STE insider transactions

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 365 units of Ordinary Shares, decreasing direct ownership by 0.97% to 37,079 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 64 units of Ordinary Shares, decreasing direct ownership by 1% to 6,259 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 239 units of Ordinary Shares, decreasing direct ownership by 2% to 12,452 units (SEC Form 4)

SVP & GM, AST Kohler Kenneth E covered exercise/tax liability with 184 units of Ordinary Shares, decreasing direct ownership by 2% to 11,482 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare covered exercise/tax liability with 311 units of Ordinary Shares, decreasing direct ownership by 2% to 14,316 units (SEC Form 4)

President and CEO Carestio Daniel A covered exercise/tax liability with 2,619 units of Ordinary Shares, decreasing direct ownership by 4% to 69,964 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L covered exercise/tax liability with 190 units of Ordinary Shares, decreasing direct ownership by 1% to 13,274 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam was granted 4,359 units of Ordinary Shares and covered exercise/tax liability with 247 units of Ordinary Shares, increasing direct ownership by 12% to 37,444 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato was granted 750 units of Ordinary Shares and covered exercise/tax liability with 41 units of Ordinary Shares, increasing direct ownership by 13% to 6,323 units (SEC Form 4)

SVP and President, Healthcare Majors Cary L was granted 4,746 units of Ordinary Shares and covered exercise/tax liability with 67 units of Ordinary Shares, increasing direct ownership by 37% to 17,338 units (SEC Form 4)

VP, Chf. Comp. & Quality Offc. Mcgowan Lindsey covered exercise/tax liability with 329 units of Ordinary Shares and was granted 1,155 units of Ordinary Shares, increasing direct ownership by 17% to 5,656 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia was granted 2,316 units of Ordinary Shares and covered exercise/tax liability with 127 units of Ordinary Shares, increasing direct ownership by 21% to 12,691 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare was granted 3,009 units of Ordinary Shares and covered exercise/tax liability with 591 units of Ordinary Shares, increasing direct ownership by 20% to 14,627 units (SEC Form 4)

SVP & GM, AST Kohler Kenneth E was granted 2,199 units of Ordinary Shares and covered exercise/tax liability with 66 units of Ordinary Shares, increasing direct ownership by 22% to 11,666 units (SEC Form 4)

President and CEO Carestio Daniel A was granted 23,736 units of Ordinary Shares and covered exercise/tax liability with 995 units of Ordinary Shares, increasing direct ownership by 46% to 72,583 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L was granted 5,325 units of Ordinary Shares, increasing direct ownership by 64% to 13,464 units (SEC Form 4)

SEC Form 4 filed by Director Boulud Pierre

Director Breeden Richard C exercised 3,781 units of Ordinary Shares at a strike of $71.40 and sold $310,284 worth of Ordinary Shares (1,481 units at $209.51), increasing direct ownership by 6% to 38,964 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 337 units of Ordinary Shares, decreasing direct ownership by 1% to 33,332 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 81 units of Ordinary Shares, decreasing direct ownership by 1% to 5,614 units (SEC Form 4)

VP, Chf. Comp. & Quality Offc. Mcgowan Lindsey covered exercise/tax liability with 198 units of Ordinary Shares, decreasing direct ownership by 4% to 4,830 units (SEC Form 4)

SVP and President, Healthcare Majors Cary L covered exercise/tax liability with 768 units of Ordinary Shares, decreasing direct ownership by 6% to 12,659 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 208 units of Ordinary Shares, decreasing direct ownership by 2% to 10,502 units (SEC Form 4)

SVP & GM, AST Kohler Kenneth E covered exercise/tax liability with 109 units of Ordinary Shares, decreasing direct ownership by 1% to 9,533 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare covered exercise/tax liability with 673 units of Ordinary Shares, decreasing direct ownership by 5% to 12,209 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L covered exercise/tax liability with 99 units of Ordinary Shares, decreasing direct ownership by 1% to 8,205 units (SEC Form 4)

President and CEO Carestio Daniel A covered exercise/tax liability with 1,254 units of Ordinary Shares, decreasing direct ownership by 2% to 49,842 units (SEC Form 4)

SEC Form 3 filed by new insider Boulud Pierre

Director Feldmann Cynthia L exercised 3,098 units of Ordinary Shares at a strike of $152.32 and sold $734,877 worth of Ordinary Shares (3,098 units at $237.21) (SEC Form 4)

VP, Chf. Comp. & Quality Offc. Mcgowan Lindsey was granted 798 units of Ordinary Shares, increasing direct ownership by 19% to 5,028 units (SEC Form 4)

New insider Mcgowan Lindsey claimed ownership of 4,478 units of Ordinary Shares (SEC Form 3)

Sr. VP and GM, Life Sciences Madsen Julia exercised 5,008 units of Ordinary Shares at a strike of $128.22 and sold $1,312,096 worth of Ordinary Shares (5,008 units at $262.00) (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato exercised 3,536 units of Ordinary Shares at a strike of $182.22 and sold $1,297,040 worth of Ordinary Shares (5,036 units at $257.55), decreasing direct ownership by 21% to 5,695 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam exercised 15,000 units of Ordinary Shares at a strike of $69.72 and sold $3,977,100 worth of Ordinary Shares (15,000 units at $265.14) (SEC Form 4)

President and CEO Carestio Daniel A sold $38,449 worth of Ordinary Shares (159 units at $241.82), decreasing direct ownership by 0.31% to 51,096 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 91 units of Ordinary Shares, decreasing direct ownership by 0.27% to 33,669 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 26 units of Ordinary Shares, decreasing direct ownership by 0.36% to 7,195 units (SEC Form 4)

SVP and President, Healthcare Majors Cary L covered exercise/tax liability with 303 units of Ordinary Shares, decreasing direct ownership by 2% to 13,427 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 52 units of Ordinary Shares, decreasing direct ownership by 0.48% to 10,710 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare covered exercise/tax liability with 207 units of Ordinary Shares, decreasing direct ownership by 2% to 12,882 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L covered exercise/tax liability with 39 units of Ordinary Shares and was granted 2,349 units of Ordinary Shares, increasing direct ownership by 39% to 8,304 units (SEC Form 4)

President and CEO Carestio Daniel A covered exercise/tax liability with 130 units of Ordinary Shares, decreasing direct ownership by 0.25% to 51,255 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato exercised 3,204 units of Ordinary Shares at a strike of $147.05 and sold $798,565 worth of Ordinary Shares (3,204 units at $249.24) (SEC Form 4)

Director Breeden Richard C exercised 4,110 units of Ordinary Shares at a strike of $64.05, increasing direct ownership by 13% to 36,664 units (SEC Form 4)

Director Sohi Mohsen exercised 4,110 units of Ordinary Shares at a strike of $64.05 and sold $994,456 worth of Ordinary Shares (4,110 units at $241.96) (SEC Form 4)

SEC Form 4 filed by Director Shapiro Louis

SEC Form 4 filed by Director Shah Nirav R

SEC Form 4 filed by Director Martin Paul Edward

SEC Form 4 filed by Director Holland Christopher S

Director Feldmann Cynthia L converted options into 3,495 units of Ordinary Shares and sold $844,252 worth of Ordinary Shares (3,495 units at $241.56) (SEC Form 4)

SEC Form 4 filed by Director Breeden Richard C

SEC Form 4 filed by Director Alegria Esther M.

VP & CAO Burton Karen L exercised 7,900 units of Ordinary Shares at a strike of $114.22 and sold $1,909,667 worth of Ordinary Shares (7,900 units at $241.73) (SEC Form 4)

SEC Form 3 filed by new insider Shapiro Louis

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam sold $477,581 worth of Ordinary Shares (1,978 units at $241.45), decreasing direct ownership by 6% to 33,760 units (SEC Form 4)

Sr. Vice Pres., CFO Tokich Michael J covered exercise/tax liability with 341 units of Ordinary Shares, decreasing direct ownership by 0.77% to 43,891 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 194 units of Ordinary Shares, decreasing direct ownership by 2% to 10,762 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 425 units of Ordinary Shares, decreasing direct ownership by 1% to 35,738 units (SEC Form 4)

VP & CAO Burton Karen L covered exercise/tax liability with 92 units of Ordinary Shares, decreasing direct ownership by 2% to 5,994 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 66 units of Ordinary Shares, decreasing direct ownership by 0.91% to 7,221 units (SEC Form 4)