SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2)

C4 Therapeutics, Inc

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

12529R107

(CUSIP Number)

12/31/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus Private Equity Fund III, L.P.

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,072,822.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,072,822.00

Aggregate Amount Beneficially Owned by Each Reporting Person

6,072,822.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

5.9 %

Type of Reporting Person (See Instructions)

Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus Private Equity Fund III, L.P. ("Soleus PE"). Soleus Private Equity GP III, LLC ("Soleus PE GP") is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, Soleus Capital Management, L.P. ("SCM") is the investment manager for Soleus PE and for Soleus Capital Master Fund, L.P. ("Master Fund"), and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC and of Soleus GP, LLC. Each of Mr. Levy, Soleus PE GP III, LLC, Soleus PE GP, SCM and Soleus GP, LLC disclaims beneficial ownership of these shares held by Soleus PE other than for the purpose of determining their obligations under Section 13(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The number of shares reported in the table above includes warrants to purchase up to 5,822,829 shares of the common stock of C4 Therapeutics, Inc. (the "Issuer"). (3) The percentage set forth in row 11 is calculated based upon 96,914,418 shares of the common stock of the Issuer outstanding as of October 29, 2025, as reported on the cover of the Issuer's Quarterly Report on Form 10-Q for the period ended September 30, 2025 filed with the Securities and Exchange Commission on November 6, 2025 (the "Form 10-Q").

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus Private Equity GP III, LLC

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,072,822.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,072,822.00

Aggregate Amount Beneficially Owned by Each Reporting Person

6,072,822.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

5.9 %

Type of Reporting Person (See Instructions)

Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC and of Soleus GP, LLC. Each of Mr. Levy, Soleus PE GP III, LLC, Soleus PE GP, SCM and Soleus GP, LLC disclaims beneficial ownership of these shares held by Soleus PE other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The number of shares reported in the table above includes warrants to purchase up to 5,822,829 shares of the common stock of the Issuer. (3) The percentage set forth in row 11 is calculated based upon 96,914,418 shares of the common stock of the Issuer outstanding as of October 29, 2025, as set forth on the cover of the Form 10-Q.

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus PE GP III, LLC

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,072,822.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,072,822.00

Aggregate Amount Beneficially Owned by Each Reporting Person

6,072,822.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

5.9 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus Capital Master Fund, L.P.

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

CAYMAN ISLANDS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,361,860.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,361,860.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,361,860.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

9.99 %

Type of Reporting Person (See Instructions)

Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, Soleus Capital Group, LLC ("SCG") is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of SCG and of Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The number of shares reported in the table above includes warrants to purchase up to 6,807,911 shares of the common stock of the Issuer, and reflects the maximum number of shares of common stock that may be held by the Reporting Person as a result of the beneficial ownership limitations set forth in such warrants. (3) The percentage set forth in row 11 is calculated based upon 96,914,418 shares of the common stock of the Issuer outstanding as of October 29, 2025, as set forth on the cover of the Form 10-Q.

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus Capital, LLC

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,361,860.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,361,860.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,361,860.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

9.99 %

Type of Reporting Person (See Instructions)

Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of SCG and of Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The number of shares reported in the table above includes warrants to purchase up to 6,807,911 shares of the common stock of the Issuer, and reflects the maximum number of shares of common stock that may be held by the Reporting Person as a result of the beneficial ownership limitations set forth in such warrants. (3) The percentage set forth in row 11 is calculated based upon 96,914,418 shares of the common stock of the Issuer outstanding as of October 29, 2025, as set forth on the cover of the Form 10-Q.

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus Capital Group, LLC

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,361,860.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,361,860.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,361,860.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

9.99 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus Capital Management, L.P.

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,334,114.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,334,114.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,334,114.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

9.99 %

Type of Reporting Person (See Instructions)

Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE and by Master Fund. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, SCM is the investment manager for Soleus PE, and Soleus GP, LLC is the sole general partner of SCM. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC, SCG and Soleus GP, LLC. Each of Soleus PE GP, Soleus PE GP III, LLC, Soleus Capital, LLC, SCG, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by Soleus PE and Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The number of shares reported in the table above includes warrants to purchase up to 6,530,172 shares of the common stock of the Issuer, and reflects the maximum number of shares of common stock that may be held by the Reporting Person as a result of the beneficial ownership limitations set forth in such warrants. (3) The percentage set forth in row 11 is calculated based upon 96,914,418 shares of the common stock of the Issuer outstanding as of October 29, 2025, as set forth on the cover of the Form 10-Q.

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Soleus GP, LLC

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,334,114.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,334,114.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,334,114.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

9.99 %

Type of Reporting Person (See Instructions)

Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE and by Master Fund. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, SSCM is the investment manager for Soleus PE, and Soleus GP, LLC is the sole general partner of SCM. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC, SCG and Soleus GP, LLC. Each of Soleus PE GP, Soleus PE GP III, LLC, Soleus Capital, LLC, SCG, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by Soleus PE and Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The number of shares reported in the table above includes warrants to purchase up to 6,530,172 shares of the common stock of the Issuer, and reflects the maximum number of shares of common stock that may be held by the Reporting Person as a result of the beneficial ownership limitations set forth in such warrants. (3) The percentage set forth in row 11 is calculated based upon 96,914,418 shares of the common stock of the Issuer outstanding as of October 29, 2025, as set forth on the cover of the Form 10-Q.

SCHEDULE 13G

CUSIP No.

12529R107

Names of Reporting Persons

Guy Levy

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,334,114.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,334,114.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,334,114.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

9.99 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

Item 1.

(a)

Name of issuer:

C4 Therapeutics, Inc

(b)

Address of issuer's principal executive offices:

490 Arsenal Way, Suite 120, Watertown, MA 02472

Item 2.

(a)

Name of person filing:

Soleus Private Equity GP III, LLC Soleus Private Equity Fund III, L.P. Soleus PE GP III, LLC Soleus Capital Master Fund, L.P. Soleus Capital, LLC Soleus Capital Group, LLC Soleus Capital Management, L.P. Soleus GP, LLC Guy Levy

(b)

Address or principal business office or, if none, residence:

Soleus Private Equity GP III, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Private Equity Fund III, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus PE GP III, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital Master Fund, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital Group, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital Management, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus GP, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Guy Levy c/o Soleus Capital Management, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830

(c)

Citizenship:

Soleus Private Equity GP III, LLC - Delaware Soleus Private Equity Fund III, L.P. - Delaware Soleus PE GP III, LLC - Delaware Soleus Capital Master Fund, L.P. - Cayman Islands Soleus Capital, LLC - Delaware Soleus Capital Group, LLC - Delaware Soleus Capital Management, L.P. - Delaware Soleus GP, LLC - Delaware Guy Levy - United States

(d)

Title of class of securities:

Common Stock, par value $0.0001 per share

(e)

CUSIP No.:

12529R107

Item 3.

If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

(b)

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

(c)

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

(d)

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);

(e)

An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

(f)

An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

(g)

A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

(h)

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:

(k)

Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).

Item 4.

Ownership

(a)

Amount beneficially owned:

The information in rows 5 through 9 and 11 on the cover pages to this Schedule 13G, including the footnotes thereto, is hereby incorporated by reference. Soleus Private Equity GP III, LLC - 6,072,822 Soleus Private Equity Fund III, L.P. - 6,072,822 Soleus PE GP III, LLC - 6,072,822 Soleus Capital Master Fund, L.P. - 10,361,860 Soleus Capital, LLC - 10,361,860 Soleus Capital Group, LLC - 10,361,860 Soleus Capital Management, L.P. - 10,334,114 Soleus GP, LLC - 10,334,114 Guy Levy - 10,334,114

(b)

Percent of class:

Soleus Private Equity GP III, LLC - 5.9% Soleus Private Equity Fund III, L.P. - 5.9% Soleus PE GP III, LLC - 5.9% Soleus Capital Master Fund, L.P. - 9.99% Soleus Capital, LLC - 9.99% Soleus Capital Group, LLC - 9.99% Soleus Capital Management, L.P. - 9.99% Soleus GP, LLC - 9.99% Guy Levy - 9.99%

(c)

Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote:

(ii) Shared power to vote or to direct the vote:

Soleus Private Equity GP III, LLC - 6,072,822 Soleus Private Equity Fund III, L.P. - 6,072,822 Soleus PE GP III, LLC - 6,072,822 Soleus Capital Master Fund, L.P. - 10,361,860 Soleus Capital, LLC - 10,361,860 Soleus Capital Group, LLC - 10,361,860 Soleus Capital Management, L.P. - 10,334,114 Soleus GP, LLC - 10,334,114 Guy Levy - 10,334,114

(iii) Sole power to dispose or to direct the disposition of:

(iv) Shared power to dispose or to direct the disposition of:

Item 5.

Ownership of 5 Percent or Less of a Class.

Not Applicable

Item 6.

Ownership of more than 5 Percent on Behalf of Another Person.

Not Applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

Not Applicable

Item 8.

Identification and Classification of Members of the Group.

Not Applicable

Item 9.

Notice of Dissolution of Group.

Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Soleus Private Equity Fund III, L.P.

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Soleus Private Equity GP III, LLC

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Soleus PE GP III, LLC

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Soleus Capital Master Fund, L.P.

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Soleus Capital, LLC

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Soleus Capital Group, LLC

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Soleus Capital Management, L.P.

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Soleus GP, LLC

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy/Managing Member
Date:	02/12/2026

Guy Levy

Signature:	/s/ Guy Levy
Name/Title:	Guy Levy
Date:	02/12/2026

Amendment: SEC Form SCHEDULE 13G/A filed by C4 Therapeutics Inc.