award above-target cash incentives for extraordinary performance as measured against pre-established stretch goals.

For 2025, our corporate goals were organized around three strategic objectives: (i) delivering on our cema‑cel ALPHA3 study, (ii) advancing our pipeline (including progress on ALLO‑329 and other pipeline initiatives), and (iii) managing Company operations. Each strategic objective is comprised of specific core goals aligned to our annual operating plan and corresponding stretch goals designed to drive performance against more ambitious outcomes. The program design weighted core goals to a total of 100% and stretch goals to a total of 50%, with achievement of the core goals intended to drive target funding levels and achievement of the stretch goals providing the opportunity for above‑target outcomes, up to 150% of target.

Throughout 2025, the Compensation Committee maintained active oversight of progress against the corporate goals. At its June 2025 meeting, the Compensation Committee conducted a mid‑year review of progress toward the 2025 Corporate Goals, including discussion of goals that had been completed, were on track, or were at risk. The Compensation Committee revisited progress later in the year, including at its December 2025 meeting, at which management reviewed progress to date and provided preliminary views on expected achievement levels.

In January 2026, the Compensation Committee and our Board undertook a more comprehensive review of performance against the 2025 Corporate Goals and determined that our 2025 goals were achieved at 85% of target. Consequently, the Compensation Committee approved awarding Dr. Roberts and Mr. Parker 85% of their respective target annual cash incentive opportunities for 2025, and recommended, with Board approval, awarding Dr. Chang 85% of his target annual cash incentive opportunity for 2025.

Below is a detailed breakdown of our 2025 annual corporate goals and the level of achievement for each goal, reflecting our ongoing commitment to transparency regarding goals, except specific clinical enrollment targets, which remain confidential due to competitive and clinical trial integrity considerations. We have disclosed comprehensive performance details for all other metrics to provide a clearer view into the rigor and alignment of our pay practices with strategic milestones. We believe this high level of transparency demonstrates our commitment to clear accountability and the alignment our program creates between executive and stockholder interests.


Goal Category	Core Goals	Core Goal Weighting	Stretch Goals	Stretch Goal Weighting
Execute on Cema-Cel ALPHA3 Study	Determine lymphodepletion regimen ✓	20%
	Activate 50th clinical trial site ✓	10%
	Activate 1st Ex-US clinical trial site ✓	10%
	Enroll X patients	15%	Exceed enrollment of X patients by 33%	20%
Advance the Pipeline	Receive ALLO-329 IND Clearance ✓	5%	Enroll Y patients in ALLO-329	5%
	Deliver ALLO-329 clinical supply ✓	5%	Expand ALLO-329 INDa submission readiness beyond SLE, IIM, SSc	5%
	Dose ALLO-329 study ✓	5%	Present ALLO-316 Ph1b data ✓	5%
	Activate Ex-US ALLO-329 study ✓	5%	Nominate next IND candidate ✓	5%
	Deliver ALLO-329 Proof of Concept	5%
Manage Company Operations	Ensure 12 months cash on hand ✓	5%	Ensure 18 months cash on hand ✓	5%
	Partner an asset	10%
	Maintain staff engagement ✓	5%

✓ - Designates the goals that the Board determined were achieved.

The 2025 annual cash incentive payments are summarized in the table below.


Name						2025 Annual Cash Incentive ($)
David Chang, M.D., Ph.D.						400,010
Zachary Roberts, M.D., Ph.D.						202,804
Geoffrey Parker						191,250

Long-Term Incentive Compensation

We provide long-term incentive compensation to our executive officers through equity awards. Our 2018 Equity Incentive Plan, as amended ("EIP"), authorizes us to grant stock options, RSUs, PSUs and other equity-based awards. Our equity award program is the primary long-term incentive ("LTI") vehicle for our NEOs, and is designed to align executive compensation with the creation of long-term stockholder value, incentivize the achievement of key strategic milestones, and promote executive retention. Equity awards comprise the largest “at-risk” component of our NEOs’ compensation packages and are a key driver of our pay-for-performance philosophy. We believe that the use of stock options and RSUs directly links executive rewards to our stock price performance and the sustained success of our business, while multi-year vesting promotes continuity in leadership. In years where included, PSUs provide an additional layer of performance alignment by rewarding executives only upon the achievement of strategic, value-creating clinical objectives.

The Compensation Committee annually evaluates our equity program design, including the mix of award types, vesting schedules, performance criteria, and market competitiveness, with the assistance of its independent compensation consultant, Compensia.

2025 Annual Equity Awards

In January 2025, the Compensation Committee reviewed, evaluated and approved the Company's annual equity award approach and the proposed annual equity awards for eligible executive officers and the Board approved the equity awards for the CEO and Executive Chair as required under our governance processes. The Compensation Committee’s review was informed by management’s recommendations and input from the Company’s independent compensation consultant, Compensia, including market benchmarking analyses and equity program design considerations.

In structuring the 2025 annual equity awards for executive officers, the Compensation Committee reintroduced PSUs into the annual equity award program. The Committee utilized a mix of RSUs, PSUs and stock options to provide a target long-term incentive ("LTI") award opportunity that was heavily weighted towards performance-based vehicles, consisting of approximately 20% PSUs, 55% stock options and 25% RSUs. The Compensation Committee continues to view stock options as strongly performance-based and aligned with long-term stockholder interests given our pre-commercial stage of maturity. Individual adjustments were then made to reflect performance and maintain consistency across positions.

Regarding vesting, the 2025 stock option and RSU awards follow the Company’s standard four-year vesting schedule, with one-fourth of the stock options vesting on the one-year anniversary of the grant and the balance vesting monthly thereafter, while RSUs vest in equal annual installments over four years, in each case subject to continued service.

The 2025 PSUs are performance-based awards with vesting tied to achievement of specified clinical development and strategic milestones related to the Company's ALLO-329 program. The PSU awards are divided into three equal tranches, with each tranche becoming eligible to vest upon achievement of a corresponding milestone. For each milestone, payouts may range from 100% to 150% of the applicable tranche based on the level of achievement.

The Compensation Committee determined not to disclose the specific performance milestones because they relate to sensitive clinical development objectives and strategic priorities, the disclosure of which could result in competitive harm to the Company.

To provide for the maximum payout opportunity, the PSU awards were issued at the 150% level, so that sufficient shares would be reserved for the full vesting opportunity. Accordingly, although the PSU component was valued at the 100% level to target the overall equity award value (stock options, RSUs, and PSUs) at the 50th percentile of peer data, the PSU share amounts shown in the tables below reflect the maximum number of shares that may be earned.

In structuring this equity mix, the Compensation Committee continued to view stock options as strongly aligned with long-term stockholder value creation, particularly given our pre-commercial stage of maturity, while PSUs link a portion of long-term incentives to the achievement of key development milestones for our ALLO-329 autoimmune program. The Committee believed the PSU component further strengthened the link between compensation and execution of strategic, value-creating clinical objectives. RSUs serve as a complementary retention and incentivization vehicle and provide a measure of program durability while still providing alignment between executive and stockholder interests.

The Company notes that certain prior PSU awards, which were subject to rigorous performance conditions tied to stock price appreciation over a specified performance period, did not result in any payout following the conclusion of the performance period in March 2026 because the applicable performance conditions were not achieved. This outcome reflects the Company’s disciplined approach to goal setting and underscores its pay-for-performance philosophy, pursuant to which realizable compensation from performance-based awards is contingent on the achievement of challenging and objective performance criteria.

In evaluating the 2025 executive equity program, the Compensation Committee considered evolving investor and governance expectations favoring performance-based equity, including stockholder feedback indicating a preference that equity programs include performance-based awards as a further expression of a pay-for-performance compensation strategy. The Compensation Committee considered these perspectives alongside retention, internal equity and long-term incentive alignment objectives in approving the 2025 annual executive equity program, including the reintroduction of a PSU component.

The following table summarizes the CEO January 2025 equity grants:

Type

Number of Shares

(#)

Vesting

Stock options

1,952,130

1/4th on the first anniversary of the vesting commencement date and 1/36th of the remaining shares each month thereafter

RSUs

552,174

1/4th annually over four years

PSUs (1)

689,855

1/3 equal installments vesting upon occurrence of specific achievements.

Equity Awards Aggregate Grant Date Fair Value

$ 4,997,865

(1) PSU amount reflects maximum possible payout of 150%.

The following table summarizes Dr. Roberts’ and Mr. Parker’s 2025 equity grants:


Type	Number of Shares (#)				Vesting
	Zachary Roberts		Geoffrey Parker
Stock options	614,844		614,844		1/4th on the first anniversary of the vesting commencement date and 1/36th of the remaining shares each month thereafter
RSUs	173,913		173,913		1/4th annually over four years
PSUs (1)	217,392		217,392		1/3 equal installments vesting upon occurrence of specific achievements.
Equity Awards Aggregate Grant Date Fair Value	$	1,574,353	$	1,574,353

(1) PSU amount reflects maximum possible payout of 150%.

Health and Welfare Benefits

Our Named Executive Officers, during their employment with us, are eligible to participate in our employee benefit plans, including our medical, dental, group term life, disability and accidental death and dismemberment insurance plans, in each case on the same basis as all of our other employees. In addition, we provide a Section 401(k) plan to our employees, including our Named Executive Officers, as discussed in the section below entitled “—Section 401(k) Plan.”

Section 401(k) Plan

We maintain a defined contribution employee retirement savings plan (the "401(k) Plan"), for our employees. Our executive officers are eligible to participate in the 401(k) Plan on the same basis as our other employees. The 401(k) Plan is intended to qualify as a tax-qualified plan under Section 401(a) of the Internal Revenue Code (the "Code"). The 401(k) Plan provides that each participant may contribute up to the lesser of 100% of compensation or the statutory limit, which was $23,500 for calendar year 2025. Participants who are 50 years or older can also make “catch-up” contributions, which in calendar year 2025 may have been up to an additional $7,500 above the statutory limit. Participants who are ages 60 to 63 by December 31 are eligible for a “super catch-up” limit of up to $11,250 above the statutory limit. We currently make matching contributions into the 401(k) Plan on behalf of participants. We match 100% of eligible contributions up to the first 3% of eligible compensation, with an additional match of 50% on the next 3% (maximum of 4.5%). Participant contributions are held and invested, pursuant to the participant’s instructions, by the plan’s trustee.

Perquisites and Other Personal Benefits

We generally do not provide perquisites or personal benefits to our Named Executive Officers. We do, however, pay a portion of the premiums for medical, dental, group term life, disability and accidental death and dismemberment insurance for all of our full-time employees. Our Board may elect to adopt qualified or nonqualified benefit plans in the future if it determines that doing so is in our best interests.

Agreements with our Named Executive Officers

We have entered into employment letter agreements with each of our Named Executive Officers. These letter agreements provide for at-will employment and set forth the Named Executive Officer’s initial base salary, eligibility for employee benefits and recommended initial equity grant. In addition, each of our Named Executive Officers has executed a form of our standard confidential information and invention assignment agreement. The key terms of the letter agreements with our Named Executive Officers are described below. Any potential payments and benefits due upon a qualifying termination of employment or a change in control of the Company are further described below under “—Potential Payments and Benefits upon Termination or Change in Control.”

David Chang, M.D., Ph.D. We entered into a letter agreement with Dr. Chang, our President and Chief Executive Officer, in June 2018 that governs the current terms of his employment with us. We have previously increased Dr. Chang’s annual base salary and annual target performance cash incentive over the levels originally set in 2018, and his current base salary is now $738,480 with an annual target performance cash incentive of 65% of his base salary.

Zachary Roberts, M.D., Ph.D. We entered into a letter agreement with Dr. Roberts, our Executive Vice President, Research and Development and Chief Medical Officer, in January 2023 that governs the current terms of his employment with us. We have previously increased Dr. Robert's annual base salary over the level originally set in 2023, and his current annual base salary is now $540,811 and he remains eligible to receive an annual target performance cash incentive of 45% of his base salary. Dr. Roberts was paid a $75,000 sign-on advance that was considered earned when Dr. Roberts successfully completed one year of continuous employment with the Company. Dr. Roberts was granted an initial stock option to purchase 873,015 shares of our common stock. Dr. Roberts was also granted an initial RSU for 251,908 shares of our common stock, which settle on an annual basis over four years. In addition, Dr. Roberts was awarded new hire PSUs for a total of 190,836 shares, which will settle within a five-year period, if at all, based on the achievement of certain stated performance metrics.

Geoffrey M. Parker. We entered into an employment letter agreement with Mr. Parker, our Executive Vice President and Chief Financial officer, in October 2023 that governs the current terms of his employment with us. We have previously increased Mr. Parker's annual base salary over the level originally set in 2023, and his current annual base salary is $510,000, and he remains eligible to receive an annual target performance cash incentive of 45% of his base salary. In connection with his appointment, Mr. Parker was granted an initial stock option to purchase 950,000 shares of our common stock. Mr. Parker was also granted an initial RSU award covering 400,000 shares of our common stock, which vests over four years. In addition, Mr. Parker was granted a performance-based RSU award covering 390,000 shares of our common stock, which vests upon the achievement of specified performance milestones, including stock price and regulatory approval objectives.

Each of the options granted to our Named Executive Officers pursuant to their letter agreements are subject to a four-year vesting schedule, with 25% vesting one year after the vesting commencement date and the balance vesting monthly over the remaining 36 months, subject to each individual’s continued service through each vesting date.

For additional information regarding our long-term compensation and equity grants, please see “Executive Compensation―Executive Compensation Program and Compensation Decisions for the Named Executive Officers―Long-Term Incentive Compensation”.

Potential Payments and Benefits Upon Termination or Change in Control

Our executive officers, including our Named Executive Officers are entitled to certain severance and change of control payments and benefits pursuant to our change in control and severance benefit plan (the "Change in Control Plan"). Given the industry in which we participate and the range of strategic initiatives that we may explore, we believe these arrangements are an essential element of our executive compensation program and assist us in recruiting and retaining talented individuals. In addition, since we believe it may be difficult for our executive officers to find comparable employment following an involuntary termination of employment in connection with or following a change of control of the Company, these payments and benefits are intended to ease the consequences to an executive officer of an unexpected termination of employment. By establishing these payments and benefits, we believe we can mitigate the distraction and loss of executive officers that may occur in connection with rumored or actual fundamental corporate changes and thereby protect stockholder interests while a transaction is under consideration or pending.

The Change in Control Plan provides for, in the event of an involuntary termination of employment without “cause” or a resignation with “good reason,” and subject to our receipt of an effective waiver and release of claims from the executive, a combination of (1) cash severance for the severance period and (2) the payment or reimbursement of premiums for continuation of coverage under group health plans for the severance period. The severance period is 24 months in the case of our Chief Executive Officer, and 12 months in the case of our other executive officers.

In the event that the involuntary termination of employment occurs within the period commencing three months before and ending 12 months after a change in control of the Company, then the participants in the Change in Control Plan are entitled to the same benefits described above, but the severance period is 18 months for our executive officers other than our Chief Executive Officer. In addition, our Chief Executive Officer would be entitled to 200% of his annual target cash incentive and our other executive officers would be entitled to 150% of their annual target cash incentive, and each of our executive officers would be entitled to accelerated vesting of outstanding equity compensation awards.

Under the Change in Control Plan, the term “cause” generally means (i) the employee’s commission of any crime involving fraud, dishonesty or moral turpitude; (ii) the employee’s attempted commission of or participation in a fraud or act of dishonesty against us that results in (or might have reasonably resulted in) material harm to our business; (iii) the employee’s intentional, material violation of any contract or agreement between us and the employee or any statutory duty that the employee owes to us; or (iv) the employee’s conduct that constitutes gross insubordination, incompetence or habitual neglect of duties and that results in (or might have reasonably resulted in) material harm to our business. Under the Change in Control Plan, the term “change in control” generally means (1) the acquisition by any person or company of more than 50% of the combined voting power of our then outstanding stock, (2) a merger, consolidation or similar transaction in which our stockholders immediately before the transaction do not own, directly or indirectly, more than 50% of the combined voting power of the surviving entity (or the parent of the surviving entity) in substantially the same proportions as their ownership immediately prior to such transaction, (3) a sale, lease, exclusive license or other disposition of all or substantially all of our assets other than to an entity, more than 50% of the combined voting power of which is owned by our stockholders in substantially the same proportions as their ownership of our outstanding voting securities immediately prior to such transaction, or (4) a complete dissolution or liquidation of the company.

Under the Change in Control Plan, the term “good reason” generally means (i) a material reduction of such employee’s annual base salary, which is a reduction of at least 10% of such employee’s base salary (unless pursuant to a salary reduction program applicable generally to the Company’s similarly situated employees); (ii) a material reduction in such employee’s authority, duties or responsibilities; (iii) a relocation of such employee’s principal place of employment with the Company (or successor to the Company, if applicable) to a place that increases such employee’s one-way commute by

more than 50 miles as compared to such employee’s then-current principal place of employment immediately prior to such relocation (excluding regular travel in the ordinary course of business).

Stock Ownership Guidelines

We maintain stock ownership and retention guidelines for our directors and executive officers to ensure that each of them has a long-term equity stake in Allogene, in order to both closely align the interests of directors and executive officers to those of our stockholders and to further our commitment to corporate governance.

Under the stock ownership guidelines, executive officers and directors must maintain stock ownership at a value equal to a multiple of their annual retainer or base salary, as applicable, as follows:


Position			Stock Retention Amount
Chief Executive Officer			6 times executive’s base salary
Non-Employee Directors			5 times director’s annual retainer
Other Executive Officers			1 times executive’s base salary

Under these guidelines, the compliance deadline for all of our executive officers and directors is the later of December 2023 and five years from an individual’s commencement of employment or appointment to our Board. In March 2026, our Board of Directors approved and adopted an amendment to our Stock Ownership Guidelines pursuant to which the forms of equity that count toward satisfaction of the ownership requirement were modified. Previously under the policy, up to 50% of vested, in-the-money stock options could be counted toward compliance. That provision was deleted, and the amended policy now provides that shares underlying unvested time-based restricted stock units and vested but deferred restricted stock units are eligible to be counted. Additionally, shares of common stock continue to count toward compliance. Unvested stock options and unvested PSUs, and vested but unexercised stock options are not counted for purposes of determining compliance with these guidelines. The Compensation Committee annually monitors compliance with this policy. All Named Executive Officers and directors are currently in compliance with our stock ownership guidelines, as applicable. One director was not in compliance as of December 31, 2025 based on the calculation required under the policy, which utilizes the average stock price over the 90 trading days prior to such date. This temporary non-compliance resulted from a decline in the Company’s stock price and not from any disposition of shares by the director. The Compensation Committee reviewed the matter and determined that no action was warranted in light of the director’s prior compliance as of December 31, 2024 and the director’s return to compliance during the first quarter of 2026 as the Company’s stock price increased. The director has remained in compliance following the policy amendments described above

Insider Trading Policy; Prohibition on Hedging, Pledging, and Speculative Trading

We have adopted an Insider Trading Policy governing the purchase, sale, and/or other dispositions of the Company’s securities by directors, officers, employees and consultants that is designed to promote compliance with insider trading laws, rules and regulations, as well as procedures designed to further the foregoing purposes. A copy of our Insider Trading Policy is filed as an exhibit to our Annual Report on Form 10-K for our fiscal year ended December 31, 2025. In addition, it is the Company’s intent to comply with applicable laws and regulations relating to insider trading.

The Company considers it inappropriate for persons employed by or associated with the Company to engage in certain transactions related to the securities of the Company (the "Subject Securities") that could result in their interests no longer being aligned with the same interests and objectives as other stockholders of the Company. Therefore, as part of our insider trading policy, Allogene prohibits our directors, officers, employees and consultants from engaging in “hedging” or other inherently speculative transactions with respect to our common stock or borrowing against our common stock. Specifically, no officer, director, employee or consultant may engage in short sales, transactions in put or call options, hedging transactions or other inherently speculative transactions with respect to our common stock at any time. Certain hedging and monetization transactions involve the establishment of a short position in the Subject Securities and limit or eliminate a person’s ability to profit from an increase in the value of the Subject Securities. Accordingly, these transactions

can cause a person’s interests to be misaligned with other stockholders of the Company. The Company therefore prohibits its directors, executive officers, employees and consultants from engaging in such transactions.

In addition, no executive officer, director, employee or consultant may margin, or make any offer to margin, or otherwise pledge as security, any of our common stock, including without limitation, borrowing against such stock, at any time. Stock held in a margin account or pledged as collateral for a loan may be sold without a person’s consent if he or she fails to meet a margin call or defaults on a loan, which may occur at a time when the covered person is aware of material nonpublic information or is otherwise not permitted to trade in Company securities. Therefore, our directors, executive officers, employees and consultants are prohibited from engaging in these activities.

Clawback Policy

In November 2023, our Board adopted an incentive compensation recoupment policy (the "Clawback Policy") in accordance with Rule 10D-1 of the Exchange Act and Nasdaq Rule 5608 that requires the Company to recover excess incentive compensation that was paid to an executive officer based in whole or in part on financial results that were subject to a restatement of the Company’s financial statements. The Clawback Policy specifies that following an accounting restatement, the Company must reasonably promptly recoup any compensation that is granted, earned or vested based wholly or in part upon the attainment of a financial reporting measure (the "Incentive Compensation") and which exceeds the amount that would have been received had such Incentive Compensation been determined based on the accounting restatement, unless the Compensation Committee determines that such recoupment would be impracticable. The Clawback Policy applies to all Incentive Compensation received during a three-year period preceding a restatement by a person (a) after beginning services as an executive officer, (b) who served as an executive officer at any time during the performance period for the applicable Incentive Compensation and (c) while the Company has securities listed on Nasdaq or another national securities exchange or association.

2025 Outstanding Equity Awards at Fiscal Year-End Table

The following table presents information concerning equity awards held by our Named Executive Officers as of December 31, 2025.


		Option Awards				Stock Awards
Name	Grant Date	Number of Securities Underlying Unexercised Options (#) Exercisable (7)	Number of Securities Underlying Unexercised Options (#) Unexercisable(7)	Option Exercise Price ($)	Option Expiration Date	Number of Shares of Stock that have not Vested (RSUs) (#) (1)	Market Value of Shares of Stock that have not Vested (RSUs) ($) (8)	Equity Incentive Plan Awards: Number of Unearned Shares or Units of Stock that have not Vested (PSUs) (#)	Equity Incentive Plan Awards: Market Value of Unearned Shares or Units of Stock that have not Vested (PSUs) ($) (8)
David Chang, M.D., Ph.D.	3/13/2019	292,700	—	26.89	3/13/2029	—	—	—	—
	3/18/2020	541,190	—	18.22	3/18/2030	—	—	—	—
	3/26/2021	298,836	—	33.78	3/26/2031	—	—	—	—
	3/23/2022	2,195,512	—	9.69	3/23/2032	—	—	—	—
	3/22/2023	1,492,200	—	5.04	3/22/2033	222,054	304,214	1,480,357 (2)	2,028,089
	1/25/2024	717,813	405,722	3.20	1/25/2034	211,866	290,256	—	—
	1/24/2025	—	1,952,130	1.94	1/24/2035	552,174	756,478	689,855 (3)	945,101
Zachary J. Roberts M.D., Ph.D.	1/20/2023	873,015	—	6.55	1/20/2033	125,954	172,557	76,336 (4)	104,580
	3/22/2023	—	—	—	—	—	—	148,035 (5)	202,808
	1/25/2024	316,217	178,732	3.20	1/25/2034	93,333	127,866	—	—
	1/24/2025	—	614,844	1.94	1/24/2035	173,913	238,261	217.392 (3)	297,827
Geoffrey Parker	10/16/2023	950,000	—	3.24	10/16/2033	200,000	274,000	390,000 (6)	534,300
	1/25/2024	66,405	37,534	3.20	1/25/2034	19,600	26,852	—	—
	1/24/2025	—	614,844	1.94	1/24/2035	173,913	238,261	217,392 (3)	297,827

(1) With exception of the RSU awards granted on January 25, 2024, RSU awards vest in four equal annual installments from the grant date. The RSU awards granted on January 25, 2024 vest in three equal annual installments from the grant date.

(2) 740,178 of PSUs granted in 2023 would vest upon our stock price achieving a 30-day weighted average trading price of $18.00 per share prior to March 22, 2026. This milestone has lapsed without achievement, therefore, 740,178 of PSU awards were forfeited. 740,179 of PSUs will vest, if at all, upon the first FDA approval of a Company product prior to March 22, 2028.

(3) PSU vesting is contingent on achieving specified milestones in our ALLO-329 autoimmune program. Each PSU milestone vests one-third of the total award, with up to 150% of target shares vesting if those milestones are achieved without chemotherapy-based lymphodepletion. The amount in the table is presented based on maximum payout of 150%.

(4) 76,336, 50% of the original grant of 152,671, is assumed to be achievable. 152,671 of PSUs will vest, if at all, in two equal installments, with (a) the first installment to vest upon the filing of a biologics license application with the FDA for ALLO-501A, provided that 125% of such installment shall vest if such filing is completed by the end of 2025, 100% of such installment shall vest if such filing is completed in 2026 and 50% of such installment shall vest if such filing is completed after 2026, and (b) the second installment to vest upon FDA approval of ALLO-501A, provided that 125% of such installment shall vest if such approval is achieved by the end of 2025, 100% of such installment shall vest if such approval is achieved in 2026 and 50% of such installment shall vest if such approval is achieved after 2026. Any unvested portion of PSUs shall expire unvested after five years.

(5) 48,852 shares of PSUs granted in 2023 would vest upon our stock price achieving a 30-day weighted average trading price of $18.00 per share prior to March 22, 2026. This milestone has lapsed without achievement; therefore, 48,852 of PSUs were forfeited. 99,183 of PSUs will vest, if at all, upon the first FDA approval of a company product prior to March 22, 2028.

(6) 50% of the 390,000 PSUs granted in 2023, or 195,000 shares, would vest upon certain stock price performance prior to March 22, 2026. This milestone has lapsed without achievement; therefore, 195,000 shares of PSUs were forfeited. The remaining 195,000 shares of PSUs will vest, if at all, upon the first FDA approval of a company product prior to March 22, 2028.

(7) With exception of the stock options granted on January 25, 2024, our stock options vest as to 1/4th of the shares subject to the option upon the first anniversary of the grant date and 1/36th of the remaining shares each month thereafter until such award is fully vested on the four-year anniversary of the grant date. Stock options granted on January 25, 2024 vest as to 1/3rd of the shares subject to the option upon the first anniversary of the grant date and 1/24th of the remaining shares each month thereafter until such award is fully vested on the three-year anniversary of the grant date.

(8) Based on the closing market price of our common stock on December 31, 2025 of $1.37 per share.

Securities Authorized for Issuance under Equity Compensation Plans

The following table sets forth the aggregate information of our equity compensation plans in effect as of December 31, 2025.

Equity Compensation Plan Information


Plan Category	Number of securities to be issued upon exercise of outstanding options, warrants and rights (a)	Weighted-average exercise price of outstanding options, warrants and rights (b)($)		Number of securities remaining available for issuance under equity compensation plans (excluding securities reflected in column (a)) (c)
Equity compensation plans approved by security holders
Amended and Restated 2018 Equity Incentive Plan (Prior Plan)(1)	686,136	6.66		—
Amended and Restated 2018 Equity Incentive Plan(2)	46,980,157	6.30		6,187,819
2018 Employee Stock Purchase Plan(3)	—	—		9,101,120
Equity compensation plans not approved by security holders	—	—		—
Total	47,666,303	$	6.31	15,288,939

(1) As of December 31, 2025, under our Amended and Restated 2018 Equity Incentive Plan (the "Prior Plan"), the number of outstanding awards under column (a) includes 686,136 shares which are issuable upon the exercise of outstanding options (including options that are immediately exercisable) at a weighted-average exercise price of $6.66.

(2) The EIP became effective on September 26, 2018, which replaced the Prior Plan. Initially, the aggregate number of shares of our common stock that may be issued under the EIP was 20,432,250 shares. On January 1 of each year, commencing on January 1, 2019 and ending on January 1, 2028, the number of shares authorized for issuance under the 2018 Plan is automatically increased by a number equal to: (a) 5% of the total number of shares of capital stock outstanding on December 31 of the preceding calendar year; or (b) such lesser number of shares of common stock as is determined by our Board or the Compensation Committee for the applicable year. All shares of our common stock reserved and available under the EIP shall constitute the maximum aggregate number of shares of common stock that may be issued through incentive stock options. As of December 31, 2025, the number of outstanding awards under column (a) includes: (1) 30,451,941 shares issuable upon the exercise of outstanding options at a weighted-average exercise price of approximately $6.30 and (2) 16,528,226 shares issuable upon the vesting of outstanding restricted stock units, including 6,515,095 shares issuable upon vesting of PSUs. The weighted-average exercise price shown in column (b) is for the outstanding options only.

(3) Our 2018 Employee Stock Purchase Plan (the "ESPP") became effective on September 26, 2018. The ESPP initially authorized the issuance of 1,160,000 shares of our common stock pursuant to purchase rights granted to our employees or to employees of any of our designated affiliates. On January 1 of each year, commencing on January 1, 2019 and ending on January 1, 2028, the number of shares authorized for issuance under the ESPP is automatically increased by a number equal to the lesser of: (a) 1% of the total number of shares of capital stock outstanding on December 31 of the preceding calendar year; (b) 2,320,000 shares; or (c) such lesser number of shares of Common Stock as is determined by our Board or the Compensation Committee for the applicable year. The ESPP is intended to qualify as an “employee stock purchase plan” within the meaning of Section 423 of the Code.

Pay Versus Performance

As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(v) of Regulation S-K, we are providing the following information about the relationship between executive “compensation actually paid” and certain financial performance of our company. Use of the term “compensation actually paid” is required

by the SEC’s rules and as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually received by the individuals and the compensation decisions described in the “Discussion of Named Executive Officer Compensation” section above.

Pay Versus Performance

Year

Summary Compensation Table Total for Principal Executive Officer (PEO)(1)

($)

Compensation Actually Paid to PEO(2)

($)

Average Summary Compensation Table Total for Non-PEO Named Executive Officers (NEOs)(3)

($)

Average Compensation Actually Paid to Non-PEO NEOs(4)

($)

Value of Initial Fixed $100 Investment Based On:

Net Income (Loss)

(thousands)(6)

Total Shareholder Return (TSR)(5)

($)

(a)

(b)

(c)

(d)

(e)

(f)

(g)

SEC Form PRE 14A filed by Allogene Therapeutics Inc.