RPID insider transactions

Director Lowenstein Inese was granted 12,787 shares, increasing direct ownership by 22% to 70,687 units (SEC Form 4)

Director Pei Melinda Litherland was granted 12,787 shares, increasing direct ownership by 15% to 100,687 units (SEC Form 4)

Director Malloy Kirk was granted 12,787 shares, increasing direct ownership by 27% to 60,687 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M was granted 12,787 shares, increasing direct ownership by 2% to 568,981 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. was granted 12,787 shares, increasing direct ownership by 1% to 1,190,571 units (SEC Form 4)

Director Malloy Kirk was granted 19,300 shares, increasing direct ownership by 67% to 47,900 units (SEC Form 4)

Director Lowenstein Inese was granted 19,300 shares, increasing direct ownership by 50% to 57,900 units (SEC Form 4)

Director Pei Melinda Litherland was granted 19,300 shares, increasing direct ownership by 28% to 87,900 units (SEC Form 4)

Director Kollender Richard S was granted 19,300 shares, increasing direct ownership by 17% to 130,318 units (SEC Form 4)

Director Bika Dafni was granted 19,300 shares (SEC Form 4)

SEC Form 4 filed by Large owner Bain Capital Life Sciences Investors, Llc

CHIEF OPERATING OFFICER Wilson John J. Addington sold $41,467 worth of shares (9,603 units at $4.32), decreasing direct ownership by 3% to 316,762 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M sold $32,299 worth of shares (7,480 units at $4.32), decreasing direct ownership by 1% to 556,194 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. sold $73,686 worth of shares (17,922 units at $4.11), decreasing direct ownership by 2% to 1,169,848 units (SEC Form 4)

Director Ricciardi Natale S exercised 842 shares at a strike of $0.75, increasing direct ownership by 3% to 29,442 units (SEC Form 4)

CHIEF OPERATING OFFICER Wilson John J. Addington sold $21,196 worth of shares (5,403 units at $3.92), decreasing direct ownership by 2% to 326,365 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M sold $67,687 worth of shares (17,254 units at $3.92), decreasing direct ownership by 3% to 563,674 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. sold $148,912 worth of shares (38,327 units at $3.89), decreasing direct ownership by 3% to 1,187,770 units (SEC Form 4)

CHIEF OPERATING OFFICER Wilson John J. Addington was granted 74,000 shares, increasing direct ownership by 29% to 331,768 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M was granted 97,000 shares, increasing direct ownership by 20% to 580,928 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. was granted 264,000 shares, increasing direct ownership by 27% to 1,226,097 units (SEC Form 4)

CHIEF OPERATING OFFICER Wilson John J. Addington sold $17,438 worth of shares (4,610 units at $3.78), decreasing direct ownership by 2% to 257,768 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M sold $22,798 worth of shares (6,027 units at $3.78), decreasing direct ownership by 1% to 483,928 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. sold $48,570 worth of shares (12,840 units at $3.78), decreasing direct ownership by 1% to 962,097 units (SEC Form 4)

Large owner Longitude Capital Partners Ii, Llc sold $190,091 worth of shares (49,000 units at $3.88) (SEC Form 4)

Large owner Longitude Capital Partners Ii, Llc exercised 629,032 in-the-money shares at a strike of $0.05 and sold $473,859 worth of shares (108,739 units at $4.36) (SEC Form 4)

Director Malloy Kirk gifted 40,000 shares, decreasing direct ownership by 58% to 28,600 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. exercised 11,233 shares at a strike of $0.75 and covered exercise/tax liability with 6,846 shares, increasing direct ownership by 0.45% to 974,937 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. converted options into 50,290 shares and sold $78,979 worth of shares (23,755 units at $3.32), increasing direct ownership by 3% to 970,550 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. converted options into 75,433 shares and sold $116,976 worth of shares (33,688 units at $3.47), increasing direct ownership by 8% to 944,015 units (SEC Form 4)

SEC Form 4 filed by Director Bika Dafni

SEC Form 3 filed by new insider Bika Dafni

Director Lowenstein Inese was granted 14,300 shares, increasing direct ownership by 59% to 38,600 units (SEC Form 4)

Director Pei Melinda Litherland was granted 14,300 shares, increasing direct ownership by 26% to 68,600 units (SEC Form 4)

Director Kollender Richard S was granted 14,300 shares, increasing direct ownership by 15% to 111,018 units (SEC Form 4)

Director Malloy Kirk was granted 14,300 shares, increasing direct ownership by 22% to 78,600 units (SEC Form 4)

Director Ricciardi Natale S was granted 14,300 shares, increasing direct ownership by 100% to 28,600 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. covered exercise/tax liability with 10,650 shares, decreasing direct ownership by 1% to 872,366 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M covered exercise/tax liability with 7,690 shares, decreasing direct ownership by 2% to 489,955 units (SEC Form 4)

CHIEF OPERATING OFFICER Wilson John J. Addington covered exercise/tax liability with 9,872 shares, decreasing direct ownership by 4% to 232,474 units (SEC Form 4)

CHIEF OPERATING OFFICER Wilson John J. Addington was granted 44,000 shares, increasing direct ownership by 22% to 242,346 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M was granted 160,000 shares, increasing direct ownership by 47% to 497,645 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. was granted 365,000 shares, increasing direct ownership by 70% to 883,016 units (SEC Form 4)

CHIEF OPERATING OFFICER Wilson John J. Addington covered exercise/tax liability with 7,075 shares, decreasing direct ownership by 3% to 198,346 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M covered exercise/tax liability with 4,621 shares, decreasing direct ownership by 1% to 337,645 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. covered exercise/tax liability with 10,755 shares, decreasing direct ownership by 2% to 516,205 units (SEC Form 4)

CHIEF OPERATING OFFICER Wilson John J. Addington covered exercise/tax liability with 4,505 shares, decreasing direct ownership by 2% to 205,421 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M covered exercise/tax liability with 5,891 shares, decreasing direct ownership by 2% to 342,266 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. covered exercise/tax liability with 13,052 shares, decreasing direct ownership by 2% to 526,960 units (SEC Form 4)

Director Pei Melinda Litherland bought $20,364 worth of shares (20,000 units at $1.02), increasing direct ownership by 58% to 54,300 units (SEC Form 4)

Director Pei Melinda Litherland bought $20,999 worth of shares (20,000 units at $1.05), increasing direct ownership by 140% to 34,300 units (SEC Form 4)

Director Malloy Kirk bought $45,335 worth of shares (50,000 units at $0.91), increasing direct ownership by 350% to 64,300 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Wirtjes Sean M bought $7,800 worth of shares (10,000 units at $0.78), increasing direct ownership by 3% to 348,157 units (SEC Form 4)

Director Kollender Richard S bought $50,128 worth of shares (65,000 units at $0.77), increasing direct ownership by 205% to 96,718 units (SEC Form 4)

PRESIDENT AND CEO Spignesi Robert G. Jr. bought $38,400 worth of shares (50,000 units at $0.77), increasing direct ownership by 10% to 540,012 units (SEC Form 4)

Ricciardi Natale S was granted 14,300 shares (SEC Form 4)

Lowenstein Inese was granted 14,300 shares, increasing direct ownership by 143% to 24,300 units (SEC Form 4)

Pei Melinda Litherland was granted 14,300 shares (SEC Form 4)

Kollender Richard S was granted 14,300 shares, increasing direct ownership by 82% to 31,718 units (SEC Form 4)

Malloy Kirk was granted 14,300 shares (SEC Form 4)