mrk-20260624

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 11-K

FOR ANNUAL REPORTS OF EMPLOYEE STOCK PURCHASE, SAVINGS AND SIMILAR PLANS

Pursuant to Section 15(d) of the Securities Exchange Act of 1934

(Mark One)

x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2025

¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 1-06571

Employer Identification Number: 22-1918501

Plan Number: 001

MERCK US SAVINGS PLAN

(Full title of the plan)

MERCK & CO., INC.

(Name of issuer of the securities held pursuant to the plan)

126 East Lincoln Avenue.

Rahway, New Jersey 07065

(Address of principal executive office)

Merck US Savings Plan

Index



			Page(s)

Report of Independent Registered Public Accounting Firm			1

Financial Statements:

Statements of Net Assets Available for Benefits as of December 31, 202 5 and 2024			2

Statement of Changes in Net Assets Available for Benefits for the Year Ended December 31, 2025			3

Notes to Financial Statements			4-12

Supplemental Schedule*:

Schedule H, Line 4i – Schedule of Assets (Held at End of Year)			13

Signature			14

Exhibit Index			15

Exhibit 23 - Consent of Independent Registered Public Accounting Firm			16

* Other schedules required by Section 2520.103-10 of the Department of Labor Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974 are omitted because they are not applicable.

Report of Independent Registered Public Accounting Firm

To the Administrator and Plan Participants of Merck US Savings Plan

Opinion on the Financial Statements

We have audited the accompanying statements of net assets available for benefits of Merck US Savings Plan (the “Plan”) as of December 31, 2025 and 2024 and the related statement of changes in net assets available for benefits for the year ended December 31, 2025, including the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the net assets available for benefits of the Plan as of December 31, 2025 and 2024, and the changes in net assets available for benefits for the year ended December 31, 2025 in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements are the responsibility of the Plan’s management. Our responsibility is to express an opinion on the Plan’s financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Plan in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits of these financial statements in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

Supplemental Information

The supplemental Schedule H, Line 4i – Schedule of Assets (Held at End of Year) as of December 31, 2025 (“supplemental schedule”) has been subjected to audit procedures performed in conjunction with the audit of the Plan’s financial statements. The supplemental schedule is the responsibility of the Plan’s management. Our audit procedures included determining whether the supplemental schedule reconciles to the financial statements or the underlying accounting and other records, as applicable, and performing procedures to test the completeness and accuracy of the information presented in the supplemental schedule. In forming our opinion on the supplemental schedule, we evaluated whether the supplemental schedule, including its form and content, is presented in conformity with the Department of Labor’s Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974. In our opinion, the supplemental schedule is fairly stated, in all material respects, in relation to the financial statements as a whole.

/s/ PricewaterhouseCoopers LLP

New York, New York

June 24, 2026

We have served as the Plan’s auditor since 2002.

PricewaterhouseCoopers LLP, 300 Madison Avenue, New York, NY 10017

T: (646) 471 3000, www.pwc.com/us

Merck US Savings Plan

Statements of Net Assets Available for Benefits


	December 31,

(in thousands)	2025		2024


Assets
Investments
Investment in Master Trust, at fair value	$	16,046,971	$	14,892,909

Receivables
Employer contributions		2,180		1,572
Participant contributions		5,918		4,137
Notes receivable from participants		77,410		72,299


Total receivables		85,508		78,008













Net assets available for benefits	$	16,132,479	$	14,970,917

The accompanying notes are an integral part of these financial statements.

Merck US Savings Plan

Statement of Changes in Net Assets Available for Benefits


		Year Ended
		December 31,
(in thousands)		2025

Additions to net assets attributed to
Investment gain
Plan interest in Master Trust investment gain	$	2,392,957

Interest income on notes receivable from participants		5,927

Contributions to the Plan
By participants		664,661
By employer		216,252


Total contributions		880,913

Transfers in		839


Total additions		3,280,636

Deductions from net assets attributed to
Participant withdrawals		(2,118,968)
Administrative expenses		(38)
Transfers out		(68)


Total deductions		(2,119,074)


Net increase		1,161,562


Net assets available for benefits
Beginning of year		14,970,917


End of year	$	16,132,479

The accompanying notes are an integral part of these financial statements.

Merck US Savings Plan

Notes to Financial Statements

1.Description of Plan

The following description of the Merck US Savings Plan (the “Plan”) provides only general information. Participants should refer to the Plan document for a more complete description of the Plan’s provisions.

General

The Plan is designed to provide a systematic means of saving and investing for the future as well as an easy and economical way for employees to become shareholders of Merck & Co., Inc. (“Merck” or the “Company”). Regular full-time, part-time, and temporary employees as defined by the Plan document are eligible to participate in the Plan on or after their dates of hire or after they transfer into a U.S. benefits-eligible position. Merck is the Plan sponsor (the “Sponsor”).

Participants direct the investment of their contributions into any fund investment option available under the Plan, including Merck common stock. The Plan offers a three-tiered approach to investing:

*Retirement Portfolios - a custom set of target date retirement funds;

*Core Funds - a selection of investment options (active and passive) that span a range of asset classes;

*Fidelity Brokerage Link® - a self-directed brokerage account that provides access to more than 8,500 mutual funds.

The Plan is administered by management committees appointed by the Company’s Chief Executive Officer, the Compensation and Management Development Committee of the Board of Directors of Merck or their delegates.

The Plan is subject to the provisions of the Employee Retirement Income Security Act of 1974, as amended (“ERISA”).

Master Trust

The assets of the Plan are maintained, for investment purposes only, on a commingled basis with a portion of the MSD Puerto Rico Savings & Security Plan (the “Puerto Rico Plan”) and all of the assets of the MSD Employee Stock Purchase and Savings Plan in the Merck & Co., Inc. Qualified Plans Master Trust (the "Master Trust)". The plans own specific interests in the Master Trust assets.

The portion of Master Trust assets allocable to each plan is based upon the participants’ account balances within each plan. Investment income for the Master Trust is allocated to each plan based on the specific investments held in the Master Trust.

Contributions

Participants may contribute up to 25% of their annual eligible compensation through a combination of before-tax and Roth contributions (in 1% increments), up to the combined statutory elective deferral limit ($23,500 in 2025). Participants may also contribute up to 25% of their annual eligible compensation on an after-tax basis. Upon reaching the statutory elective deferral limit for combined before-tax and Roth contributions, the participant may elect to suspend contributions for the remainder of the year or elect to continue on an after-tax basis. The sum of before-tax, Roth and after-tax contributions cannot exceed 50% of annual eligible compensation.

In addition, the Company makes matching contributions of $0.75 for every $1.00 of an employee's contributions, up to 6% of such employee's eligible compensation (maximum match is 4.5% of eligible compensation) per pay period (to the statutory limit). The combination of before-tax, Roth, after-tax and Company matching contributions may not exceed the statutory limit ($70,000 in 2025). Participant and Company matching contributions are invested according to a participant’s elections.

Participants are automatically enrolled in the Plan sixty days after first becoming eligible with a before-tax base pay contribution rate of 6%. In addition, each participant with a before-tax base pay contribution rate of at least 1% may elect to participate in an annual automatic increase program, in whole percentages of at least 1% and not more than 3% per year. The annual percentage increase continues automatically up to 10%. The participant may elect to change or extend it up to 25%. This feature applies to before-tax bonus and base pay contributions.

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Merck US Savings Plan

Notes to Financial Statements

In addition, the Plan permits matched before-tax and Roth "catch-up contributions" of up to the statutory limit ($7,500 in 2025) by participants who are at least age 50 by year-end. Participants who turn age 60-63 during a calendar year are allowed to make up to $3,750 in additional before-tax and Roth catch-up contributions for those years, after which the maximum amount returns to the normal level.

Participant Accounts

Each participant’s account is credited with the participant’s contributions, the Company’s contributions and an allocation of Plan earnings. The allocation is based on participants’ account balances, as defined in the Plan document.

Vesting

Participants are immediately vested in their contributions, all Company matching contributions, plus actual earnings thereon.

Notes Receivable from Participants

Participants may borrow from their account balances with interest charged at the prime rate in effect on the last business day of the prior month plus 1%. Once set, the interest rate is in effect for the duration of the loan. Loan terms range from one to five years for a short-term loan or up to fifteen years for the purchase of a primary residence and bear interest at rates that range from 4.25% to 10.50%. The minimum loan is $1,000 and the maximum loan is the lesser of (i) $50,000 less the highest outstanding loan balance(s) during the one-year period prior to the new loan application date, or (ii) 50% of the participant’s account balance less any current outstanding loan balance(s) and defaulted loan amounts. Principal and interest are paid ratably through payroll deductions. Loan terms are grandfathered into the Plan in accordance with the legacy plan guidelines, including loan terms for participants that transferred into the Plan from a legacy plan.

Payment of Benefits

Participants are entitled to receive automatic, voluntary, in-service (which include hardship withdrawals), or mandatory distributions as provided in the applicable Plan provisions.

Transfers

Transfers in and out during 2025 relate primarily to transfers between the Plan and the MSD Employee Stock Purchase and Savings Plan for employees who changed their status during the year.

2.Summary of Accounting Policies

Basis of Accounting

The accompanying financial statements are prepared on the accrual basis of accounting.

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and changes therein, and disclosure of contingent assets and liabilities at the date of the financial statements. Management believes that these estimates are adequate. Actual results could differ from those estimates.

Investment Valuation and Income Recognition

All investments are recorded at fair value in the accompanying financial statements. Valuation of investments of the Plan represents the Plan’s specific interest in the Master Trust. The Plan’s investment in the Master Trust is stated at fair value and is based on the beginning of year value of the Plan’s interest in the Master Trust plus actual Plan contributions and specific investment income less Plan distributions, specific investment losses and allocated expenses.

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Merck US Savings Plan

Notes to Financial Statements

Purchases and sales of securities are recorded on a trade-date basis. Dividend income is recorded on the ex-dividend date. Interest income is recorded as earned. Realized gains and losses from security transactions are reported on the average cost method.

Notes Receivable from Participants

Notes receivable from participants are measured at their unpaid principal balance plus any accrued but unpaid interest. Delinquent participant loans are reclassified as benefit payments based upon the terms of the Plan document. No allowance for credit losses has been recorded as of December 31, 2025 and 2024.

Contributions

Employee and Company matching contributions are recorded in the year in which participant compensation is earned.

Payment of Benefits

Benefits are recorded when paid.

Administrative Expenses

Administrative expenses primarily include certain recordkeeping and loan fees along with other fees and credits. Other administrative expenses are paid by the Company.

Risks and Uncertainties

The Plan provides for various investment options in investment securities. Investment securities, in general, are exposed to various risks and may decline in value for a number of reasons, including changes in prevailing interest rates and credit availability, increases in defaults, increases in voluntary prepayments for investments that are subject to prepayment risk under normal market conditions, widening of credit spreads and overall market volatility. Due to the level of risk associated with certain investment securities, it is reasonably possible that changes in the values of investment securities will occur in the near term and that such changes could materially affect participants’ account balances and the amounts reported in the Statements of Net Assets Available for Benefits.

3.Related-Party Transactions

Contributions are held and managed by Fidelity Management Trust Company (“Fidelity” or the “Trustee”), which invests cash received, interest and dividend income and makes distributions to the participants. The Trustee also administers the participants’ payment of interest and principal on the notes receivable from participants. These transactions qualify as permitted party-in-interest transactions.

Certain Plan investments are shares of registered investment companies (mutual funds) and common/collective trusts managed by the Trustee or its affiliates. Fidelity is the trustee as defined by the Plan and, therefore, these transactions qualify as party-in-interest transactions. The total market value of the Plan’s portion of the investments managed by the Trustee was $794.1 million and $648.3 million at December 31, 2025 and 2024, respectively. During 2025, the Plan’s portion of interest and dividends, realized and unrealized gains from investments managed by the Trustee was $10.5 million, $21.9 million and $197.8 million, respectively.

Merck also is a party-in-interest to the Plan under the definition provided in Section 3(14) of ERISA. Therefore, Plan transactions of Merck common stock qualify as both related party transactions and party-in-interest transactions. The market value of the Plan’s portion of the investment in Merck common stock was $812.0 million and $926.9 million at December 31, 2025 and 2024, respectively. During 2025, the Plan’s portion of dividends, realized gains and unrealized losses from Merck common stock was $28.0 million, $77.6 million and $53.3 million, respectively. The Plan’s portion of purchases and sales of Merck common stock during 2025 was $28.7 million and $162.6 million, respectively.

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Merck US Savings Plan

Notes to Financial Statements

4.Plan Termination

Although it has not expressed any intent to do so, the Company has the right under the Plan to discontinue its contributions at any time and to terminate the Plan subject to the provisions of ERISA. Upon termination of the Plan, each participant thereby affected would receive the entire value of his or her account as though he or she had retired as of the date of such termination.

5.Tax Status

The Plan obtained a tax determination letter from the Internal Revenue Service (“IRS”) dated February 8, 2018, indicating that the Plan had been designed in accordance with applicable sections of the Internal Revenue Code (“IRC”). The Plan has been amended since receiving the determination letter. However, the Sponsor believes that the Plan is designed and currently operates in compliance with the IRC. Therefore, no provision for income taxes has been made.

Accounting principles generally accepted in the United States of America require Plan management to evaluate tax positions taken by the Plan and recognize a tax liability (or asset) if the Plan has taken an uncertain position that more likely than not would not be sustained upon examination by the IRS. The Plan administrator has analyzed the tax positions taken by the Plan and has concluded that, as of December 31, 2025 and 2024, there are no uncertain tax positions taken or expected to be taken that would require recognition of a liability (or asset) or disclosure in the financial statements. The Plan is subject to routine audits by taxing jurisdictions. The Plan administrator believes the Plan is no longer subject to income tax examinations for years prior to 2022.

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Merck US Savings Plan

Notes to Financial Statements

6.Master Trust

The net assets of the Master Trust and the Plan's interest are as follows:


	2025
(in thousands)	Master Trust		Merck US Savings Plan Interest

Registered investment companies (mutual funds)	$	97,747	$	91,946
Common/collective trusts		12,677,091		12,108,089
Equity securities		2,307,397		2,189,256
Fixed income securities		406,994		386,758
Self-directed brokerage accounts		459,800		435,989
Merck common stock		907,977		812,041

Accrued interest and dividends		15,877		14,659
Other net assets		8,648		8,233

	$	16,881,531	$	16,046,971

	2024
(in thousands)	Master Trust		Merck US Savings Plan Interest

Registered investment companies (mutual funds)	$	500,106	$	474,904
Common/collective trusts		11,107,463		10,620,120
Equity securities		2,244,340		2,130,066
Fixed income securities		386,182		367,820
Self-directed brokerage accounts		368,784		352,416
Merck common stock		1,026,831		926,902

Accrued interest and dividends		17,180		15,934
Other net assets		4,994		4,747

	$	15,655,880	$	14,892,909

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Merck US Savings Plan

Notes to Financial Statements

Total investment income (loss) of the Master Trust for the year ended December 31, 2025, is as follows:


	2025
	Master Trust
(in thousands)
Investment income
Net appreciation	$	2,354,281
Interest and dividends		157,490

Total investment income	$	2,511,771

7.Fair Value Measurements

Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Entities are required to use a fair value hierarchy that maximizes the use of observable inputs and minimizes the use of unobservable inputs when measuring fair value. There are three levels of inputs that may be used to measure fair value:

Level 1 – Quoted prices in active markets for identical assets or liabilities. The Master Trust's Level 1 investments primarily include registered investment companies (mutual funds), self-directed brokerage accounts and common stocks.

Level 2 – Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. The Master Trust's Level 2 investments primarily include investments in certain fixed income investments such as government and agency obligations, corporate obligations and mortgage and asset-backed securities.

Level 3 – Unobservable inputs that are supported by little or no market activity and that are financial instruments whose values are determined using pricing models, discounted cash flow methodologies, or similar techniques, as well as instruments for which the determination of fair value requires significant judgment or estimation. The Master Trust did not hold any Level 3 investments at December 31, 2025 and 2024.

If the inputs used to measure the financial assets and liabilities fall within more than one level described above, the categorization is based on the lowest level input that is significant to the fair value measurement of the instrument. There have been no changes in the valuation methodologies used at December 31, 2025 and 2024.

Within the Master Trust, investments are recorded at fair value as follows:

Registered Investment Companies (Mutual Funds)

Registered investment companies (mutual funds) are valued at their respective net asset values. The net asset values are typically determined by the fund at the close of regular trading. Investments in registered investment companies (mutual funds) generally may be redeemed daily.

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Merck US Savings Plan

Notes to Financial Statements

Common/Collective Trusts

The common/collective trusts are valued at their respective net asset values, as a practical expedient for fair value. The fair value of investments in the common/collective trusts are determined by their trustee. The Master Trust's investments in common/collective trusts generally may be redeemed daily.

Fixed Income Securities

Fixed income securities, including U.S. government and agency obligations, corporate obligations and mortgage and asset-backed securities, are generally valued on the basis of valuations furnished by a pricing service approved by the Trustee or at fair value as determined in good faith by the Trustee and the Company. The Trustee has the discretionary authority to hire a pricing service to determine valuations using methods based on current market transactions, prices for comparable securities and various relationships between securities which are generally recognized by institutional traders.

Self-Directed Brokerage Accounts

Self-directed brokerage accounts are comprised of mutual funds, which are valued at the net asset value reported by the managers of the funds, typically determined at the close of regular trading.

Equity Securities / Common Stocks

Common stocks, for which market quotations are readily available, are generally valued at the last reported sales price on their principal exchange on the valuation date, or official close price for certain markets. If no sales are reported for that day, these investments are valued at the more recent of (i) the last published sale price or (ii) the mean between the last reported bid and asked prices for long positions, or at fair value as determined in good faith by the Trustee and the Company.

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Merck US Savings Plan

Notes to Financial Statements

Master Trust Investments Measured at Fair Value

Master Trust investments measured at fair value as of December 31, 2025 are summarized below:



	December 31, 2025
	Fair Value Measurements Using

(in thousands)	Quoted Prices						Total
	In Active		Significant
	Markets for		Other		Significant
	Identical		Observable		Unobservable
	Assets		Inputs		Inputs
	(Level 1)		(Level 2)		(Level 3)

Investments in the Master Trust

Registered investment companies	$	97,747	$	—	$	—	$	97,747
Equity securities		2,307,397		—		—		2,307,397
Fixed income securities		—		406,994		—		406,994
Self-directed brokerage accounts		459,800		—		—		459,800
Merck common stock		907,977		—		—		907,977

Investments measured within the fair value hierarchy	$	3,772,921	$	406,994	$	—	$	4,179,915

Common/collective trusts measured at NAV practical expedient (1)							$	12,677,091

Master trust investments at fair value							$	16,857,006

(1) Certain investments that were measured at net asset value (NAV) per share or its equivalent have not been classified in the fair value hierarchy. The fair value amounts presented in this table also do not include the Master Trust's accrued interest and dividends or other net assets.

The Plan's interests within the Master Trust as specifically identified in Note 6 are leveled in the same manner as the Master Trust investment categories presented above.

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Merck US Savings Plan

Notes to Financial Statements

Master Trust Investments Measured at Fair Value

Master Trust investments measured at fair value as of December 31, 2024 are summarized below:



	December 31, 2024
	Fair Value Measurements Using

(in thousands)	Quoted Prices						Total
	In Active		Significant
	Markets for		Other		Significant
	Identical		Observable		Unobservable
	Assets		Inputs		Inputs
	(Level 1)		(Level 2)		(Level 3)

Investments in the Master Trust

Registered investment companies	$	500,106	$	—	$	—	$	500,106
Equity securities		2,244,340		—		—		2,244,340
Fixed income securities		—		386,182		—		386,182
Self-directed brokerage accounts		368,784		—		—		368,784
Merck common stock		1,026,831		—		—		1,026,831

Investments measured within the fair value hierarchy	$	4,140,061	$	386,182	$	—	$	4,526,243

Common/collective trusts measured at NAV practical expedient (1)								11,107,463

Master trust investments at fair value							$	15,633,706

The Plan's interests within the Master Trust as specifically identified in Note 6 are leveled in the same manner as the Master Trust investment categories presented above.

8.Subsequent Events

The Plan has evaluated subsequent events through the date the financial statements were issued and no events were noted which warrant adjustments to, or disclosure in the financial statements.

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Merck US Savings Plan

Schedule H

Schedule H, Line 4i - Schedule of Assets (Held at End of Year)

December 31, 2025

(a)

(b)

(c)

(d)

(e)

Identity of Issue, Borrower, Lessor or Similar Party

Description of Investment Including Maturity Date, Rate of Interest, Collateral, Par or Maturity Value

Cost

Current Value

Master Trust

Investment in Master Trust

***

16,046,970,628

Notes receivable from participants

Interest rates ranging from 4.25% to 10.50% and with maturities through 2048

77,409,564

Total

16,124,380,192

Denotes a party-in-interest to the Plan.

There are certain investments within the Master Trust that are party-in-interest.

***

Cost information not required to be presented for participant directed investments.

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the trustees (or other persons who administer the Plan) have duly caused this annual report to be signed on its behalf by the undersigned hereunto duly authorized.

Merck US Savings Plan



By:			/s/ Melissa Leonard
			Melissa Leonard
			Senior Vice President and Treasurer

June 24, 2026

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EXHIBIT INDEX

Exhibit
Number

Document

Page

Consent of Independent Registered Public Accounting Firm

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SEC Form 11-K filed by Merck & Company Inc.