SEC FORM 3

SEC FORM 3SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

UPPALURI SUBBARAO V

(Last)

(First)

(Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI

FLORIDA

33137

(City)

(State)

(Zip)

UNITED STATES

(Country)

2. Date of Event Requiring Statement (Month/Day/Year)
03/18/2026

3. Issuer Name and Ticker or Trading Symbol
OPKO HEALTH, INC. [ OPK ]

3a. Foreign Trading Symbol

5. If Amendment, Date of Original Filed (Month/Day/Year)

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
	Officer (give title below)	Other (specify below)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	622,817	D
Common Stock	2,000,000	I	See Footnote⁽¹⁾
Common Stock	500,000	I	See Footnore⁽²⁾
Common Stock	36,000	I	See Footnote⁽³⁾

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)

Explanation of Responses:

1. Uppaluri Investments, LLC ("Uppaluri Investments"), owns these shares. Dr. Uppaluri is the Manager of Uppaluri Investments. Each of the Uppaluri 2012 Family Trust ("2012 Trust") and the Ajay Uppaluri 2020 Gift Trust ("2020 Trust") owns 50% of Uppaluri Investments. The 2012 Trust is for the benefit of Dr. Uppaluri's spouse, Anita Uppaluri, and she is the trustee. The 2020 Trust is for the benefit of Dr. Uppaluri's son, Ajay Uppaluri, and Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by Uppaluri Investments except to the extent of his pecuniary interest therein.

2. The shares are owned by the 2020 Trust, which is for the benefit of Ajay Uppaluri. Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by the 2020 Trust, except to the extent of his pecuniary interest therein.

3. The shares are owned by Dr. Uppaluri's spouse. Dr. Uppaluri disclaims beneficial ownership of the shares held by his spouse, except to the extent of his pecuniary interest therein.

	/s/ Subbarao V. Uppaluri	03/20/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 3: SEC 1473 (03-26)

SEC Form 3 filed by new insider Uppaluri Subbarao V