tm261440-1_def14a - none

tm261440-1_def14a - none - 8.5509897s

TABLE OF CONTENTS

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 14A

(Rule 14a-101)

Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

☐ Preliminary Proxy Statement

☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☒ Definitive Proxy Statement

☐ Definitive Additional Materials

☐ Soliciting Material under §240.14a-12

SCHOLAR ROCK HOLDING CORPORATION

Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

☒ No fee required.

☐ Fee paid previously with preliminary materials.

☐ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

TABLE OF CONTENTS

SCHOLAR ROCK HOLDING CORPORATION
301 Binney Street, 3rd Floor
Cambridge, MA 02142

NOTICE OF 2026 ANNUAL MEETING OF STOCKHOLDERS
To be held June 4, 2026

Notice is hereby given that the 2026 Annual Meeting of Stockholders (the “Annual Meeting”) of Scholar Rock Holding Corporation, will be held on June 4, 2026 at 12:00 noon Eastern Time. The Annual Meeting will be held entirely online. You will be able to attend and participate in the Annual Meeting online by visiting www.virtualshareholdermeeting.com/SRRK2026 and entering the 16-digit control number included on your proxy card. You will not be able to attend the Annual Meeting in person. The purpose of the Annual Meeting is the following:

To elect four Class II directors to our Board of Directors, each to serve until the 2029 Annual Meeting of stockholders and until his or her successor has been duly elected and qualified, or until his or her earlier death, resignation, or removal;

To ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026;

To approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers; and

To transact any other business properly brought before the Annual Meeting or any adjournment or postponement of the Annual Meeting.

Only Scholar Rock Holding Corporation stockholders of record at the close of business on April 10, 2026 will be entitled to vote at the Annual Meeting and any adjournment or postponement thereof. You can find more information, including information regarding the nominees for election to our Board of Directors, in the accompanying proxy statement.

We are pleased to comply with the rules of the Securities and Exchange Commission that allow companies to distribute their proxy materials over the Internet under the “notice and access” approach. As a result, we are mailing to our stockholders a Notice of Internet Availability of Proxy Materials (the “Notice of Internet Availability”) instead of a paper copy of our proxy materials and our Annual Report for the fiscal year ended December 31, 2025 (the “2025 Annual Report”). We will mail the Notice of Internet Availability on or about April 22, 2026 and it contains instructions on how to access those documents and to cast your vote over the Internet. This process allows us to provide our stockholders with the information they need on a timely basis, while reducing the environmental impact and lowering the costs of printing and distributing our proxy materials. If you would like to receive a printed copy of our proxy materials, including our proxy statement, our 2025 Annual Report and a form of proxy card, free of charge, please follow the instructions on the Notice of Internet Availability.

The Board of Directors recommends that you vote “FOR” of each of proposals one, two, and three as outlined in the accompanying proxy statement.

Your vote is important. Whether or not you are able to attend the meeting online, it is important that your shares be represented. To ensure that your vote is recorded promptly, please vote as soon as possible, even if you plan to attend the meeting online, by submitting your proxy via the Internet at the address listed on the proxy card or by signing, dating, and returning the proxy card.

By order of the Board of Directors,

David Hallal
Chief Executive Officer and Chairman

Cambridge, Massachusetts
April 22, 2026

TABLE OF CONTENTS

Table of Contents

	Page
PROXY STATEMENT FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS		1
GENERAL INFORMATION		2
PROPOSAL NO. 1 – ELECTION OF CLASS II DIRECTORS		6
PROPOSAL NO. 2 – RATIFICATION OF THE APPOINTMENT OF DELOITTE & TOUCHE LLP		12
PROPOSAL NO. 3 – NON-BINDING, ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS		15
CORPORATE GOVERNANCE		16
DIRECTOR COMPENSATION		22
EXECUTIVE COMPENSATION		25
CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS		40
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT		42
REPORT OF THE AUDIT COMMITTEE		45
HOUSEHOLDING		46
STOCKHOLDER PROPOSALS		47
OTHER MATTERS		47

TABLE OF CONTENTS

SCHOLAR ROCK HOLDING CORPORATION
301 Binney Street, 3rd Floor
Cambridge, MA 02142

PROXY STATEMENT
FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD JUNE 4, 2026

This proxy statement contains information about the 2026 Annual Meeting of Stockholders (the “Annual Meeting”) of Scholar Rock Holding Corporation, which will be held on June 4, 2026 at 12:00 noon Eastern Time. The Annual Meeting will be held entirely online this year. You will be able to attend and participate in the Annual Meeting online by visiting www.virtualshareholdermeeting.com/SRRK2026 and entering the 16-digit control number included on your proxy card. The Board of Directors of Scholar Rock Holding Corporation (the “Board of Directors”) is using this proxy statement to solicit proxies for use at the Annual Meeting. In this proxy statement, the terms “Scholar Rock,” “we,” “us,” and “our” refer to Scholar Rock Holding Corporation. The mailing address of our principal executive offices is Scholar Rock Holding Corporation, 301 Binney Street, 3rd Floor, Cambridge, Massachusetts 02142.

All properly submitted proxies will be voted in accordance with the instructions contained in those proxies. If no instructions are specified, the proxies will be voted in accordance with the recommendation of our Board of Directors with respect to each of the matters set forth in the accompanying Notice of Meeting (the “Notice”). You may revoke your proxy at any time before it is exercised at the virtual meeting by giving our Corporate Secretary written notice to that effect and as otherwise described in this proxy statement.

We made this proxy statement and our Annual Report to Stockholders for the fiscal year ended December 31, 2025 first available to stockholders on or around April 22, 2026.

Your vote is important. We encourage you to vote in advance, even if you plan to attend the Annual Meeting online. To vote online or by phone, you will need to use your 16-digit control number found on the Notice of Internet Availability (as defined below), the proxy card, or the voting instruction form.

As permitted by U.S. Securities and Exchange Commission (“SEC”) rules, proxy materials were made available via the internet. Notice regarding availability of proxy materials and instructions on how to access those materials were mailed to certain stockholders of record on or about April 22, 2026 (the “Notice of Internet Availability”). The Notice of Internet Availability included instructions on how to vote and how to request a paper copy of the proxy materials. This method of notice and access gives Scholar Rock a low-cost way to furnish stockholders with their proxy materials. If you previously chose to receive proxy materials electronically, you will continue to receive access to these materials via email unless you elect otherwise.

Important Notice Regarding the Availability of Proxy Materials for
the Annual Meeting of Stockholders to be Held on June 4, 2026:

This proxy statement, the Notice of Internet Availability and our 2025 Annual Report to
Stockholders are available for viewing, printing, and downloading at www.proxyvote.com.

A copy of our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, as filed with the SEC, except for exhibits, will be furnished without charge to any stockholder upon written request to Scholar Rock Holding Corporation, 301 Binney Street, 3rd Floor, Cambridge, Massachusetts 02142, Attention: Legal. This proxy statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2025 are also available on the SEC’s website at www.sec.gov.

TABLE OF CONTENTS

SCHOLAR ROCK HOLDING CORPORATION

PROXY STATEMENT
FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS

GENERAL INFORMATION

Who is soliciting my vote?

Scholar Rock’s Board of Directors is soliciting your vote for the Annual Meeting.

When is the record date for the Annual Meeting?

The record date for determination of stockholders entitled to vote at the Annual Meeting is the close of business on April 10, 2026.

How many votes can be cast by all stockholders?

There were 119,301,886 shares of our common stock, par value $0.001 per share, outstanding on April 10, 2026, all of which are entitled to vote with respect to all matters to be acted upon at the Annual Meeting. Each stockholder of record is entitled to one vote for each share of our common stock held by such stockholder. No shares of our undesignated preferred stock were outstanding as of April 10, 2026.

How do I vote?

If you are a stockholder of record, there are several ways for you to vote your shares.

•

By Telephone. You may vote using a touch-tone telephone by calling 1-800-690-6903, 24 hours a day, seven days a week. You will need the 16-digit control number included on the Notice of Internet Availability or the proxy card. Votes submitted by telephone must be received by 11:59 p.m., Eastern Time, on June 3, 2026.

•

By Internet (before the Annual Meeting). You may vote at www.proxyvote.com, 24 hours a day, seven days a week. You will need the 16-digit control number included on the Notice of Internet Availability or the proxy card. Votes submitted through the Internet must be received by 11:59 p.m., Eastern Time, on June 3, 2026.

•

By Mail. You may vote by mail by completing, signing, and dating the enclosed proxy card and returning it in the enclosed prepaid envelope. Proxy cards submitted by mail must be received no later than by June 3, 2026 to be voted at the Annual Meeting.

•

During the Annual Meeting. You may vote during the Annual Meeting by going to www.virtualshareholdermeeting.com/SRRK2026. You will need the 16-digit control number included on the Notice of Internet Availability, the proxy card, or the voting instruction form. If you previously voted via the Internet (or by telephone or mail), you will not limit your right to vote virtually at the Annual Meeting.

•

By QR Code. You may vote using your mobile device to scan the QR code on your proxy card. Votes submitted by scanning your QR code must be received no later than 11:59 p.m. Eastern Time on June 3, 2026.

Telephone and Internet voting for stockholders of record will be available until 11:59 p.m. Eastern Time on June 3, 2026, and mailed proxy cards must be received by June 3, 2026 in order to be counted at the Annual Meeting. If the Annual Meeting is adjourned or postponed, these deadlines may be extended.

The voting deadlines and availability of telephone and Internet voting for beneficial owners of shares held in “street name” will depend on the voting processes of the organization that holds your shares. Therefore, we urge you to carefully review and follow the voting instruction card and any other materials that you receive from that organization. If you hold your shares of Scholar Rock common stock in multiple accounts, you should vote your shares as described in each set of proxy materials you receive.

TABLE OF CONTENTS

Why is the Annual Meeting a virtual, online meeting?

We believe that hosting a virtual meeting will facilitate shareholder attendance and participation by enabling shareholders to participate from any location around the world and improves our ability to communicate more effectively with our shareholders. We have designed the virtual meeting to provide substantially the same opportunities to participate as you would have at an in-person meeting.

How do I participate in the Virtual Annual Meeting?

We are pleased to use the virtual meeting format to facilitate stockholder attendance, voting and questions by leveraging technology to communicate more effectively and efficiently with our stockholders. This format allows stockholders to participate fully from any location, without the cost of travel.

To participate in the virtual meeting, visit www.virtualshareholdermeeting.com/SRRK2026 and enter the 16-digit control number included on the Notice of Internet Availability, the proxy card or the voting instruction form. You may begin to log into the meeting platform beginning at 11:45 a.m. Eastern Time on June 4, 2026. The meeting will begin promptly at 12:00 noon Eastern Time on June 4, 2026. We encourage you to access the Annual Meeting before it begins.

Stockholders will also have the opportunity to submit questions during the Annual Meeting through www.virtualshareholdermeeting.com/SRRK2026. Stockholders may submit questions during the Annual Meeting using the “Ask a Question” field on the virtual meeting website. A technical support telephone number will be posted on the log-in page of www.virtualshareholdermeeting.com/SRRK2026 that you can call if you encounter any difficulties accessing the virtual meeting during the check-in or during the meeting.

How do I ask questions during the Virtual Annual Meeting?

Stockholders may submit questions during the Annual Meeting using the “Ask a Question” field on the virtual meeting website.

You will need to log in to the virtual meeting through www.virtualshareholdermeeting.com/SRRK2026 with your 16-digit control number found on the Notice of Internet Availability, the proxy card or the voting instruction form to submit a question during the meeting.

Time has been allocated on the agenda to respond to questions submitted during the Annual Meeting. Questions we do not answer during the Annual Meeting will be answered in writing and posted on Scholar Rock’s website at investors.scholarrock.com. Please refer to the Annual Meeting Rules of Conduct and Procedures for more information on how to ask questions. The Rules of Conduct and Procedures are available at www.proxyvote.com and during the Annual Meeting at www.virtualshareholdermeeting.com/WSRRK2026.

We encourage you to access the Annual Meeting early. Online check-in will begin approximately 15 minutes before the 12:00 noon Eastern Time start time. If you encounter difficulties during the check-in or meeting time, we have technicians available to help you. The technical support contact information will be posted on the virtual meeting login page.

Where may I find copies of Proxy Materials and the Annual Report?

The Notice of Internet Availability and Proxy Statement and Annual Report are posted on Scholar Rock’s website at investors.scholarrock.com and at www.proxyvote.com.

How do I revoke my proxy?

You may revoke your proxy by (1) following the instructions on the Notice and entering a new vote by mail that we receive before the start of the Annual Meeting or over the Internet by the cutoff time of 11:59 p.m. Eastern Time on June 3, 2026, (2) attending and voting at the virtual Annual Meeting (although attendance at the virtual Annual Meeting will not in and of itself revoke a proxy), or (3) by filing an instrument in writing revoking the proxy or another duly executed proxy bearing a later date with our Corporate Secretary. Any written notice of revocation or subsequent proxy card must be received by our Corporate Secretary prior to the taking of the vote at the Annual Meeting. Such written notice of revocation or

TABLE OF CONTENTS

subsequent proxy card should be hand delivered to our Corporate Secretary or sent to our principal executive offices at Scholar Rock Holding Corporation, 301 Binney Street, 3rd Floor, Cambridge, Massachusetts 02142, Attention: Legal.

If a broker, bank, or other nominee holds your shares, you must contact such broker, bank, or nominee in order to find out how to change your vote.

How is a quorum reached?

Our Amended and Restated Bylaws (“bylaws”) provide that a majority of the outstanding shares entitled to vote, represented at the virtual Annual Meeting or by proxy, will constitute a quorum for the transaction of business at the Annual Meeting. There were 119,301,886 shares of our common stock outstanding and entitled to vote on the record date. Therefore, a quorum will be present if at least 59,650,944 shares of our common stock are present in person or represented by executed proxies timely received by us at the Annual Meeting. Shares present virtually during the Annual Meeting will be considered shares of common stock represented in person at the meeting.

Under the General Corporation Law of the State of Delaware, shares that are voted “abstain” or “withheld” and broker “non-votes” are counted as present for purposes of determining whether a quorum is present at the Annual Meeting. If a quorum is not present, the meeting may be adjourned until a quorum is obtained.

How is the vote counted?

Under our bylaws, any proposal other than an election of directors is decided by a majority of the votes properly cast for and against such proposal, except where a larger vote is required by law or by our Amended and Restated Certificate of Incorporation (“certificate of incorporation”), or bylaws. Abstentions and broker “non-votes” are not included in the tabulation of the voting results on any such proposal and, therefore, do not have an impact on such proposals. A broker “non-vote” occurs when a broker or nominee holding shares for a beneficial owner does not vote on a particular proposal because the nominee does not have discretionary voting power with respect to that item because it is considered to be a non-routine matter, and has not received voting instructions from the beneficial owner.

If your shares are held in “street name” by a brokerage firm, your brokerage firm is required to vote your shares according to your instructions. If you do not give instructions to your brokerage firm, the brokerage firm will still be able to vote your shares with respect to certain “routine” matters, but will not be allowed to vote your shares with respect to “non-routine” matters. Proposal No. 1, to elect four Class II directors to our Board of Directors, each to serve until the 2029 Annual Meeting of stockholders and until his or her successor has been duly elected and qualified, or until his or her earlier death, resignation, or removal, and Proposal No. 3, to approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers, are “non-routine” matters. If you do not instruct your broker how to vote with respect to these proposals, your broker may not vote for these proposals, and those votes will be counted as broker “non-votes.” Proposal No. 2, the ratification of the appointment of Deloitte & Touche LLP, is considered to be a “routine” matter, and your brokerage firm will be able to vote on this proposal even if they do not receive voting instructions from you.

Under our bylaws, directors are elected by a plurality of the votes properly cast on the election of directors. This means that the four (4) director nominees receiving the highest number of affirmative votes will be elected as directors. You may vote for all the director nominees, “withhold” authority to vote your shares for all the director nominees or withhold authority to vote your shares with respect to any one or more of the director nominees. Withholding authority to vote your shares with respect to one or more director nominees will have no effect on the election of those nominees. Broker non-votes, if any, will have no effect on the election of the nominees. If nominees are unopposed, election requires only a single “for” vote.

The appointment of the Company’s auditor is approved by the affirmative vote of a majority of the votes properly cast thereon. This means that there must be more “for” votes than “against” votes. You may abstain from voting your shares with respect to this proposal. Abstaining from voting your shares with respect to Proposal 2 will have no effect on the outcome of the vote. Broker “non-votes” will also have no effect on the

TABLE OF CONTENTS

outcome of the vote. However, we expect there will be no broker non-votes on this proposal because brokers have discretionary voting authority with respect to this proposal.

The say-on-pay vote is a “non-routine” matter. If you do not instruct your broker how to vote with respect to this proposal, your broker may not vote for this proposal, and those votes will be counted as broker “non-votes.” For this proposal, a majority of the votes properly cast thereon is required to approve on a non-binding, advisory basis, the compensation of the Company’s named executive officers. Abstentions and broker non-votes, if any, will have no effect on the outcome of the vote on this proposal.

The vote required, and the method of calculation, for each proposal at the Annual Meeting is described below.

Proposal	Vote Required	Discretionary Voting Permitted?
1. Election of Directors	Plurality	No
2. Approval of the Ratification of the Appointment of Deloitte & Touche LLP as our Independent Registered Public Accounting Firm	Majority of votes properly cast	Yes
3. The advisory, non-binding vote on the compensation of our named executive officers	Majority of votes properly cast	No

Who pays the cost for soliciting proxies?

We are making this solicitation and will pay the entire cost of preparing and distributing the Notice and our proxy materials and soliciting votes. If you choose to access the proxy materials or vote over the Internet, you are responsible for any Internet access charges that you may incur. Our officers and employees may, without compensation other than their regular compensation, solicit proxies through further mailings, personal conversations, facsimile transmissions, e-mails, or otherwise. We have hired Broadridge Financial Solutions, Inc. to assist us in the distribution of proxy materials and the solicitation of votes described above. Proxy solicitation expenses that we will pay include those for preparation, mailing, returning, and tabulating the proxies.

How can I know the voting results?

We plan to announce preliminary voting results at the Annual Meeting and will publish final results in a Current Report on Form 8-K to be filed with the SEC within four business days following the Annual Meeting.

TABLE OF CONTENTS

PROPOSAL NO. 1 — ELECTION OF CLASS II DIRECTORS

Our Board of Directors currently consists of nine members. In accordance with the terms of our certificate of incorporation and bylaws, our Board of Directors is divided into three classes, Class I, Class II, and Class III, with members of each class serving staggered three-year terms. The members of the classes are divided as follows:

•

the Class II directors are David Hallal (Chair), Kristina Burow, Michael Gilman, Ph.D. and Katie Peng and their terms will expire at the Annual Meeting of stockholders to be held this year;

•

the Class III directors are Richard Brudnick, Jeffrey S. Flier, M.D. and Akshay Vaishnaw, M.D., Ph.D., and their terms will expire at the Annual Meeting of stockholders to be held in 2027; and

•

the Class I directors are Srinivas Akkaraju, M.D., Ph.D. and Joshua Reed, and their terms will expire at the Annual Meeting of stockholders to be held in 2028.

Upon the expiration of the term of a class of directors, directors in that class will be eligible to be elected for a new three-year term at the Annual Meeting of stockholders in the year in which their term expires.

Our certificate of incorporation and bylaws provide that the authorized number of directors may be changed only by resolution of our Board of Directors. Our certificate of incorporation also provides that our directors may be removed only for cause by the affirmative vote of the holders of at least two-thirds (2/3) of the outstanding shares then entitled to vote in an annual election of directors, and that any vacancy on our Board of Directors, including a vacancy resulting from an enlargement of our Board of Directors, may be filled only by vote of a majority of our directors then in office.

Our Board of Directors has nominated David Hallal (Chair), Kristina Burow, Michael Gilman, Ph.D. and Katie Peng for election as the Class II directors at the Annual Meeting. The nominees are presently directors, and have indicated a willingness to continue to serve as directors, if elected. If the nominees become unable or unwilling to serve, however, the proxies may be voted for a substitute nominee selected by our Board of Directors.

Nominees for Election as Class II Directors

The following table identifies our nominees for Class II directors and sets forth their principal occupation and business experience during the last five years and their ages as of April 10, 2026.

Name	Positions and Offices Held with Scholar Rock	Director Since	Age
David Hallal	Chief Executive Officer, Chairman and Director	2017	59
Kristina Burow	Director	2014	53
Michael Gilman, Ph.D.	Director	2013	71
Katie Peng	Director	2024	55

David Hallal has served as Chief Executive Officer of Scholar Rock since April 2025 and has served as the Chairman of our Board of Directors since July 2017. He also serves as the Chairman of the Board of Directors of ElevateBio, LLC, and Kalaris Therapeutics, Inc. From December 2017 until April 2025, Mr. Hallal served as Chairman and Chief Executive Officer of ElevateBio, LLC. From September 2018 until May 2021, Mr. Hallal served as Chairman and Chief Executive Officer of AlloVir, Inc. and since May 2021, served as its Executive Chairman which merged with Kalaris Therapeutics, Inc in March 2025. Prior to that, Mr. Hallal served in executive roles of increasing responsibility at Alexion Pharmaceuticals, Inc. (“Alexion”), most recently serving as Chief Executive Officer and a board member. Prior to his role as Chief Executive Officer, Mr. Hallal served Alexion as Chief Operating Officer and a board member as well as Chief Commercial Officer and Head of Commercial Operations. From February 2018 until July 2025, Mr. Hallal served as a member of the Board of Directors of Seer, Inc, and from June 2018 until August 2025, Mr. Hallal served as Chairman of the Board of Directors of iTeos Therapeutics SA. Mr. Hallal holds a B.A. in psychology from the University of New Hampshire. Our Board of Directors believes that Mr. Hallal’s

TABLE OF CONTENTS

experience as an executive at numerous pharmaceutical companies qualifies him to serve as our Chairman of the Board of Directors.

Kristina Burow has served as a director since August 2014. Ms. Burow is a Managing Director of ARCH Venture Partners focused on the creation and development of biotechnology, pharmaceutical and health tech companies. She joined ARCH in 2002 as an Associate and has played a significant role in the growth of ARCH’s life science portfolio, including multiple public companies exceeding billion-dollar valuations. Ms. Burow is a co-founder and director of Neumora Therapeutics, Inc., and a director of Boundless Bio, Inc., Mirador Therapeutics, Inc., Treeline Biosciences, Inc., and Magnet Biomedicine, Inc., among others. She previously was a co-founder and director of Receptos, Inc. (acquired by Celgene), Orbital Therapeutics, Inc. (acquired by Bristol Myers-Squibb), Vividion Therapeutics, Inc. (acquired by Bayer AG), and Metsera, Inc. (acquired by Pfizer), and a former director at Beam Therapeutics Inc., Gossamer Bio, Inc., Metacrine, Inc., Unity Biotechnology, Inc., and Vir Biotechnology, among others. Ms. Burow has participated and led investments in a number of other ARCH portfolio companies including Amplitude Therapeutics, Inc., Aspen Neuroscience, Inc., CREATE Medicines Inc., Aledade, Inc., Erasca, Inc., Kura Oncology, Inc., KYTHERA Biopharmaceuticals Inc. (acquired by Allergan), and Ikaria, Inc. (acquired by Mallinckrodt Pharmaceuticals). Prior to joining ARCH, Ms. Burow was an Associate with the Novartis BioVenture Fund in San Diego. As an early employee at the Genomics Institute of the Novartis Research Foundation (GNF), she directed Chemistry Operations and was active in Business Development where she helped create numerous companies as spin-outs from GNF. Ms. Burow holds a M.B.A. from the University of Chicago, a M.A. in Chemistry from Columbia University and a B.S. in Chemistry from the University of California, Berkeley. Our Board of Directors believes that Ms. Burow’s extensive experience investing in biopharmaceutical and biotechnology companies and her experience on Boards of Directors in the medical industry qualifies her to serve on our Board of Directors.

Michael Gilman, Ph.D. has served as a director since November 2013. Dr. Gilman is currently Chief Executive Officer for Arrakis Therapeutics, Inc., a role he has served in since 2016. From October 2016 to April 2019, Dr. Gilman was Chief Executive Officer for Obsidian Therapeutics, Inc. Previously, from 2014 to 2016, Dr. Gilman was Founder and Chief Executive Officer of Padlock Therapeutics, Inc. Dr. Gilman is on the board of directors of several private companies. Dr. Gilman was a postdoctoral fellow with Dr. Robert Weinberg at the Whitehead Institute. He holds a Ph.D. in Biochemistry from University of California, Berkeley, and a S.B. in Life Sciences from the Massachusetts Institute of Technology. Our Board of Directors believes that Dr. Gilman’s extensive experience in the pharmaceuticals industry qualifies him to serve on our Board of Directors.

Katie Peng has served as a director since February 2024. Ms. Peng is currently the Chief Commercial Officer and member of the management team at Denali Therapeutics, a role she has served in since September 2021. From November 2019 to September 2021, Ms. Peng served as Senior Vice President, OMNI Business Unit Head of Genentech, Inc, where she was responsible for the neurology, ophthalmology, immunology, respiratory and rare disease portfolio and from April 2017 to October 2019 she served as Senior Vice President, IMPACT Business Unit Head. Ms. Peng is a member of the Board of Directors for Adicet Bio, Inc. Ms. Peng received a B.A. in Biology from the University of California, Berkeley and an M.B.A. with concentrations in Marketing and Finance from the Kelley School of Business, Indiana University. Our Board of Directors believes that Ms. Peng’s experience as an executive at pharmaceutical companies launching commercial drugs globally qualifies her to serve on our Board of Directors.

Vote Required and Board of Directors’ Recommendation

The Board of Directors unanimously recommends voting “FOR” the election of David Hallal, Kristina Burow, Michael Gilman, Ph.D. and Katie Peng as the Class II directors, each to serve for a three-year term ending at the Annual Meeting of stockholders to be held in 2029 or until their successors have been duly elected and qualified.

TABLE OF CONTENTS

Directors Not Standing for Election or Re-Election

The following table and paragraphs identify our directors who are not standing for election or re-election at this year’s Annual Meeting, and sets forth their principal occupation and business experience during the last five years and their ages as of April 10, 2026.

Name

Positions and Offices Held with
Scholar Rock

Director
Since

Class and Year
in Which Term
Will Expire

Age

Richard Brudnick

Director

2022

Class III — 2027

Jeffrey S. Flier, M.D.

Director

2022

Class III — 2027

Akshay Vaishnaw, M.D., Ph.D.

Director

2021

Class III — 2027

Srinivas Akkaraju, M.D., Ph.D.

Director

2022

Class I — 2028

Joshua Reed

Director

2021

Class I — 2028

Class III Directors

Richard H. Brudnick has served as a director since April 2023. Mr. Brudnick joined Prime Medicine, Inc. in July 2022, and has served as Chief Business Officer until July 2025. Prior to joining Prime Medicine from June 2018 to June 2022, Mr. Brudnick was Chief Business Officer and Head of Strategy for Codiak BioSciences, Inc. From May 2016 to March 2018, Mr. Brudnick was Executive Vice President of Business Development and Alliance Management at Bioverativ, Inc., and Mr. Brudnick served as Biogen Inc.’s Senior Vice President of Corporate Development from August 2014 until May 2016. Mr. Brudnick is a member of the Board of Directors for InflaRx N.V. Mr. Brudnick previously served as a director of Volition RX Limited. Mr. Brudnick received a B.S. and M.S. in Management Science from the Massachusetts Institute of Technology. Our Board of Directors believes that Mr. Brudnick’s biotechnology leadership experience qualifies him to serve on our Board of Directors.

Jeffrey S. Flier, M.D. has served as a director since October 2016. Since August 2016, Dr. Flier has served as the Higginson Professor of Physiology and Medicine and Harvard University Distinguished Service Professor, and from 2007 to August 2016 served as the twenty-first Dean of the Faculty of Medicine at Harvard University. An elected member of the National Academy of Medicine and a fellow of the American Academy of Arts and Sciences, his many honors include the Eli Lilly Award of the American Diabetes Association, and the Berson Lecture of the American Physiological Society. He was the recipient of the 2005 Banting Medal from the American Diabetes Association, its highest scientific honor. Dr. Flier received his B.S. from City College of New York and his M.D. from Mount Sinai School of Medicine with highest academic honors, and he completed his residency training at Mount Sinai School of Medicine. Our Board of Directors believes that Dr. Flier’s extensive medical and scientific experience and his leadership skills qualify him to serve on our Board of Directors.

Akshay Vaishnaw, M.D., Ph.D. has served as President of R&D of Scholar Rock since April 2025 and has served as a director since May 2019. Dr. Vaishnaw has been a venture partner at Atlas Venture since March 2024. From September 2023 to December 2024, Dr. Vaishnaw served as Chief Innovation Officer and Member of the Scientific Advisory Board at Alnylam Pharmaceuticals. From January 2022 to September 2023, Dr. Vaishnaw served as President of Alnylam and from March 2018 to January 2022, he served as President, R&D. Dr. Vaishnaw also served in various other roles of increasing responsibility at Alnylam since joining in 2006. Dr. Vaishnaw currently serves on the board of directors for Hemab Inc. since January 2024. Dr. Vaishnaw previously served on the board of directors for Editas Medicine, Inc. and Visterra, Inc. He received his M.D. from the University of Wales College of Medicine, U.K., and his Ph.D. from the University of London, U.K., in molecular immunology. He is a Fellow of the Royal College of Physicians, U.K. Our Board of Directors believes that Dr. Vaishnaw’s extensive medical, drug development and business experience, combined with his leadership skills, qualify him to serve on our Board of Directors.

Class I Directors

Srinivas Akkaraju, M.D., Ph.D. has served as a director since July 2022. Since March 2017, Dr. Akkaraju has been Managing General Partner at Samsara BioCapital, a firm that he founded. Dr. Akkaraju is a

TABLE OF CONTENTS

member of the Board of Directors for Alumis, Inc., Mineralys Therapeutics Inc., vTv Therapeutics, Inc., Inventiva S.A., and Kalaris Therapeutics, Inc. Dr. Akkaraju previously served as director of Syros Pharmaceuticals, Inc., Chinook Therapeutics, Inc., Intercept Pharmaceuticals, Inc., Jiya Acquisition Corp., Seattle Genetics, Inc., and Principia Biopharma, Inc. Dr. Akkaraju received his M.D. and a Ph.D. in Immunology from Stanford University. He received his undergraduate degrees in Biochemistry and Computer Science from Rice University. Our Board of Directors believes that Dr. Akkaraju’s biotechnology investment experience qualifies him to serve on our Board of Directors.

Joshua Reed has served as a director since March 2021. Since September 2025, Mr. Reed has served as Chief Financial Officer of Alkermes, plc. In this role, he leads the Financial Planning & Analysis, Accounting & Financial Operations, Tax, Procurement and Strategic Sourcing functions. Mr. Reed previously served as Chief Financial Officer of Omega Therapeutics, Inc. (“Omega”), from May 2022 to May 2024, where he was responsible for finance, investor relations, and information technology. From July 2018 until May 2022, Mr. Reed served as Chief Financial Officer of Aldeyra Therapeutics, Inc., where he was responsible for finance, business development, investor relations, compliance, human resources, and information technology. Prior to joining Aldeyra, from June 2016 to July 2018, Mr. Reed served as Vice President and Head of Finance for Bristol-Myers Squibb’s (“BMS”) United States and Puerto Rico operations, a $12 billion business unit. Prior to that, Mr. Reed held roles of increasing responsibility at BMS, including positions in financial planning and analysis, supply chain finance, operations finance, and mergers and acquisitions. Mr. Reed received a B.S. in Finance from Rutgers University and an M.B.A. with concentrations in Finance and Corporate Strategy from the University of Michigan’s Ross School of Business. Our Board of Directors believes that Mr. Reed’s years of pharmaceutical industry, financial operations, strategy, and investment banking experience qualifies him to serve on our Board of Directors.

Executive Management

The following table identifies our executive officers and executive team members and sets forth their current positions at Scholar Rock and their ages as of April 10, 2026.

Name	Position Held with Scholar Rock	Officer Since	Age
Executive Officers
David Hallal	Chief Executive Officer and Chairman	2025	59
Akshay Vaishnaw M.D., Ph.D.	President of Research & Development	2025	63
R. Keith Woods	Chief Operating Officer	2025	58
Vikas Sinha	Chief Financial Officer	2025	62
Executive Team Members
Junlin Ho, J.D.	General Counsel & Corporate Secretary
Jing Marantz, M.D., Ph.D.	Chief Medical Officer
Rebecca McLeod	Chief Brand Officer & U.S. General Manager
Caryn Parlavecchio	Chief Human Resources Officer
Mo Qatanani, Ph.D.	Chief Scientific Officer
Lisa Wyman	Chief Technical & Quality Officer

David Hallal has served as Chief Executive Officer of Scholar Rock since April 2025 and has served as the Chairman of our Board of Directors since July 2017. For a description of Mr. Hallal’s relevant experience, please refer to Mr. Hallal’s biography contained in the section above titled “Proposal No. 1: Election of Class II Directors.”

Akshay Vaishnaw M.D., Ph.D. has served as President of R&D of Scholar Rock since April 2025 and has served as a director of our Board of Directors since May 2019. For a description of Dr. Vaishnaw’s relevant experience, please refer to Dr. Vaishnaw’s biography contained in the section above titled “Proposal No. 1: Election of Class II Directors.”

TABLE OF CONTENTS

R. Keith Woods has served as our Chief Operating Officer since April 2025. Mr. Woods has over three decades of experience in the biopharmaceutical sector, having served most recently as Chief Operating Officer of argenx U.S. Inc., from April 2018 to June 2023, where he led the company through its transition from an R&D organization to a global commercial organization. During this time, he oversaw key teams in preparation for argenx’s first product launch, including sales, marketing, market access and reimbursement, business operations, patient services and medical affairs. In 2023, Mr. Woods transitioned from this role to serve as a strategic commercial advisor to the board of directors of argenx. Prior to argenx, Mr. Woods served as senior vice president of North American operations for Alexion, where he managed a team of several hundred people in the U.S. and Canada and was responsible for more than $1 billion in annual sales. Prior to joining Alexion, Mr. Woods held various positions of increasing responsibility within Roche, Amgen, and Eisai Co., Ltd., over a span of 20 years. Mr. Woods currently serves on the board of directors of Neurogene Inc., and TScan Therapeutics, Inc. and served on the board of directors of X4 Pharmaceuticals until August 2025. He holds a Bachelor of Science in marketing from Florida State University.

Vikas Sinha has served as Chief Financial Officer of Scholar Rock since April 2025. Mr. Sinha brings over 30 years of executive leadership experience in the life sciences industry, with a proven track record across finance, investor relations, business development, strategy, IT, and human resources. Prior to joining Scholar Rock, he co-founded and served as CFO of ElevateBio, LLC from December 2017 to April 2025, where he is currently a Board member. He also served in roles of increasing responsibility, most recently as CEO, President and CFO, at AlloVir, Inc. from December 2018 to March 2025. Earlier in his career, Mr. Sinha served as CFO at Alexion, where he played a pivotal role in the company’s growth — from a market capitalization of $600 million to over $30 billion, and from no revenue to more than $3 billion annually. Before Alexion, he held multiple leadership positions at Bayer AG across the United States, Japan, Germany, and Canada, including Vice President and CFO of Bayer Pharmaceuticals Corporation (U.S.) and Vice President and CFO of Bayer Yakuhin Ltd. (Japan). Mr. Sinha currently serves as a board member at Orna Therapeutics. He previously served as an independent board member and Audit Committee Chair at Verona Pharma Plc. He holds an MBA from the Asian Institute of Management in Manila, Philippines. He is a qualified Chartered Accountant and an associate member of the Institute of Chartered Accountants of India, as well as a Certified Public Accountant in the U.S.

Junlin Ho, J.D. has served as our General Counsel & Corporate Secretary since February 2021. Ms. Ho joined Scholar Rock in March 2018 as our VP, Head of Corporate Legal and served as our SVP, Head of Legal & Corporate Secretary from March 2020 to January 2021. Prior to Scholar Rock, Ms. Ho worked at Foundation Medicine from 2013 to 2018 in roles of increasing responsibility, most recently as Associate General Counsel. Prior to that, Ms. Ho was a corporate attorney in the life sciences practice of Ropes & Gray LLP. Ms. Ho received her B.S. from the Massachusetts Institute of Technology and J.D. from the University of Chicago Law School.

Jing Marantz, M.D., Ph.D. has served as our Chief Medical Officer since November 2022. Prior to joining us, from January 2022 to August 2022, Dr. Marantz served as Chief Business Officer for Krystal Biotech, Inc. after serving on its board for a year. From October 2020 to January 2022, she served as Senior Vice President of Medical Affairs of Acceleron Pharma Inc. until its acquisition by Merck & Co., Inc. From June 2018 to September 2020, she served as Senior Vice President of Medical Affairs at Alnylam Pharmaceuticals. Previously, she held leadership positions at Alexion, Biogen, ARIAD, Millennium Pharmaceuticals, and Strategic Decisions Group across development, medical affairs, business development, and strategy. Dr. Marantz is a member of the Board of Directors for Arcturus Therapeutics, Inc. She received her medical training from Tongji Medical College, a Ph.D. in Biochemistry and Molecular Biology from Medical University of South Carolina, and an M.B.A. from the University of California, Berkeley.

Rebecca McLeod has served as our Chief Brand Officer and U.S. General Manager since June 2025. She oversees Global Brand and Commercial Strategy and is responsible for leading the anticipated U.S. commercial launch of apitegromab for patients with spinal muscular atrophy (SMA) — along with establishing the global apitegromab brand strategy and market positioning for Europe, Asia-Pacific and Latin America. From January 2018 to June 2025, she served in roles of increasing responsibility, most recently as U.S. General Manager, at argenx, where she led market access, distribution, patient services, medical affairs, operations, marketing, and sales for the U.S. organization. Under her leadership, argenx has delivered one of the most successful biopharmaceutical franchise launches with VYVGART. Ms. McLeod has over two

TABLE OF CONTENTS

decades of biopharmaceutical industry experience, with much of her career focused on rare disease programs while serving in commercial leadership positions across sales, marketing and product management at Alexion and Takeda Pharmaceuticals. Ms. McLeod holds an M.B.A. from The University of Arkansas at Little Rock and a B.A. from the University of Mississippi.

Caryn Parlavecchio has served as our Chief Human Resources Officer since August 2021. Prior to joining us, she most recently served as Vice President and Chief Human Resources Officer at Holy Name Medical Center from August 2020 to July 2021, where she was a member of the executive team, HR committee, finance committee, and compensation and benefits committees. From 2001 to July 2020, she held various human resource leadership positions at Novartis Pharmaceuticals, including Vice President and Global HR Head, Oncology & Pharma Development, Vice President and Country HR Head, and Vice President, Human Resources Services, North America. She received a M.A. in Counseling Psychology and a B.A. in English, both from Seton Hall University.

Mo Qatanani, Ph.D. has served as our Chief Scientific Officer since January 2024. Dr. Qatanani joined Scholar Rock in September 2021 as our Senior Vice President, Head of Discovery Biology and served as our Senior Vice President, Head of Research from September 2022 to January 2024. Prior to joining us, he was Vice President, and Head of Research at Dyne Therapeutics, Inc. from February 2018 to September 2021. Prior to Dyne, from 2009 to 2014, he held research positions of increasing responsibility at Alexion, Synageva BioPharma Corp, and Merck & Co., Inc. He holds a Ph.D. in molecular and human genetics from Baylor College of Medicine and completed a post-doctoral fellowship at the University of Pennsylvania School of Medicine. He has a B.Sc. and a M.Sc. in Biology from the American University of Beirut.

Lisa Wyman has served as our Chief Technical and Quality Officer since January 2025. Prior to joining us, she served as Chief Technical Operations Officer at Generate:Biomedicines from September 2022 to January 2025, where she was a member of the Executive Leadership Team. From January 2019 to September 2022, she held roles of increasing responsibility at Acceleron Pharma Inc. (acquired by Merck), including Senior Vice President of Technical Operations and Quality, and was a member of the Executive Committee from July 2020 until the company’s acquisition by Merck in November 2021. Before joining Acceleron, she held leadership positions at Mersana Therapeutics, Inc., Shire plc, and Boston Scientific Corporation. Ms. Wyman is a member of the Board of Directors for PepGen, Inc. She received a B.S. in Biology from Ithaca College and an M.S. in Engineering Management from Tufts University.

The principal occupation and employment during the past five years of each of our executive officers and executive team members was carried on, in each case except as specifically identified above, with a corporation or organization that is not a parent, subsidiary or other affiliate of us. There is no arrangement or understanding between any of our executive officers and executive team members and any other person or persons pursuant to which he or she is to be selected as an executive officer or executive team member.

There are no material legal proceedings to which any of our executive officers or executive team members are a party adverse to us or our subsidiaries or in which any such person has a material interest adverse to us or our subsidiaries, other than as specified below.

Involvement in Certain Legal Proceedings

Mr. Reed, one of our directors, previously served as Chief Financial Officer of Omega from May 2022 to May 2024. Approximately nine months after Mr. Reed left that position, Omega filed a voluntary petition for relief under Chapter 11 of the United States Bankruptcy Code, in the United States Bankruptcy Court for the District of Delaware.

TABLE OF CONTENTS

PROPOSAL NO. 2 — RATIFICATION OF THE APPOINTMENT OF DELOITTE & TOUCHE LLP
AS SCHOLAR ROCK’S INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
FOR THE FISCAL YEAR ENDING DECEMBER 31, 2026

Scholar Rock’s stockholders are being asked to ratify the appointment by the audit committee of the Board of Directors of Deloitte & Touche LLP as Scholar Rock’s independent registered public accounting firm for the fiscal year ending December 31, 2026. Deloitte & Touche LLP has served as our independent registered accounting firm since June 3, 2025. From 2015 until our engagement of Deloitte & Touche LLP, Ernst & Young LLP served as our independent accounting firm to perform audit services.

Stockholder approval is not required to appoint Deloitte & Touche LLP as Scholar Rock’s independent registered public accounting firm. However, the Board of Directors believes that submitting the appointment of Deloitte & Touche LLP to the stockholders for ratification is good corporate governance. If the stockholders do not ratify this appointment, the audit committee will reconsider whether to retain Deloitte & Touche LLP. Even if the selection of Deloitte & Touche LLP is ratified, the audit committee may, at its discretion, direct the appointment of a different independent registered public accounting firm at any time it decides that such a change would be in the best interest of Scholar Rock and its stockholders.

A representative of Deloitte & Touche LLP is expected to be present at the Annual Meeting and will have an opportunity to make a statement if he or she desires to do so and to respond to appropriate questions from our stockholders.

As previously disclosed, on May 6, 2025, Scholar Rock received notice from Ernst & Young LLP of its decision to decline to stand for re-election as Scholar Rock’s independent registered public accounting firm for the fiscal year ended December 31, 2025. Ernst & Young LLP ceased providing services following the filing of the Form 10-Q for the quarter ended March 31, 2025.

The reports of Ernst & Young LLP on the consolidated financial statements of Scholar Rock as of and for the fiscal years ended December 31, 2024 and 2023 did not contain an adverse opinion or a disclaimer of opinion and were not qualified or modified as to uncertainty, audit scope, or accounting principles.

During the fiscal years ended December 31, 2024 and 2023 and during the interim period through May 6, 2025, there were (i) no “disagreements” within the meaning of Item 304(a)(1)(iv) of Regulation S-K between Scholar Rock and Ernst & Young LLP on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure, any of which, if not resolved to Ernst & Young LLP’s satisfaction, would have caused Ernst & Young’s LLP to make reference thereto in their reports, and (ii) no “reportable events” within the meaning of Item 304(a)(1)(v) of Regulation S-K.

As a result of this process and in connection with evaluating the proposals from participating firms, on June 3, 2025, the audit committee of our Board of Directors approved the appointment of Deloitte & Touche LLP as Scholar Rock’s independent registered public accounting firm for the fiscal year ended December 31, 2025 as Ernst & Young LLP ceased providing services following the filing of the Form 10-Q for the quarter ended March 31, 2025.

During the fiscal years ended December 31, 2024 and 2023 and the subsequent interim period through June 3, 2025, neither Scholar Rock nor anyone on its behalf consulted with Deloitte & Touche LLP with respect to (a) the application of accounting principles to a specified transaction, either completed or proposed, or the type of audit opinion that might be rendered on Scholar Rock’s consolidated financial statements, and neither a written report nor oral advice was provided to Scholar Rock that Deloitte & Touche LLP concluded was an important factor considered by Scholar Rock in reaching a decision as to any accounting, auditing or financial reporting issue, or (b) any matter that was either the subject of a “disagreement” (as defined in Item 304(a)(1)(iv) of Regulation S-K and the related instructions thereto) or a “reportable event” (as described in Item 304(a)(1)(v) of Regulation S-K).

Ernst & Young LLP has furnished Scholar Rock with a letter addressed to the SEC stating that it agrees with the above statements, a copy of which is filed as Exhibit 16.1 to our Current Report on Form 8-K filed with the SEC on May 12, 2025.

TABLE OF CONTENTS

Scholar Rock incurred the following fees from Deloitte and Touche LLP, our current independent registered public accounting firm, for the audit of the consolidated financial statements and for other services provided during the year ended December 31, 2025 (in thousands).

	2025			2024
Audit fees(1)		$	1,172		$	—
Audit-related fees(2)			—			—
Tax fees(3)			757			—
All other fees			—			—
Total fees		$	1,929		$	—

(1)

Audit fees in 2025 consisted of fees for the audit of our annual financial statements, the review of our interim financial statements included in our Quarterly Reports on Form 10-Q, and services in connection with our “at-the-market offerings,” including registration statements, comfort letters and consents.

(2)

Audit-related fees consist of services that are reasonably related to the performance of the audit or review of our consolidated financial statements.

(3)

Tax fees consist of fees for tax advisory and tax compliance services.

Scholar Rock incurred the following fees from Ernst & Young LLP for the audit of the consolidated financial statements and for other services provided during the years ended December 31, 2024 (in thousands).

	2025			2024
Audit fees(1)		$	—		$	866
Audit-related fees(2)			—			—
Tax fees(3)			—			109
All other fees			—			—
Total fees		$	—		$	975

(1)

Audit fees in 2024 consisted of fees for the audit of our annual financial statements, the review of our interim financial statements included in our Quarterly Reports on Form 10-Q, and services in connection with our follow-on public offering and “at-the-market offerings,” including registration statements, comfort letters and consents.

(2)

Audit-related fees consist of services that are reasonably related to the performance of the audit or review of our consolidated financial statements.

(3)

Tax fees consist of fees for tax advisory and tax compliance services.

Audit Committee Pre-approval Policy and Procedures

Our audit committee has adopted a policy relating to the approval of all audit and non-audit services that are to be performed by our independent registered public accounting firm, which policy became effective as of May 23, 2018. This policy provides that we will not engage our independent registered public accounting firm to render audit or non-audit services unless the service is specifically approved in advance by our audit committee, or the engagement is entered into pursuant to the pre-approval procedure described below. From time to time, our audit committee may pre-approve specified types of services that are expected to be provided to us by our independent registered public accounting firm during the next 12 months. Any such pre-approval details the particular service or type of services to be provided and is also generally subject to a maximum dollar amount.

Prior to the adoption of this policy, our Board of Directors pre-approved all audit and non-audit services to be performed by our independent registered public accounting firm.

During 2025 and 2024, no services were provided to us by Deloitte & Touche LLP or Ernst & Young LLP, respectively, other than in accordance with the policies and procedures described above.

TABLE OF CONTENTS

Vote Required and Board of Directors’ Recommendation

A majority of the votes properly cast FOR this proposal is required to ratify the appointment of our independent public accountant. Shares that are voted “abstain” and broker non-votes, if any, will have no effect on the outcome of this proposal. However, we expect there will be no broker non-votes on this proposal because brokers have discretionary voting authority with respect to this proposal.

The Board of Directors unanimously recommends voting “FOR” Proposal No. 2 to ratify the appointment of Deloitte & Touche LLP as Scholar Rock’s independent registered public accounting firm for the fiscal year ending December 31, 2026.

TABLE OF CONTENTS

PROPOSAL NO. 3 — NON-BINDING, ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS

Under the Dodd-Frank Wall Street Reform and Consumer Protection Act (the “Dodd-Frank Act”) and Section 14A of the Exchange Act, our stockholders are entitled to vote to approve, on an advisory basis, the compensation of our named executive officers as disclosed in this proxy statement in accordance with SEC rules. Although this is a non-binding advisory vote, because we value the opinion of our stockholders, our Board of Directors and our compensation committee will consider the outcome of the “Say-on-Pay” vote described in this Proposal No. 3 of this proxy statement at the Annual Meeting, as well as feedback received throughout the year, when making compensation determinations for our executive officers in the future.

This vote is not intended to address any specific item of compensation, but rather the overall compensation our named executive officers and the philosophy, policies and practices described in this proxy statement. The compensation of our named executive officers subject to the vote is disclosed under the “Executive Compensation” section, the 2025 Summary Compensation Table, and the related narrative disclosure that accompanies the compensation tables contained in this proxy statement. As discussed in those disclosures, we believe that our compensation policies and decisions are strongly aligned with our stockholders’ interests and are consistent with current market practices. Compensation of our named executive officers is designed to enable us to attract and retain talented and experienced executives to lead us successfully in a competitive environment. Accordingly, we are asking our stockholders to vote for the following resolution:

RESOLVED, that the Company’s stockholders hereby approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers, as disclosed in the proxy statement for the 2026 Annual Meeting of Stockholders, the “Executive Compensation,” the 2025 Summary Compensation Table and narrative discussion that accompanies the compensation tables.

This vote is advisory, and therefore not binding on us, the Board of Directors, or our compensation committee. However, our Board of Directors and compensation committee value your opinion and intend to consider the outcome of the vote when making compensation decisions in the future.

Vote Required and Board of Directors’ Recommendation

A majority of the votes properly cast FOR this proposal is required to approve, on an advisory basis, the compensation of our named executive officers. Shares that are voted “abstain” and broker non-votes, if any, will have no effect on the outcome of this proposal.

The Board of Directors unanimously recommends voting “FOR” Proposal No. 3 to approve, on a non-binding, advisory basis, the compensation of our named executive officers.

TABLE OF CONTENTS

CORPORATE GOVERNANCE

Director Nomination Process

Our nominating and corporate governance committee is responsible for identifying individuals qualified to serve as directors, consistent with criteria approved by our Board of Directors, and recommending such persons to be nominated for election as directors.

The process followed by our nominating and corporate governance committee to identify and evaluate director candidates includes requests to board members for recommendations, use of external search firms to assist with identification of director candidates, meetings from time to time to evaluate biographical information and background material relating to potential candidates, and interviews of selected candidates by management, members of the committee and our Board of Directors. The minimum qualifications, qualities and skills that a committee-recommended nominee must satisfy for a position on our Board of Directors are set forth in our corporate governance guidelines, including experience at a strategic or policymaking level, accomplishments in his or her field, being well regarded in the community, having integrity, having sufficient time and availability to devote to the affairs of Scholar Rock, and to the extent such nominee serves or has previously served on other boards, contributions to such boards.

While we have no formal policy regarding board diversity, our nominating and corporate governance committee considers various forms of diversity when evaluating potential candidates, including diversity of backgrounds and personal and professional experiences. Our priority in selection of board members is identification of members with an established record of professional accomplishment, knowledge of our business and understanding of the competitive landscape, and their skills and independence as board members.

Stockholders may recommend individuals to the nominating and corporate governance committee for consideration as potential director candidates. Any such proposals should be submitted to our Corporate Secretary at our principal executive offices no later than the close of business on the 90th day nor earlier than the close of business on the 120th day prior to the one-year anniversary of the date of the preceding year’s annual meeting and should include appropriate biographical and background material to allow the nominating and corporate governance committee to properly evaluate the potential director candidate and the number of shares of our stock beneficially owned by the stockholder proposing the candidate. Stockholder proposals should be addressed to Scholar Rock Holding Corporation, 301 Binney Street, 3rd Floor, Cambridge, Massachusetts 02142, Attention: Legal. Assuming that biographical and background material has been provided on a timely basis in accordance with our bylaws, any recommendations received from stockholders will be evaluated in the same manner as potential nominees proposed by the nominating and corporate governance committee. If our Board of Directors determines to nominate a stockholder- recommended candidate and recommends his or her election, then his or her name will be included on our proxy card for the next annual meeting of stockholders. See “Stockholder Proposals” for a discussion of submitting stockholder proposals.

Director Independence

Applicable Nasdaq Stock Market LLC (“Nasdaq”) rules require a majority of a listed company’s Board of Directors to be comprised of independent directors within one year of listing. In addition, the Nasdaq rules require that, subject to specified exceptions, each member of a listed company’s audit, compensation and nominating and corporate governance committees be independent and that audit committee members also satisfy independence criteria set forth in Rule 10A-3 under the Exchange Act and that compensation committee members satisfy independence criteria set forth in Rule 10C-1 under the Exchange Act. Under applicable Nasdaq rules, a director will only qualify as an “independent director” if, in the opinion of the listed company’s Board of Directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. In order to be considered independent for purposes of Rule 10A-3, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the Board of Directors, or any other board committee, accept, directly or indirectly, any consulting, advisory, or other compensatory fee from the listed company or any of its subsidiaries or otherwise be an affiliated person of the listed company or any of its subsidiaries. In addition, in affirmatively determining the independence of any director who will serve on a company’s compensation committee, Rule 10C-1 under the Exchange Act

TABLE OF CONTENTS

requires that a company’s Board of Directors must consider all factors specifically relevant to determining whether a director has a relationship to such company which is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, including: the source of compensation to the director, including any consulting, advisory or other compensatory fee paid by such company to the director, and whether the director is affiliated with the company or any of its subsidiaries or affiliates.

Our Board of Directors has determined that all members of the Board of Directors, except David Hallal and Akshay Vaishnaw, are independent directors, including for purposes of the rules of Nasdaq and the SEC. In making such independence determination, our Board of Directors considered the relationships that each non-employee director has with us and all other facts and circumstances that our Board of Directors deemed relevant in determining their independence, including the beneficial ownership of our capital stock by each non-employee director. In considering the independence of the directors listed above, our Board of Directors considered the association of our directors with the holders of more than 5% of our common stock. There are no family relationships among any of our directors or executive officers. Mr. Hallal and Dr. Vaishnaw are not independent directors under these rules because they serve as our Chief Executive Officer and President of R&D, respectively.

Board Committees

Our Board of Directors has established an audit committee, a compensation committee, a nominating and corporate governance committee and a science, innovation, and technology committee. Each of these committees operates under a charter that satisfies the applicable standards of the SEC and Nasdaq. Each such committee reviews its respective charter annually. A current copy of the charter for each of the audit committee, compensation committee, nominating and corporate governance committee, and science, innovation and technology committee is posted on the corporate governance section of our website, investors.scholarrock.com/investors-media/corporate-governance.

Audit Committee

Richard Brudnick, Joshua Reed, and Katie Peng serve on the audit committee, which is chaired by Mr. Reed. Our Board of Directors has determined that each member of our current audit committee is “independent” for audit committee purposes as that term is defined in the rules of the SEC and the applicable Nasdaq rules, and each has sufficient knowledge in financial and auditing matters to serve on the audit committee. Our Board of Directors has designated Mr. Reed as an “audit committee financial expert,” as defined under the applicable rules of the SEC. During the fiscal year ended December 31, 2025, the audit committee met nine times. The report of the audit committee is included in this proxy statement under “Report of the Audit Committee.” The audit committee’s responsibilities include:

•

appointing, approving the compensation of, and assessing the independence of our independent registered public accounting firm;

•

pre-approving auditing and permissible non-audit services, and the terms of such services, to be provided by our independent registered public accounting firm;

•

reviewing the overall audit plan with our independent registered public accounting firm and members of management responsible for preparing our financial statements;

•

reviewing and discussing with management and our independent registered public accounting firm our annual and quarterly financial statements and related disclosures as well as critical accounting policies and practices used by us;

•

coordinating the oversight and reviewing the adequacy of our internal control over financial reporting;

•

establishing policies and procedures for the receipt and retention of accounting-related complaints and concerns;

•

recommending based upon the audit committee’s review and discussions with management and our independent registered public accounting firm whether our audited financial statements shall be included in our Annual Report on Form 10-K;

TABLE OF CONTENTS

•

monitoring the integrity of our financial statements and our compliance with legal and regulatory requirements as they relate to our financial statements and accounting matters;

•

preparing the audit committee report required by SEC rules to be included in our annual proxy statement;

•

reviewing all related person transactions for potential conflict of interest situations and approving all such transactions;

•

reviewing quarterly earnings releases;

•

reviewing our enterprise risk management framework and major risk exposures, including our cybersecurity risks; and

•

developing and recommending to the Board of Directors a code of business conduct and ethics.

All audit and non-audit services, other than de minimis non-audit services, to be provided to us by our independent registered public accounting firm must be approved in advance by our audit committee.

Compensation Committee

Kristina Burow, Michael Gilman, and Katie Peng serve on the compensation committee, which is chaired by Ms. Burow. Mr. Hallal served on the compensation committee until April 2025, at which time, Ms. Peng joined the compensation committee. Our Board of Directors has determined that each member of the compensation committee is “independent” as defined in the applicable Nasdaq rules. During the fiscal year ended December 31, 2025, the compensation committee met thirteen times. The compensation committee’s responsibilities include:

•

annually reviewing and recommending to the Board of Directors corporate goals and objectives relevant to the compensation of our chief executive officer and other executives and employees;

•

evaluating the performance of our chief executive officer in light of the achievement of such corporate goals and objectives and recommending to the Board of Directors the compensation of our chief executive officer;

•

reviewing and approving the compensation of our other executive officers and employees at the level of senior vice president and above;

•

reviewing and establishing our overall management compensation, philosophy, and policy;

•

overseeing and administering our compensation and similar plans;

•

evaluating and assessing potential and current compensation advisors in accordance with the independence standards identified in the applicable Nasdaq rules;

•

retaining and approving the compensation of any compensation advisors;

•

reviewing and approving the retention or termination of any consulting firm or outside advisor to assist in the evaluation of compensation matters;

•

reviewing our policies and procedures for the grant of equity-based awards;

•

evaluating and making recommendations to the Board of Directors about director compensation;

•

preparing the compensation committee report required by SEC rules, if and when required, to be included in our annual proxy statement;

•

in consultation with the Board of Directors, establishing criteria for, soliciting a firm for, and conducting the search process, for the hiring of our chief executive officer; and

•

reviewing and discussing with the Board of Directors corporate succession plans for our chief executive officer and our other executive officers.

Nominating and Corporate Governance Committee

Jeffrey Flier, Joshua Reed and Srinivas Akkaraju serve on the nominating and corporate governance committee, which has been chaired by Dr. Flier since April 2025. Mr. Hallal and Dr. Vaishnaw served on the

TABLE OF CONTENTS

nominating and corporate governance committee until April 2025, at which time, Mr. Reed and Dr. Akkaraju became members of our nominating and corporate governance committee. Our Board of Directors has determined that each member of the nominating and corporate governance committee is “independent” as defined in the applicable Nasdaq rules. During the fiscal year ended December 31, 2025, the nominating and corporate governance committee met two times. The nominating and corporate governance committee’s responsibilities include:

•

developing and recommending to the Board of Directors criteria for board and committee membership;

•

establishing procedures for identifying and evaluating Board of Director candidates, including nominees recommended by stockholders;

•

reviewing the size and composition of the Board of Directors to ensure that it is composed of members containing the appropriate skills and expertise to advise us;

•

identifying individuals qualified to become members of the Board of Directors;

•

recommending to the Board of Directors the persons to be nominated for election as directors and to each of the Board of Directors committees;

•

overseeing the evaluation of our Board of Directors, and

•

developing and recommending to the Board of Directors a set of corporate governance guidelines.

The nominating and corporate governance committee considers candidates for Board of Director membership suggested by its members, other members of the Board of Directors, and the Chief Executive Officer. Additionally, in selecting nominees for directors, the nominating and corporate governance committee will review candidates recommended by stockholders in the same manner and using the same general criteria as candidates recruited by the committee and/or recommended by our Board of Directors. Any stockholder who wishes to recommend a candidate for consideration by the committee as a nominee for director should follow the procedures described later in this proxy statement under the heading “Stockholder Proposals.” The nominating and corporate governance committee will also consider whether to nominate any person proposed by a stockholder in accordance with the provisions of our bylaws relating to stockholder nominations as described later in this proxy statement under the heading “Stockholder Proposals.”

Identifying and Evaluating Director Nominees. Our Board of Directors is responsible for filling vacancies on our Board of Directors and for nominating candidates for election by our stockholders each year in the class of directors whose term expires at the relevant annual meeting. The Board of Directors delegates the selection and nomination process to the nominating and corporate governance committee, with the expectation that other members of the Board of Directors, and of management, will be requested to take part in the process as appropriate.

Generally, the nominating and corporate governance committee identifies candidates for director nominees in consultation with management, through the use of search firms or other advisors, through the recommendations submitted by stockholders or through such other methods as the nominating and corporate governance committee deems to be helpful to identify candidates. Once candidates have been identified, the nominating and corporate governance committee confirms that the candidates meet all of the minimum qualifications for director nominees established by the nominating and corporate governance committee. The nominating and corporate governance committee may gather information about the candidates through interviews, detailed questionnaires, comprehensive background checks or any other means that the nominating and corporate governance committee deems to be appropriate in the evaluation process. The nominating and corporate governance committee then meets as a group to discuss and evaluate the qualities and skills of each candidate, both on an individual basis and taking into account the overall composition and needs of our Board of Directors. Based on the results of the evaluation process, the nominating and corporate governance committee recommends candidates for the Board of Directors’ approval to fill a vacancy or as director nominees for election to the Board of Directors by our stockholders each year in the class of directors whose term expires at the relevant annual meeting.

TABLE OF CONTENTS

Science, Innovation and Technology Committee

Srinivas Akkaraju, Jeffrey Flier, and Michael Gilman serve on the science, innovation, and technology committee, which is chaired by Dr. Flier. Dr. Vaishnaw served on the science, innovation, and technology committee until April 2025. During the fiscal year ended December 31, 2025, the science, innovation, and technology committee met two times. The science, innovation and technology committee’s responsibilities include:

•

providing a general oversight function regarding our research and development activities;

•

providing recommendations to our Board of Directors and us regarding our long-term strategic goals and objectives related to our research and development programs;

•

providing recommendations regarding key discovery and development strategies to align with our business needs; and

•

providing feedback to the Board of Directors and to our research and development functions.

Board and Committee Meetings Attendance

The Board of Directors met seventeen times during 2025. During 2025, each member of the Board of Directors attended in person or participated by teleconference in 75% or more of the aggregate of (i) the total number of meetings of the Board of Directors (held during the period for which such person has been a director) and (ii) the total number of meetings held by all committees of the Board of Directors on which such person served (during the periods that such person served).

Director Attendance at Annual Meeting of Stockholders

Our directors are expected to participate in the virtual Annual Meeting unless they have a conflict that cannot be resolved. Present at the Annual Meeting of Stockholders in 2025 were all of our then nine directors.

Policy on Trading, Pledging and Hedging of Company Stock

Certain transactions in our securities (such as purchases and sales of publicly traded put and call options, and short sales) create a heightened compliance risk or could create the appearance of misalignment between management and stockholders. In addition, securities held in a margin account or pledged as collateral may be sold without consent if the owner fails to meet a margin call or defaults on the loan, thus creating the risk that a sale may occur at a time when an officer or director is aware of material, non-public information or otherwise is not permitted to trade in Company securities. Our insider trading policy expressly prohibits short sales, derivative transactions, or any hedging transactions with respect to our stock by our executive officers, directors, employees and certain designated consultants and contractors, whether made directly or indirectly. Our insider trading policy expressly prohibits, without the advance approval of our audit committee, purchases or sales of puts, calls, or other derivative securities of the company or any derivative securities that provide the economic equivalent of ownership. It is our policy to comply with applicable insider trading laws, rules and regulations, and any exchange listing standards when engaging in transactions in Company securities.

Code of Business Conduct and Ethics

We have adopted a written code of business conduct and ethics that applies to our directors, officers, and employees, including our principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions. A current copy of the code is posted on the corporate governance section of our website, which is located at investors.scholarrock.com/investors-media/corporate-governance. If we make any substantive amendments to, or grant any waivers from, the code of business conduct and ethics for any officer or director, we will disclose the nature of such amendment or waiver on our website or in a Current Report on Form 8-K.

Board Leadership Structure and Board’s Role in Risk Oversight

Our Board of Directors has not adopted a policy requiring the separation of the roles of the Chairman of the Board and the Chief Executive Officer. Currently, Mr. Hallal serves as our Chief Executive Officer

TABLE OF CONTENTS

and as Chairman of the Board. The Board believes that combining these roles is appropriate at this time given Mr. Hallal’s deep knowledge of the Company, its strategy and operations, his experience as Chairman of the Board since 2017, and the efficiencies gained from unified leadership. The Board believes that having a single individual serve as both Chairman and Chief Executive Officer who has experience with the Company since 2017, promotes clear accountability, effective decision-making and strong alignment between management and the Board on strategic priorities. The Board retains flexibility to revisit its leadership structure from time to time based on the Company’s circumstances and the Board’s assessment of what structure would best serve the interests of the Company and its stockholders.

Seven of our nine directors are considered independent. Our board holds regular executive sessions of independent directors only at each regularly scheduled Board meeting. Our Audit, Compensation, Nominating and Corporate Governance and Science, Innovation and Technology committees are each comprised solely of independent directors.

Risk is inherent to every business, and how well a business manages risk can ultimately determine its success. We face a number of risks, including risks relating to our financial condition, development and commercialization activities, operations, strategic direction, and intellectual property. Management is responsible for the day-to-day management of risks we face, while our Board of Directors, as a whole and through the audit committee, has responsibility for the oversight of enterprise risk management, including cybersecurity risk.

The role of the Board of Directors in overseeing the management of our enterprise risk is conducted primarily through the audit committee of the Board of Directors, as disclosed in the description of the audit committee above and in the charter of the audit committee. The audit committee discusses with management our enterprise risk exposures, their potential impact on us, and the steps we take to manage them. The chairman of the audit committee reports on the discussion to the full Board of Directors during the committee reports portion of the next Board of Directors meeting. This enables the Board of Directors and its audit committee to coordinate the enterprise risk oversight role, particularly with respect to risk interrelationships.

Communication with the Directors of Scholar Rock

Any interested party with concerns about our company may report such concerns to the Board of Directors or any member of the Board of Directors, by submitting a written communication to the attention of such director at the following address:

c/o Scholar Rock Holding Corporation
301 Binney Street, 3rd Floor
Cambridge, MA 02142

You may submit your concern anonymously or confidentially by postal mail. You may also indicate whether you are a stockholder, customer, supplier, or other interested party.

A copy of any such written communication may also be forwarded to Scholar Rock’s legal counsel and a copy of such communication may be retained for a reasonable period of time. The director may discuss the matter with Scholar Rock’s legal counsel, with independent advisors, with non-management directors, or with Scholar Rock’s management, or may take other action or no action as the director determines in good faith is necessary, using reasonable judgment, and applying his or her own discretion.

Communications may be forwarded to other directors if they relate to important substantive matters and include suggestions or comments that may be important for other directors to know. In general, communications relating to corporate governance and long-term corporate strategy are more likely to be forwarded than communications relating to ordinary business affairs, personal grievances, and matters as to which we tend to receive repetitive or duplicative communications.

The audit committee oversees the procedures for the receipt, retention, and treatment of complaints received by Scholar Rock regarding accounting, internal accounting controls, or audit matters, and the confidential, anonymous submission by employees of concerns regarding questionable accounting, internal accounting controls or auditing matters. Scholar Rock has also established a toll-free telephone number for the reporting of such activity, which is 1-866-352-1896.

TABLE OF CONTENTS

DIRECTOR COMPENSATION

The table below shows all compensation paid to our non-employee directors during 2025. Mr. Hallal and Dr. Vaishnaw earned cash fees for their service as non-employee directors prior to becoming executive officers in April 2025. Jay Backstrom, our former President and Chief Executive Officer, received no compensation for his service as a director in 2025, and, consequently, is not included in this table. The compensation received by Mr. Hallal and Dr. Vaishnaw for their service as non-employee directors, and the compensation received by Mr. Hallal, Dr. Vaishnaw and Dr. Backstrom as employees during 2025 is presented in the “Summary Compensation Table.”

Name	Fees Earned or Paid in Cash ($)(1)(4)		Option Awards ($)(2)(3)		Stock Awards ($)(2)(3)		Total ($)
Srinivas Akkaraju, M.D., Ph.D.		61,077		232,479		232,471		526,027
Richard Brudnick		59,574		232,479		232,471		524,524
Kristina Burow		66,099		232,479		232,471		531,049
Jeffrey S. Flier, M.D.		75,712		232,479		232,471		540,662
Michael Gilman, Ph.D.		66,099		232,479		232,471		531,049
Katie Peng		66,188		232,479		232,471		531,138
Joshua Reed		75,102		232,479		232,471		540,052

(1)

Amounts reported represent cash retainer payments made pursuant to our Non-Employee Director Compensation Policy (as defined below) for services performed during the period from January 1, 2025 through December 31, 2025.

(2)

Amounts reported reflect the aggregate grant date fair value of option awards granted during 2025 calculated in accordance with the provisions of Financial Accounting Standards Board Accounting Standard Codification Topic 718, Compensation — Stock Compensation. Such grant date fair value does not take into account any estimated forfeitures related to service-vesting conditions. For information regarding assumptions underlying the valuation of equity awards, see Note 10 to our financial statements for the year ended December 31, 2025. These amounts do not correspond to the actual value that may be recognized by the named director upon vesting or exercise of such awards.

(3)

As of December 31, 2025, each director held options to purchase shares of the Company’s common stock and outstanding restricted stock units as follows:

Name	Number of Shares Underlying Options		Number of Restricted Shares
Srinivas Akkaraju, M.D., Ph.D.		119,206		7,632
Richard Brudnick		83,206		7,632
Kristina Burow		142,480		7,632
Jeffrey S. Flier, M.D.		126,979		7,632
Michael Gilman, Ph.D.		157,794		7,632
Katie Peng		50,973		18,064
Joshua Reed		106,806		7,632

(4)

Dr. Akkaraju earned cash compensation under our Non-Employee Director Compensation Policy, which was paid directly to Dr. Akkaraju’s employer.

Under our Non-Employee Director Compensation Policy (as amended from time to time, the “Non-Employee Director Compensation Policy”), we pay our non-employee directors a cash retainer for service on the Board of Directors and for service on each committee of the Board of Directors on which the director serves as a member. In addition, each non-employee director elected or appointed to our Board of Directors is granted an equity award following such director’s election or appointment to the Board of Directors and at each of our annual shareholder meetings (other than a director who was appointed or elected to our Board of Directors within three months prior to such annual meeting), subject to certain vesting

TABLE OF CONTENTS

conditions, provided the director continues to serve on our Board of Directors on the applicable vesting date. Our Non-Employee Director Compensation Policy is intended to provide a total compensation package that enables us to attract and retain qualified and experienced individuals to serve as directors and to align our directors’ interests with those of our stockholders. Non-employee director compensation under this policy is reviewed by our compensation committee on a regular basis and the compensation committee engages a compensation consultant to assist the compensation committee in its review. Any changes to non-employee director compensation are reviewed and approved by our Board of Directors.

Cash retainer fees to directors are payable in arrears in four equal quarterly installments on the last day of each quarter, provided that the amount of such payment is prorated for any portion of such quarter that the director is not serving on our Board of Directors or a particular committee. As of December 31, 2025, the fees paid to non-employee directors for service on the Board of Directors and for service on each committee of the Board of Directors on which the director is a member are as follows:

	2025 Annual Retainer
Board of Directors:
Nonemployee member		$	50,000*
Audit Committee:
Member		$	12,500*
Additional fee for Chair		$	12,500*
Compensation Committee:
Member		$	10,000*
Additional fee for Chair		$	10,000*
Nominating and Corporate Governance Committee:
Member		$	6,000*
Additional fee for Chair		$	6,000*
Science, Innovation and Technology Committee:
Member		$	10,000*
Additional fee for Chair		$	10,000*

On May 22, 2025, our Non-Employee Director Compensation Policy was revised to increase the Board Member retainer from $45,000 to $50,000, to remove the Non-Executive Chair of the Board of Directors additional cash retainer, to increase the Audit Committee Member retainer from $10,000 to $12,500, to increase the Compensation Committee Chair additional cash retainer from $10,000 to $12,500, to increase the Compensation Committee Member retainer from $7,500 to $10,000, to increase the Compensation Committee Chair additional cash retainer from $7,500 to $10,000, to increase the Nominating and Corporate Governance Committee Member retainer from $5,000 to $6,000, to increase the Nominating and Corporate Governance Committee Chair additional cash retainer from $5,000 to $6,000, to increase the Science, Innovation and Technology Committee Member retainer from $7,500 to $10,000, and to increase the Science, Innovation and Technology Committee Chair additional cash retainer from $7,500 to $10,000.

In addition, each non-employee director elected or appointed to our Board of Directors is granted a one-time equity award (the “Initial Equity Grant”) upon such director’s election or appointment to the Board of Directors, which vests monthly over three years, subject to continued service through such vesting dates. Through March 31, 2025, the Initial Equity Grant with respect to newly-appointed directors was a mix of stock options and restricted stock units, specifically an option to purchase 36,000 shares of common stock and 27,000 restricted stock units, provided that the total value of the Initial Equity Grant does not exceed $800,000 in the aggregate at the time of grant.

On May 22, 2025, our Non-Employee Director Compensation Policy was revised for newly elected non-employee directors to receive (i) an option to purchase a number of shares of the Company’s common stock with a grant date value of $400,000, and (ii) restricted stock units with a grant date value of $400,000,

TABLE OF CONTENTS

which (y) option shall vest monthly over three years and (z) restricted stock units shall vest annually over three years commencing on the 15th day of the month of the anniversary following the date of grant, provided, however, that all vesting shall cease if the director resigns from the Board of Directors or otherwise ceases to serve as a director of the Company.

On the date of each annual meeting of stockholders of our company, each non-employee director (other than a director who was appointed or elected to the Board of Directors within three months prior to such annual meeting) is granted an equity award (the “Annual Equity Grant”), which vests in full on the earlier to occur of the first anniversary of the date of grant or the next scheduled annual meeting, subject to continued service as a director through such vesting date. Our Non-Employee Director Compensation Policy, as revised on May 22, 2025, provides that the Annual Equity Grant shall be comprised of an option to purchase a number of shares of the Company’s common stock with a grant date value of $232,500, and restricted stock units with a grant date value of $232,500.

We also reimburse our non-employee directors for reasonable travel and out-of-pocket expenses incurred in connection with attending our Board of Director and committee meetings.

TABLE OF CONTENTS

EXECUTIVE COMPENSATION

Our named executive officers (“NEOs”) for the year ended December 31, 2025 are the following individuals:

•

David Hallal, our Chief Executive Officer and Chairman;

•

Akshay Vaishnaw, M.D., Ph.D., our President of R&D;

•

R. Keith Woods, our Chief Operating Officer;

•

Vikas Sinha, our Chief Financial Officer; and

•

Jay Backstrom, our former President and Chief Executive Officer.

Summary Compensation Table for Fiscal 2025

The following table presents the compensation awarded to, earned by or paid to (i) each individual who served as our principal executive officer (“PEO”) during the fiscal year ended December 31, 2025, (ii) the individual who served as our principal financial officer as of the end of the fiscal year ended December 31, 2025 (“PFO”) and (iii) the two most highly-compensated executive officers (other than the principal executive officer and principal financial officer) who were serving as executive officers on December 31, 2025. The following table also presents information regarding the compensation awarded to, earned by, and paid to each such individual during the fiscal year ended December 31, 2025, to the extent he or she was a named executive officer for such year.

Name and Principal Position	Year		Salary ($)		Bonus ($)		Stock Awards ($)(1)		Option Award ($)(1)		Non-Equity Incentive Plan Compensation ($)(2)		All Other Compensation ($)(3)		Total ($)
David Hallal(4) Chief Executive Officer and Chairman		2025		637,500		2,000,000(5)		22,518,500		7,624,988		452,293		67,646(6)		33,300,927
Akshay Vaishnaw, M.D., Ph.D.(4) President of R&D		2025		523,077		2,000,000(5)		9,007,400		3,050,001		278,334		32,555(7)		14,891,367
R. Keith Woods(4) Chief Operating Officer		2025		523,077		—		9,007,400		3,050,001		278,334		57,187(8)		12,915,999
Vikas Sinha(4) Chief Financial Officer		2025		523,077		—		9,007,400		3,050,001		278,334		14,036(9)		12,872,848
Jay Backstrom, M.D., M.P.H.(10) Former President and Chief Executive Officer		2025		600,231		—		5,895,227		9,848,049		—		1,145,317(11)		17,488,824
		2024		649,500				3,374,989		3,457,723		487,500		22,221		7,991,933

(1)

Except as set forth below, the amounts reported reflect the aggregate grant date fair value of restricted stock units, performance-based restricted stock units or option awards granted during the year calculated in accordance with the provisions of Financial Accounting Standards Board Accounting Standard Codification Topic 718, Compensation — Stock Compensation. Such aggregate grant date fair values do not take into account any estimated forfeitures related to service vesting conditions. For performance-based restricted stock units, the value reported includes the value of the award at the grant date based upon the probable outcome of the performance conditions. The value of performance-based restricted stock units at the grant date assuming that the highest level of performance condition will be achieved (at a maximum achievement level of 250%), is $14,316,000 for Mr. Hallal and $5,726,400 for each of Dr. Vaishnaw, Mr. Woods and Mr. Sinha. The performance-based restricted stock units are subject to performance-based and time-based vesting conditions. For information regarding assumptions underlying the valuation of this stock award, see Note 10 to our financial statements for the year ended December 31, 2025. The amounts reported for Dr. Backstrom include the incremental fair value associated with the modification of his outstanding stock options and restricted stock units that were accelerated in October 2025.

TABLE OF CONTENTS

(2)

Amounts reflect the actual cash incentive bonuses received by our named executive officers for performance of services in 2025 and 2024, as indicated, and were paid in the subsequent year. Bonuses for individuals were based upon achievement of corporate performance goals as determined by the Board of Directors and pro-rated based on the individual’s partial year of employment.

(3)

Amounts consist of group term life insurance and long-term disability, HSA contributions and taxable parking benefits.

(4)

Mr. Hallal, Dr. Vaishnaw, Mr. Woods and Mr. Sinha commenced employment with us on April 27, 2026. The amounts reported in the Salary column reflect the amounts actually earned for their partial year of employment.

(5)

Amount represents a signing bonus the named executive received upon commencing employment with us.

(6)

Amount also includes $7,767 in 401(k) matching contributions and $57,054 in fees paid as BOD compensation for Mr. Hallal prior to commencing employment.

(7)

Amount also includes $10,500 in 401(k) matching contributions and $18,482 in fees paid as BOD compensation for Dr. Vaishnaw prior to commencing employment.

(8)

Amount also includes $10,500 in 401(k) matching contributions and $43,718 in taxable housing costs.

(9)

Amount also includes $10,500 in 401(k) matching contributions.

(10)

Dr. Backstrom stepped down as our President and Chief Executive Officer and as a director on April 27, 2025, but remained as an employee in the role of senior advisor until October 31, 2025.

(11)

Amounts for Dr. Backstrom consist of: $1,061,664 in severance costs, consisting of costs related to salary continuance, payment of bonus and payment of employer portion of health insurance premiums, $65,079 in amounts paid for earned but unused vacation, $10,500 for 401(k) matching contributions, as well as costs for group term life insurance and long-term disability.

Narrative Disclosure to 2025 Summary Compensation Table

Our executive compensation program consists of a combination of base salary, non-equity incentive compensation, and long-term equity incentives. The program is structured based on consideration of compensation levels for comparable positions at peer companies, historical compensation levels for individual executives, individual executive performance, criticality of role, achievement of corporate objectives, and other relevant considerations.

Our compensation committee is primarily responsible for determining the compensation of all employees at or above the level of senior vice president (“Executives”). The compensation committee reviews all aspects of compensation, including base salary, non-equity incentive compensation, long-term equity incentives, severance benefits, and other forms of compensation. The compensation committee has authority to review and approve the compensation for all Executives, other than the chief executive officer, whose compensation it recommends to the Board of Directors for approval.

The compensation committee engaged Pay Governance as an independent compensation consultant to assist in the design of our executive compensation program and in making compensation decisions for our Executives during the fiscal year ended December 31, 2025. Pay Governance reported directly to the compensation committee. In accordance with Nasdaq listing standards, the compensation committee has assessed the independence of Pay Governance and concluded that its engagement presents no conflict of interest.

Role of Market Data

To evaluate the competitiveness of our Executive compensation program, the compensation committee reviews and considers the compensation levels and practices among a designated peer group of similarly situated companies. This peer group consists of publicly-traded biotechnology and pharmaceutical companies that are generally in late-stage clinical development or the commercial stage and are generally comparable to us in terms of market capitalization and employee headcount. The compensation committee conducts an annual review of the peer group and makes adjustments to our peer group, if necessary, to reflect changes in both our business and that of our peers.

TABLE OF CONTENTS

To determine the composition of the peer group for 2025, the compensation committee considered, among other items, the following criteria

•

publicly-traded biotechnology and pharmaceutical companies headquartered in the United States;

•

a mix of companies with late-stage clinical development programs or early commercial programs;

•

market capitalization and headcount levels such that we are generally positioned around median; and

•

other quantitative or qualitative metrics that are generally comparable to us.

This analysis resulted in the selection of the following peer group, which was used to assess competitive compensation levels and design for comparable positions in the market for 2025 and to assist the compensation committee in its review of compensation of our Executives in 2025.

2025 Compensation Peer Group

Agios Pharmaceuticals, Inc.
Apellis Pharmaceuticals, Inc.
Arcus Biosciences, Inc.
Arrowhead Pharmaceuticals, Inc.
Avidity Biosciences, Inc.
Axsome Therapeutics, Inc.
Biohaven Ltd.

Blueprint Medicines Corporation
BridgeBio Pharma, Inc.
Crinetics Pharmaceuticals, Inc.
Day One Biopharmaceuticals, Inc.
Denali Therapeutics Inc.
Dyne Therapeutics, Inc.
Madrigal Pharmaceuticals, Inc.

PTC Therapeutics, Inc.
Rhythm Pharmaceuticals, Inc.
Rocket Pharmaceuticals, Inc.
SpringWorks Therapeutics, Inc.
Syndax Pharmaceuticals, Inc.
Ultragenyx Pharmaceutical Inc.
Viridian Therapeutics, Inc.

Base Salary

Each Executive’s base salary is a fixed component of annual compensation, established or recommended by the compensation committee, reflecting each individual’s role, responsibilities, skills, and experience. Executive base salaries are reviewed annually, with adjustments made based on the achievement of corporate objectives, the individual’s contributions to Scholar Rock during the previous year, and a competitive analysis of compensation for similar positions at our peer companies.

In February 2025, the compensation committee reviewed and approved the base salaries of our Executives, other than our former chief executive officer, whose base salary was reviewed separately by the Board of Directors based upon the recommendation of the compensation committee. In determining base salaries for 2025, the Board of Directors and compensation committee reviewed market data provided by Pay Governance, the current compensation levels of our Executives, and Scholar Rock’s 2024 performance. In setting the base salaries for our NEOs, the Board of Directors and compensation committee reviewed market data provided by Pay Governance. The 2025 annual base salaries below were effective as of April 27, 2025, in the case of Mr. Hallal, Dr. Vaishnaw, Mr. Woods, and Mr. Sinha and as of January 1, 2025, in the case of Dr. Backstrom. The table below reflects the annual base salaries in effect in 2024 (if applicable) and 2025:

Named Executive Officer

2024
Base Salary
($)

2025
Base Salary
($)

Percentage
Increase

David Hallal

N/A

975,000

N/A

Akshay Vaishnaw

N/A

800,000

N/A

R. Keith Woods

N/A

800,000

N/A

Vikas Sinha

N/A

800,000

N/A

Jay Backstrom

650,000

695,000

6.9%

Non-Equity Incentive Compensation

We provide non-equity incentive compensation to our Executives through our annual bonus program. Our annual bonus program is intended to reward our NEOs for achieving corporate performance goals for

TABLE OF CONTENTS

a fiscal year. The 2025 target annual bonus for each of our NEOs is expressed as a pro rata percentage of the NEO’s respective annual base salary specified below:

Named Executive Officer	2025 Target Bonus (% of Base Salary)
David Hallal		80%
Akshay Vaishnaw		60%
R. Keith Woods		60%
Vikas Sinha		60%
Jay Backstrom		60%

The actual cash incentive bonus determined or recommended by the compensation committee for our chief executive officer is based 100% on the achievement of our corporate goals as determined by our Board of Directors, and for our other NEOs is 85% based on the achievement of our corporate goals and 15% on individual performance. The amounts earned under our annual performance-based cash bonus plan with respect to 2025 are reported under the “Non-Equity Incentive Compensation” column in the 2025 Summary Compensation Table above.

Long-Term Equity Incentives

We believe that long-term equity grants align the interests of our NEOs with those of our stockholders. We use a mix of equity awards for our NEOs, including stock option awards and starting in 2025, performance-based restricted stock unit awards, to ensure alignment with our stockholders.

In February 2025, our compensation committee approved the grant of stock option awards and restricted stock unit awards to Dr. Backstrom, with both awards subject to time-based vesting. The amounts granted were based in part on individual performance and the achievement of our corporate goals, as well as reviewing data on equity awards granted to individuals in similar positions at other companies.

In April 2025, in connection with their commencement of employment with us, our board of directors approved the grant of stock options, restricted stock units and performance-based restricted stock units to Mr. Hallal, Dr. Vaishnaw, Mr. Woods and Mr. Sinha. The amounts granted and the mix of equity were negotiated with such NEOs in connection with their commencement of employment with us, and were based upon market data, recommendations by Pay Governance, and review by our compensation committee and board of directors. A significant portion of the equity awards granted to these NEOs in April 2025 consisted of performance-based restricted stock units (“PSUs”) designed to directly align realized compensation with sustained stock price appreciation and long-term stockholder value creation.

The compensation committee and board of directors believe that this deliberate mix of equity ensures that a substantial component of compensation for our NEOs remains tied to stock price performance through stock options and performance-based restricted stock units. The performance-based restricted stock units vest only upon the Company’s stock price achieving specified stock price targets, subject to the NEO’s continued service through the applicable vesting dates. Any performance-based restricted stock units for which the applicable stock price targets are not achieved by the end of the performance period will be forfeited for no consideration. The compensation committee and the board of directors believes that this structure places meaningful compensation for our NEOs at risk and strongly aligns executive incentives with long-term stockholder interests by providing value only in the event of sustained stock price appreciation, while also supporting executive retention through continued service requirements.

Outstanding Equity Awards at 2025 Fiscal Year End Table

The following table presents information regarding all outstanding equity awards held by each of our named executive officers on December 31, 2025.

TABLE OF CONTENTS

Name and Principal Position(9)	Grant Date		Option Awards									Stock Awards				Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights That Have Not Vested (#)		Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested ($)(1)
Name and Principal Position(9)	Grant Date		Number of Securities Underlying Unexercised Options (# Exercisable)		Number of Securities Underlying Unexercised Options (# Unexercisable)		Option Exercise Price			Expiration Date		Number of Shares or Units of Stock That Have Not Vested (#)		Market Value of Shares That Have Not Vested ($)(1)
David Hallal Chief Executive Officer and Chairman		2/20/2018(2)		110,924		—		$	5.77		2/20/2028
		6/22/2018(3)		20,316		—		$	21.62		6/22/2028
		5/21/2019(4)		10,158		—		$	21.21		5/21/2029
		6/16/2020(5)		20,000		—		$	17.65		6/16/2030
		5/27/2021(6)		7,800		—		$	26.78		5/27/2031
		5/26/2022(7)		28,000		—		$	4.75		5/26/2032
		6/16/2022(8)		14,000		—		$	4.86		6/16/2032
		6/21/2023(9)		36,000		—		$	9.11		6/21/2033
		6/27/2024(10)		18,000		—		$	8.36		6/27/2034
		4/27/2025(11)											250,000		11,012,500
		4/27/2025(12)															1,250,000		55,062,500
		5/2/2025(13)				275,167		$	32.91		5/2/2035
Akshay Vaishnaw President of R&D		2/20/2018(2)		1,313		—		$	5.77		2/20/2028
		5/21/2019(14)		20,136		—		$	21.21		5/21/2029
		6/16/2020(5)		13,000		—		$	17.65		6/16/2030
		5/27/2021(6)		7,800		—		$	26.78		5/27/2031
		5/26/2022(7)		28,000		—		$	4.75		5/26/2032
		6/16/2022(8)		14,000		—		$	4.86		6/16/2032
		6/21/2023(9)		36,000		—		$	9.11		6/21/2033
		6/27/2024(10)		18,000		—		$	8.36		6/27/2034
		4/27/2025(11)											100,000		4,405,000
		4/27/2025(12)															500,000		22,025,000
		5/2/2025(13)				110,067		$	32.91		5/2/2035
R. Keith Woods Chief Operating Officer		4/27/2025(11)											100,000		4,405,000
Vikas Sinha Chief Financial Officer		4/27/2025(11)											100,000		4,405,000
		4/27/2025(12)															500,000		22,025,000
		5/2/2025(13)				110,067		$	32.91		5/2/2035
Jay Backstrom Former President and Chief Executive Officer		9/20/2022(15)		600,000		—		$	8.85		9/20/2032
		2/13/2023(16)		146,786		—		$	10.00		2/13/2033
		2/12/2024(17)		89,285		—		$	15.75		2/12/2034
		3/10/2025(18)		9,464		—		$	35.15		3/10/2035

(1)

The market value of unvested restricted stock units is based on $44.05, the closing market price of our common stock on December 31, 2025.

(2)

Shares under this option vested in equal quarterly installments for a period of 16 quarters, with the first quarterly amount vesting on May 13, 2018. Award was associated with service as a BOD member.

TABLE OF CONTENTS

(3)

Shares under this option vested in equal monthly installments for a period of 36 months, with the first monthly amount vesting on June 29, 2018. Award was associated with service as a BOD member.

(4)

Shares under this option vested on May 21, 2020. Award was associated with service as a BOD member.

(5)

Shares under this option vested on May 27, 2021. Award was associated with service as a BOD member.

(6)

Shares under this option vested on May 26, 2022. Award was associated with service as a BOD member.

(7)

Shares under this option vested on May 26, 2023. Award was associated with service as a BOD member.

(8)

Shares under this option vested on June 16, 2023. Award was associated with service as a BOD member.

(9)

Shares under this option vested on June 21, 2024. Award was associated with service as a BOD member.

(10)

Shares under this option vested on May 22, 2025. Award was associated with service as a BOD member.

(11)

RSU award vests in equal annual installments for a period of four years with the first annual vesting on April 15, 2026.

(12)

Performance-based stock unit (“PSU”) award vests subject to performance- and time-based vesting condition. The amount reported herein represents the maximum number of shares of our common stock that may be issued under this award. The shares subject to this PSU vest in tranches of a combination of performance vesting tied to our common stock achieving certain price targets and time-based vesting over four years, provided the NEO continues to have a service relationship with us on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

(13)

Shares under this option vest 25% on April 27, 2026, with the remainder vesting in equal quarterly installments for a period of 12 quarters, thereafter.

(14)

Shares under this option vested in equal monthly installments for a period of 36 months, with the first monthly amount vesting on June 21, 2019.

(15)

Shares under this option vested 25% on September 20, 2023, with the remainder vesting in equal quarterly installments for a period of 12 quarters, thereafter. Vesting was modified to fully vest on October 31, 2025.

(16)

Shares under this option were scheduled to vest in equal quarterly installments for a period of 16 quarters with the first quarterly amount vesting on April 1, 2023. Vesting was modified to fully vest on October 31, 2025.

(17)

Shares under this option were scheduled to vest in equal quarterly installments for a period of 16 quarters with the first quarterly amount vesting on April 1, 2024. Vesting was modified to fully vest on October 31, 2025.

(18)

Shares under this option were scheduled to vest in equal quarterly installments for a period of 16 quarters with the first quarterly amount vesting on April 1, 2025. Vesting was modified to fully vest on October 31, 2025.

Employment Arrangements with Our Named Executive Officers

David Hallal

We entered into an employment agreement with Mr. Hallal on April 27, 2025 (the “Hallal Agreement”), pursuant to which Mr. Hallal is entitled to receive an annual base salary and annual cash bonus. Mr. Hallal is also eligible to participate in the employee benefit plans available to Scholar Rock’s employees, subject to the terms of those plans. In connection with his commencement of employment, Mr. Hallal received a $2 million signing bonus. The Hallal Agreement provides that if Scholar Rock terminates Mr. Hallal without cause

TABLE OF CONTENTS

or if Mr. Hallal terminates employment for good reason (as each such term is defined in the Hallal Agreement), Mr. Hallal is entitled to receive (i) eighteen months of the base salary then in effect plus target annual incentive compensation, (ii) the bonus for the immediately preceding calendar year if such termination occurs subsequent to the calendar year but prior to the bonus being paid (the “Prior Year Bonus”), (iii) the prorated portion of the bonus for the current year of termination based on actual performance (the “Prorated Current Year Bonus”), (iv) eighteen months of health benefits continuation, and (v) twelve months acceleration of vesting for time-based outstanding equity awards and acceleration of a prorated portion of the performance-based restricted stock units (“PSUs”) granted pursuant to the Hallal Agreement that have achieved the applicable price targets during employment or within four months thereafter. If Scholar Rock terminates Mr. Hallal’s employment without cause or if Mr. Hallal terminates employment for good reason in connection with a change in control, in lieu of the foregoing payments and benefits, Mr. Hallal is entitled to receive: (i) a lump sum in cash in an amount equal to two times the sum of Mr. Hallal’s base salary then in effect plus target annual incentive compensation, (ii) the Prior Year Bonus, (iii) Prorated Current Year Bonus, based on the higher of actual or target performance, (iv) twenty-four months of health benefits continuation, and (v) acceleration of vesting for all time-based outstanding awards and acceleration of any PSUs based on actual achievement (and any other performance-based awards based on the higher of actual or target performance).

Akshay Vaishnaw, M.D., Ph.D.

We entered into an employment agreement with Dr. Vaishnaw on April 27, 2025 (the “Vaishnaw Agreement”), pursuant to which Dr. Vaishnaw is entitled to receive an initial annual base salary and an annual cash bonus. Dr. Vaishnaw is also eligible to participate in the employee benefit plans available to Scholar Rock’s employees, subject to the terms of those plans. In connection with his commencement of employment, Dr. Vaishnaw received a $2 million signing bonus. Pursuant to the Vaishnaw Agreement , if Scholar Rock terminates Dr. Vaishnaw without cause or if Dr. Vaishnaw terminates employment for good reason (as each such term is defined in the Vaishnaw Agreement), Dr. Vaishnaw is entitled to receive (i) twelve months of the base salary then in effect plus target annual incentive compensation, (ii) the Prior Year Bonus, (iii) the Prorated Current Year Bonus, (iv) twelve months of health benefits continuation, and (v) twelve months acceleration of vesting for time-based outstanding equity awards and acceleration of a prorated portion of the PSUs granted pursuant to the Vaishnaw Agreement that have achieved the applicable price targets during employment or within four months thereafter. If Scholar Rock terminates Dr. Vaishnaw’s employment without cause or if Dr. Vaishnaw terminates employment for good reason in connection with a change in control, in lieu of the foregoing payments and benefits, Dr. Vaishnaw is entitled to receive: (i) a lump sum in cash in an amount equal to 1.5 times the sum of Dr. Vaishnaw’s base salary then in effect plus target annual incentive compensation, (ii) the Prior Year Bonus, (iii) Prorated Current Year Bonus, based on the higher of actual or target performance, (iv) twenty-four months of health benefits continuation, and (v) acceleration of vesting for all time-based outstanding awards and acceleration of any PSUs based on actual achievement (and any other performance-based awards based on the higher of actual or target performance).

R. Keith Woods

We entered into an employment agreement with Mr. Woods on April 27, 2025 (the “Woods Agreement”), pursuant to which Mr. Woods is entitled to receive an annual base salary and annual cash bonus. Mr. Woods is also eligible to participate in the employee benefit plans available to Scholar Rock’s employees, subject to the terms of those plans.

Pursuant to the Woods Agreement, if Scholar Rock terminates Mr. Woods without cause or if Mr. Woods terminates employment for good reason (as each such term is defined in the Woods Agreement), Mr. Woods is entitled to receive (i) twelve months of the base salary then in effect plus target annual incentive compensation, (ii) the Prior Year Bonus, (iii) the Prorated Current Year Bonus, (iv) twelve months of health benefits continuation, and (v) twelve months acceleration of vesting for time-based outstanding equity awards and acceleration of a prorated portion of the PSUs granted pursuant to the Woods Agreement that have achieved the applicable price targets during employment or within four months thereafter. If Scholar Rock terminates Mr. Woods without cause or if Mr. Woods terminates employment for good reason in connection with a change in control, in lieu of the foregoing payments and benefits, Mr. Woods is

TABLE OF CONTENTS

entitled to receive: (i) a lump sum in cash in an amount equal to 1.5 times the sum of Mr. Woods’ base salary then in effect plus target annual incentive compensation, (ii) the Prior Year Bonus, (iii) Prorated Current Year Bonus, based on the higher of actual or target performance, (iv) twenty-four months of health benefits continuation, and (v) acceleration of vesting for all time-based outstanding awards and acceleration of any PSUs based on actual achievement (and any other performance-based awards based on the higher of actual or target performance).

Vikas Sinha

We entered into an employment agreement with Mr. Sinha on April 27, 2025 (the “Sinha Agreement”), pursuant to which Mr. Sinha is entitled to receive an annual base salary and annual cash bonus. Mr. Sinha is also eligible to participate in the employee benefit plans available to Scholar Rock’s employees, subject to the terms of those plans.

Pursuant to the Sinha Agreement, if Scholar Rock terminates Mr. Sinha without cause or if Mr. Sinha terminates employment for good reason (as each such term is defined in the Sinha Agreement), Mr. Sinha is entitled to receive (i) twelve months of the base salary then in effect plus target annual incentive compensation, (ii) the Prior Year Bonus, (iii) the Prorated Current Year Bonus, (iv) twelve months of health benefits continuation, and (v) twelve months acceleration of vesting for time-based outstanding equity awards and acceleration of a prorated portion of the PSUs granted pursuant to the Sinha Agreement that have achieved the applicable price targets during employment or within four months thereafter. If Scholar Rock terminates Mr. Sinha without cause or if Mr. Sinha terminates employment for good reason in connection with a change in control, in lieu of the foregoing payments and benefits, Mr. Sinha is entitled to receive: (i) a lump sum in cash in an amount equal to 1.5 times the sum of Mr. Sinhas’ base salary then in effect plus target annual incentive compensation, (ii) the Prior Year Bonus, (iii) Prorated Current Year Bonus, based on the higher of actual or target performance, (iv) twenty-four months of health benefits continuation, and (v) acceleration of vesting for all time-based outstanding awards and acceleration of any PSUs based on actual achievement (and any other performance-based awards based on the higher of actual or target performance).

Jay Backstrom, M.D., M.P.H.

We entered into an employment agreement with Dr. Backstrom on September 19, 2022, effective upon Dr. Backstrom’s first day of employment at the Company, which occurred on September 19, 2022, pursuant to which Dr. Backstrom was entitled to receive an annual base salary and target bonus based upon our Board of Directors’ assessment of his performance and our attainment of targeted goals as set by our Board of Directors in its sole discretion. Dr. Backstrom was also eligible to participate in the employee benefit plans available to our employees, subject to the terms of those plans. The employment agreement provided that, in the event that his employment was terminated by us without “cause” or by him for “good reason,” subject to the execution and effectiveness of a separation agreement and release, he would be entitled to receive (i) an amount equal to (x) 12 months of base salary, payable on our normal payroll cycle if such termination is not in connection with a “change in control,” or (y) 1.5 times his annual base salary if such termination occurs within 3 months prior to or 18 months following such “change in control,” plus 1.5 times his average incentive compensation he would have been entitled to receive in the fiscal year of such termination and (ii) reimbursement of COBRA premiums for health benefit coverage for him and his immediate family in an amount equal to the monthly employer contribution that we would have made to provide health insurance to Dr. Backstrom had he remained employed with us for up to (x) 12 months following termination if such termination is not in connection with a “change in control” or (y) 18 months if such termination is in connection with a “change in control”. In addition, if Dr. Backstrom was terminated by us without “cause” or he resigned for “good reason,” 12 months of all stock options and other stock-based awards that are subject to solely time-based vesting held by Dr. Backstrom would accelerate and vest immediately and, if such termination occurred within 3 months prior to or 18 months following a “change in control,” all stock options and other stock-based awards that are subject to solely time-based vesting held by Dr. Backstrom would accelerate and vest immediately.

Dr. Backstrom transitioned from his roles as President and Chief Executive Officer and entered into a transitional services agreement (“the Backstrom Agreement”), pursuant to which Dr. Backstrom served as

TABLE OF CONTENTS

Senior Advisor to Scholar Rock during the period from April 28, 2025 to October 31, 2025 when his employment relationship ended (the “Transition Period”). During the Transition Period, Dr. Backstrom received what was his current base salary, was eligible for employee benefits and continued to vest in certain time-based equity awards. Pursuant to the Backstrom Agreement, following the termination of his employment, Dr. Backstrom received: (i) twelve months of what was his current base salary, (ii) a prorated bonus for the fiscal year ended December 31, 2025, (iii) twelve months of health benefits continuation and (iv) acceleration of certain time-based equity awards and extension of the exercise period for any vested stock options through July 31, 2026.

Additional Narrative Disclosure

401(k) Savings Plan. We maintain the Scholar Rock Holding Corporation 401(k) Plan, a tax-qualified retirement plan for our employees. Our 401(k) plan is intended to qualify under Section 401(k) of the Code so that contributions to our 401(k) plan by employees or by us, and the investment earnings thereon, are not taxable to the employees until withdrawn from our 401(k) plan, and so that contributions by us, if any, will be deductible by us when made. Under our 401(k) plan, employees may elect to reduce their current compensation by up to the statutorily prescribed annual limit and to have the amount of such reduction contributed to our 401(k) plan. Scholar Rock matches 50% of an employee’s contribution to the employee’s 401(k) up to 6% of the employee’s base salary.

Health and Welfare Benefits. All of our full-time employees, including our named executive officers are eligible to participate in certain medical, disability and life insurance benefit programs offered by us. We pay the premiums for term life insurance and long-term disability for all of our employees, including our named executive officers. We also provide all employees, including the named executive officers, paid time off benefits including, vacation, sick time, and holidays, as well as the option for a flexible spending account plan. We do not sponsor any non-qualified defined benefit plans for any of our employees or executives.

Equity Grant Timing

We grant our annual equity awards during the first calendar quarter of the year, following a pre-scheduled meeting of the board or compensation committee. In addition, new hires receive equity awards on the second Monday of the month following their employment commencement. During 2025, our board and compensation committee did not take into account any material nonpublic information when determining the timing and terms of equity incentive awards, and we did not time the disclosure of material nonpublic information for the purpose of affecting the value of executive compensation.

The following table presents information regarding stock options issued to our NEOs during 2025 in any period beginning four business days before and ending one business day after the filing or furnishing of a Form 10-Q, 10-K or 8-K that disclosed material nonpublic information:

Name	Grant Date		Number of Securities Underlying the Award		Exercise Price of the Award ($/Sh)			Grant Date Fair Value of the Award			Percentage Change in the Closing Market Price of the Securities Underlying the Award Between the Trading Day Ending Immediately Prior to the Disclosure of Material Non-Public Information and the Trading Day Beginning Immediately Following the Disclosure of Material Non-Public Information
David Hallal		5/2/2025		275,167		$	32.91		$	27.71		2.3150%(1)
Akshay Vaishnaw		5/2/2025		110,067		$	32.91		$	27.71		2.3150%(1)
R. Keith Woods		5/2/2025		110,067		$	32.91		$	27.71		2.3150%(1)
Vikas Sinha		5/2/2025		110,067		$	32.91		$	27.71		2.3150%(1)

(1)

Based on closing prices of the Company’s common stock of $30.67 on May 9, 2025 and $31.40 on May 13, 2025.

TABLE OF CONTENTS

Compensation Risk Assessment

We believe that although a portion of the compensation provided to our Executives is performance-based, our executive compensation program does not encourage excessive or unnecessary risk taking. This is primarily due to the fact that our compensation programs are designed to encourage our Executives to remain focused on both short-term strategic goals by providing non-equity incentive compensation and long-term strategic goals by providing long-term equity incentives. As a result, we do not believe that our compensation programs are reasonably likely to have a material adverse effect on us.

No Hedging and Pledging

Our insider trading policy prohibits employees, officers and directors from engaging in any hedging or monetization transactions or similar arrangements (including transactions involving zero-cost collars, prepaid variable forward sale contracts, equity swaps and exchange funds) that are designed to hedge or speculate on any change in the market value of our securities. It also explicitly prohibits employees, officers and directors from effecting short sales of our securities, which are inherently speculative in nature and contrary to the best interests of Scholar Rock and our shareholders. Our insider trading policy also prohibits employees, officers and directors from buying or selling puts or calls or other derivative securities on our securities and from pledging our securities as collateral for a loan or holding our securities in a margin account.

Compensation Recovery Policy

Our Board of Directors adopted a Compensation Recovery Policy adopted as of November 28, 2023 (the “Compensation Recovery Policy”), in compliance with the Nasdaq listing rules, which requires recovery from executive officers of incentive-based compensation that is earned, granted or vested based on the achievement of a financial reporting measure in the event of a required accounting restatement of previously issued financial statements. The recoverable compensation includes any compensation received after the effective date of the Compensation Recovery Policy and in the three-year fiscal period preceding the date we were required to prepare the accounting restatement that is in excess of the amount that would have been earned, paid or vested had it been calculated based on the restated financial statements. Recovery is required regardless of fault or a covered officer’s role in the financial reporting process. The Compensation Recovery Policy has been filed as Exhibit 97 to Scholar Rock’s Annual Report on Form 10-K for the year ended December 31, 2025. At no time during or after the year ended December 31, 2025, was Scholar Rock required to prepare an accounting restatement that required recovery of erroneously awarded compensation pursuant to the Compensation Recovery Policy, nor was there, on December 31, 2025, an outstanding balance of erroneously awarded compensation to be recovered from the application of the policy to a prior restatement.

Equity Compensation Plan Information

The following table summarizes Scholar Rock’s equity compensation plan information as of December 31, 2025.

Plan Category	Number of securities to be issued upon exercise of outstanding options, warrants and rights (a)		Weighted-average exercise price of outstanding options, warrants and rights (b)			Number of securities available for future issuance under equity compensation plans (excluding securities reflected in column (a)) (c)
Equity compensation plans approved by security holders(1)		7,613,385		$	20.34(2)		6,609,624(3)
Equity compensation plans not approved by security holders(4)		4,616,014		$	22.39(2)		1,160,822
Total		12,229,399					7,770,446

TABLE OF CONTENTS

(1)

Includes Scholar Rock’s 2017 Stock Option and Incentive Plan, 2018 Stock Option and Incentive Plan and 2018 ESPP.

(2)

The weighted average exercise price is calculated based solely on outstanding stock options.

(3)

As of December 31, 2025, a total of 4,059,319 shares of our common stock have been reserved for issuance pursuant to the 2018 Stock Option and Incentive Plan. The 2018 Stock Option and Incentive Plan provides that the number of shares reserved and available for issuance under the plan will automatically increase each January 1, beginning on January 1, 2019, by 4% of the outstanding number of shares of our common stock on the immediately preceding December 31 or such lesser number of shares as determined by the compensation committee. This number will be subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization. The shares of common stock underlying any awards that are forfeited, cancelled, held back upon exercise or settlement of an award to satisfy the exercise price or tax withholding, reacquired by us prior to vesting, satisfied without the issuance of stock, expire or are otherwise terminated, other than by exercise, under the 2018 Stock Option and Incentive Plan and the 2017 Stock Option and Incentive Plan will be added back to the shares of common stock available for issuance under the 2018 Stock Option and Incentive Plan. Scholar Rock no longer makes grants under the 2017 Stock Option and Incentive Plan. As of December 31, 2025, a total of 2,550,305 shares of our common stock have been reserved for issuance pursuant to the 2018 ESPP. The 2018 ESPP provides that the number of shares reserved and available for issuance under the plan will automatically increase each January 1, beginning on January 1, 2019, by the lesser of 353,614 shares of our common stock, 1% of the outstanding number of shares of our common stock on the immediately preceding December 31 or such lesser number of shares as determined by the compensation committee. This number will be subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization.

(4)

This includes the 2022 Inducement Plan. The 2022 Inducement Plan was adopted by the Board of Directors without stockholder approval pursuant to Rule 5635(c)(4) of the Nasdaq Listing Rules. In accordance with Rule 5635(c)(4) of the Nasdaq Listing Rules, awards under the 2022 Inducement Plan may only be made to a newly hired employee who has not previously been an employee or director of Scholar Rock or any subsidiary, or following a bona fide period of non-employment by Scholar Rock or subsidiary, if that individual is granted such award in connection with their commencement of employment with Scholar Rock or a subsidiary and such grant is an inducement material to their entering into employment with Scholar Rock or such subsidiary.

Pay Versus Performance

As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(v) of Regulation S-K, we are providing information about the relationship between executive compensation actually paid to our PEO and the other NEOs (as calculated in accordance with Item 402(v) of Regulation S-K). In April 2025, our former CEO, Jay Backstrom (referred to in the tables below as “PEO 2”) resigned and David Hallal (referred to in the tables below as “PEO 1”) was appointed as our new CEO. We provide compensation actually paid for both CEOs during the covered years in the following tables.

TABLE OF CONTENTS

Pay-Versus-Performance Table

Year	Summary Compensation Table Total for PEO 1(1)		Summary Compensation Table Total for PEO 2(1)		Compensation Actually Paid to PEO 1(2)		Compensation Actually Paid to PEO 2(2)		Average Summary Compensation Table Total for Non-PEO Named Executive Officers(3)		Average Compensation Actually Paid to Non-PEO Named Executive Officers(4)		Value of Initial Fixed $100 Investment Based On:			Net Income/(Loss)(6) (in millions)
Year	Summary Compensation Table Total for PEO 1(1)		Summary Compensation Table Total for PEO 2(1)		Compensation Actually Paid to PEO 1(2)		Compensation Actually Paid to PEO 2(2)						Total Shareholder Return(5)			Net Income/(Loss)(6) (in millions)
(a)	(b1)		(b2)		(c1)		(c2)		(d)		(e)		(f)			(h)
2025		33,300,927		17,488,824		44,340,712		6,152,175		13,560,071		17,933,442		$	486.74		$	(378)
2024		N/A		7,991,933		N/A		35,208,138		3,018,890		9,289,804		$	477.57		$	(246)
2023		N/A		4,111,853		N/A		10,538,048		2,159,711		4,201,772		$	207.73		$	(166)

(1)

The dollar amounts reported in columns (b1) and (b2) represent the amount of total compensation reported for David Hallal (“PEO 1”) and Jay Backstrom (“PEO 2”) (collectively, our “PEOs”) for each corresponding covered fiscal year in the “Total” column of the Summary Compensation Table for each applicable fiscal year.

(2)

The Compensation Actually Paid to our PEOs reflects the following adjustments required by applicable SEC rules from total compensation reported in the Summary Compensation Table:

PEO 1

2025

Summary Compensation Table – Total Compensation

(a)

33,300,927

- Grant Date Fair Value of Stock Awards and Option Awards Granted in Fiscal Year

(b)

30,143,488

+ Fair Value at Fiscal Year End of Outstanding and Unvested Stock Awards and Option Awards Granted in Fiscal Year

(c)

40,318,103

+ Change in Fair Value of Outstanding and Unvested Stock Awards and Option Awards Granted in Prior Fiscal Years

(d)

—

+ Fair Value at Vesting of Stock Awards and Option Awards Granted in Fiscal Year
That Vested During Fiscal Year

(e)

—

SEC Form DEF 14A filed by Scholar Rock Holding Corporation