SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934

(Amendment No. 2)

ACELYRIN, INC.

(Name of Issuer)

Common Stock, $0.00001 par value

(Title of Class of Securities)

00445A100

(CUSIP Number)

Alejandro Moreno
Access Industries, Inc., 40 West 57th St., 28th Floor
New York, NY, 10019
(212) 247-6400

Langhorne S. Perrow
Access Industries, Inc., 40 West 57th St., 28th Floor
New York, NY, 10019
(212) 247-6400

Nicholas P. Pellicani
Debevoise & Plimpton LLP, The Northcliffe, 28 Tudor Street
London, X0, EC4Y 0AY
44 20 7786 9000

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

05/21/2025

(Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13D

CUSIP No.

00445A100

Name of reporting person

Access Industries Management, LLC

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 0.00

Aggregate amount beneficially owned by each reporting person

0.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

0 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

00445A100

Name of reporting person

Access Industries Holdings LLC

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 0.00

Aggregate amount beneficially owned by each reporting person

0.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

0 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

00445A100

Name of reporting person

AI ACEL LLC

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 0.00

Aggregate amount beneficially owned by each reporting person

0.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

0 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

00445A100

Name of reporting person

Len Blavatnik

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 0.00

Aggregate amount beneficially owned by each reporting person

0.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

0 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

Item 1.

Security and Issuer

(a)

Title of Class of Securities:

Common Stock, $0.00001 par value

(b)

Name of Issuer:

ACELYRIN, INC.

(c)

Address of Issuer's Principal Executive Offices:

4149 Liberty Canyon Road, Agoura Hills, CALIFORNIA , 91301.

Item 1 Comment:

This Amendment No. 2 to Schedule 13D is being filed by Access Industries Management, LLC ("AIM"), Access Industries Holdings LLC ("AIH"), AI ACEL LLC ("AI ACEL"), and Len Blavatnik (collectively, the "Reporting Persons", and each, a "Reporting Person") in respect of common stock, $0.00001 par value per share (the "Common Stock"), of ACELYRIN, INC. (the "Issuer"). The Schedule 13D filed by the Reporting Persons with the SEC on May 19, 2023 (the "Schedule"), as amended and supplemented by Amendment No. 1 to the Schedule 13D filed by the Reporting Persons with the SEC on February 10, 2025, is hereby amended and supplemented by the Reporting Persons as set forth below in this Amendment No. 2. This amendment is filed by the Reporting Persons in accordance with Rule 13d-2 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and refers only to information that has materially changed since the filing of the Schedule. The items identified below, or the particular paragraphs of such items which are identified below, are amended as set forth below. Unless otherwise indicated, all capitalized terms used and not defined herein have the respective meanings assigned to them in the Schedule. This Amendment No. 2 is the final amendment to the Schedule and is an exit filing for the Reporting Persons.

Item 4.

Purpose of Transaction

The information set forth in Item 4 of the Schedule 13D is hereby supplemented to include the following information: On May 21, 2025, pursuant to the Agreement and Plan of Merger, dated as of February 6, 2025, as amended on April 20, 2025 (as amended, the "Merger Agreement"), by and among the Issuer, Alumis Inc., a Delaware corporation ("Alumis") and Arrow Merger Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Alumis ("Merger Sub"), the Issuer completed its merger with Merger Sub, whereby Merger Sub merged with and into the Issuer, in accordance with the General Corporation Law of the State of Delaware, with the Issuer continuing as the surviving corporation and as a wholly owned subsidiary of Alumis (the "Merger"). In connection with the Merger, and upon the terms and subject to the conditions set forth in the Merger Agreement, at the effective time of the Merger (the "Effective Time"), each share of Common Stock issued and outstanding was converted into the right to receive 0.4814 shares of voting common stock of Alumis, par value $0.0001 per share, and cash in lieu of any fractional shares. At the Effective Time, each holder of Common Stock outstanding immediately prior to the Effective Time ceased to have any rights as a stockholder of the Issuer other than the right to receive the consideration for such stockholder's shares of Common Stock under the Merger Agreement. In connection with the closing of the Merger, on May 21, 2025, the Issuer (i) notified The Nasdaq Stock Market LLC ("Nasdaq") that the Merger had been completed and (ii) requested that Nasdaq suspend trading of the Common Stock, effective as of the open of business on May 21, 2025, and filed with the SEC a Form 25, Notification of Removal from Listing and/or Registration, to delist all Common Stock from Nasdaq and deregister the Common Stock under Section 12(b) of the Exchange Act. The Issuer also intends to file a Certification and Notice of Termination of Registration on Form 15 with the SEC requesting the termination of registration of the Common Stock under Section 12(g) of the Exchange Act and the suspension of the Issuer's reporting obligations under Sections 13 and 15(d) of the Exchange Act. As a result of the Merger, on May 21, 2025, each of the Reporting Persons ceased to be the beneficial owner of more than five percent of Common Stock.

Item 5.

Interest in Securities of the Issuer

(a)

The information set forth in Item 5(a) of Schedule 13D is hereby amended and restated as follows: The responses of each of the Reporting Persons with respect to Rows 11, 12, and 13 of the cover pages of this Schedule 13D that relate to the aggregate number and percentage of Common Stock (including but not limited to footnotes to such information) are incorporated herein by reference.

(b)

The information set forth in Item 5(b) of Schedule 13D is hereby amended and restated as follows: The responses of each of the Reporting Persons with respect to Rows 7, 8, 9, and 10 of the cover pages of this Schedule 13D that relate to the number of Common Stock as to which each of the persons or entities referenced in Item 2 above has sole or shared power to vote or to direct the vote of and sole or shared power to dispose of or to direct the disposition of (including but not limited to footnotes to such information) are incorporated herein by reference. As a result of the Merger, on May 21, 2025, none of the Reporting Persons holds any shares of Common Stock.

(c)

The information set forth in Item 5(c) of Schedule 13D is hereby supplemented to incorporate by reference the information set forth in Item 4 above.

(d)

On May 21, 2025, each of the Reporting Persons ceased to be the beneficial owner of more than five percent of Common Stock.

Item 7.

Material to be Filed as Exhibits.

99.7 Joint Filing Agreement, dated as of May 23, 2025

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Access Industries Management, LLC

Signature:	/s/ Alejandro Moreno
Name/Title:	Executive Vice President, General Counsel/Alejandro Moreno
Date:	05/23/2025

Access Industries Holdings LLC

Signature:	/s/ Alejandro Moreno
Name/Title:	By: Access Industries Management, LLC, its manager; its Executive Vice President, General Counsel/Alejandro Moreno
Date:	05/23/2025

AI ACEL LLC

Signature:	/s/ Alejandro Moreno
Name/Title:	By: Access Industries Management, LLC, its manager; its Executive Vice President, General Counsel/Alejandro Moreno
Date:	05/23/2025

Len Blavatnik

Signature:	*/s/ Alejandro Moreno
Name/Title:	By: Alejandro Moreno as Attorney-in-Fact
Date:	05/23/2025

Comments accompanying signature:

*The above signed, by signing his name hereto, executes this Amendment No. 2 to Schedule 13D pursuant to the Limited Power of Attorney executed on behalf of Mr. Blavatnik and filed herewith.

Amendment: SEC Form SCHEDULE 13D/A filed by ACELYRIN INC.