VRTX insider transactions

EVP and Chief Legal Officer Liu Joy sold $364,245 worth of shares (828 units at $439.91) as part of a pre-agreed trading plan, decreasing direct ownership by 4% to 19,959 units (SEC Form 4)

EVP and CMO Bozic Carmen sold $888,300 worth of shares (1,974 units at $450.00) as part of a pre-agreed trading plan, decreasing direct ownership by 8% to 22,760 units (SEC Form 4)

EVP, Chief Scientific Officer Bunnage Mark E. sold $14,964 worth of shares (33 units at $453.45) as part of a pre-agreed trading plan, decreasing direct ownership by 0.45% to 7,284 units (SEC Form 4)

EVP and CMO Bozic Carmen sold $613,971 worth of shares (1,354 units at $453.45) as part of a pre-agreed trading plan, decreasing direct ownership by 5% to 24,734 units (SEC Form 4)

EVP and CMO Bozic Carmen sold $3,144,600 worth of shares (6,988 units at $450.00) as part of a pre-agreed trading plan, decreasing direct ownership by 21% to 26,088 units (SEC Form 4)

Director Upadhyay Suketu returned 796 shares to the company, decreasing direct ownership by 34% to 1,558 units (SEC Form 4)

Director Thornberry Nancy was granted 472 shares and returned 398 shares to the company, increasing direct ownership by 4% to 2,109 units (SEC Form 4)

Director Schneider Jennifer was granted 472 shares and returned 796 shares to the company, decreasing direct ownership by 19% to 1,394 units (SEC Form 4)

SEC Form 4 filed by Director Sachs Bruce I

Director Mckenzie Diana returned 796 shares to the company and was granted 943 shares, increasing direct ownership by 7% to 2,378 units (SEC Form 4)

EVP and Chief Legal Officer Liu Joy sold $469,222 worth of shares (1,104 units at $425.02) as part of a pre-agreed trading plan, decreasing direct ownership by 5% to 20,729 units (SEC Form 4)

SEC Form 4 filed by Director Lagarde Michel

Director Garber Alan M was granted 472 shares, increasing direct ownership by 7% to 7,344 units (SEC Form 4)

SEC Form 4 filed by Director Carney Lloyd

Director Bhatia Sangeeta N. was granted 943 shares and sold $134,746 worth of shares (318 units at $423.73) as part of a pre-agreed trading plan, increasing direct ownership by 15% to 4,924 units (SEC Form 4)

SEC Form 4 filed by Upadhyay Suketu

SEC Form 4 filed by Sachs Bruce I

SEC Form 4 filed by Garber Alan M

SEC Form 4 filed by Liu Joy

SEC Form 4 filed by Bozic Carmen

EVP and CMO Bozic Carmen sold $1,122,089 worth of shares (2,329 units at $481.79), decreasing direct ownership by 6% to 35,405 units (SEC Form 4)

EVP, Chief Commercial Officer Mckechnie Duncan sold $1,312,340 worth of shares (2,633 units at $498.42), decreasing direct ownership by 17% to 12,489 units (SEC Form 4)

EVP, Chief Commercial Officer Mckechnie Duncan sold $1,158,306 worth of shares (2,437 units at $475.30), decreasing direct ownership by 14% to 15,122 units (SEC Form 4)

EVP and Chief Legal Officer Liu Joy sold $442,396 worth of shares (892 units at $495.96), decreasing direct ownership by 4% to 22,811 units (SEC Form 4)

New insider Liu Joy claimed ownership of 23,703 shares (SEC Form 3)

CEO & President Kewalramani Reshma sold $19,738,855 worth of shares (40,000 units at $493.47), decreasing direct ownership by 29% to 98,278 units (SEC Form 4)

EVP and CMO Bozic Carmen sold $1,118,642 worth of shares (2,329 units at $480.31), decreasing direct ownership by 6% to 37,734 units (SEC Form 4)

SVP & Chief Accounting Officer Ambrose Kristen sold $172,560 worth of shares (357 units at $483.36), decreasing direct ownership by 5% to 6,624 units (SEC Form 4)

EVP, CO & FO Wagner Charles F Jr covered exercise/tax liability with 1,744 shares, decreasing direct ownership by 4% to 47,042 units (SEC Form 4)

EVP, Chief Reg. & Quality Off. Tatsis Ourania covered exercise/tax liability with 1,627 shares and sold $126,451 worth of shares (260 units at $486.35), decreasing direct ownership by 4% to 46,763 units (SEC Form 4)

EVP Chief Patient & Ext Af Off Sachdev Amit covered exercise/tax liability with 1,518 shares and sold $897,802 worth of shares (1,846 units at $486.35), decreasing direct ownership by 6% to 55,570 units (SEC Form 4)

EVP, Chief Commercial Officer Mckechnie Duncan covered exercise/tax liability with 873 shares and sold $2,394,365 worth of shares (4,910 units at $487.65), decreasing direct ownership by 25% to 17,559 units (SEC Form 4)

Executive Chairman Leiden Jeffrey M covered exercise/tax liability with 3,547 shares, decreasing direct ownership by 9% to 34,797 units (SEC Form 4)

CEO & President Kewalramani Reshma covered exercise/tax liability with 4,981 shares, decreasing direct ownership by 3% to 138,278 units (SEC Form 4)

EVP, Chief Scientific Officer Bunnage Mark E. covered exercise/tax liability with 582 shares and sold $301,537 worth of shares (620 units at $486.35), decreasing direct ownership by 14% to 7,284 units (SEC Form 4)

EVP and CMO Bozic Carmen covered exercise/tax liability with 1,453 shares, decreasing direct ownership by 3% to 40,063 units (SEC Form 4)

EVP and Chief Legal Officer Biller Jonathan covered exercise/tax liability with 1,144 shares and sold $459,601 worth of shares (945 units at $486.35), decreasing direct ownership by 13% to 13,659 units (SEC Form 4)

EVP, Chief Technical Ops. Off. Atkinson Edward Morrow Iii covered exercise/tax liability with 1,627 shares and sold $324,882 worth of shares (668 units at $486.35), decreasing direct ownership by 11% to 18,432 units (SEC Form 4)

SVP & Chief Accounting Officer Ambrose Kristen covered exercise/tax liability with 546 shares and sold $108,456 worth of shares (223 units at $486.35), decreasing direct ownership by 10% to 6,981 units (SEC Form 4)

EVP Chief Patient & Ext Af Off Sachdev Amit exercised 48,505 shares at a strike of $172.06 and sold $27,479,583 worth of shares (58,613 units at $468.83), decreasing direct ownership by 15% to 58,934 units (SEC Form 4)

EVP, CO & FO Wagner Charles F Jr was granted 7,365 shares and covered exercise/tax liability with 2,294 shares, increasing direct ownership by 12% to 48,786 units (SEC Form 4)

EVP, Chief Reg. & Quality Off. Tatsis Ourania was granted 5,789 shares, covered exercise/tax liability with 2,294 shares and sold $472,395 worth of shares (977 units at $483.52), increasing direct ownership by 5% to 48,650 units (SEC Form 4)

EVP Chief Patient & Ext Af Off Sachdev Amit was granted 5,789 shares and covered exercise/tax liability with 2,140 shares, increasing direct ownership by 6% to 69,042 units (SEC Form 4)

EVP, Chief Commercial Officer Mckechnie Duncan was granted 4,962 shares and covered exercise/tax liability with 1,148 shares, increasing direct ownership by 20% to 23,342 units (SEC Form 4)

Executive Chairman Leiden Jeffrey M covered exercise/tax liability with 2,964 shares and was granted 8,269 shares, increasing direct ownership by 16% to 38,344 units (SEC Form 4)

CEO & President Kewalramani Reshma covered exercise/tax liability with 6,554 shares and was granted 16,326 shares, increasing direct ownership by 7% to 143,259 units (SEC Form 4)

EVP, Chief Scientific Officer Bunnage Mark E. was granted 2,584 shares, covered exercise/tax liability with 1,110 shares and sold $1,752,704 worth of shares (3,619 units at $484.31), decreasing direct ownership by 20% to 8,486 units (SEC Form 4)

EVP and CMO Bozic Carmen was granted 5,375 shares and covered exercise/tax liability with 1,912 shares, increasing direct ownership by 9% to 41,516 units (SEC Form 4)

EVP and Chief Legal Officer Biller Jonathan was granted 4,135 shares, covered exercise/tax liability with 1,505 shares and sold $1,801,161 worth of shares (3,720 units at $484.18), decreasing direct ownership by 6% to 15,748 units (SEC Form 4)

EVP, Chief Technical Ops. Off. Atkinson Edward Morrow Iii was granted 4,962 shares, covered exercise/tax liability with 1,530 shares and sold $1,381,090 worth of shares (2,848 units at $484.93), increasing direct ownership by 3% to 20,727 units (SEC Form 4)

SVP & Chief Accounting Officer Ambrose Kristen covered exercise/tax liability with 598 shares, sold $1,064,297 worth of shares (2,195 units at $484.87) and was granted 1,809 shares, decreasing direct ownership by 11% to 7,750 units (SEC Form 4)

EVP, CO & FO Wagner Charles F Jr covered exercise/tax liability with 4,565 shares, decreasing direct ownership by 9% to 43,715 units (SEC Form 4)

EVP, Chief Reg. & Quality Off. Tatsis Ourania covered exercise/tax liability with 3,804 shares and sold $749,985 worth of shares (1,500 units at $499.99), decreasing direct ownership by 10% to 46,132 units (SEC Form 4)

EVP Chief Patient & Ext Af Off Sachdev Amit covered exercise/tax liability with 3,548 shares, decreasing direct ownership by 5% to 65,393 units (SEC Form 4)

EVP, Chief Commercial Officer Mckechnie Duncan covered exercise/tax liability with 2,283 shares, decreasing direct ownership by 10% to 19,528 units (SEC Form 4)

CEO & President Kewalramani Reshma covered exercise/tax liability with 13,041 shares, decreasing direct ownership by 9% to 133,487 units (SEC Form 4)

EVP, Chief Scientific Officer Bunnage Mark E. covered exercise/tax liability with 2,283 shares, decreasing direct ownership by 18% to 10,631 units (SEC Form 4)

EVP and CMO Bozic Carmen covered exercise/tax liability with 3,804 shares, decreasing direct ownership by 9% to 38,053 units (SEC Form 4)

EVP and Chief Legal Officer Biller Jonathan covered exercise/tax liability with 2,993 shares and sold $493,012 worth of shares (988 units at $499.00), decreasing direct ownership by 19% to 16,838 units (SEC Form 4)

Director Bhatia Sangeeta N. sold $133,000 worth of shares (266 units at $500.00), decreasing direct ownership by 6% to 4,299 units (SEC Form 4)