SLNO insider transactions

Officer Yen Kristen returned 37,639 shares to the company, closing all direct ownership in the company (SEC Form 4)

Director Volck Birgitte returned 17,536 shares to the company, closing all direct ownership in the company (SEC Form 4)

Director Sinclair Andrew returned 10,491 shares to the company, closing all direct ownership in the company (SEC Form 4)

Director Pauls Matthew returned 10,491 shares to the company, closing all direct ownership in the company (SEC Form 4)

Chief Business Officer Norrett Kevin returned 17,786 shares to the company, closing all direct ownership in the company (SEC Form 4)

Chief Commercial Officer Manning Meredith returned 64,507 shares to the company, closing all direct ownership in the company (SEC Form 4)

Chief Development Officer Joshi Manher returned 20,171 shares to the company, closing all direct ownership in the company (SEC Form 4)

Sr. VP of Clinical Development Huang Michael F. returned 39,823 shares to the company, closing all direct ownership in the company (SEC Form 4)

Officer Hirano Patricia C returned 22,702 shares to the company, closing all direct ownership in the company (SEC Form 4)

Director Hahn Mark W returned 10,046 shares to the company, closing all direct ownership in the company (SEC Form 4)

CHIEF FINANCIAL OFFICER Fulk Jennifer returned 39,200 shares to the company, closing all direct ownership in the company (SEC Form 4)

Director Bir Dawn Carter returned 16,991 shares to the company, closing all direct ownership in the company (SEC Form 4)

CHIEF EXECUTIVE OFFICER Anish Bhatnagar returned 583,656 shares to the company, closing all direct ownership in the company (SEC Form 4)

SEC Form 4 filed by Manning Meredith

SEC Form 4 filed by Huang Michael F.

CHIEF FINANCIAL OFFICER Fulk Jennifer was granted 39,200 shares (SEC Form 4)

SEC Form 3 filed by new insider Fulk Jennifer

Officer Yen Kristen was granted 10,400 shares, increasing direct ownership by 38% to 37,639 units (SEC Form 4)

Chief Business Officer Norrett Kevin was granted 3,500 shares, increasing direct ownership by 24% to 17,786 units (SEC Form 4)

Chief Commercial Officer Manning Meredith was granted 28,600 shares, increasing direct ownership by 66% to 72,029 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Mackaness James H was granted 28,600 shares, increasing direct ownership by 28% to 131,763 units (SEC Form 4)

Chief Development Officer Joshi Manher was granted 4,100 shares, increasing direct ownership by 26% to 20,171 units (SEC Form 4)

Sr. VP of Clinical Development Huang Michael F. was granted 10,400 shares, increasing direct ownership by 29% to 46,405 units (SEC Form 4)

Officer Hirano Patricia C was granted 10,400 shares, increasing direct ownership by 85% to 22,702 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Anish Bhatnagar was granted 114,200 shares, increasing direct ownership by 24% to 583,656 units (SEC Form 4)

Officer Yen Kristen covered exercise/tax liability with 904 shares, decreasing direct ownership by 3% to 27,239 units (SEC Form 4)

Chief Commercial Officer Manning Meredith covered exercise/tax liability with 1,922 shares, decreasing direct ownership by 4% to 43,429 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Mackaness James H covered exercise/tax liability with 2,013 shares, decreasing direct ownership by 2% to 103,163 units (SEC Form 4)

Sr. VP of Clinical Development Huang Michael F. covered exercise/tax liability with 812 shares, decreasing direct ownership by 2% to 36,005 units (SEC Form 4)

Officer Hirano Patricia C covered exercise/tax liability with 904 shares, decreasing direct ownership by 7% to 12,302 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Anish Bhatnagar covered exercise/tax liability with 7,620 shares and gifted 100,000 shares, decreasing direct ownership by 19% to 469,456 units (SEC Form 4)

Chief Business Officer Norrett Kevin was granted 14,286 shares (SEC Form 4)

SEC Form 3 filed by new insider Norrett Kevin

Chief Development Officer Joshi Manher was granted 16,071 shares (SEC Form 4)

SEC Form 3 filed by new insider Joshi Manher

Director Hahn Mark W was granted 10,046 shares (SEC Form 4)

SEC Form 3 filed by new insider Hahn Mark W

Officer Hirano Patricia C sold $316,971 worth of shares (3,830 units at $82.76), decreasing direct ownership by 22% to 13,206 units (SEC Form 4)

Officer Hirano Patricia C exercised 266 shares at a strike of $44.25 and sold $22,410 worth of shares (266 units at $84.25) (SEC Form 4)

Director Volck Birgitte was granted 3,991 shares, increasing direct ownership by 29% to 17,536 units (SEC Form 4)

Director Sinclair Andrew was granted 3,991 shares, increasing direct ownership by 61% to 10,491 units (SEC Form 4)

Director Pauls Matthew was granted 3,991 shares, increasing direct ownership by 61% to 10,491 units (SEC Form 4)

Director Harris William G was granted 3,991 shares, increasing direct ownership by 26% to 19,392 units (SEC Form 4)

Director Bir Dawn Carter was granted 3,991 shares, increasing direct ownership by 31% to 16,991 units (SEC Form 4)

Officer Hirano Patricia C sold $265,156 worth of shares (3,782 units at $70.11), decreasing direct ownership by 12% to 27,036 units (SEC Form 4)

Director Pauls Matthew exercised 5,937 shares at a strike of $4.60 and sold $424,797 worth of shares (5,937 units at $71.55) (SEC Form 4)

Officer Yen Kristen sold $6,376,789 worth of shares (95,500 units at $66.77) and exercised 40,638 shares at a strike of $4.97, decreasing direct ownership by 66% to 28,143 units (SEC Form 4)

Chief Commercial Officer Manning Meredith sold $3,044,343 worth of shares (45,249 units at $67.28) and exercised 37,000 shares at a strike of $46.31, decreasing direct ownership by 15% to 45,351 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Mackaness James H sold $6,293,177 worth of shares (90,622 units at $69.44) and exercised 70,000 shares at a strike of $11.72, decreasing direct ownership by 16% to 105,176 units (SEC Form 4)

Sr. VP of Clinical Development Huang Michael F. sold $1,013,627 worth of shares (14,583 units at $69.51) and exercised 10,000 shares at a strike of $21.93, decreasing direct ownership by 11% to 36,817 units (SEC Form 4)

Officer Hirano Patricia C sold $10,709,353 worth of shares (156,315 units at $68.51) and exercised 74,831 shares at a strike of $8.14, decreasing direct ownership by 73% to 30,818 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Anish Bhatnagar sold $47,271,960 worth of shares (699,095 units at $67.62) and exercised 523,809 shares at a strike of $12.17, decreasing direct ownership by 23% to 577,076 units (SEC Form 4)

Large owner Vivo Opportunity, Llc sold $124,449,124 worth of shares (1,833,557 units at $67.87) (SEC Form 4)

Officer Yen Kristen was granted 6,400 shares, increasing direct ownership by 8% to 83,005 units (SEC Form 4)

Chief Commercial Officer Manning Meredith was granted 13,600 shares, increasing direct ownership by 34% to 53,600 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Mackaness James H was granted 14,500 shares, increasing direct ownership by 13% to 125,798 units (SEC Form 4)

Sr. VP of Clinical Development Huang Michael F. was granted 6,400 shares, increasing direct ownership by 18% to 41,400 units (SEC Form 4)

Officer Hirano Patricia C was granted 6,400 shares, increasing direct ownership by 6% to 112,302 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Anish Bhatnagar was granted 53,900 shares, increasing direct ownership by 8% to 752,362 units (SEC Form 4)

Officer Yen Kristen sold $222,484 worth of shares (4,860 units at $45.78), decreasing direct ownership by 6% to 76,605 units (SEC Form 4)