Document

DEF 14A 1 a2023seraproxy-definitive.htm DEF 14A Document

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

___________________________________

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934

(Amendment No. )

___________________________________

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:


☐			Preliminary Proxy Statement

☐			Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☒			Definitive Proxy Statement

☐			Definitive Additional Materials

☐			Soliciting Material Pursuant to §240.14a-12

SERA PROGNOSTICS, INC.

_________________________________________________________________________________________________

(Name of Registrant as Specified In Its Charter)

_________________________________________________________________________________________________

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

☒

No fee required.

☐

Fee paid previously with preliminary materials.

☐

Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

SERA PROGNOSTICS, INC.

2749 East Parleys Way, Suite 200

Salt Lake City, Utah 84109

NOTICE OF 2023 ANNUAL MEETING OF STOCKHOLDERS

to be held June 8, 2023

To Stockholders of Sera Prognostics, Inc.:

The 2023 Annual Meeting of Stockholders (the “2023 Annual Meeting”) of Sera Prognostics, Inc. (“Sera Prognostics” or the “Company”), a Delaware corporation, will be conducted solely online via live webcast at www.virtualshareholdermeeting.com/SERA2023 on Thursday, June 8, 2023, at 8:00 a.m. Mountain Time, for the following purposes as more fully described in the accompanying proxy statement for the 2023 Annual Meeting to:

1.elect three Class II directors to serve three-year terms expiring in 2026;

2.ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for our current fiscal year ending December 31, 2023;

3.approve a proposed amendment to our amended and restated certificate of incorporation to include a provision to permit exculpation of officers of the Company for breaches of the fiduciary duty of care to the extent permitted by recent amendments to the Delaware General Corporation Law; and

4.transact such other business as may properly come before the annual meeting or any adjournments or postponements thereof.

The record date for the 2023 Annual Meeting is April 11, 2023. If you were the record owner of Sera Prognostics Class A common stock at the close of business on that date, you may vote at the meeting. A list of stockholders of record will be available during the 10 days prior to the 2023 Annual Meeting at our principal executive offices located at 2749 East Parleys Way, Suite 200 Salt Lake City, Utah 84109. If you wish to view this list, please contact our Corporate Secretary at Sera Prognostics, Inc., 2749 East Parleys Way, Suite 200 Salt Lake City, Utah 84109, (801) 990-0660. Such list will also be available for examination by the stockholders during the annual meeting at www.virtualshareholdermeeting.com/SERA2023. Additional information regarding voting rights and the matters to be voted upon is presented in our proxy statement.

We have determined that the 2023 Annual Meeting will be held in a virtual meeting format only, via the Internet, with no physical in-person meeting because hosting a virtual annual meeting enables greater stockholder attendance and participation from any location around the world, improves meeting efficiency and our ability to communicate effectively with our stockholders, and reduces the cost and environmental impact of our annual meeting. We may institute in-person stockholder meetings in future years. If you plan to participate in the virtual meeting, please see the “Questions and Answers” section. Stockholders will be able to attend, vote and submit questions from any location via the Internet.

Under Securities and Exchange Commission rules that allow companies to furnish proxy materials to stockholders over the Internet, we have elected to deliver our proxy materials to certain of our stockholders over the Internet. This delivery process allows us to provide stockholders with the information they need, while at the same time conserving natural resources and lowering the cost of delivery. On or about April 25, 2023, we intend to begin sending to our stockholders a Notice of Internet Availability of Proxy Materials (the “Notice”) containing instructions on how to access our proxy statement for our 2023 Annual Meeting and our 2022 annual report to stockholders. The Notice also provides instructions on how to vote online or by telephone, how to access the virtual annual meeting, and how to receive a copy of our proxy materials and annual report by mail.

It is important that your shares be represented at this meeting. Whether or not you expect to attend the virtual annual meeting, please vote at your earliest convenience by following the instructions in the Notice you received in the mail in order to ensure the presence of a quorum. You may change or revoke your proxy at any time before it is voted at the meeting.

We appreciate your continued support of Sera Prognostics.


						By order of the Board of Directors,


						Gregory C. Critchfield, M.D., M.S. Chairman, President and Chief Executive Officer

						April 25, 2023
						Salt Lake City, Utah

PROXY STATEMENT

FOR 2023 ANNUAL MEETING OF STOCKHOLDERS

TABLE OF CONTENTS


QUESTIONS AND ANSWERS			8

BOARD OF DIRECTORS AND CORPORATE GOVERNANCE			16
Nominees for Director			16
Continuing Directors			17
Class III Directors continuing in Office until the 2024 Annual Meeting of Stockholders			17
Class I Directors continuing in Office until the 2025 Annual Meeting of Stockholders			18
Board Composition			19
Director Independence			20
Board Leadership Structure and Risk Oversight			21
Board Meetings			21
Attendance of Directors at Annual Meetings of Stockholders			22
Board Committees			21
Audit Committee			22
Compensation Committee			22
Nominating and Governance Committee			23
Considerations in Evaluating Director Nominees			24
Stockholder Recommendations for Nominations to the Board of Directors			24
Stockholder and Interested Party Communications with the Board of Directors			24
Board Diversity			25
Corporate Code of Conduct and Ethics			25
Non-Employee Director Compensation			26
2022 Director Compensation			26
Director Compensation Program			27

PROPOSAL NO. 1 - ELECTION OF DIRECTORS			29

PROPOSAL NO. 2 - RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM			30
Fees Paid to the Independent Registered Public Accounting Firm			30
Auditor Independence			30
Audit Committee Policy on Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm			30

REPORT OF THE AUDIT COMMITTEE			32

PROPOSAL NO. 3 - AMENDMENT OF OUR CERTIFICATE OF INCORPORATION TO REFLECT NEW DELAWARE LAW PROVISIONS REGARDING OFFICER EXCULPATION			33

EXECUTIVE OFFICERS			35

EXECUTIVE COMPENSATION			38
General Compensation Philosophy and Process for Compensation Decisions			38
Summary Compensation Table			38
Narrative Disclosure to Summary Compensation Table			39
Base Salaries			39
Non-Equity Incentive Compensation Plan			39
Equity Compensation			40
Employment Arrangements			40
Severance and Change of Control Benefits			41
Outstanding Equity Awards at December 31, 2022			42
Equity Compensation Plan Information			43


401(k) Plan			43
Pension Benefits			43
Nonqualified Deferred Compensation			43
Compensation Committee Interlocks and Insider Participation			43
Prohibition on Hedging and Pledging			44
Conclusion			44

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT			45

CERTAIN RELATIONSHIPS, RELATED PARTY AND OTHER TRANSACTIONS			48
Policies and Procedures for Related Party Transactions			48
Series E Financing			48
Agreements with Stockholders			49
Elevance Health Commercialization Agreement			49
Elevance Health Laboratory Services Agreement			49
Agreements with Blue Ox Healthcare Partners, LLC			49
Vivo Management Rights Letter			49
Investors ’ Rights Agreement			49
Indemnification Agreements			50
Other Transactions			51

OTHER MATTERS			52
2022 Annual Report and SEC Filings			52
Incorporation by Reference			52
Stockholder Proposals and Nominations for Director			52
Other Matters			52

SERA PROGNOSTICS, INC.

2749 East Parleys Way, Suite 200

Salt Lake City, Utah 84109

PROXY STATEMENT

FOR 2023 ANNUAL MEETING OF STOCKHOLDERS

to be held on Thursday, June 8, 2023 at 8:00 a.m. Mountain Time

This proxy statement, along with the accompanying notice of 2023 Annual Meeting of Stockholders, contains information about the 2023 Annual Meeting of Stockholders of Sera Prognostics, Inc., including any adjournments or postponements of the annual meeting. We are holding the 2023 Annual Meeting at 8:00 a.m. Mountain Time, on Thursday, June 8, 2023. We have decided to hold this year’s meeting virtually via live webcast on the Internet because hosting a virtual annual meeting enables greater stockholder attendance and participation from any location around the world, improves meeting efficiency and our ability to communicate effectively with our stockholders, and reduces the cost and environmental impact of our annual meeting. You will be able to attend our annual meeting, vote and submit your questions during the meeting by visiting www.virtualshareholdermeeting.com/SERA2023. You will not be able to attend the annual meeting in person.

In this proxy statement, we refer to Sera Prognostics, Inc. as “the Company,” “we,” and “us.”

This proxy statement relates to the solicitation of proxies by our board of directors for use at the annual meeting.

On or about April 25, 2023, we intend to begin sending to our stockholders the Important Notice Regarding the Availability of Proxy Materials containing instructions on how to access this proxy statement and our 2022 annual report to stockholders.

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR THE STOCKHOLDER MEETING TO BE HELD ON JUNE 8, 2023

The notice of 2023 annual meeting of stockholders, this proxy statement, our form of proxy card and our 2022 annual report to stockholders are available for viewing, printing and downloading at www.proxyvote.com. To view these materials please have your 16-digit control number(s) available that appears on your Notice or proxy card. On this website, you can also elect to receive future distributions of our proxy statements and annual reports to stockholders by electronic delivery.

Additionally, you can find a copy of our Annual Report on Form 10-K, which includes our financial statements for the fiscal year ended December 31, 2022, on the website of the Securities and Exchange Commission, or the SEC, at www.sec.gov, or in the “Financial Information” section of the “Investors” section of our website at www.seraprognostics.com. You may also obtain a printed copy of our Annual Report on Form 10-K, including our financial statements, free of charge, from us by sending a written request to: Sera Prognostics, Inc., Attn: Investor Relations, 2749 East Parleys Way, Suite 200, Salt Lake City, Utah 84109. Exhibits will be provided upon written request and payment of an appropriate processing fee.

QUESTIONS AND ANSWERS

The information provided in the “question and answer” format below addresses certain frequently asked questions but is not intended to be a summary of all matters contained in this proxy statement. Please read the entire proxy statement carefully before voting your shares. Information contained on, or that can be accessed through, our website is not intended to be incorporated by reference into this proxy statement and references to our website address in this proxy statement are inactive textual references only.

Why am I receiving these materials?

Our board of directors is providing these proxy materials to you in connection with its solicitation of proxies for use at the 2023 Annual Meeting, which will take place on June 8, 2023 at 8:00 am Mountain Time. We have made available to you on the Internet or have sent you this proxy statement, the Notice of Annual Meeting of Stockholders, the proxy card, and a copy of our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 and you are invited to attend the 2023 Annual Meeting because you owned shares of our Class A common stock on the record date. You are requested to vote on the proposals described in this proxy statement. This proxy statement and the accompanying proxy card are being mailed on or about April 25, 2023 in connection with the solicitation of proxies on behalf of our board of directors. All stockholders will have the ability to access via the Internet this proxy statement as filed with the SEC on April 25, 2023 and our Annual Report as filed with the SEC on March 22, 2023.

Why is the Company holding a virtual annual meeting?

We have decided to hold this year’s meeting virtually via live webcast on the Internet because hosting a virtual annual meeting enables greater stockholder attendance and participation from any location around the world, improves meeting efficiency and our ability to communicate effectively with our stockholders, and reduces the cost and environmental impact of our annual meeting. We have designed our virtual format to enhance, rather than constrain, stockholder access, participation and communication. For example, the virtual format allows stockholders to communicate with us in advance of, and during, the annual meeting so they can ask questions of our board of directors or management, as time permits. We may institute in-person stockholder meetings in future years.

What happens if there are technical difficulties during the annual meeting?

We will have technicians ready to assist you with any technical difficulties you may have accessing the virtual annual meeting, voting at the annual meeting or submitting questions at the annual meeting. If you encounter any difficulties accessing the virtual meeting during the check-in or meeting time, please call the technical support number that will be posted on the Virtual Stockholder Meeting login page.

Why did I receive a Notice in the mail regarding the internet availability of proxy materials instead of a full set of proxy materials?

As permitted by the rules of the SEC, we may furnish our proxy materials to our stockholders by providing access to such documents on the Internet, rather than mailing printed copies of these materials to each stockholder. Most stockholders will not receive printed copies of the proxy materials unless they request them. We believe that this process should expedite stockholders’ receipt of proxy materials, lower the costs of the annual meeting, and help to conserve natural resources. If you received a Notice by mail or electronically, you will not receive a printed or email copy of the proxy materials unless you request one by following the instructions included in the Notice. Instead, the Notice instructs you as to how you may access and review all of the proxy materials and submit your proxy on the Internet. If you requested a paper copy of the proxy materials, you may authorize the voting of your shares by following the instructions on the proxy card, in addition to the other methods of voting described in this proxy statement.

Will I be able to ask questions and have these questions answered during the virtual annual meeting?

Stockholders may submit questions for the annual meeting after logging in. If you wish to submit a question, you may do so by logging into the virtual meeting platform at www.virtualshareholdermeeting.com/SERA2023, typing your question into the “Ask a Question” field, and clicking “Submit.” Please submit any questions before the start time of the meeting.

Appropriate questions related to the business of the 2023 Annual Meeting (the proposals being voted on) will be answered during the 2023 Annual Meeting, subject to time constraints. Additional information regarding the ability of stockholders to ask questions during the 2023 Annual Meeting, related to rules of conduct and other materials for the 2023 Annual Meeting will be available at investors.seraprognostics.com under Investors — Governance — Documents & Charters.

What proposals will be voted on at the 2023 Annual Meeting?

There are three proposals scheduled to be voted on at the 2023 Annual Meeting:

•the election of Kim Kamdar, Ph.D., Sandra A.J. Lawrence, and Ryan Trimble as Class II directors to serve until the 2026 Annual Meeting of stockholders or until their successors are duly elected and qualified;

•the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2023; and

•the approval of a proposed amendment to our amended and restated certificate of incorporation to include a provision to permit exculpation of officers of the Company for breaches of the fiduciary duty of care to the extent permitted by recent amendments to the Delaware General Corporation Law.

At the time this proxy statement was mailed, our management and board of directors were not aware of any other matters to be presented at the 2023 Annual Meeting other than those set forth in this proxy statement and in the notice accompanying this proxy statement.

How does our board of directors recommend that I vote?

Our board of directors recommends that you vote:

•“FOR” the election of each of Dr. Kamdar, Ms. Lawrence, and Mr. Trimble as Class II directors;

•“FOR” the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2023; and

•“FOR” a proposed amendment to our amended and restated certificate of incorporation to include a provision to permit exculpation of officers of the Company for breaches of the fiduciary duty of care to the extent permitted by recent amendments to the Delaware General Corporation Law.

If any other matter is presented at the 2023 Annual Meeting, your proxy provides that your shares will be voted by the persons acting as your proxy in accordance with his or her best judgment. At the time this proxy statement was first made available, we knew of no matters that needed to be acted on at the annual meeting, other than those discussed in this proxy statement.

Who is entitled to vote at the 2023 Annual Meeting?

Holders of our Class A common stock at the close of business on April 11, 2023, the record date for the 2023 Annual Meeting (the “Record Date”) are entitled to notice of and to vote at the 2023 Annual Meeting. Each stockholder is entitled to one vote for each share of our Class A common stock held as of the Record Date. As of the Record Date, there were 29,642,033 shares of Class A common stock outstanding and entitled to vote. Stockholders are not permitted to cumulate votes with respect to the election of directors.

Stockholders of Record – Shares Registered in Your Name. If, at the close of business on the Record Date, your shares were registered directly in your name with American Stock Transfer & Trust Company, LLC, our transfer agent, then you are considered the stockholder of record with respect to those shares, and this proxy statement was provided to you directly by us. As the stockholder of record, you have the right to grant your voting proxy directly to the individuals

listed on the proxy card or to vote at the 2023 Annual Meeting virtually. Throughout this proxy statement, we refer to these registered stockholders as “stockholders of record.”

Street Name Stockholders – Shares Registered in the Name of a Broker, Bank or Other Nominee. If, at the close of business on the Record Date, your shares were held, not in your name, but rather in a stock brokerage account or by a bank or other nominee on your behalf, then you are considered the beneficial owner of shares held in “street name,” and this proxy statement was forwarded to you by your broker or nominee, who is considered the stockholder of record with respect to those shares. As the beneficial owner, you have the right to direct your broker, bank or other nominee how to vote your shares by following the voting instructions your broker, bank or other nominee provides. If you do not provide your broker, bank or other nominee with instructions on how to vote your shares, your broker, bank or other nominee may, in its discretion, vote your shares with respect to routine matters but may not vote your shares with respect to any non-routine matters. Throughout this proxy statement, we refer to stockholders who hold their shares through a broker, bank or other nominee as “street name stockholders.”

How many votes are needed for approval of each proposal?

•Proposal No. 1: The election of each Class II director requires a plurality of the votes of the shares of our Class A common stock present in person (including virtually) or represented by proxy at the 2023 Annual Meeting and entitled to vote thereon to be approved. “Plurality” means that the three nominees who receive the most votes cast FOR will be elected as Class II directors. You may (i) vote FOR all nominees, (ii) WITHHOLD your vote as to all nominees, or (iii) vote FOR all nominees except for those specific nominees from whom you WITHHOLD your vote. Any shares not voted FOR a particular nominee (whether as a result of voting withheld or a broker non-vote) will not be counted in such nominee’s favor and will have no effect on the outcome of the election. If you WITHHOLD your vote as to all nominees, you will be deemed to have abstained from voting on Proposal No. 1, and such abstention will have no effect on the outcome of the proposal.

•Proposal No. 2: The ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ended December 31, 2023 requires an affirmative FOR vote of a majority of the shares of our Class A common stock voted affirmatively or negatively for this proposal present in person (including virtually) or represented by proxy at the 2023 Annual Meeting and entitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. If you ABSTAIN from voting on Proposal No. 2, the abstention will have no effect on results of the proposal. Brokerage firms have authority to vote their customers’ unvoted shares held by the firms in street name on this proposal. If a broker does not exercise this authority, such broker non-votes will have no effect on the outcome of this proposal. We are not required to obtain the approval of our stockholders to select our independent registered public accounting firm. However, if our stockholders do not ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for 2023, the audit committee of our board of directors will reconsider its appointment.

•Proposal No. 3: The amendment of our Certificate of Incorporation to include a provision to permit exculpation of officers of the Company for breaches of the fiduciary duty of care to the extent permitted by recent amendments to the Delaware General Corporation Law requires an affirmative FOR vote of a majority of the voting power of all of the outstanding shares of our Class A common stock present in person (including virtually) or represented by proxy at the 2023 Annual Meeting and entitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. Abstentions will count as present and entitled to vote for purposes of this proposal and will have the effect of a vote against this proposal. Broker non-votes will have the effect of a vote against this proposal.

What is a quorum?

A quorum is the minimum number of shares required to be present at the 2023 Annual Meeting for the annual meeting of stockholders to be properly held under our amended and restated bylaws and Delaware law. A majority of the shares of Class A common stock outstanding and entitled to vote, in person (including virtually) or by proxy, constitutes a quorum for the transaction of business at the 2023 Annual Meeting. Abstentions, withhold votes, and broker non-votes are counted as shares present and entitled to vote for purposes of determining a quorum. If there is no quorum, a majority of the shares present at the 2023 Annual Meeting may adjourn the meeting to a later date.

What do I need to do to attend the 2023 Annual Meeting?

You will be able to attend the 2023 Annual Meeting virtually, submit your questions during the meeting and vote your shares electronically at the meeting by visiting www.virtualshareholdermeeting.com/SERA2023. To participate in the 2023 Annual Meeting, you will need the control number from your proxy card. The 2023 Annual Meeting webcast will begin promptly at 8:00 a.m. Mountain Time on Thursday, June 8, 2023. We encourage you to access the meeting prior to the start time. Online check-in will begin at 7:45 a.m. Mountain Time, and you should allow ample time for the check-in procedures. You need not attend the annual meeting in order to vote. To be admitted to the virtual 2023 Annual Meeting, you will need to log in at www.virtualshareholdermeeting.com/SERA2023 using the 16-digit control number found on the proxy card or voting instruction card previously mailed or made available to stockholders entitled to vote at the 2023 Annual Meeting.

How do I vote and what are the voting deadlines?

Stockholders of Record. If you are a stockholder of record, you can vote in one of the following ways:

•You may vote via the Internet. To vote via the Internet prior to the 2023 Annual Meeting, go to www.proxyvote.com to complete an electronic proxy card. You will be asked to provide the control number from the proxy card you receive. Internet voting facilities for stockholders of record will be available 24 hours a day and will close at 11:59 p.m. Eastern Time on June 7, 2023. Your vote must be received by then to be counted. If you vote via the Internet prior to the 2023 Annual Meeting, you do not need to return a proxy card by mail.

•You may vote by telephone. To vote by telephone, dial 1-800-690-6903 (toll-free in the United States and Canada; toll charges apply to calls from other countries) and follow the recorded instructions. You will be asked to provide the control number from the proxy card. Your vote must be received by 11:59 p.m. Eastern Time on June 7, 2023 to be counted. If you vote by telephone, you do not need to return a proxy card by mail.

•You may vote by mail. To vote by mail, you need to complete, date and sign the proxy card that accompanies this proxy statement and return it promptly by mail so that it is received no later than June 7, 2023. The persons named in the proxy card will vote the shares you own in accordance with your instructions on the proxy card you mail. If you return the proxy card, but do not give any instructions on a particular matter to be voted on at the 2023 Annual Meeting, the persons named in the proxy card will vote the shares you own in accordance with the recommendations of our board of directors.

•You may vote virtually during the 2023 Annual Meeting. If you plan to attend the 2023 Annual Meeting by visiting www.virtualshareholdermeeting.com/SERA2023, you may vote electronically and submit questions during the meeting. Please have your proxy card in hand when you visit the website.

Even if you plan to attend the 2023 Annual Meeting, we recommend that you also vote by proxy so that your vote will be counted if you later decide not to attend the 2023 Annual Meeting.

Street Name Stockholders. If you are the beneficial owner of shares held of record by a broker, bank or other nominee, you will receive voting instructions from your broker, bank or other nominee. You must follow the voting instructions provided by your broker, bank or other nominee in order to instruct your broker, bank or other nominee how to vote your shares. The availability of Internet and telephone voting options will depend on the voting process of your broker, bank or other nominee. As discussed above, if you are a street name stockholder, you may not vote your shares live at the 2023 Annual Meeting unless you obtain a legal proxy from your broker, bank or other nominee.

Can I change my vote or revoke my proxy?

Stockholders of Record. If you are a stockholder of record, you may revoke your proxy or change your proxy instructions at any time before your proxy is voted at the 2023 Annual Meeting by:

•entering a new vote by Internet or telephone;

•signing and returning a new proxy card with a later date;

•delivering a written revocation to our Corporate Secretary at Sera Prognostics, Inc., 2749 East Parleys Way, Suite 200, Salt Lake City, Utah 84109, by 11:59 p.m. Eastern Time on June 7, 2023; or

•attending the 2023 Annual Meeting and voting at the meeting virtually. Attending the annual meeting will not in and of itself revoke a previously submitted proxy. You must specifically request at the annual meeting that it be revoked.

Street Name Stockholders. If you are a street name stockholder, you must contact the broker, bank or other nominee holding your shares and follow their instructions to change your vote or revoke your proxy.

What is the effect of giving a proxy?

Proxies are solicited by and on behalf of our board of directors. Gregory C. Critchfield, M.D., M.S. and Benjamin G. Jackson have been designated as proxy holders by our board of directors. When a proxy is properly dated, executed and returned, the shares represented by such proxy will be voted at the 2023 Annual Meeting in accordance with the instructions of the stockholder. If the proxy is dated and signed, but no specific instructions are given, the shares will be voted in accordance with the recommendations of our board of directors. If any matters not described in this proxy statement are properly presented at the 2023 Annual Meeting, the proxy holders will use their own judgment to determine how to vote your shares. If the 2023 Annual Meeting is postponed or adjourned, the proxy holders can vote your shares on the new meeting date, unless you have properly revoked your proxy, as described above.

What if I do not specify how my shares are to be voted?

Stockholders of Record. If you are a stockholder of record and you submit a proxy but you do not provide voting instructions, your shares will be voted:

•“FOR” the election of each of the three directors nominated by our board of directors and named in this proxy statement as Class II directors (Proposal No. 1);

•“FOR” the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2023 (Proposal No. 2);

•In the discretion of the named proxy holders regarding any other matters properly presented for a vote at the 2023 Annual Meeting.

Street Name Stockholders. If you are a street name stockholder and you do not provide your broker, bank or other nominee that holds your shares with voting instructions, then your broker, bank or other nominee will determine if it has discretion to vote on each matter. Brokers do not have discretion to vote on non-routine matters. Proposal No. 1 (election of directors) and Proposal No. 3 (amendment of our Certificate of Incorporation) are non-routine matters, while Proposal No. 2 (ratification of appointment of independent registered public accounting firm) is a routine matter. As a result, if you do not provide voting instructions to your broker, bank or other nominee, then your broker, bank or other nominee may not vote your shares with respect to Proposal No. 1 and Proposal No. 3, which would result in a “broker non-vote,” but may, in its discretion, vote your shares with respect to Proposal No. 2. For additional information regarding broker non-votes, see “—What are the effects of abstentions and broker non-votes?” below.

What are the effects of abstentions and broker non-votes?

An abstention represents a stockholder’s affirmative choice to decline to vote on a proposal. If a stockholder indicates on its proxy card that it wishes to abstain from voting its shares, or if a broker, bank or other nominee holding its customers’

shares of record causes abstentions to be recorded for shares, these shares will be considered present and entitled to vote at the 2023 Annual Meeting. Because the outcome of Proposal No. 1 (election of directors) will be determined by a plurality vote and the outcomes of Proposal No. 2 (ratification of the appointment of the independent registered public accounting firm) will be approved if a majority of the shares voted affirmatively or negatively voted FOR this proposal, abstentions will have no impact on the outcome of such proposals as long as a quorum exists. Because the outcome of Proposal No. 3 (amendment of our Certificate of Incorporation) will be approved if a majority of the voting power of all of the outstanding shares of Class A common stock votes in favor of such proposal, the abstentions will count as present and entitled to vote for purposes of this proposal and will have the effect of a vote against this proposal.

A broker non-vote occurs when a broker, bank or other nominee holding shares for a beneficial owner does not vote on a particular proposal because the broker, bank or other nominee does not have discretionary voting power with respect to such proposal and has not received voting instructions from the beneficial owner of the shares. Broker non-votes will be counted for purposes of calculating whether a quorum is present at the 2023 Annual Meeting but will not be counted for purposes of determining the number of votes cast. Therefore, a broker non-vote will make a quorum more readily attainable but will not otherwise affect the outcome of the vote on any proposal.

How are proxies solicited for the 2023 Annual Meeting and who is paying for such solicitation?

Our board of directors is soliciting proxies for use at the 2023 Annual Meeting by means of the proxy materials. We will bear the entire cost of proxy solicitation, including the preparation, assembly, printing, mailing and distribution of the proxy materials. Copies of solicitation materials will also be made available upon request to brokers, banks and other nominees to forward to the beneficial owners of the shares held of record by such brokers, banks or other nominees. The original solicitation of proxies may be supplemented by solicitation by telephone, electronic communication or other means by our directors, officers, employees or agents. No additional compensation will be paid to these individuals for any such services, although we may reimburse such individuals for their reasonable out-of-pocket expenses in connection with such solicitation. We do not plan to retain a proxy solicitor to assist in the solicitation of proxies.

If you choose to access the proxy materials and/or vote over the Internet, you are responsible for Internet access charges you may incur. If you choose to vote by telephone, you are responsible for telephone charges you may incur.

What does it mean if I received more than one Notice?

If you receive more than one Notice, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on each Notice to ensure that all of your shares are voted.

Is my vote confidential?

Proxy instructions, ballots and voting tabulations that identify individual stockholders are handled in a manner that protects your voting privacy. Your vote will not be disclosed either within the Company or to third parties, except as necessary to meet applicable legal requirements, to allow for the tabulation of votes and certification of the vote, or to facilitate a successful proxy solicitation.

I share an address with another stockholder, and we received only one paper copy of the proxy materials. How may I obtain an additional copy of the proxy materials?

We have adopted a procedure approved by the SEC called “householding,” under which we can deliver a single copy of the proxy materials and annual report to multiple stockholders who share the same address unless we received contrary instructions from one or more of the stockholders. This procedure reduces our printing and mailing costs. The rule applies to our annual reports, proxy statements, and information statements. The practice of householding does not apply to the Notice. Once you receive notice from your broker or from us that communications to your address will be “householded,” the practice will continue until you are otherwise notified or until you revoke your consent to the practice. Stockholders who participate in householding will continue to be able to access and receive separate proxy cards. Upon written or oral request, we will promptly deliver a separate copy of the proxy materials and annual report to any stockholder at a shared address to which we delivered a single copy of any of these documents. To receive a separate

copy, or, if you are receiving multiple copies, to request that we only send a single copy of next year’s proxy materials and annual report, you may contact us as follows:


Sera Prognostics, Inc.
Attention: Corporate Secretary
2749 East Parleys Way, Suite 200
Salt Lake City, Utah 84109
(801) 990-0660

Stockholders who hold shares in street name may contact their brokerage firm, bank, broker-dealer or other nominee to request information about householding.

How can I find out the results of the voting at the 2023 Annual Meeting?

We will announce preliminary voting results at the 2023 Annual Meeting. In addition, we will disclose final voting results on a Current Report on Form 8-K that we expect to file within four business days after the 2023 Annual Meeting. If final voting results are not available to us in time to file a Form 8-K within four business days after the 2023 Annual Meeting, we intend to file a Form 8-K to publish preliminary results and, within four business days after the final results are known to us, we will file an amendment to the Form 8-K to disclose the final results.

What is the deadline to propose actions for consideration at next year’s annual meeting of stockholders or to nominate individuals to serve as directors?

Stockholder Proposals

Stockholders may present proper proposals for inclusion in our proxy statement and for consideration at next year’s annual meeting of stockholders by submitting their proposals in writing to our Secretary in a timely manner. For a stockholder proposal to be considered for inclusion in our proxy statement for our 2024 Annual Meeting of Stockholders, our Secretary must receive the written proposal at our principal executive offices not later than December 27, 2023. In addition, stockholder proposals must comply with the requirements of Rule 14a-8 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”) regarding the inclusion of stockholder proposals in company-sponsored proxy materials. Stockholder proposals should be addressed to:


Sera Prognostics, Inc.
Attention: Corporate Secretary
2749 East Parleys Way, Suite 200
Salt Lake City, Utah 84109

Our amended and restated bylaws also establish an advance notice procedure for stockholders who wish to present a proposal before an annual meeting of stockholders but do not intend for the proposal to be included in our proxy statement. Our amended and restated bylaws provide that the only business that may be conducted at an annual meeting is business that is (i) specified in our proxy materials with respect to such meeting, (ii) otherwise properly brought before the annual meeting by or at the direction of our board of directors, or (iii) properly brought before the annual meeting by a stockholder of record entitled to vote at the annual meeting who has delivered timely written notice to our Secretary, which notice must contain the information specified in our bylaws. To be timely for our 2024 Annual Meeting of Stockholders, our Secretary must receive the written notice at our principal executive offices:

•not earlier than February 9, 2024, and

•not later than March 10, 2024.

In the event that we hold our 2024 Annual Meeting of stockholders more than 30 days before or more than 60 days after the first anniversary of the date of the 2023 Annual Meeting, then notice of a stockholder proposal that is not intended to

be included in our proxy statement must be received no earlier than the close of business on the 120th day before such annual meeting and no later than the close of business on the later of the following two dates:

•the 90th day prior to such annual meeting; or

•the 10th day following the day on which public announcement of the date of such annual meeting is first made.

If a stockholder who has notified us of his, her or its intention to present a proposal at an annual meeting does not appear to present his, her or its proposal at such annual meeting, we are not required to present the proposal for a vote at such annual meeting.

Nomination of Director Candidates

You may propose director candidates for consideration by our corporate nominating and governance committee. Any such recommendations should include the nominee’s name and qualifications for membership on our board of directors and should be directed to our Secretary at the address set forth above. For additional information regarding stockholder recommendations for director candidates, see the section titled “Board of Directors and Corporate Governance—Stockholder Recommendations for Nominations to the Board of Directors.”

In addition, our bylaws permit stockholders to nominate directors for election at an annual meeting of stockholders. To nominate a director, the stockholder must provide the information required by our bylaws. In addition, the stockholder must give timely notice to our Secretary in accordance with our bylaws, which, in general, require that the notice be received by our Secretary within the time period described above under “Stockholder Proposals” for stockholder proposals that are not intended to be included in a proxy statement.

Availability of Bylaws

A copy of our amended and restated bylaws may be obtained by accessing our public filings on the SEC’s website at www.sec.gov. You may also contact our Secretary at our principal executive office for a copy of the relevant bylaw provisions regarding the requirements for making stockholder proposals and nominating director candidates.

Electronic Delivery of Company Stockholder Communications

Most stockholders can elect to view or receive copies of future proxy materials over the Internet instead of receiving paper copies in the mail.

You can choose this option and save us the cost of producing and mailing these documents by:

•following the instructions provided on your Notice or proxy card; or

•following the instructions provided when you vote over the Internet.

BOARD OF DIRECTORS AND CORPORATE GOVERNANCE

Our amended and restated bylaws provide that our business affairs are managed under the direction of our board of directors, which currently consists of nine members. Our board of directors has affirmatively determined that eight of our nine directors qualify as “independent” within the meaning of the listing standards of the Nasdaq Stock Market LLC (“Nasdaq”). Our board of directors is divided into three classes with staggered three-year terms. At each annual meeting of stockholders, a class of directors will be elected for a three-year term to succeed the same class whose term is then expiring.

Each director’s term continues until his or her successor is duly elected and qualified or until his or her death, resignation, or removal. Any increase or decrease in the number of directors will be distributed among the three classes so that, as nearly as possible, each class will consist of one-third of the directors. This classification of our board of directors may have the effect of delaying or preventing changes in control of our company.

The following table sets forth the names and certain other information for each of the nominees for election as a director and for each of the continuing members of the board of directors as of March 31, 2023.


Name		Class	Age	Position	Director Since	Current Term Expires	Expiration of Term For Which Nominated
Director Nominees
Kim Kamdar, Ph.D.(2)		II	55	Director	2011	2023	2026
Sandra A.J. Lawrence(1)		II	65	Director	2021	2023	2026
Ryan Trimble(1)		II	71	Director	2011	2023	2026
Continuing Directors
Gregory C. Critchfield, M.D., M.S.		III	71	Chairman, President and Chief Executive Officer	2011	2024	—
Zhenya Lindgardt(2)		III	49	Director	2021	2024	—
Joshua Phillips(1)(2)		III	56	Director	2011	2024	—
Jane F. Barlow, M.D.(3)		I	62	Director	2022	2025	—
Mansoor Raza Mirza, M.D.(3)		I	62	Director	2014	2025	—
Marcus Wilson, Pharm.D.(3)		I	60	Director	2021	2025	—

(1)	Member of the audit committee
(2)	Member of the compensation committee
(3)	Member of the nominating and governance committee

Nominees for Director

Kim Kamdar, Ph.D. has served as a member of our board of directors since her appointment in November 2011. Dr. Kamdar is currently a Partner at Domain Associates, LLC, a venture capital firm, where she has worked since 2005. Prior to Domain, Dr. Kamdar was a Kauffman Fellow with MPM Capital, as well as a research director at Novartis International AG. Dr. Kamdar is currently Chair of the Board of Directors of Seraphina Therapeutics and Truvian Sciences, Inc. and serves on the board of directors of EvoFem Biosciences, Inc., Obalon Therapeutics, Inc. and Singular Genomics Systems. Dr. Kamdar currently serves on the board of several private companies including: Epic Sciences, Inc., Alume Biosciences and Pleno, Inc. Dr. Kamdar serves as an advisory board member of Dr. Eric Topol’s NIH supported Clinical and Translational Science Award for Scripps Medicine and is also on the nonprofit board for Access Youth Academy, an organization that is transforming the lives of underserved youth through academic enrichment, health and wellness, social responsibility and leadership through squash. Dr. Kamdar received her B.A. from Northwestern University and her Ph.D. in biochemistry and genetics from Emory University. We believe Dr. Kamdar is qualified to serve on our Board of Directors based on her extensive experience working and serving on the boards of

directors of life sciences companies and her experience working in the venture capital industry and her knowledge of our business through service on our board since November 2011.

Sandra A.J. Lawrence has served as a member of our board of directors since her appointment in November 2021. Ms. Lawrence has served as trustee of the Delaware Funds by Macquarie, as a director of its New York and Australian Stock Exchange-Listed close-end funds, DEW/VCF/DDF/VMM/VFL/IVH, and on its Audit and Investments Committees since 2021. She has served as a trustee of its legacy Ivy and Waddell and Reed Mutual Funds Complex Trust, and on its Governance Committee, since 2019. Ms. Lawrence was the Executive Vice President and Chief Financial Officer of Children’s Mercy Hospital, a comprehensive pediatric medical center in Kansas City, Missouri, from 2005 to 2016 and the Executive Vice President and Chief Administrative Officer of Children’s Mercy Hospital from 2016 to February 2019. She was Senior Vice President and Treasurer of Midwest Research Institute, an independent, non-profit, contract research organization, located in Kansas City, Missouri, and subsequently its Chief Financial Officer. Ms. Lawrence spent twenty-six years in professional or management positions in the architecture, real estate, investment banking, financial services, packaging, and medical research industries. Ms. Lawrence also serves as a member of the board of directors of Evergy, Inc., a publicly traded company that provides clean, safe and reliable energy to 1.6 million customers in Kansas and Missouri, where she serves as chair of the Nominating, Governance, and Corporate Responsibility Committee, and as a member of the Compensation and Leadership Development Committee. Ms. Lawrence serves on the board of directors of American Shared Hospital Services, a publicly traded company that provides radiosurgical and radiation therapy equipment and services, based in San Francisco, California, where she serves as chair of the Audit Committee and as a member of the Nominating and Corporate Governance Committee. Additionally, she serves on the board, as chair of the Risk Oversight Committee, and on the Governance, Compliance, and Talent and Compensation Committees, of Recology, a large, private, Employee Stock Ownership Plan company that provides collection and disposal of municipal solid waste, recycling, and organic/compost to commercial and residential customers in California, Oregon, and Washington. Ms. Lawrence has been the chair of the board of directors of the Heartland Chapter of the National Association of Corporate Directors (NACD), was named one of its Directorship 100, and an NACD board leadership fellow. She serves on the boards of directors of various charitable, non-profit and civic organizations, including the Hall Family Foundation, the Nelson-Atkins Museum of Art, and Women Corporate Directors. Ms. Lawrence is a graduate of Vassar College, where she received her Bachelor of Arts in psychology. She also received a Master of Architecture from the Massachusetts Institute of Technology and a Master in Business Administration from Harvard Business School. We believe Ms. Lawrence is qualified to serve as a member of our Board because of her work experience, financial background, academic background and service on corporate and charitable boards, particularly her combined experience as the Chief Financial Officer and then the Chief Administrative Officer of a comprehensive pediatric medical center for a period spanning more than a decade.

Ryan Trimble has served as a member of our board of directors since his appointment in March 2011. He brings over 30 years of experience in the healthcare services industry. He is a former senior executive with FHP International, Wellpoint Health Networks, P5 eHealth Systems, and SCAN Health Plan. He recently completed service on the boards of SCAN Health Plan and The Scan Foundation. Dr. Trimble has a B.S. in Microbiology from Brigham Young University, a D.D.S. from Loyola University in Chicago, and an M.B.A. from the University of Utah. We believe Mr. Trimble’s qualifications to serve on our board include his leadership experience with public companies and other board member experience, and his knowledge of our business through service on our board since March 2011.

Continuing Directors

Class III Directors continuing in Office until the 2024 Annual Meeting of Stockholders

Gregory C. Critchfield, M.D., M.S. has served as a member of our board of directors since his appointment in 2010 and as our Chairman, President and Chief Executive Officer since November 2011. Dr. Critchfield brings decades of experience in the diagnostics industry, including a proven track record of successfully launching diagnostics products and significantly growing revenues for leading diagnostics companies. Previously, Dr. Critchfield was President of Myriad Genetic Laboratories, a wholly-owned subsidiary of Myriad Genetics, Inc., a molecular diagnostics company, from 1998-2010. Under his leadership, Myriad launched seven novel molecular diagnostic products across a variety of technology platforms and increased annual revenues from $2.2 million to $326.5 million. Prior to Dr. Critchfield’s role at Myriad, he served as Senior Vice President, Chief Medical and Science Officer of Quest Diagnostics (formerly Corning Clinical Laboratories). Prior to Quest Diagnostics, Dr. Critchfield was the Director of Clinical Pathology at

Intermountain Health Care. Dr. Critchfield has served on the boards of Saladax Biomedical Inc., BioTrove Inc., Biocius Life Sciences, Inc., Integrated Diagnostics, Inc., Nodality, Inc., Metamark Genetics, Inc., Lantos Technologies and Condor Therapeutics, Inc., and currently serves as a director of Epic Sciences. He also served as both a reviewer and an NIH Study Section Chair for biomedical computing grants over a period of time encompassing fifteen years. He holds a B.S. in Microbiology from Brigham Young University, an M.S. in Biophysical Sciences from the University of Minnesota and an M.D. from the University of Utah College of Medicine. We believe that Dr. Critchfield’s perspective and experience as our President and Chief Executive Officer, as well as his depth of experience in the diagnostics industry, provide him with the qualifications and skills to serve on our board of directors.

Zhenya Lindgardt has served as a member of our board of directors since her appointment in November 2021. Ms. Lindgardt has served as Chief Executive Officer of The Commons Project Foundation, a non-profit public trust established with support from the Rockefeller Foundation, since October 2021. From August 2020 to October 2021, Ms. Lindgardt served as a Managing Director of her Family office. From April 2019 to August 2020, Ms. Lindgardt served as Vice President of Platform and Customer Engagement of the Executive Team at Uber Technologies Inc., a publicly traded transportation network company. Prior to this role, from October 2000 to April 2019, Ms. Lindgardt served as Senior Partner and Managing Director at The Boston Consulting Group, a global consulting company. Ms. Lindgardt also served on the board of directors of City Harvest, a New York City hunger charity from June 2017 to June 2020. Ms. Lindgardt received her B.S. degree in business administration from the University of Southern California and her MBA from Harvard University. We believe Ms. Lindgardt is qualified to serve as a member of our Board based on her deep understanding of both healthcare and consumer technologies and vast experience holding senior leadership positions at large, global technology and consulting companies, including Uber Technologies Inc. and The Boston Consulting Group.

Joshua Phillips has served as a member of our board of directors since his appointment in January 2011. Since 2008, Mr. Phillips has been a Managing Partner of Catalyst Health Ventures (CHV), a venture capital fund investing in medical technology and life science companies. Mr. Phillips led Catalyst’s investments in Novazyme Pharmaceuticals, Inc. (acquired by Genzyme Corp.), BioTrove, Inc. (acquired by Life Technologies Corp.), Biocius Life Sciences, Inc. (acquired by Agilent Technologies, Inc.), Vortex Medical, Inc. (acquired by AngioDynamics), Allegro Diagnostics, Inc. (acquired by Veracyte, Inc.), SevenOaksBiosciences (acquired by Medline Industries, Inc.), Pavilion Medical Innovations and Cruzar Medsystems, in addition to our company. Mr. Phillips is a director at several privately held companies, including Conformal Medical, Inc., Brixton Biosciences, Inc., Saphena Medical, Inc., and Cruzar Medsystems, Inc. Mr. Phillips holds an M.B.A. from the Harvard Business School and a B.E. in Electrical Engineering and Mathematics from Vanderbilt University. We believe that Mr. Phillips’ qualifications to serve on our board include his extensive experience in the life science, diagnostics and medical device markets, his extensive experience serving on boards as Chairman, Lead Director, Audit & Compensation Committee Chair and Member and his knowledge of our business through service on our board since January 2011.

Class I Directors continuing in Office until the 2025 Annual Meeting of Stockholders

Jane F. Barlow, M.D. has served as a member of our board of directors since her appointment in April 2022. Dr. Barlow has served as Chief Executive Officer of Jane Barlow & Associates, LLC, a consulting firm focused on value-based health care services, since January 2017, and Executive Vice President and Chief Clinical Officer at Real Endpoints, a data, analytics, and advisory firm, since January 2017. She currently serves on the board of directors of ContraFect Corp., a publicly traded biotechnology company, and Viracta Therapeutics, Inc., a publicly traded precision oncology company. Dr. Barlow also serves on the board of directors of Point Health, a healthcare navigation platform, the advisory board of Refactor Health, and the Biotech Advisory Board of Pictet Asset Management, an asset management firm. Prior to her current roles, Dr. Barlow was Associate Chief Medical Officer at CVS Health and Chief Medical Officer of CVS Health’s Government Services arm where she successfully implemented industry-leading clinical strategies supporting drug purchasing, distribution, and utilization management. Formerly, she served as Vice President of Clinical Innovation at Medco Health Solutions, leading the adoption of cutting-edge therapeutic programs through all aspects of pharmacy. Dr. Barlow previously served on the board of directors of Momenta Pharmaceuticals, Inc., (prior to and during its sale to Johnson and Johnson), Therapeutics MD Inc., and SilverScript Insurance Company. Dr. Barlow received her medical degree from Creighton University School of Medicine and subsequently completed her residency in occupational and environmental medicine at The Johns Hopkins University, where she also earned her M.P.H. Additionally, she holds an M.B.A. from the University of Alabama. She is board-certified in occupational medicine and a fellow of the American College of Occupational and Environmental Medicine and the American College of Preventive Medicine. She is a

diplomat of the American College of Physician Executives and a member of the American Medical Association. We believe that Dr. Barlow is qualified to serve as a member of our Board because of her extensive experience in steering pharmaceutical development, academic background and service on corporate and charitable boards.

Mansoor Raza Mirza, M.D. has served as a member of our board of directors since his appointment in December 2014. Dr. Mirza is Chief Oncologist at the Department of Oncology, Rigshopitalet — the Copenhagen University Hospital, Denmark and Medical Director of the Nordic Society of Gynaecological Oncology (“NSGO”). Dr. Mirza is Chairman of the European Network of Gynaecological Oncological Trial groups (“ENGOT”). Dr. Mirza is both a medical and radiation oncologist, with a primary focus in non-surgical treatment of gynecologic cancers. His key academic goals are to promote clinical research, international trial collaboration and education, and he has broad experience in clinical protocol development, trial conduct and clinical trial regulations. Dr. Mirza is the author of several phase 1, 2 and 3 studies. Several of those studies led to FDA and European Medicines Agency registrations. He serves on several Independent Data Safety Monitoring Committees of international studies. He is an invited speaker at several international conferences, such as “Meet the Professor” at American Society of Clinical Oncology and “Presidential Symposium” at European Society for Medical Oncology. He is the author of global consensus guidelines for the management of ovarian cancer and of European guidelines for the management of several gynecological malignancies. His other current appointments include service as ESGO Council Member (European Society of Gynaecological Oncology), Executive Director of GCIG (Gynecologic Cancer InterGroup), Vice-Chairman of the Danish Gynecological Cancer Society, faculty member of the European Society of Medical Oncology and of ESGO. He also serves on the board of directors of Karyopharm Therapeutics Inc., a public pharmaceutical company and has served as a clinical consultant to Karyopharm Therapeutics Inc. since 2010. He has multiple publications in high-impact journals, including several publications in the New England Journal of Medicine and the Lancet. He holds an M.D., Diploma in Surgery and Diploma in Clinical Oncology from the Pirogov Moscow State Medical Institute as well as post-graduate education and certification in radiation and medical oncology from the University of Southern Denmark. We believe Dr. Mirza’s qualifications to serve on our board include his expertise in gynecologic cancers, and his knowledge of our company and its business through service on our board since December 2014.

Marcus Wilson, Pharm.D., has served as a member of our board of directors since his appointment in March 2021. He has served as the Chief Analytics Officer (“CAO”), at Elevance Health (formerly Anthem) since November 2020. Previously, from October 2003 to November 2020, Dr. Wilson was President of Carelon Research (formerly Healthcore, Inc.), a subsidiary of Elevance Health. In his role as CAO at Elevance Health, Dr. Wilson has accountability for efforts to derive critical clinical and business insight from Elevance Health’s healthcare ecosystem to drive decisions for a broad range of healthcare stakeholders to improve healthcare quality, safety, access, and affordability. He is charged with defining and implementing Elevance Health’s enterprise analytics strategy. Efforts include setting analytic priorities, building new analytic capabilities, and driving value creation through the coordination of business and technical resources. He also has administrative oversight accountability for Carelon Research, Elevance Health’s subsidiary that collaborates with various external stakeholders within the FDA, NIH, and life sciences industry, among others. Dr. Wilson currently has approximately five hundred employees under management. Additionally, Dr. Wilson founded, managed and grew a healthcare research organization for twenty-four years, seven years as an independent company and seventeen years as a subsidiary post-acquisition by WellPoint Health Network Inc. (now Elevance Health, Inc.). Prior to co-founding HealthCore in 1996, Dr. Wilson spent seven years on faculty at the Philadelphia College of Pharmacy and established and managed a clinical practice within an integrated delivery system owned by Blue Cross Blue Shield of Delaware where he oversaw the physician and patient clinical decision support, pharmacy policy, and clinical trials programs. Dr. Wilson was previously a member of the board of directors of Techulon, Inc., a biotechnology research company, and a member of the board of directors of The Center for Medical Technology Policy (“CMTP”), an independent, non-profit 501(c) (3) organization. He holds a PharmD from the Medical College of Virginia, a B.S. in Biochemistry from Virginia Tech and attended the Medical University of South Carolina for his residency in Family Medicine. We believe that Dr. Wilson’s background and experience within the healthcare industry, including acting as President of Carelon Research, qualifies him to serve on our board.

Board Composition

Our board of directors currently consists of nine members. All nine of our directors are members pursuant to the board composition provisions of our amended and restated certificate of incorporation and amended and restated bylaws. Our board of directors may consider a broad range of factors relating to the qualifications and background of nominees,

including diversity, which is not limited only to race, gender or national origin. We have no formal policy regarding board diversity. Our board of directors’ priority in selecting board members is identification of persons who will further the interests of our stockholders through their established records of professional accomplishment, the ability to contribute positively to the collaborative culture among board members, knowledge of our business, understanding of the competitive landscape, professional and personal experiences, and expertise relevant to our growth strategy. Our directors hold office until their successors have been elected and qualified or until the earlier of their death, resignation or removal. Our amended and restated certificate of incorporation and amended and restated bylaws provide that our directors may be removed only for cause by the affirmative vote of the holders of at least 75% of the votes that all our stockholders would be entitled to cast in an annual election of directors, and that any vacancy on our board of directors, including a vacancy resulting from an enlargement of our board of directors, may be filled only by vote of a majority of our directors then in office.

Pursuant to an amended letter agreement with Baker Bros. Advisors LP, or Baker Bros., at any time that Baker Bros. beneficially owns shares or other equity securities representing at least 9.9% of our then-outstanding total voting power, it is entitled to nominate one individual, or an Investor Designee, to serve as a director on our board of directors. We are required to include the Investor Designee in the slate of nominees recommended to our stockholders for election as our directors at each annual or special meeting of our stockholders at which directors are to be elected. Baker Bros. is restricted from exercising this right during certain periods of time.

Pursuant to a letter agreement with Vivo Capital Fund IX, L.P., or Vivo, at any time that Vivo beneficially owns shares or other equity securities representing at least (a) 75% of the securities which Vivo and its fund affiliates had originally purchased at the time of the letter agreement, or (b) 4% of our then-outstanding total voting power, it is entitled to nominate one individual, or a Vivo Investor Designee, to serve as a director on our board of directors. As of the date hereof, Vivo had not exercised its rights to nominate a Vivo Investor Designee to serve as a director on our board of directors.

Director Independence

Our Class A common stock is listed on the Nasdaq Global Market. Under the listing standards of Nasdaq, independent directors must comprise a majority of a listed company’s board of directors within one year of the completion of its initial public offering. In addition, the listing standards of Nasdaq require that, subject to specified exceptions, each member of a listed company’s audit, compensation and nominating and governance committees be independent. Audit committee members and compensation committee members must also satisfy the independence criteria set forth in Rule 10A-3 and Rule 10C-1, respectively, under the Exchange Act. Under the listing standards of Nasdaq, a director will only qualify as an “independent director” if, in the opinion of that company’s board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director.

To be considered to be independent for purposes of Rule 10A-3 and under the listing standards of Nasdaq, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the board of directors or any other board committee: (1) accept, directly or indirectly, any consulting, advisory or other compensatory fee from the listed company or any of its subsidiaries or (2) be an affiliated person of the listed company or any of its subsidiaries.

To be considered independent for purposes of Rule 10C-1 and under the listing standards of Nasdaq, the board of directors must affirmatively determine that each member of the compensation committee is independent, including a consideration of all factors specifically relevant to determining whether the director has a relationship to the company which is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, including: (1) the source of compensation of such director, including any consulting, advisory or other compensatory fee paid by the company to such director and (2) whether such director is affiliated with the company, a subsidiary of the company or an affiliate of a subsidiary of the company.

Our board of directors has undertaken a review of its composition, the composition of its committees and the independence of each director and considered whether any director has a material relationship with us that could compromise his or her ability to exercise independent judgment in carrying out his or her responsibilities. Based upon

information requested from and provided by each director concerning his or her background, employment and affiliations, including family relationships, our board of directors has determined that, except for Dr. Critchfield, none of our directors have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director and that each of these directors is “independent” as that term is defined under the listing standards of Nasdaq. In addition, our board of directors has determined that all members of our audit, compensation, and corporate governance and nominating committees satisfy the independence standards for committee members established by applicable SEC rules and regulations and the listing standards of Nasdaq.

In making these determinations, our board of directors considered the current and prior relationships that each non-employee director has with our company and all other facts and circumstances our board of directors deemed relevant in determining their independence, including the beneficial ownership of our capital stock by each non-employee director, and the transactions involving them described in the section titled “Certain Relationships and Related Party and Other Transactions.”

Board Leadership Structure and Risk Oversight

Our board of directors is currently chaired by Gregory C. Critchfield, M.D., M.S., who also serves as our President and Chief Executive Officer. Our board of directors does not have a policy regarding the separation of the roles of Chief Executive Officer and Chairman of the board of directors, as our board of directors believes it is in our best interest to make that determination based on our position and direction and the membership of the board of directors. Our board of directors has determined that having an employee director serve as Chairman is in the best interest of our stockholders at this time because of the efficiencies achieved in having the role of Chief Executive Officer and Chairman combined, and because the detailed knowledge of our day-to-day operations and business that the Chief Executive Officer possesses greatly enhances the decision-making processes of our board of directors as a whole. We have a governance structure in place, including independent directors, designed to ensure the powers and duties of the dual role are handled responsibly. Our board of directors has also appointed Kim Kamdar, Ph.D. as our lead independent director. Our board of directors has determined that we would be best served by also having a lead independent director to be responsible for conducting sessions with the independent directors as part of every board of directors meeting, calling special meetings of the independent directors and chairing all meetings of the independent directors.

Our board of directors oversees the management of risks inherent in the operation of our business and the implementation of our business strategies. Our board of directors performs this oversight role by using several different levels of review. In connection with its reviews of our operations and corporate functions, our board of directors addresses the primary risks associated with those operations and corporate functions. In addition, our board of directors reviews the risks associated with our business strategies periodically throughout the year as part of its consideration of undertaking any such business strategies.

Each of our board committees also oversees the management of our risks that fall within the committee’s areas of responsibility. In performing this function, each committee has full access to management, as well as the ability to engage advisors. Our Chief Executive Officer reports to the audit committee and is responsible for identifying, evaluating and implementing risk management controls and methodologies to address any identified risks. In connection with its risk management role, our audit committee meets privately with representatives from our independent registered public accounting firm and our Chief Executive Officer. The audit committee oversees the operation of our risk management program, including the identification of the primary risks associated with our business and periodic updates to such risks, and reports to our board of directors regarding these activities.

Board Meetings

During our fiscal year ended December 31, 2022, there were six meetings of our board of directors (including regularly scheduled and special meetings), and the various committees of the board of directors met a total of ten times, and each director attended at least 75% of the aggregate of (i) the total number of meetings of our board of directors held during the period for which he or she has been a director and (ii) the total number of meetings held by all committees of our board of directors on which he or she served during the periods that he or she served on such committee.

Attendance of Directors at Annual Meetings of Stockholders

Although we do not have a formal policy regarding attendance by members of our board of directors at annual meetings of stockholders, we strongly encourage, but do not require, our directors to attend.

Board Committees

Our board of directors has established an audit committee, a compensation committee, and a nominating and governance committee. The composition and responsibilities of each of the committees of our board of directors are described below. Members serve on these committees until their resignation or until otherwise determined by our board of directors. Our board of directors may establish other committees as it deems necessary or appropriate from time to time.

Audit Committee

Our audit committee consists of Joshua Phillips, Sandra A.J. Lawrence, and Ryan Trimble, with Mr. Phillips serving as Chair. Zhenya Lindgardt also attends most Audit Committee meetings as a formal observer. Our board of directors has determined that each member of our audit committee satisfies the independence requirements under the listing standards of Nasdaq and Rule 10A-3 of the Exchange Act. Our board of directors has determined that Mr. Phillips is an “audit committee financial expert” within the meaning of SEC regulations and the applicable rules of the The Nasdaq Stock Market. Each member of our audit committee can read and understand fundamental financial statements in accordance with applicable requirements. In arriving at these determinations, our board of directors examined each audit committee member’s scope of experience and the nature of their employment in the corporate finance sector.

Our audit committee oversees our corporate accounting and financial reporting process and assists our board of directors in monitoring our financial systems. Our audit committee is also responsible for, among other things:

•selecting a firm to serve as the independent registered public accounting firm to audit our financial statements;

•ensuring the independence of the independent registered public accounting firm;

•discussing the scope and results of the audit with the independent registered public accounting firm, and reviewing, with management and that firm, our interim and year-end operating results;

•establishing procedures for employees to anonymously submit concerns about questionable accounting or audit matters;

•considering the effectiveness of our internal controls and internal audit function;

•reviewing material related-party transactions or those that require disclosure; and

•approving or, as permitted, pre-approving all audit and non-audit services to be performed by the independent registered public accounting firm.

During 2022, our audit committee met seven times. Our audit committee operates under a written charter that satisfies the applicable rules and regulations of the SEC and the listing standards of Nasdaq. A copy of the charter for our audit committee is available on our investor relations website at investors.seraprognostics.com under Investors — Governance — Documents & Charters.

Compensation Committee

Our compensation committee consists of Kim Kamdar, Ph.D., Joshua Phillips, and Zhenya Lindgardt, with Dr. Kamdar serving as Chair. Our board of directors has determined that each member of our compensation committee is independent under the listing standards of Nasdaq and a “non-employee director” as defined in Rule 16b-3 under the Exchange Act, and an outside director, as defined pursuant to Section 162(m) of the Internal Revenue Code of 1986, as amended. Our board of directors has determined that each member of the compensation committee is “independent” as defined in the

rules of The Nasdaq Stock Market. The composition of our compensation committee meets the requirements for independence under the listing standards of The Nasdaq Stock Market.

Our compensation committee oversees our compensation policies, plans, and benefits programs. The compensation committee is also responsible for, among other things:

•reviewing and approving, or recommending that our board of directors approve, the compensation of our executive officers;

•reviewing and recommending to our board of directors the compensation of our directors;

•reviewing and recommending to our board of directors the terms of any compensatory agreements with our executive officers;

•administering our stock and equity incentive plans;

•reviewing and approving, or making recommendations to our board of directors with respect to, incentive compensation and equity plans; and

•reviewing all overall compensation policies and practices.

During 2022, our compensation committee met three times. Our compensation committee operates under a written charter that satisfies the applicable rules and regulations of the SEC and the listing standards of Nasdaq. A copy of the charter for our compensation committee is available on our investor relations website at investors.seraprognostics.com under Investors — Governance — Documents & Charters.

Nominating and Governance Committee

Our nominating and governance committee consists of Marcus Wilson, Pharm.D., Jane F. Barlow, M.D., and Mansoor Raza Mirza, M.D., with Dr. Wilson serving as Chair. Our board of directors has determined that each of the members of our nominating and governance committee is independent under the listing standards of Nasdaq.

Our nominating and governance committee oversees and assists our board of directors in reviewing and recommending nominees for election as directors. The corporate governance and nominating committee is also responsible for, among other things:

•identifying and recommending candidates for membership on our board of directors;

•recommending directors to serve on board committees;

•reviewing and recommending our corporate governance guidelines and policies;

•reviewing proposed waivers of the code of conduct for directors and executive officers;

•evaluating, and overseeing the process of evaluating, the performance of our board of directors and individual directors; and

•assisting our board of directors on corporate governance matters.

During 2022, our nominating and governance committee did not formally meet. Our nominating and governance committee operates under a written charter that satisfies the applicable rules and regulations of the SEC and the listing standards of Nasdaq. A copy of the charter for our compensation committee is available on our investor relations website at investors.seraprognostics.com under Investors — Governance — Documents & Charters.

Considerations in Evaluating Director Nominees

Our nominating and governance committee uses a variety of methods, including engaging the services of outside consultants and search firms, to identify and evaluate director nominees. In its evaluation of director candidates, our nominating and governance committee will consider the current size and composition of our board of directors and the needs of our board of directors and the respective committees of our board of directors. Some of the qualifications that our corporate governance and nominating committee considers include such factors as character, integrity, judgment, diversity (including, without limitation, diversity in terms of gender, race, ethnicity and experience), age, independence, skills, education, expertise, business acumen, corporate experience, length of service, understanding of our business and other commitments, among other things.

Nominees must also have the highest personal and professional ethics and integrity and skills that are complementary to those of the existing directors. Director candidates must have the ability to assist and support management and make significant contributions to our success based on proven achievement and competence in the nominee’s field and the ability to exercise sound business judgment. Nominees must also have an understanding of the fiduciary responsibilities that are required of a member of our board of directors and the commitment of time and energy necessary to diligently carry out those responsibilities. Members of our board of directors are expected to prepare for, attend, and participate in all board of directors and applicable committee meetings. Our nominating and governance committee may also consider such other factors as it may deem, from time to time, are in our and our stockholders’ best interests.

The nominating and governance committee considers the suitability of each director candidate, including current directors, in light of the current size and composition of our board. Although our board of directors does not maintain a specific policy with respect to board diversity, our board of directors believes that our board of directors should be a diverse body, and our nominating and governance committee considers a broad range of backgrounds and experiences. In making determinations regarding nominations of directors, our nominating and governance committee may take into account the benefits of diverse viewpoints. Our nominating and governance committee also considers these and other factors as it oversees the annual board of director and committee evaluations. After completing its review and evaluation of director candidates, our nominating and governance committee recommends to our full board of directors the director nominees for selection.

Stockholder Recommendations for Nominations to the Board of Directors

The nominating and governance committee will consider candidates for directors recommended by stockholders so long as such recommendations comply with the certificate of incorporation and bylaws of our company and applicable laws, rules and regulations, including those promulgated by the SEC. The committee will evaluate such recommendations in accordance with its charter, our bylaws and the regular nominee criteria described above. This process is designed to ensure that the board of directors includes members with diverse backgrounds, skills and experience, including appropriate financial and other expertise relevant to our business. Eligible stockholders wishing to recommend a candidate for nomination should contact our corporate secretary in writing. Such recommendations must include information about the candidate, a statement of support by the recommending stockholder, evidence of the recommending stockholder’s ownership of our stock and a signed letter from the candidate confirming willingness to serve on our board of directors. The committee has discretion to decide which individuals to recommend for nomination as directors.

A stockholder of record can nominate a candidate directly for election to the board of directors by complying with the requirements and procedures in our bylaws. For additional information regarding stockholder nominations of director candidates, see “Questions and Answers — What is the deadline to propose actions for consideration at next year’s annual meeting of stockholders or to nominate individuals to serve as directors?”

Stockholder and Interested Party Communications with the Board of Directors

Interested parties wishing to communicate with non-management members of our board of directors may do so by writing and mailing the correspondence to: Sera Prognostics, Inc., Attention: Corporate Secretary, 2749 East Parleys Way, Suite 200, Salt Lake City, Utah 84109. Our Corporate Secretary monitors these communications and will provide a summary of all received bona fide messages to our board of directors at each regularly scheduled meeting of our board of

directors. Where the nature of a communication warrants, our Corporate Secretary may determine, in his or her judgment, to obtain the more immediate attention of the appropriate committee of the board of directors or non-management director, of independent advisors or of our management.

This procedure does not apply to (a) communications to non-management directors from officers or directors who are stockholders, (b) stockholder proposals submitted pursuant to Rule 14a-8 under the Exchange Act or (c) communications to our audit committee pursuant to our complaint procedures for accounting and auditing matters.

Board Diversity

We believe that our board of directors should be diverse, including a diversity of experience, competency in relevant fields, gender, race, ethnicity and age. In making determinations regarding nominations of directors, our nominating and governance committee takes into account the benefits of diverse viewpoints. Our nominating and governance committee will also consider these and other factors as it oversees any annual board of directors and committee evaluations.

The table below provides certain information regarding the diversity of our board of directors:


Board Diversity Matrix (As of March 31, 2023)
Board Size:
Total Number of Directors	9
	Female	Male	Non-Binary	Did not Disclose Gender
Gender Identity:
Directors	4	4	—	1
Number of Directors Who Identify in Any of the Categories Below:
African American or Black	1	—	—	—
Alaskan Native or Native American	—	—	—	—
Asian	1	1	—	—
Hispanic	—	—	—	—
Native Hawaiian or Pacific Islander	—	—	—	—
White	2	3	—	—
Two or More Races or Ethnicities	—	—	—	—
LGBTQ+	—
Persons with Disabilities	—
Did Not Disclose Demographic Background	1

Corporate Code of Conduct and Ethics

We are committed to the highest standards of integrity and ethics in the way we conduct our business. Our board of directors has adopted a Corporate Code of Conduct and Ethics, which applies to all of our employees, officers and directors, including our chief executive officer, chief financial officer, and other executive and senior financial officers. Our code of conduct establishes our policies and expectations with respect to a wide range of business conduct, including preparation and maintenance of financial and accounting information, compliance with laws and conflicts of interest. In accordance with our code of conduct, each of our employees, officers and directors is required to report suspected or actual violations to the extent permitted by law. In addition, our board of directors has adopted separate policies and procedures concerning the receipt and investigation of complaints relating to accounting, internal accounting controls or auditing matters, which are administered by our audit committee. Our Corporate Code of Conduct and Ethics is posted on our investor relations website at investors.seraprognostics.com under Investors — Governance — Documents & Charters. Disclosure regarding any amendments to, or waivers from, provisions of the code of conduct and ethics that apply to our directors, principal executive officer and principal financial officer will be included in a Current Report on Form 8-K within four business days following the date of the amendment or waiver, unless website posting or the

issuance of a press release of such amendments or waivers is then permitted by the applicable Nasdaq rules and regulations.

Non-Employee Director Compensation

Directors who are also our employees receive no additional compensation for their service as a director. Compensation for Dr. Critchfield, who is our chief executive officer, is discussed under the caption “Executive Compensation.”

2022 Director Compensation

The following table provides information concerning compensation earned by our non-employee directors during the fiscal year ended December 31, 2022:


Name		Fees Earned or Paid in Cash ($)	Option Awards ($)(1)	Total ($)
Mansoor Raza Mirza, M.D.		39,500	120,000	159,500
Marcus Wilson, Pharm.D.(2)		—	—	—
Kim Kamdar, Ph.D.		67,750	120,000	187,750
Sandra A.J. Lawrence		38,750	120,000	158,750
Ryan Trimble		44,500	120,000	164,500
Zhenya Lindgardt		37,500	120,000	157,500
Joshua Phillips		55,000	120,000	175,000
Jane F. Barlow, M.D.		27,171	240,000	267,171

(1)	Represents the aggregate grant date fair value of option awards granted to each director in 2022. These amounts have been computed in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) Topic 718. For the assumptions relating to valuations of equity awards made to our directors and named executive officers, see Note 11 to our audited financial statements, which are included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 filed with the SEC on March 22, 2023.
(2)	Dr. Wilson has waived his right to receive any compensation under the director compensation policy described below in the section titled “Board of Directors and Corporate Governance — Director Compensation Program.”

The following table lists all outstanding equity awards held by non-employee directors as of December 31, 2022:


Name		Grant Date	Number of Securities Underlying Unexercised Options (#)	Option Exercise Price Per Share ($)	Option Expiration Date
Mansoor Raza Mirza, M.D.		2/25/2015	37,549(1)	0.91	2/25/2025
		6/03/2022	149,675(2)	1.35	6/03/2032
Marcus Wilson, Pharm.D.(3)		—	—	—	—
Kim Kamdar, Ph.D.		6/03/2022	149,675(2)	1.35	6/03/2032
Sandra A.J. Lawrence		11/29/2021	40,332(4)	10.41	11/29/2031
		6/03/2022	149,675(2)	1.35	6/03/2032
Ryan Trimble		6/03/2022	149,675(2)	1.35	6/03/2032
Zhenya Lindgardt		11/08/2021	38,325(4)	10.92	11/08/2031
		6/03/2022	149,675(2)	1.35	6/03/2032
Joshua Phillips		6/03/2022	149,675(2)	1.35	6/03/2032
Jane F. Barlow, M.D.		4/11/2022	140,823(4)	2.83	4/11/2032

(1)	These stock options vest over four years as follows: 1/48 of the original grant amount vests in monthly installments for four years following the grant date.
(2)	These stock options vest over one year as follows: 1/12 of the original grant amount vests in monthly installments for one year following the grant date.
(3)	Dr. Wilson has waived his right to receive any compensation under the director compensation policy described below in the section titled “Board of Directors and Corporate Governance — Director Compensation Program.”
(4)	These stock options vest over three years as follows: 1/36 of the original grant amount vests in monthly installments for three years following the grant date.

Director Compensation Program

The compensation policy for our non-employee directors was developed with input from our compensation committee’s independent compensation consultant, Compensia, Inc. (“Compensia”), regarding practices and compensation levels at comparable companies. It is designed to attract, retain, and reward non-employee directors.

Each non-employee director is eligible to receive the following annual cash retainer, which will be paid quarterly in arrears on a prorated basis. Each non-employee director who serves as a committee Chair receives only the additional annual cash fee as the Chair of the committee, and not the additional annual fee as a member of the committee. Dr. Wilson has waived his right to receive cash compensation under this policy. Dr. Critchfield will not receive separate compensation from us for serving as a member of our board of directors.


Position						Annual Retainer
Non-Employee Board Member						$35,000
Lead Independent Director						15,000
Audit Committee Chair						15,000
Audit Committee Member						7,500
Compensation Committee Chair						10,000
Compensation Committee Member						5,000
Nominating and Corporate Governance Committee Chair						8,000
Nominating and Corporate Governance Committee Member						4,000

In addition, each non-employee director who is initially elected or appointed to the board of directors after the non-employee director compensation policy became effective shall receive options to purchase shares of our Class A common stock with a grant date fair value of $240,000 (based on the Black-Scholes valuation method and rounded down

to the nearest whole share), on the date of such initial election or appointment (the “Initial Award”). No non-employee director shall be granted more than one initial award. Each Initial Award will vest and become exercisable in 36 substantially equal monthly installments following the date of grant, such that the Initial Award will be fully vested on the third anniversary of the grant date, subject to the non-employee director continuing in service as a non-employee director through each such vesting date.

A non-employee director who (i) has been serving as a non-employee director for at least six months as of the date of any annual meeting of our stockholders and (ii) will continue to serve as a non-employee directors immediately following such meeting, shall receive options to purchase shares of our Class A common stock with a grant date fair value of $120,000 (based on the Black-Scholes valuation method and rounded down to the nearest whole share), on the date of such annual meeting (a “Subsequent Award”). A non-employee director elected for the first time to the board of directors at an annual meeting of our stockholders shall only receive an Initial Award in connection with such election, and shall not receive any Subsequent Award on the date of such meeting as well. Each Subsequent Award will vest and become exercisable in 12 substantially equal monthly installments following the date of grant, such that the Subsequent Award will be fully vested on the first anniversary of the grant date, subject to the non-employee director continuing in service as a non-employee director through each such vesting date.

Each Initial Award and Subsequent Award will be granted under our 2021 Equity Incentive Plan (or its successor plan, as applicable) and will be subject to award agreements under such plan. These awards will have a maximum term to expiration of ten years from their grant date and a per share exercise price equal to 100% of the fair market value of a share of our Class A common stock at the close of the market on the award’s grant date.

PROPOSAL NO. 1

ELECTION OF DIRECTORS

The board of directors has voted to nominate Kim Kamdar, Ph.D., Sandra A.J. Lawrence, and Ryan Trimble for election at the annual meeting for a term of three years to serve until the 2026 annual meeting of stockholders and until their respective successors are elected and qualified. The terms of the Class III directors (Gregory C. Critchfield, M.D., M.S., Zhenya Lindgardt, and Joshua Phillips) and Class I directors (Jane F. Barlow, M.D., Mansoor Raza Mirza, M.D., and Marcus Wilson, Pharm.D.) will continue until the annual meetings of stockholders to be held in 2024 and 2025, respectively, and each director will hold office until his or her successor has been elected and qualified or until his or her earlier death, resignation, or removal.

Unless authority to vote for any of these nominees is withheld, the shares represented by proxy will be voted FOR the election of Kim Kamdar, Ph.D., Sandra A.J. Lawrence, and Ryan Trimble as directors. In the event that any nominee becomes unable or unwilling to serve, the shares represented by proxy will be voted for the election of such other person as the board of directors may recommend in that nominee’s place. We have no reason to believe that any nominee will be unable or unwilling to serve as a director.

The three nominees who receive the most votes (also known as a “plurality” of votes cast) “FOR” such nominee at the annual meeting will be elected as a director.

THE BOARD OF DIRECTORS RECOMMENDS THE ELECTION OF KIM KAMDAR, PH.D., SANDRA A.J. LAWRENCE, AND RYAN TRIMBLE AS DIRECTORS, AND PROXIES SOLICITED BY THE BOARD WILL BE VOTED IN FAVOR THEREOF UNLESS A STOCKHOLDER HAS INDICATED OTHERWISE ON THE PROXY.

PROPOSAL NO. 2

RATIFICATION OF APPOINTMENT OF

INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The audit committee has appointed Ernst & Young LLP (“EY”) as our independent registered public accounting firm to audit our financial statements for the year ending December 31, 2023. EY has served as our independent registered accounting firm since 2012 and audited our financial statements for the fiscal year ended December 31, 2022.

Notwithstanding its selection and even if our stockholders ratify the selection, our audit committee, in its discretion, may appoint another independent registered public accounting firm at any time during the year if the audit committee believes that such a change would be in the best interests of our company and stockholders. At the 2023 Annual Meeting the stockholders are being asked to ratify the appointment of EY as our independent registered public accounting firm for the year ending December 31, 2023. Our audit committee is submitting the selection of EY to our stockholders because we value our stockholders’ views on our independent registered public accounting firm and as a matter of good corporate governance. Representatives of EY will be present at the 2023 Annual Meeting, and they will have an opportunity to make statements and will be available to respond to appropriate questions from stockholders.

In deciding to appoint EY, the audit committee reviewed auditor independence issues with EY and concluded that EY has no commercial relationship with the Company that would impair its independence for the fiscal year ending December 31, 2023.

If the stockholders do not ratify the appointment of EY, the board of directors will reconsider the appointment.

Fees Paid to the Independent Registered Public Accounting Firm

The following table presents fees for professional audit services and other services rendered to us by EY for the years ended December 31, 2022 and 2021.


		Year Ended December 31,
		2022		2021
Audit Fees(1)		$	546,345	$	1,628,479
Audit-Related Fees		—		—
Tax Fees		—		—
All Other Fees		—		—
Total Fees		$	546,345	$	1,628,479

(1)	Audit fees consist of fees billed for professional services rendered in connection with the audit of our annual financial statements and reviews of our quarterly financial statements for the fiscal years indicated. This category also includes $1,134,479 in fees for services incurred in connection with our initial public offering in 2021.

Auditor Independence

In our fiscal year ended December 31, 2022, there were no other professional services provided by EY that would have required our audit committee to consider their compatibility with maintaining the independence of EY.

Audit Committee Policy on Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm

Our audit committee has established a policy governing our use of the services of our independent registered public accounting firm. Under the policy, our audit committee is required to pre-approve all audit and permissible non-audit services performed by our independent registered public accounting firm in order to ensure that the provision of such services does not impair such accounting firm’s independence. All fees paid to EY for our fiscal years ended December 31, 2022 and 2021 were pre-approved by our audit committee.

Prior to engagement of an independent registered public accounting firm for the next year’s audit, management will submit an aggregate of services expected to be rendered during that year for each of four categories of services to the audit committee for approval.

1.Audit services include audit work performed in the preparation of financial statements, as well as work that generally only an independent registered public accounting firm can reasonably be expected to provide, including comfort letters, statutory audits, and attest services and consultation regarding financial accounting and/or reporting standards.

2.Audit-Related services are for assurance and related services that are traditionally performed by an independent registered public accounting firm, including due diligence related to mergers and acquisitions, employee benefit plan audits, and special procedures required to meet certain regulatory requirements.

3.Tax services include all services performed by an independent registered public accounting firm’s tax personnel except for those services specifically related to the audit of the financial statements, and includes fees in the areas of tax compliance, tax planning, and tax advice.

4.Other Fees are those associated with services not captured in the other categories. The Company generally does not request such services from our independent registered public accounting firm.

Prior to engagement, the audit committee pre-approves these services by category of service. The fees are budgeted and the audit committee requires our independent registered public accounting firm and management to report actual fees versus the budget periodically throughout the year by category of service. During the year, circumstances may arise when it may become necessary to engage our independent registered public accounting firm for additional services not contemplated in the original pre-approval. In those instances, the audit committee requires specific pre-approval before engaging our independent registered public accounting firm.

The audit committee may delegate pre-approval authority to one or more of its members. The member to whom such authority is delegated must report, for informational purposes only, any pre-approval decisions to the audit committee at its next scheduled meeting.

In the event the stockholders do not ratify the appointment of EY as our independent registered public accounting firm, the audit committee will reconsider its appointment.

The affirmative vote of a majority of the shares cast affirmatively or negatively at the annual meeting is required to ratify the appointment of the independent registered public accounting firm.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR OUR FISCAL YEAR ENDING DECEMBER 31, 2023 AND PROXIES SOLICITED BY THE BOARD WILL BE VOTED IN FAVOR OF SUCH RATIFICATION UNLESS A STOCKHOLDER INDICATES OTHERWISE ON THE PROXY.

REPORT OF THE AUDIT COMMITTEE

The audit committee is a committee of the board of directors comprised solely of independent directors as required by the listing standards of the Nasdaq Stock Market LLC and the rules and regulations of the Securities and Exchange Commission (the “SEC”). The composition of the audit committee, the attributes of its members and the responsibilities of the audit committee, as reflected in its charter, are intended to be in accordance with applicable requirements for corporate audit committees. The audit committee operates under a written charter approved by the board of directors, which is available on our website at investors.seraprognostics.com under Investors — Governance — Documents & Charters. The audit committee reviews and assesses the adequacy of its charter and the audit committee’s performance on an annual basis.

With respect to the Company’s financial reporting process, the Company’s management is responsible for (1) establishing and maintaining internal controls and (2) preparing the Company’s financial statements. The audit committee assists the board of directors in overseeing and monitoring the integrity of the Company’s financial reporting process, compliance with legal and regulatory requirements, and the quality of internal and external audit processes. The audit committee is responsible for overseeing the Company’s overall financial reporting process, and for the appointment, compensation, retention, and oversight of the work of Ernst & Young LLP (“EY”), the Company’s independent registered public accounting firm. EY is responsible for performing an independent audit of the Company’s financial statements. It is not the responsibility of the audit committee to prepare the Company’s financial statements. These are the fundamental responsibilities of management.

In the performance of its oversight function, the audit committee has:

•reviewed and discussed the audited financial statements for the fiscal year ended December 31, 2022 with management and EY;

•discussed with EY the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (“PCAOB”) and the SEC; and

•received the written disclosures and the letter from EY regarding its independence as required by applicable requirements of the PCAOB regarding the independent accountant’s communications with the audit committee concerning independence and has discussed with EY its independence. The audit committee also considered the status of pending litigation, taxation matters, and other areas of oversight relating to the financial reporting and audit process that the committee determined appropriate.

Based on the audit committee’s review and discussions with management and EY, the audit committee recommended to the board of directors that the audited financial statements be included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2022 for filing with the SEC.

Respectfully submitted by the members of the audit committee of the board of directors:

Joshua Phillips (Chair)

Sandra A.J. Lawrence

Ryan Trimble

This report of the audit committee is required by the SEC and, in accordance with the SEC’s rules, will not be deemed to be part of or incorporated by reference by any general statement incorporating by reference this proxy statement into any filing under the Securities Act of 1933, as amended (the “Securities Act”), or under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), except to the extent that we specifically incorporate this information by reference, and will not otherwise be deemed “soliciting material” or “filed” under either the Securities Act or the Exchange Act.

PROPOSAL NO. 3

AMENDMENT OF OUR CERTIFICATE OF INCORPORATION TO REFLECT NEW DELAWARE LAW PROVISIONS REGARDING OFFICER EXCULPATION

The State of Delaware, which is our state of incorporation, recently enacted legislation that enables Delaware corporations to limit the liability of certain of their officers for breaches of their fiduciary duty in certain limited circumstances under Section 102(b)(7) of the Delaware General Corporation Law. In light of this legislation and for the reasons set forth below, our board of directors has determined that it is advisable to amend the Company’s amended and restated certificate of incorporation (the “Certificate of Incorporation”), subject to stockholder approval, to provide for the elimination or limitation of personal liability of certain of the Company’s officers for monetary damages in the specific circumstances authorized by Delaware law, and has voted to recommend that the stockholders approve such amendment.

Our proposed amendment would eliminate or limit the personal liability of certain of the Company’s officers for monetary damages for breach of the duty of care in certain actions. The provision would not apply to breaches of the duty of loyalty to the Company or its stockholders, acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law, or any transaction in which the officer derived an improper personal benefit. The provision also would not eliminate or limit the liability of such officers for claims brought by or in the right of the corporation, such as derivative claims.

We believe that it is in the Company's and its stockholders' interest that senior officers receive exculpatory protection from certain liabilities and expenses that is similar to what directors already receive. This protection is important to limit our officers' concern about personal risk and to empower them to exercise their business judgment in furtherance of stockholder interests. In the absence of such protection, qualified officers might be deterred from serving as officers or, while officers, from making business decisions that involve appropriate risk, due to potential exposure to personal monetary liability for business decisions that in hindsight are not successful.

We also believe that such protection is necessary in order to continue to attract and retain experienced and qualified executives, as similar officer exculpation provisions are likely to be adopted by our peers and others with whom we compete for executive talent. Additionally, we believe the limited officer exculpation afforded under Delaware law and the proposed amendment to our Certificate of Incorporation will benefit stockholders by reducing threatened litigation, attorneys' fees, and costs of litigation.

Given these considerations, including the narrow class and type of claims from which the senior officers would be exculpated from liability, the limited number of our senior officers to which the protections would apply, and the benefits the board of directors believes would accrue to the Company by extending exculpation protection to its senior officers in addition that already extended to its directors, the board of directors determined that it is in the best interests of our company that the Certificate of Incorporation be amended to limit the personal liability of certain senior officers of the Company.

Language of Proposed Amendment

If approved, the amendment would enable us to amend our Certificate of Incorporation to add a new Article THIRTEENTH which would read as follows:

“No officer shall be personally liable to the Corporation or its stockholders for any monetary damages for breaches of fiduciary duty as an officer; provided that this provision shall not eliminate or limit the liability of an officer, to the extent that such liability is imposed by applicable law, (i) for any breach of the officer’s duty of loyalty to the Corporation or its stockholders; (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law; (iii) for any transaction from which the officer derived an improper personal benefit, or (iv) in any action by or in the right of the Corporation. No amendment to or repeal of this provision shall apply to or have any effect on the liability or alleged liability of any officer for or with respect to any acts or omissions of such officer occurring prior to such amendment or repeal. If the Delaware General Corporation Law is amended to authorize corporate action further eliminating or limiting the personal liability of officers, then the liability of an officer of the

Corporation shall be eliminated or limited to the fullest extent permitted by the Delaware General Corporation Law, as so amended.”

The affirmative vote of at least a majority of the outstanding shares of our Class A common stock is required for this proposal to be approved. Abstentions will count as present and entitled to vote for purposes of this proposal and will have the effect of a vote against this proposal. Broker non-votes will have the effect of a vote against this proposal.

If our stockholders approve the proposed amendment to our Certificate of Incorporation, it will become effective upon filing with the Secretary of State of the State of Delaware of a certificate setting forth the amendment, which we anticipate doing as soon as practicable following the stockholder approval of the amendment. The Board retains the discretion to abandon, and not implement, the amendment at any time before the certificate setting forth the amendment becomes effective even if the amendment is approved by our stockholders.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE AMENDMENT TO OUR CERTIFICATE OF INCORPORATION TO INCLUDE A PROVISION TO REFLECT NEW DELAWARE LAW PROVISIONS REGARDING OFFICER EXCULPATION AND PROXIES SOLICITED BY THE BOARD WILL BE VOTED IN FAVOR OF SUCH AMENDMENT UNLESS A STOCKHOLDER INDICATES OTHERWISE ON THE PROXY.

EXECUTIVE OFFICERS

The names of our executive officers, their ages, their positions with Sera Prognostics, and other biographical information as of March 31, 2023, are set forth below. Executive officers are elected by our board of directors to hold office until their successors are elected and qualified. There are no family relationships among our directors or executive officers.

Name

Age

Position

Gregory C. Critchfield, M.D., M.S.

Chairman, President, and Chief Executive Officer

Jay Moyes

Chief Financial Officer

Nadia F. Altomare

Chief Commercial Officer

Michael R. Foley, M.D.

Chief Medical Officer

John J. Boniface, Ph.D.

Chief Scientific Officer

Paul Kearney, Ph.D.

Chief Data Officer

Robert G. Harrison

Chief Information Officer

Benjamin G. Jackson

General Counsel

Dr. Critchfield’s biography can be found under “Board of Directors and Corporate Governance — Class III Directors continuing in Office until the 2024 Annual Meeting of Stockholders.”

Jay Moyes has served as our Chief Financial Officer since March 2020. Mr. Moyes has been a member of the board of directors of Achieve Life Sciences, Inc., a public specialty pharmaceutical company, since August 2017. He has been a member of the board of directors of Puma Biotechnology, Inc., a public biotherapeutics company focused on oncology, since April 2012. He has been a member of the board of directors of Biocardia, Inc., a publicly held cardiovascular regenerative medicine company, since January 2011. Mr. Moyes served as a member of the board of directors of Predictive Technology Group, Inc., a public molecular diagnostics and regenerative medicine company, from February 2019 to December 2019. Mr. Moyes was a director of Integrated Diagnostics, Inc., a privately held molecular diagnostics company from March 2011 to November 2016. Mr. Moyes was a member of the board of directors of Osiris Therapeutics, Inc., a public bio-surgery company, from May 2006 until December 2017 and Amedica Corporation, a public orthopedic implant company, from November 2012 to August 2014. He served as Chief Financial Officer of Amedica from October 2013 to August 2014, where he was responsible for developing and executing the company’s financial strategy. From May 2008 through July 2009, Mr. Moyes served as the Chief Financial Officer of XDx, Inc. (now CareDx, Inc.), a privately held molecular diagnostics company. In that role, he orchestrated the company’s right-sizing strategy. Prior to that, Mr. Moyes served as the Chief Financial Officer of Myriad Genetics, Inc., a public healthcare diagnostics company, from June 1996 until November 2007, and as its Vice President of Finance from July 1993 until May 1996, where he led the financial team as it transitioned from a small private company to a publicly held enterprise. From 1991 to 1993, Mr. Moyes served as Vice President of Finance and Chief Financial Officer of Genmark, Inc., a privately held genetics company. In that role he established the company’s financial infrastructure. Mr. Moyes held various positions with the accounting firm of KPMG LLP from 1979 through 1991, most recently as a Senior Manager. At KPMG LLP, he was primarily responsible for conducting financial audits of high-tech and biotech clients. Mr. Moyes also served as a member of the Board of Trustees of the Utah Life Science Association from 1999 through 2006. He holds an M.B.A. from the University of Utah, a B.A. in economics from Weber State University, and is formerly a Certified Public Accountant.

Nadia F. Altomare has more than 20 years of women’s healthcare diagnostics experience. Ms. Altomare has served as our Chief Commercial Officer since May 2017 and leads the company’s commercialization strategy and execution, accountable for the company’s marketing, public relations, sales, market access, customer service and billing functions. From May 2015 to May 2017, Ms. Altomare served as President and then CEO and member of the Board of Directors at Abcodia Ltd, an early detection cancer diagnostics company, where she set up the U.S. subsidiary and held full P&L accountability over the global business. Prior to Abcodia, Ms. Altomare was the Vice President & General Manager of a global DNA analysis business at ThermoFisher Scientific with full P&L accountability. Previously, Ms. Altomare was the Vice President & General Manager of a cytogenetic DNA business at PerkinElmer. Earlier in her career, Ms. Altomare held a number of leadership positions through a series of mergers and acquisitions and an IPO, resulting in a company ultimately acquired by PerkinElmer. Among her accomplishments was the startup, build and scale of the

ViaCord division. Ms. Altomare is currently on the Board of Savran Technologies, a private healthcare company focused on enabling the next generation of non-invasive diagnostics. She received an M.B.A from Northeastern University and a B.S. in Business Administration from the State University of New York at Stony Brook.

Michael R. Foley, M.D. has served as our Chief Medical Officer since December 2021. Dr. Foley is considered a national authority on Critical Care Medicine in Obstetrics. Before joining Sera, Dr. Foley practiced Maternal-Fetal Medicine in private practice for more than 20 years and recently retired from a 10-year role as Chairman of Obstetrics and Gynecology at the University of Arizona College of Medicine Phoenix/Banner University Medicine. He was the President of the Society for Maternal-Fetal Medicine (2008) and the recipient of the Society for Maternal-Fetal Medicine Lifetime Achievement Award (2013). He has also served as a Board Examiner in the subspecialty of Maternal-Fetal Medicine. Dr. Foley received his medical degree from Chicago Medical School in 1984. His Obstetrics and Gynecology residency and Maternal-Fetal Medicine fellowship were completed at The Ohio State University Hospital in 1988 and 1990, respectively. In addition to a long list of professional clinical accomplishments, Dr. Foley is a founding instructor and faculty member for the Dan O’Keeffe, M.D. Society for Maternal Fetal Medicine’s Academy for Leadership and Development which is in its eighth year of training hundreds of medical leaders and professionals. Dr. Foley is also the Lead Editor of Obstetric Intensive Care: A Practical Manual (McGraw-Hill) which is currently in its fifth edition (2018). He is also a co-editor for Critical Care Obstetrics-Fifth and Sixth Editions (Wiley-Blackstone).

John J. Boniface, Ph.D. has served as our Chief Scientific Officer since November 2011. Prior to that, Dr. Boniface briefly served as our Vice President of Research from September 2011 to November 2011. In his role as Chief Scientific Officer, Dr. Boniface is involved with our product development. Dr. Boniface previously served as scientist and program director for multiple biotechnology companies focused on protein discovery and small molecule and immunotherapeutic drug development, including Myrexis, Myriad Genetics, Prolexys Pharmaceuticals and Eos Biotechnology. Dr. Boniface holds a Ph.D. in Biochemistry from Albany Medical College and a B.S. in Biochemistry from the University of Massachusetts, Amherst. Dr. Boniface was a post-doctoral scholar in the laboratory of Dr. Mark Davis, Department of Microbiology and Immunology, Stanford University School of Medicine.

Paul Kearney, Ph.D. has served as our Chief Data Officer since October 2021. Dr. Kearney’s passion is working at the intersection of healthcare, data science and innovation where many of the hardest societal and clinical unmet needs can be found and addressed through partnership, data exploration and focused, persistent hard work. Prior to joining Sera Prognostics, Dr. Kearney co-founded multiple successful biotech companies resulting in the development and commercialization of breakthrough products in the disease areas of oncology, pregnancy and food allergy as well as technological products in bioinformatics and proteomics. From August 2018 to February 2022, Dr. Kearney served as Chief Executive Officer of Data Incites, a consultant firm. From September 2009 to July 2018, Dr. Kearney served as Chief Science Officer of Integrated Diagnostics, a publicly traded biotech company. Dr. Kearney has extensive experience building and nurturing integrated teams, conducting clinical research, developing evidence for improved health outcomes as well as fund raising. Dr. Kearney has published over 100 papers in diverse areas and has been awarded over 12 patents. Dr. Kearney’s past experiences include SVP of Special Projects at the Institute for Systems Biology, VP of Bioinformatics at Caprion (now CellCarta), VP of Science at Bioinformatics Solutions, VP of Product Development at AllerGenis as well as a member of the Computer Science Faculty of the University of Waterloo. He received his Ph.D. in computer science from the University of Toronto.

Robert G. Harrison has served as our Chief Information Officer since March 2021. For more than three decades, Mr. Harrison has served in several senior leadership positions of both public and private companies. His most recent appointment has been with Myriad Genetics, Inc., a leading genetic testing and precision medicine company, as Chief Information Officer from August 1996 to March 2021, where he architected the IT infrastructure that enabled Myriad to grow from its first product launch in 1996 with fewer than 100 employees in a single location, to a leading global precision medicine company, with multiple products, more than 2,700 employees and deploying testing facilities and services in three continents. Mr. Harrison successfully directed the IT integration of strategic acquisitions of four companies, simultaneously facilitating international business expansion over the past decade in the company’s growth. Serving as a long-standing board member of the Utah Technology Council, Mr. Harrison remains an active member of the Association for Information Management (AIM) Utah CIO Council, and is also a respected community leader committed to charitable causes that benefit the well-being of women. Mr. Harrison received his BA in Business/Computer Science from the University of Utah.

Benjamin G. Jackson has served as our General Counsel since April 2021. From February 2006 to April 2021, Mr. Jackson was employed by Myriad Genetics, Inc., a leading genetic testing and precision medicine company, most recently serving as Executive Vice President, General Counsel and Secretary. Mr. Jackson held various positions in Myriad’s Legal Department, including serving as associate general counsel prior to assuming the role of general counsel. Mr. Jackson received his J.D. from the J. Reuben Clark Law School at Brigham Young University and his B.S. in microbiology, immunology and molecular genetics from the University of California, Los Angeles.

EXECUTIVE COMPENSATION

General Compensation Philosophy and Process for Compensation Decisions

Our general executive compensation philosophy is to provide programs that attract, motivate, reward and retain highly qualified executives and motivate them to pursue our corporate objectives while encouraging the creation of long-term value for our stockholders. We evaluate and reward our executive officers through compensation intended to motivate them to identify and capitalize on opportunities to grow our business and maximize stockholder value over time. We strive to provide an executive compensation program that is market competitive, rewards achievement of our business objectives and is designed to provide a foundation of fixed compensation (base salary) and a significant portion of performance-based compensation (short-term and long-term incentive opportunities) that are intended to align the interests of executives with those of our stockholders.

The decisions with respect to executive officer compensation, including the compensation of our named executive officers, are made by our compensation committee, with input from our chief executive officer (except with respect to his own compensation) and Compensia, an independent compensation consultant. Compensia was engaged by our compensation committee pursuant to the authority delegated under its charter and serves at the discretion of the compensation committee.

Our compensation committee believes our chief executive officer has valuable insight into the day-to-day contributions of our executive officers and solicits the advice and input from our chief executive officer with respect to performance objectives under our annual bonus plan and target compensation levels for our other executive officers, including our other named executive officers. At the request of our compensation committee, Compensia provides our compensation committee with relevant market data and alternatives to consider when making compensation decisions regarding our executive officers and considering the recommendations of our chief executive officer regarding the compensation of other executive officers. Although the compensation committee considers Compensia’s advice and recommendations about our executive compensation program, our compensation committee ultimately makes its own decisions about executive compensation matters.

Summary Compensation Table

Our named executive officers for the fiscal year ended December 31, 2022, which consist of (1) our principal executive officer during the fiscal year ended December 31, 2022, (2) the next two most highly compensated executive officers who earned more than $100,000 during the fiscal year ended December 31, 2022 and were serving as executive officers as of such date, and (3) any individual who would otherwise be included in (2) above but for the fact that such individual was not serving as an executive officer of ours as of December 31, 2022, are: Gregory C. Critchfield, M.D.,M.S., Michael R. Foley, M.D., and Jay Moyes. The following table provides information regarding the compensation of our named executive officers paid or accrued during the years ended December 31, 2022 and 2021. These executive officers are referred to as our “named executive officers” in this proxy statement.


Name and Principal Position		Year	Salary ($)	Option Awards ($)(1)	Non-Equity Incentive Plan Compensation ($)(2)	All Other Compensation ($)(3)	Total ($)
Gregory C. Critchfield, M.D., M.S.		2022	584,000	989,624	206,736	—	1,780,360
Chairman, President, and Chief Executive Officer		2021	500,100	453,519	275,000	—	1,228,619
Michael R. Foley, M.D.(4)		2022	428,369	1,070,870	134,980	12,200	1,646,419
Chief Medical Officer		2021	—	10,000	—	—	10,000
Jay Moyes		2022	421,100	388,250	126,300	9,889	945,539
Chief Financial Officer		2021	380,100	398,591	167,200	—	945,891

(1)	Represents the aggregate grant date fair value of option awards granted in the applicable fiscal year. Grant date fair value is calculated in accordance with Accounting Standards Codification (“ASC”) Topic 718 (“ASC 718”) issued by the Financial Accounting Standards Board. For the assumptions relating to valuations of equity awards made to our named executive officers, see Note 11 to our audited financial statements, which are included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 filed with the SEC on March 22, 2023.
(2)	Consists of bonus payments received under our non-equity incentive compensation plans based upon satisfaction of performance goals. See “Executive Compensation — Non-Equity Incentive Compensation Plan.”
(3)	Consists of matching contributions made under our 401(k) plan on behalf of each NEO.
(4)	Dr. Foley’s employment commenced on December 30, 2021, and his compensation in 2021 consisted of a sign-on bonus.

Narrative Disclosure to Summary Compensation Table

Base Salaries

Each named executive officer’s base salary is a fixed component of annual compensation for performing specific duties and functions, and has been established by our board of directors taking into account each individual’s role, responsibilities, skills and expertise. Base salaries are reviewed annually, typically in connection with our annual performance review process, approved by our board of directors and adjusted from time to time to realign salaries with market levels after taking into account individual responsibilities, performance, and experience. During 2022, the annual base salaries for Dr. Critchfield, Dr. Foley, and Mr. Moyes were $584,000, $425,000, and $421,000, respectively.

Non-Equity Incentive Compensation

Our board of directors has adopted an Annual Incentive Plan, which we refer hereto as our Bonus Plan. Our Bonus Plan allows our compensation committee to provide cash incentive awards to selected employees, including our named executive officers, based upon performance goals established by our compensation committee. Pursuant to the Bonus Plan, our compensation committee, in its sole discretion, will establish a target award for each participant and a bonus pool, with actual awards payable from such bonus pool with respect to the applicable performance period.

Our compensation committee may, in its sole discretion and at any time, increase, reduce or eliminate a participant’s actual award, or increase, reduce or eliminate the amount allocated to the bonus pool for a particular performance period. The actual award may be below, at or above a participant’s target award, in our compensation committee’s discretion. Our compensation committee may determine the amount of any reduction on the basis of such factors as it deems relevant, and it is not required to establish any allocation or weighting with respect to the factors it considers.

Actual awards are paid in cash (or its equivalent) in a single lump sum as soon as practicable after the end of the performance period during which they are earned and after they are approved by our compensation committee. Unless otherwise determined by our compensation committee, to earn an actual award, a participant must be employed by us (or an affiliate of ours) through the date the bonus is paid.

Our board of directors, in its sole discretion, may alter, suspend or terminate the Bonus Plan provided such action does not, without the consent of the participant, alter or impair the rights or obligations under any award theretofore earned by such participant.

Our compensation committee’s principal objectives in structuring the Bonus Plan for 2022 were rewarding employees who drive company achievement and meet or exceed strategic goals, remaining competitive within the industry, aligning the organization around common goals and aligning management and stockholder interests. On July 18, 2022, our board

of directors established the corporate performance objectives for the employees participating in our Bonus Plan for 2022. On March 6 and 7, 2023, our board of directors approved the payment of cash incentive awards for 2022 to our executive officers.

As a result, Dr. Critchfield was awarded an annual cash bonus of $206,736 for 2022. Dr. Critchfield’s performance in 2022 was measured relative to five corporate metrics that included milestones related to the commercialization of the PreTRM test, certain financial operating metrics, advancement of key outcome studies, and laboratory and process improvements. Dr. Critchfield’s target bonus was 60% of his base salary, and based on the level of corporate performance in 2022, Dr. Critchfield’s bonus was 59% of his target bonus.

Dr. Foley was awarded an annual cash bonus of $134,980 for 2022. Dr. Foley’s performance in 2022 was measured relative to the same five corporate metrics as Dr. Critchfield, blended with five department performance metrics that included milestones related to evidence and product development, customer outreach, and employee development. Dr. Foley’s target bonus was 40% of his base salary, and based on his performance in 2022, Dr. Foley’s bonus was 79% of his target bonus.

Mr. Moyes was awarded an annual cash bonus of $126,300 for 2022. Mr. Moyes’s performance in 2022 was measured relative to the same five corporate metrics as Dr. Critchfield, blended with six department performance metrics that included milestones related to the commercialization of the PreTRM test, various operating budget goals, enhancing the internal controls environment, and launching certain employee benefit programs. Mr. Moyes’s target bonus was 40% of his base salary, and based on his performance in 2022, Mr. Moyes’s bonus was 75% of his target bonus.

Equity Compensation

Although we do not have a formal policy with respect to the grant of equity incentive awards to our executive officers, we believe that equity grants provide our executives with a strong link to our long-term performance, create an ownership culture and help to align the interests of our executives and our stockholders. In addition, we believe that equity grants promote executive retention because they incentivize our executive officers to remain in our employment during the vesting period. Accordingly, our board of directors periodically reviews the equity incentive compensation of our named executive officers and may grant equity incentive awards to them from time to time. Our named executive officers have been granted certain options to purchase shares of our Class A common stock, as described in more detail in the “Outstanding Equity Awards at December 31, 2022” table below.

Employment Arrangements

Gregory C. Critchfield, M.D., M.S. We entered into an employment agreement dated as of November 8, 2011 with Dr. Critchfield with respect to his service as our Chairman and Chief Executive Officer. Under the terms of the agreement, Dr. Critchfield was entitled to an initial annual base salary of $300,000, subject to increase by our board of directors or the compensation committee. Dr. Critchfield’s base salary for the fiscal year ended December 31, 2021 was $500,000 and $584,000 for the fiscal year ended December 31, 2022. The agreement also provides that Dr. Critchfield is eligible to participate in an annual bonus plan provided by the Company. Dr. Critchfield’s annual target bonus opportunity for 2023 is 60% of his base salary, with the actual amount of the bonus, if any, to be determined by our board of directors.

Michael R. Foley, M.D. We entered into an employment agreement dated as of January 3, 2022 and amended as of December 30, 2021 with Dr. Foley with respect to his service as our Chief Medical Officer. Under the terms of the agreement, Dr. Foley was entitled to an initial annual base salary of $425,000, subject to increase by our board of directors, or the compensation committee. Dr. Foley’s base salary for the fiscal year ended December 31, 2022 was $425,000. The agreement also provides that Dr. Foley is eligible to participate in an annual bonus plan provided by the Company. Dr. Foley’s annual target bonus opportunity for 2023 is 40% of his annual base salary, with the actual amount of the bonus, if any, to be determined by our board of directors. The employment agreement also provides for a grant of a stock option to purchase 276,000 shares of our Class A common stock, which was granted in January 2022, vesting as to 25% on the first anniversary of Dr. Foley’s start date and thereafter in equal monthly installments over the next 36 months.

Jay Moyes. We entered into an employment agreement dated as of March 24, 2020 with Mr. Moyes with respect to his service as our Chief Financial Officer. Under the terms of the agreement, Mr. Moyes was entitled to an initial annual base salary of $355,000, subject to increase by our board of directors, or the compensation committee. Mr. Moyes’s base salary for the fiscal year ended December 31, 2022 was $421,000. The agreement also provides that Mr. Moyes is eligible to participate in an annual bonus plan provided by the Company. Mr. Moyes’s annual target bonus opportunity for 2023 is 40% of his annual base salary, with the actual amount of the bonus, if any, to be determined by our board of directors.

Severance and Change of Control Benefits

Dr. Critchfield’s employment agreement provides that in the event that (1) Dr. Critchfield’s employment is terminated other than for cause, death or disability or (2) Dr. Critchfield terminates his own employment for Good Reason, as defined in the agreement, he is entitled to receive the following severance benefits: (i) on the 60th day following the termination, the Company shall pay a lump sum amount equal to 12 months of his base salary at the rate in effect at the time of the termination; (ii) a pro-rata bonus for the year in which Dr. Critchfield’s employment is terminated, provided that the Company then has a bonus plan in place; and (iii) any unvested equity will immediately be forfeited and any vested stock options will be exercisable for the balance of the remaining term of the original option grant. If the Company terminates Dr. Critchfield’s employment due to death or disability, the Company will provide health insurance reimbursement until the earliest of (x) the close of the 12 month period following Dr. Critchfield’s termination date, and (y) the date when Dr. Critchfield becomes eligible to receive health insurance coverage in connection with new employment or self-employment. Notwithstanding the foregoing, in connection with a Change of Control (as defined in our equity incentive plans) or if a termination of Dr. Critchfield occurs within two months prior thereto, then the vesting of all equity then owned by the Dr. Critchfield shall accelerate with respect to 100% of the unvested shares.

Dr. Foley’s employment agreement provides that in the event that (1) Dr. Foley’s employment is terminated other than for cause, death or disability or (2) Dr. Foley terminates his own employment for Good Reason, as defined in the agreement, on the 60th day following the termination, (i) he is entitled to receive a lump sum amount equal to 6 months of his base salary at the rate in effect at the time of the termination, and (ii) the Company will provide health insurance reimbursement until the earliest of (x) the close of the 12 month period following Dr. Foley’s termination date, and (y) the date when Dr. Foley becomes eligible to receive health insurance coverage in connection with new employment or self-employment. In the event that Dr. Foley’s employment is terminated without cause or by Dr. Foley for Good Reason, then the vesting of all options held by Dr. Foley at the time of termination shall accelerate (i) with respect to 37.5% of the unvested shares subject thereto, or (ii) if such termination occurs within 30 days prior to or within 12 months after a Change of Control (as defined in our equity incentive plans), with respect to 100% of the unvested shares subject thereto.

In the event that Dr. Foley’s employment is terminated due to his death or disability and if the Company does not provide any insurance benefits payable to Dr. Foley or his beneficiaries upon his death or disability and the Company has previously, but not necessarily in the then applicable calendar year, achieved $10,000,000 in annual gross revenue in a calendar year, then the Company shall pay Dr. Foley a lump sum amount equal to 6 months of the base salary at the rate in effect at the time of the termination of employment.

Mr. Moyes’s employment agreement provides that in the event that (1) Mr. Moyes’s employment is terminated other than for cause, death or disability or (2) Mr. Moyes terminates his own employment for Good Reason, as defined in the agreement, on the 60th day following the termination, (i) he is entitled to receive a lump sum amount equal to 6 months of his base salary at the rate in effect at the time of the termination, and (ii) the Company will provide health insurance reimbursement until the earliest of (x) the close of the 12 month period following Mr. Moyes’s termination date, and (y) the date when Mr. Moyes becomes eligible to receive health insurance coverage in connection with new employment or self-employment. In the event that Mr. Moyes’s employment is terminated without cause or by Mr. Moyes for Good Reason, then the vesting of all options held by Mr. Moyes at the time of termination shall accelerate (i) with respect to 37.5% of the unvested shares subject thereto, or (ii) if such termination occurs within 30 days prior to or within 12 months after a Change of Control (as defined in our equity incentive plans), with respect to 100% of the unvested shares subject thereto.

In the event that Mr. Moyes’s employment is terminated due to his death or disability and if the Company does not provide any insurance benefits payable to Mr. Moyes or his beneficiaries upon his death or disability and the Company has previously, but not necessarily in the then applicable calendar year, achieved $10,000,000 in annual gross revenue in a calendar year, then the Company shall pay Mr. Moyes a lump sum amount equal to 6 months of the base salary at the rate in effect at the time of the termination of employment.

Outstanding Equity Awards at December 31, 2022

The following table provides information regarding outstanding equity awards held by our named executive officers as of December 31, 2022.


			Option Awards
Name		Grant Date	Number of Securities Underlying Unexercised Options (#) Exercisable	Number of Securities Underlying Unexercised Options (#) Unexercisable	Option Exercise Price ($)	Option Expiration Date
Gregory C. Critchfield, M.D., M.S.		5/18/2017	300,609	—	1.98	5/18/2027
		2/27/2020	327,488	134,848(1)	1.77	2/27/2030
		3/8/2021	43,019	55,310(2)	5.32	3/8/2031
		3/23/2022	48,288	380,937(3)	3.75	3/23/2032
Michael R. Foley, M.D.		8/20/2020	9,620	—	1.77	8/20/2030
		1/28/2022	69,000	207,000(4)	6.59	1/28/2032
Jay Moyes		3/26/2020	190,314	86,506(5)	1.77	3/26/2030
		3/8/2021	37,812	48,615(6)	5.32	3/8/2031
		3/23/2022	18,931	149,344(7)	3.75	3/23/2032

(1)	Represents 134,848 unexercisable shares underlying the unexercised stock option granted to Dr. Critchfield on February 27, 2020, entitling him to purchase an aggregate of 462,336 shares of our Class A common stock. The stock option vests and becomes exercisable over four years as follows: 1/48 of the original grant amount vests in monthly installments following the grant date.
(2)	Represents 55,310 unexercisable shares underlying the unexercised stock option granted to Dr. Critchfield on March 8, 2021, entitling him to purchase an aggregate of 98,329 shares of our Class A common stock. The stock option vests and becomes exercisable over four years as follows: 1/48 of the original grant amount vests in monthly installments following the grant date.
(3)	Represents 380,937 unexercisable shares underlying the unexercised stock option granted to Dr. Critchfield on March 23, 2022, entitling him to purchase an aggregate of 429,225 shares of our Class A common stock. The stock option vests and becomes exercisable over four years as follows: 15% of the original grant amount vests in equal monthly installments over the first year following the grant date, 20% of the original grant amount vests in equal monthly installments over the second year following the grant date, 25% of the original grant amount vests in equal monthly installments over the third year following the grant date, and 40% of the original amount vests in equal monthly installments over the fourth year following the grant date.
(4)	Represents 207,000 unexercisable shares underlying the unexercised stock option granted to Dr. Foley on January 28, 2022, entitling him to purchase an aggregate of 276,000 shares of our Class A common stock. The stock option vests over four years as follows: 25% of the original grant amount vests on the first anniversary of the vesting commencement date, which is December 30, 2021, and 1/36 of the remaining amount vests in monthly installments for three years thereafter.
(5)	Represents 86,506 unexercisable shares underlying the unexercised stock option granted to Mr. Moyes on March 26, 2020, entitling him to purchase an aggregate of 276,820 shares of our Class A common stock. The stock option vests over four years as follows: 25% of the original grant amount vests on the first anniversary of the vesting commencement date, which is March 24, 2020, and 1/36 of the remaining amount vests in monthly installments for three years thereafter.
(6)	Represents 48,615 unexercisable shares underlying the unexercised stock option granted to Mr. Moyes on March 8, 2021, entitling him to purchase an aggregate of 86,427 shares of our Class A common stock. The stock option vests and becomes exercisable over four years as follows: 1/48 of the original grant amount vests in monthly installments following the grant date.
(7)	Represents 149,344 unexercisable shares underlying the unexercised stock option granted to Mr. Moyes on March 23, 2022, entitling him to purchase an aggregate of 168,275 shares of our Class A common stock. The stock option vests and becomes exercisable over four years as follows: 15% of the original grant amount vests in equal monthly installments over the first year following the grant date, 20% of the original grant amount vests in equal monthly installments over the second year following the grant date, 25% of the original grant amount vests in equal monthly installments over the third year following the grant date, and 40% of the original amount vests in equal monthly installments over the fourth year following the grant date.

Equity Compensation Plan Information

The following table provides information as of December 31, 2022, with respect to the shares of our Class A common stock that may be issued under existing equity compensation plans.


Plan Category		Number of Securities to be Issued Upon Exercise of Outstanding Options, Warrants and Rights (#)	Weighted-Average Exercise Price of Outstanding Options, Warrants and Rights ($)	Number of Securities Remaining Available for Future Issuance Under Equity Compensation Plans (Excluding Securities Reflected in the first Column) (#)
Equity compensation plans approved by security holders		8,428,441(1)	3.65	2,525,133(2)
Equity compensation plans not approved by security holders		—	—	—
Total		8,428,441(1)	3.65	2,525,133(2)

(1)	Consists of 4,913,814 shares of Class A common stock underlying outstanding stock options granted under the 2011 Employee, Director and Consultant Equity Incentive Plan and 3,514,627 shares of Class A common stock underlying outstanding stock options granted under the 2021 Equity Incentive Plan.
(2)	Represents the number of securities remaining available for future issuance under the 2021 Equity Incentive Plan and the 2021 Employee Stock Purchase Plan. The number of shares available for issuance under the 2021 Equity Incentive Plan is subject to an annual increase on the first day of each year equal to the lesser of 4% of the number of outstanding shares of Class A common stock as of the last day of the immediately preceding fiscal year and a number of shares determined by the board of directors or a committee thereof. The number of shares available for issuance under the 2021 Employee Stock Purchase Plan is subject to an annual increase on the first day of each year equal to the lesser of 1% of the number outstanding shares of Class A common stock as of the last day of the immediately preceding fiscal year and a number of shares determined by the board of directors or a committee thereof.

401(k) Plan

We maintain a 401(k) retirement savings plan, for the benefit of our employees, including our named executive officers, who satisfy certain eligibility requirements. This plan provides our eligible employees with an opportunity to save for retirement on a tax advantaged basis, and participants are able to defer a portion of their eligible compensation. All participants’ interests in their deferrals are 100% vested when contributed. Beginning in the year ended December 31, 2022, we transitioned to a safe harbor 401(k) plan. We make safe harbor matching contributions equal to 100% of the first 3% of a plan participant’s eligible compensation, plus 50% of the next 2% of a plan participant’s eligible compensation. We may also make an additional discretionary match or profit sharing contribution to the plan. Pre-tax contributions are allocated to each participant’s individual account and are then invested in selected investment alternatives according to the participants’ directions. The 401(k) plan is intended to qualify under Sections 401(a) and 501(a) of the Internal Revenue Code. As a tax-qualified retirement plan, contributions to the 401(k) plan and earnings on those contributions are not taxable to the employees until distributed from the 401(k) plan.

Pension Benefits

We do not have any qualified or non-qualified defined pension benefit plans.

Nonqualified Deferred Compensation

We do not have any nonqualified defined contribution plans or other deferred compensation plans.

Compensation Committee Interlocks and Insider Participation

Currently, the members of our compensation committee are Dr. Kamdar, Mr. Phillips, and Ms. Lindgardt. In 2022, none of the foregoing members of our compensation committee served as an officer or employee of Sera Prognostics. None of our executive officers, except for Dr. Critchfield, currently serves, or in the past year has served, as a member of the board of directors, and none of our executive officers currently serves, or in the past year has served, as a member of the compensation committee (or other board committee performing equivalent functions or, in the absence of any such committee, the entire board of directors) of any entity that has one or more executive officers serving on our board of

directors or compensation committee. There are no family relationships between or among the members of our board of directors or executive officers.

Prohibition on Hedging and Pledging

Our Insider Trading Policy prohibits members of the board of directors, named executive officers, and all other subject personnel from purchasing financial instruments designed to hedge the economic risk of owning our securities (or entering any transaction that has the same economic effect), and prohibits certain persons, including members of the board of directors and the named executive officers, from pledging our securities.

Conclusion

It is the opinion of the compensation committee that the compensation policies and elements described above provide the necessary incentives to properly align our executive officers’ performance with the interests of our stockholders while maintaining equitable and competitive executive compensation practices that enable us to attract and retain the highest caliber of executive officers.

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information with respect to the beneficial ownership of our Class A common stock as of March 31, 2023 for:

•each person or group of affiliated persons known by us to be the beneficial owner of more than five percent of our capital stock;

•each of our directors and director nominees;

•each of our named executive officers; and

•all of our current directors and executive officers as a group.

Beneficial ownership is determined in accordance with the rules of the SEC and generally includes voting or investment power with respect to securities. Under those rules, beneficial ownership includes any shares as to which the individual or entity has sole or shared voting power or investment power. Except as noted by footnote, and subject to community property laws where applicable, we believe, based on the information provided to us, that the persons and entities named in the table below have sole voting and investment power with respect to all common stock shown as beneficially owned by them.

The percentage of beneficial ownership in the table below is based on 31,022,040 shares of Class A common stock and Class B common stock outstanding as of March 31, 2023. Warrants or Options to purchase shares of Class A common stock that are exercisable within 60 days of March 31, 2023 are deemed to be beneficially owned by the persons holding these options for the purpose of computing percentage ownership of that person, but are not treated as outstanding for the purpose of computing any other person’s ownership percentage.

Unless otherwise indicated, the address of all listed stockholders is c/o Sera Prognostics, Inc., 2749 East Parleys Way, Suite 200, Salt Lake City, UT 84109.


		Class A Common Stock Beneficially Owned
Name of Beneficial Owner		Shares	Percentage
5% Stockholders:
ATH Holding Company, LLC(1)		3,201,271	10.0	%
Entities affiliated with Domain Associates, LLC(2)		2,573,417	8.3	%
InterWest Partners X, LP(3)		2,542,499	8.2	%
Chione, Ltd.(4)		1,980,350	6.3	%
aMoon Growth Fund Limited Partnership(5)		1,918,511	6.2	%
Vivo Capital Fund IX, L.P.(6)		1,856,011	6.0	%
Named Executive Officers and Directors:
Gregory C. Critchfield, M.D., M.S.(7)		1,616,075	5.1	%
Michael R. Foley, M.D.(8)		109,149	*
Jay Moyes(9)		301,802	1.0	%
Kim Kamdar, Ph.D.(10)		174,751	*
Sandra A.J. Lawrence(11)		156,248	*
Ryan Trimble(12)		250,634	*
Zhenya Lindgardt(13)		155,300	*
Joshua Phillips(14)		1,136,198	3.6	%
Jane F. Barlow, M.D.(15)		50,853	*
Mansoor Raza Mirza, M.D.(16)		174,751	*
Marcus Wilson, Pharm.D.(17)		—	*
All current executive officers and directors as a group (16 persons)(18)		5,370,069	15.6	%

*	Indicates beneficial ownership of less than 1%.
(1)	Based solely on Schedule 13G filed with the SEC on February 22, 2022. Consists of (i) 2,201,974 shares of Class A common stock and (ii) 999,297 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023 held by ATH Holding Company, LLC. Elevance Health, Inc., an Indiana corporation, holds one hundred percent (100%) of the beneficial ownership of ATH Holding Company, LLC. Elevance Health, Inc. is a publicly traded corporation whose beneficial ownership is held by numerous individuals and entities. The address of ATH Holding Company, LLC is c/o Elevance Health, Inc., 220 Virginia Avenue, Indianapolis, IN 46204.
(2)	Based solely on Schedule 13G filed with the SEC on January 4, 2022. Consists of (i) 2,398,443 shares of Class A common stock held by Domain Partners VIII, L.P. (Domain VIII), (ii) 17,796 shares of Class A common stock held by DP VIII Associates, L.P. (DP VIII), (iii) 30,920 shares of Class A common stock held by Domain Associates, LLC (Domain Associates) and (iv) 125,328 shares of Class A common stock underlying warrants held by Domain VIII and 930 shares of Class A common stock underlying warrants held by DP VIII, that are exercisable as of March 31, 2023. One Palmer Square Associates VIII, LLC, a Delaware limited liability company (OPSA VIII), is the sole general partner of Domain VIII and DP VIII, and therefore may be deemed to indirectly beneficially own the securities reported herein as directly beneficially owned by Domain VIII and DP VIII, however OPSA VIII expressly disclaims beneficial ownership of such securities. The address of Domain VIII, DP VIII and Domain Associates is 103 Carnegie Center, Suite 300, Princeton, NJ 08540.
(3)	Based solely on Schedule 13G/A filed with the SEC on February 10, 2023. Consists of (i) 2,416,241 shares of Class A common stock and (ii) 126,258 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023. InterWest Management Partners X, LLC (IMP10), is the general partner of InterWest Partners X, LP and may be deemed to have voting, investment and dispositive power with respect to the shares held by InterWest Partners X, LP. Gilbert H. Kliman, managing director of IMP10, and Khaled A. Nasr and Keval Desai, venture members of IMP10, each may be deemed to share voting, investment and dispositive power with respect to these shares. The address of InterWest Partners X, LP and IMP10 is 467 First Street, Suite 201, Los Altos, CA 94022.
(4)	Based solely on Schedule 13D filed with the SEC on July 26, 2021. Consists of (i) 1,771,684 shares of Class A common stock and (ii) 208,666 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023. Chione’s directors, Marcin Czernik, Andreas Hadjimichael and Anastasios Nikolaou, and its sole stockholder, Wiaczeslaw Smolokowski, may be deemed to share voting and investment power and beneficial ownership with respect to such shares. Each of such directors and stockholder disclaims such voting and investment power and beneficial ownership. Chione’s address is Simou Menardou 5, Kifisia Court. Office 225, 6015 Larnaca, Cyprus.
(5)	Based solely on Schedule 13G/A filed with the SEC on January 9, 2023. Consists of 1,918,511 shares of Class A common stock held by aMoon Growth Fund Limited Partnership, or aMoon. aMoon Growth Fund G.P. Limited Partnership, or aMoon GP, is the sole general partner of aMoon. aMoon General Partner Ltd., or aMoon Ltd., is the sole general partner of aMoon GP. Dr. Yair Schindel is the sole shareholder of aMoon Ltd. By virtue of such relationships, aMoon GP, aMoon Ltd. and Dr. Schindel may be deemed to have shared voting and investment power with respect to the shares of Class A common stock held by aMoon. Dr. Schindel disclaims beneficial ownership of the shares of Class A common stock held by aMoon, aMoon G.P. and aMoon Ltd., except to the extent of his pecuniary interest therein, if any. The address of aMoon, aMoon GP, aMoon Ltd., and Dr. Schindel is 34 Yerushalaim Rd, Beit Gamla, 6th Floor, Ra’anana, 4350110, Israel.
(6)	Based solely on Schedule 13G filed with the SEC on July 23, 2021. Consists of 1,856,011 shares of Class A common stock held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the general partner of Vivo Capital Fund IX, L.P. The voting members of Vivo Capital IX, LLC are Frank Kung, Edgar Engleman, Shan Fu, Hongbo Lu, Mahendra Shah, Jack Nielsen and Michael Chang, none of whom has individual voting or investment power with respect to these shares and each of whom disclaims beneficial ownership of such shares. The principal business address of Vivo Capital IX, LLC is 192 Lytton Avenue, Palo Alto, CA 94301.


(7)			Consists of (i) 630,832 shares of Class A common stock held by the Critchfield Family Trust, of which Dr. Critchfield is a Trustee, and in such capacity, may be deemed to indirectly beneficially own the securities owned by the trust except to the extent of his pecuniary interest therein, if any, (ii) 164,113 shares of Class A common stock held by Dr. Critchfield, (iii) 8,824 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023 held by Dr. Critchfield, and (iv) 812,306 shares of Class A common stock underlying options that are exercisable as of March 31, 2023 or will become exercisable within 60 days of such date, held by Dr. Critchfield.
(8)			Consists of 109,149 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Dr. Foley.
(9)			Consists of (i) 2,830 shares of Class A common stock held by Mr. Moyes, and (ii) 298,972 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Mr. Moyes.
(10)			Consists of (i) 30,920 shares of Class A common stock held by Domain Associates, (ii) 6,629 shares of Class A common stock held by Dr. Kamdar, and (iii) 137,202 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Dr. Kamdar. Dr. Kamdar, a member of our board of directors, is a Member of One Palmer Square Associates VIII, LLC, the General Partner of Domain VIII and DP VIII, and a Managing Member of Domain Associates. Dr. Kamdar has no voting or investment control over the shares held by Domain VIII and DP VIII. Dr. Kamdar may be deemed to beneficially own the shares held by Domain Associates. Dr. Kamdar disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.
(11)			Consists of 156,248 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Ms. Lawrence.
(12)			Consists of (i) 37,549 shares of Class A common stock held by Mr. Trimble, (ii) 63,005 shares of Class A common stock held by the Trimble Trust, (iii) 12,878 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023 held by the Trimble Trust, and (iv) 137,202 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Mr. Trimble. Mr. Trimble is the Trustee for the Trimble Trust and may be deemed to beneficially own the shares held by the Trimble Trust.
(13)			Consists of 155,300 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Ms. Lindgardt.
(14)			Consists of (i) 388,622 shares of Class A common stock held by Catalyst Health Ventures, L.P. (CHV LP), (ii) 12,470 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023 held by CHV LP, (iii) 166,098 shares of Class A common stock held by Catalyst Health Ventures (PF), L.P. (CHV PF), (iv) 374,344 shares of Class A common stock held by CHV Investments, LLC (CHV Investments), (v) 19,558 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023 held by CHV Investments, (vi) 36,048 shares of Class A common stock held by Catalyst Health Ventures Follow-on Fund, L.P. (CHV FO) (together with CHV LP, CHV PF and CHV Investments, the CHV Funds), (vii) 1,856 shares of Class A common stock underlying warrants that are exercisable as of March 31, 2023 held by CHV FO, and (viii) 137,202 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Mr. Phillips. CHV GP LLC is the general partner of CHV LP and CHV PF. CHV III GP LLC is the general partner of CHV Investments and CHV FO. Joshua Phillips, a member of our board of directors, is a managing member of CHV GP LLC and CHV III GP LLC, and a limited partner of CHV PF, CHV Investments, CHV GP LLC and CHV III GP LLC. The securities held by the CHV Funds may be deemed to be beneficially owned by Joshua Phillips. Joshua Phillips disclaims beneficial ownership of these securities except to the extent of his pecuniary benefit therein.
(15)			Consists of 50,853 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Dr. Barlow.
(16)			Consists of 174,751 shares of Class A common stock underlying options that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date, held by Dr. Mirza.
(17)			Dr. Wilson, a member of our board of directors, is the CAO at Elevance Health, which is affiliated with ATH Holding Company, LLC. Mr. Wilson has no voting or investment power with respect to the securities described in footnote 1.
(18)			See footnotes 7 to 17. Also includes shares beneficially owned by Nadia F. Altomare, John J. Boniface, Ph.D., Paul Kearney, Ph.D, Robert G. Harrison, and Benjamin G. Jackson. Consists of (i) 1,956,344 shares of Class A common stock and (ii) 3,413,725 shares of Class A common stock underlying options or warrants that are exercisable as of March 31, 2023, or will become exercisable within 60 days of such date.

CERTAIN RELATIONSHIPS, RELATED PARTY AND OTHER TRANSACTIONS

We describe below transactions and series of similar transactions since January 1, 2021, to which we were a party or will be a party, in which:

•the amounts involved exceeded or will exceed the lesser of (i) $120,000 or (ii) 1% of the average of our total assets as of December 31, 2021 and 2022; and

•any of our directors, nominees for director, executive officers or beneficial holders of more than 5% of our outstanding capital stock, or any immediate family member of, or person sharing the household with, any of these individuals or entities (each, a related person), had or will have a direct or indirect material interest.

Policies and Procedures for Related Party Transactions

We have adopted a written policy that requires all future transactions between us and any director, executive officer, holder of 5% or more of any class of our capital stock or any member of the immediate family of, or entities affiliated with, any of them, or any other related persons, as defined in Item 404 of Regulation S-K, or their affiliates, in which the amount involved is equal to or greater than $120,000, be approved in advance by our audit committee. Any request for such a transaction must first be presented to our audit committee for review, consideration and approval. In approving or rejecting any such proposal, our audit committee will consider the relevant facts and circumstances available and deemed relevant to the audit committee, including, but not limited to, the extent of the related party’s interest in the transaction, and whether the transaction is on terms no less favorable to us than terms we could have generally obtained from an unaffiliated third party under the same or similar circumstances.

Series E Financing

From February to April 2021, we issued an aggregate of 8,054,139 shares of our Series E convertible preferred stock at a purchase price of $12.46 per share for consideration of $100.1 million, net of issuance costs, together with warrants to purchase an aggregate of 722,223 shares of our Class A common stock, exercisable at $20.77 per share. We refer to these transactions collectively as our Series E Preferred Stock Financing.

The table below sets for the aggregate number and purchase price of shares of Series E convertible preferred stock issued to our directors, executive officers or holders of more than 5% of our capital stock, or an affiliate or immediate family member thereof in 2021:


Name		Shares	Warrants at $20.77	Aggregate Purchase Price
ATH Holding Company, LLC(1)		1,204,508	722,223	$	15,000,000
Entities affiliated with Blue Ox Healthcare Partners SP, LLC(2)		1,204,508	—	$	15,000,000
Vivo Capital Fund IX, L.P.(3)		1,606,011	—	$	20,000,000
aMoon Growth Fund Limited Partnership(4)		1,606,011	—	$	20,000,000
CHV Investments, LLC(5)		160,601	—	$	2,000,000

(1)	ATH Holding Company, LLC beneficially owns more than 5% of our outstanding Class A common stock. Elevance Health, Inc. holds one hundred percent (100%) of the beneficial ownership of ATH Holding Company, LLC. Marcus Wilson, Pharm.D., a member of our board of directors, is the CAO of Elevance Health, Inc.
(2)	Entities affiliated with Blue Ox Healthcare Partners SP, LLC beneficially owned more than 5% of our outstanding Class A common stock.
(3)	Vivo Capital Fund IX, L.P. beneficially owns more than 5% of our outstanding Class A common stock.
(4)	aMoon Growth Fund Limited Partnership beneficially owns more than 5% of our outstanding Class A common stock.
(5)	Joshua Phillips, a member of our board of directors, is the Managing Partner of Catalyst Health Ventures, which is affiliated with CHV Investments, LLC.

Agreements with Stockholders

Elevance Health Commercialization Agreement

In February 2021, we entered into the Commercial Collaboration Agreement with Elevance Health (formerly known as Anthem). The Commercial Collaboration Agreement provides defined payment within a defined period for use of the PreTRM test within Elevance Health’s network of covered members. Pursuant to the Commercial Collaboration Agreement, Elevance Health agreed to purchase a certain minimum number of tests for each of the first three years of the term of the Commercial Collaboration Agreement. Additionally, Elevance Health agreed to pay a certain minimum amount per year for the first three years of the term of the Commercial Collaboration Agreement. The Commercial Collaboration Agreement contains terms, conditions and pricing that are consistent with the terms, conditions and pricing customarily used by Elevance Health in similar agreements they have with third parties.

Elevance Health Laboratory Services Agreement

In November 2020, we entered into a laboratory services agreement with Elevance Health, called the Laboratory Services Agreement, relating to our provision of PreTRM tests and related services during the course of the Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs (“PRIME”) study. The Laboratory Services Agreement contains terms, conditions and pricing that are consistent with the terms, conditions and pricing customarily used by Elevance Health in similar agreements they have with third parties.

Agreements with Blue Ox Healthcare Partners, LLC

In February 2021, we entered into a consulting agreement with Blue Ox Healthcare Partners, LLC (“Blue Ox”), pursuant to which Blue Ox agreed to provide consulting services to effect the strategic rollout of the PreTRM test on Elevance Health’s network, as specified in the Commercial Collaboration Agreement with Elevance Health, to help establish widespread insurance coverage for the PreTRM test. In October 2021, we entered into an additional consulting agreement with Blue Ox to advise the Company on development of strategies with the goal of increasing Medicaid coverage of the PreTRM test. The consulting agreements with Blue Ox contain terms, conditions and pricing that are consistent with the terms, conditions and pricing customarily used by Blue Ox in similar agreements they have with third parties.

Vivo Management Rights Letter

We entered into a letter agreement with Vivo Capital Fund IX, L.P. (“Vivo”) dated as of March 29, 2021. Under the letter agreement, at any time that Vivo beneficially owns shares or other equity securities representing at least (a) 75% of the securities which Vivo and its fund affiliates had originally purchased at the time of the letter agreement, or (b) 4% of our then-outstanding total voting power, it is entitled to nominate one individual, or a Vivo Investor Designee, to serve as a director on our board of directors. As of the date hereof, Vivo had not exercised its rights to nominate a Vivo Investor Designee to serve as a director on our board of directors. Further, so long as it satisfies the above beneficial ownership threshold(s), we agreed to invite a representative of Vivo to attend all meetings of our board of directors in a nonvoting observer capacity.

Investors’ Rights Agreement

We entered into a Fourth Amended and Restated Investors’ Rights Agreement, dated as of February 23, 2021, or the Investors’ Rights Agreement, with certain holders of our capital stock. Under the Investors’ Rights Agreement, holders of registrable shares can demand that we file a registration statement or request that their shares be included on a registration statement that we are otherwise filing, in either case, registering the resale of their shares of common stock. These registration rights are subject to conditions and limitations, including the right, in certain circumstances, of the underwriters of an offering to limit the number of shares included in such registration and our right, in certain circumstances, not to effect a registration upon demand of the holders of registrable shares within 90 days following the effective date of any registration statement that we file covering a firm commitment underwritten public offering in which the holders of registrable shares were entitled to join and in which we effectively registered all registrable shares that were requested to be registered.

Demand Registration Rights

The holders of at least a majority of registrable securities outstanding under the Investors’ Rights Agreement may require us to file a registration statement under the Securities Act on a Form S-1 at our expense, subject to certain exceptions, with respect to the then outstanding registrable securities of such holders having an anticipated aggregate offering price of at least $5.0 million, and we are required to effect the registration as soon as practicable, and in any event within 120 days. Any time after we are eligible to use a registration statement on Form S-3, the holders of at least 25% of our registrable securities under the Investors’ Rights Agreement may require us to file a registration statement on Form S-3 at our expense, subject to certain exceptions, with respect to the then outstanding registrable securities of such holders having an anticipated aggregate offering price of at least $3.0 million, and we are required to effect the registration as soon as practicable, and in any event within 90 days.

Piggyback Registration Rights

If we propose to file a registration statement under the Securities Act for the purposes of a public offering of our securities (including, but not limited to, registration statements relating to a secondary offering of our securities but excluding (i) a registration statement relating to the sale of securities to employees pursuant to a stock option, stock purchase, or similar plan; (ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act; (iii) a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the registrable securities; or (iv) a registration in which the only Class A common stock being registered is Class A common stock issuable upon conversion of debt securities that are also being registered), the holders of registrable securities are entitled to receive notice of such registration and to request that we include their registrable securities for resale in the registration statement. The underwriters of the offering will have the right to limit the number of shares to be included in such registration.

Expenses of Registration

We will pay all registration expenses, other than underwriting discounts and commissions, related to any demand or piggyback registration. The Investors’ Rights Agreement contains customary cross-indemnification provisions, pursuant to which we are obligated to indemnify the selling stockholders, in the event of misstatements or omissions in the registration statement attributable to us except in the event of fraud, and they are obligated to indemnify us for misstatements or omissions attributable to them.

Expiration of Registration Rights

The registration rights will terminate upon the earliest to occur of the closing of certain liquidation events, such time when all of the holder’s registrable securities may be sold without limitation (and without the requirement for us to be in compliance with the current public information requirement) under Rule 144 of the Securities Act and the fifth anniversary of the closing date of our initial public offering (“IPO”), which was completed in July 2021.

Indemnification Agreements

We have entered into agreements to indemnify our directors and certain executive officers. These agreements will, among other things, require us to indemnify these individuals for certain expenses (including attorneys’ fees), judgments, fines and settlement amounts reasonably incurred by such person in any action or proceeding, including any action by or in our right, on account of any services undertaken by such person on behalf of our company or that person’s status as a member of our board of directors to the maximum extent allowed under Delaware law.

Other Transactions

We have granted stock options to our named executive officers, other executive officers and certain of our directors.

The following table lists certain details about shares of our Class A common stock that were purchased by related parties as part of our IPO in July 2021.


Name		Shares Purchased	Price Per Share		Aggregate Purchase Price
aMoon Growth Fund Limited Partnership(1)		312,500	$	16.00	$	5,000,000
Vivo Capital Fund IX, L.P.(2)		250,000	$	16.00	$	4,000,000
Entities affiliated with Blue Ox Healthcare Partners, LLC(3)		200,000	$	16.00	$	3,200,000
Chione, Ltd.(4)		156,250	$	16.00	$	2,500,000

(1)	aMoon Growth Fund Limited Partnership beneficially owns more than 5% of our outstanding Class A common stock.
(2)	Vivo Capital Fund IX, L.P. beneficially owns more than 5% of our outstanding Class A common stock.
(3)	Entities affiliated with Blue Ox Healthcare Partners, LLC beneficially owned more than 5% of our outstanding Class A common stock.
(4)	Chione, Ltd. beneficially owns more than 5% of our outstanding Class A common stock.

OTHER MATTERS

2022 Annual Report and SEC Filings

Our financial statements for the year ended December 31, 2022 are included in our annual report on Form 10-K. Our annual report and this proxy statement are posted on our investor relations website at investors.seraprognostics.com and are available from the SEC at its website at www.sec.gov. You may also obtain a copy of our annual report without charge by sending a written request to Sera Prognostics, Inc., Attention: Investor Relations, 2749 East Parleys Way, Suite 200, Salt Lake City, Utah 84109. Copies of all exhibits to the annual report on Form 10-K for the fiscal year ended December 31, 2022 may be obtained for a nominal fee, which fee will not exceed our reasonable expenses in furnishing such copies by sending a written request to Sera Prognostics, Inc., Attention: Investor Relations, 2749 East Parleys Way, Suite 200, Salt Lake City, Utah 84109.

Incorporation by Reference

In our filings with the SEC, information is sometimes “incorporated by reference.” This means that we are referring you to information that has previously been filed with the SEC and the information should be considered as part of the particular filing. As provided under SEC regulations, the “Report of the Audit Committee” contained in this proxy statement specifically is not incorporated by reference into any other filings with the SEC. In addition, this proxy statement includes several website addresses. These website addresses are intended to provide inactive, textual references only. The information on these websites is not part of this proxy statement.

Stockholder Proposals and Nominations for Director

To be considered for inclusion in the proxy statement relating to our 2024 annual meeting of stockholders, we must receive stockholder proposals (other than for director nominations) no later than December 27, 2023. To be considered for presentation at the 2024 annual meeting of stockholders, although not included in the proxy statement, proposals (including director nominations that are not requested to be included in our proxy statement) must be received no earlier than February 9, 2024 and no later than March 10, 2024. In addition to satisfying the foregoing advance notice requirements, to comply with the universal proxy rules under the Exchange Act, stockholders who intend to solicit proxies in support of director nominees other than the Company’s nominees must follow the requirements set forth in Rule 14a-19 promulgated under the Exchange Act.

Proposals that are not received in a timely manner will not be voted on at the 2024 annual meeting of stockholders. If a proposal is received on time, the proxies that management solicits for the meeting may still exercise discretionary voting authority on the proposal under circumstances consistent with the proxy rules of the SEC. All stockholder proposals should be marked for the attention of Corporate Secretary, Sera Prognostics, Inc., 2749 East Parleys Way, Suite 200 Salt Lake City, Utah 84109.

Other Matters

The board of directors knows of no other matters to be presented at the 2023 Annual Meeting. If any additional matters are properly presented at the 2023 Annual Meeting, our designated proxies listed in this proxy statement will have discretion to vote shares they represent in accordance with their own judgment on such matters.

It is important that your shares be represented at the 2023 Annual Meeting, regardless of the number of shares that you hold. You are, therefore, urged to vote by telephone or by using the Internet as instructed in the Notice or on the accompanying proxy card or, or if you requested to receive a printed copy of the proxy materials, by executing and returning, at your earliest convenience, the accompanying proxy card in the envelope that has also been provided.

* * *

SEC Form DEF 14A filed by Sera Prognostics Inc.