REPL insider transactions

Chief Commercial Officer Sarchi Christopher sold $110,880 worth of shares (12,000 units at $9.24) as part of a pre-agreed trading plan, decreasing direct ownership by 6% to 180,962 units (SEC Form 4)

Chief Medical Officer Xynos Konstantinos sold $71,237 worth of shares (14,023 units at $5.08), decreasing direct ownership by 6% to 235,662 units (SEC Form 4) to satisfy tax liability

Chief Accounting Officer Schwendenman Andrew sold $40,102 worth of shares (7,894 units at $5.08), decreasing direct ownership by 7% to 107,057 units (SEC Form 4) to cover taxes

Chief Commercial Officer Sarchi Christopher sold $43,820 worth of shares (8,626 units at $5.08), decreasing direct ownership by 4% to 192,962 units (SEC Form 4) (for tax liability)

Director Astley-Sparke Philip sold $89,698 worth of shares (17,657 units at $5.08), decreasing direct ownership by 1% to 1,412,414 units (SEC Form 4) to satisfy withholding tax

Chief Executive Officer Patel Sushil sold $189,606 worth of shares (37,324 units at $5.08), decreasing direct ownership by 5% to 747,492 units (SEC Form 4) (tax liability)

Chief Financial Officer Hill Emily Luisa sold $39,685 worth of shares (7,812 units at $5.08), decreasing direct ownership by 3% to 236,556 units (SEC Form 4) (withholding obligation)

SEC Form 4 filed by Baker Bros. Advisors Lp

SEC Form 4 filed by Sarchi Christopher

SEC Form 4 filed by Astley-Sparke Philip

SEC Form 4 filed by Oliger Christy J.

SEC Form 4 filed by Xynos Konstantinos

SEC Form 4 filed by Balachandran Madhavan

SEC Form 4 filed by Schwendenman Andrew

SEC Form 4 filed by Patel Sushil

SEC Form 4 filed by Dhingra Kapil

SEC Form 4 filed by Pucci Paolo

SEC Form 4 filed by Slattery Joseph P

SEC Form 4 filed by Hill Emily Luisa

SEC Form 4 filed by Peeples-Dyer Veleka

SEC Form 4 filed by Weinand Dieter

SEC Form 4 filed by Sarchi Christopher

Director Astley-Sparke Philip gifted 25,000 shares, decreasing direct ownership by 2% to 1,380,071 units (SEC Form 4)

Chief Executive Officer Patel Sushil was granted 200,000 shares, increasing direct ownership by 60% to 533,576 units (SEC Form 4)

Chief Medical Officer Xynos Konstantinos was granted 60,000 shares, increasing direct ownership by 43% to 199,685 units (SEC Form 4)

Chief Financial Officer Hill Emily Luisa was granted 60,000 shares, increasing direct ownership by 45% to 194,368 units (SEC Form 4)

Chief Commercial Officer Sarchi Christopher was granted 35,000 shares, increasing direct ownership by 28% to 158,088 units (SEC Form 4)

Chief Accounting Officer Schwendenman Andrew was granted 10,000 shares, increasing direct ownership by 15% to 78,284 units (SEC Form 4)

Director Dhingra Kapil exercised 3,169 shares at a strike of $1.75 and sold $32,958 worth of shares (3,169 units at $10.40) (SEC Form 4)

Chief Executive Officer Patel Sushil sold $111,300 worth of shares (10,000 units at $11.13), decreasing direct ownership by 3% to 333,576 units (SEC Form 4)

Chief Commercial Officer Sarchi Christopher sold $47,393 worth of shares (5,208 units at $9.10), decreasing direct ownership by 4% to 123,088 units (SEC Form 4)

Chief Medical Officer Xynos Konstantinos sold $65,957 worth of shares (7,248 units at $9.10), decreasing direct ownership by 5% to 139,685 units (SEC Form 4)

Chief Financial Officer Hill Emily Luisa sold $49,157 worth of shares (9,154 units at $5.37), decreasing direct ownership by 6% to 134,368 units (SEC Form 4)

Director Astley-Sparke Philip sold $260,169 worth of shares (32,279 units at $8.06), decreasing direct ownership by 2% to 1,405,071 units (SEC Form 4)

Chief Medical Officer Xynos Konstantinos sold $64,093 worth of shares (7,952 units at $8.06), decreasing direct ownership by 5% to 146,933 units (SEC Form 4)

Chief Accounting Officer Schwendenman Andrew sold $26,460 worth of shares (3,287 units at $8.05), decreasing direct ownership by 5% to 68,284 units (SEC Form 4)

Chief Executive Officer Patel Sushil sold $202,346 worth of shares (25,105 units at $8.06), decreasing direct ownership by 7% to 343,576 units (SEC Form 4)

Chief Financial Officer Hill Emily Luisa sold $20,407 worth of shares (2,535 units at $8.05), decreasing direct ownership by 2% to 143,522 units (SEC Form 4)

Chief Commercial Officer Sarchi Christopher sold $30,179 worth of shares (3,749 units at $8.05), decreasing direct ownership by 3% to 128,296 units (SEC Form 4)

SEC Form 4 filed by Director Peeples-Dyer Veleka

Chief Executive Officer Patel Sushil was granted 166,667 shares, increasing direct ownership by 83% to 368,681 units (SEC Form 4)

SEC Form 4 filed by Director Pucci Paolo

SEC Form 4 filed by Director Balachandran Madhavan

Chief Medical Officer Xynos Konstantinos was granted 45,000 shares, increasing direct ownership by 41% to 154,885 units (SEC Form 4)

SEC Form 4 filed by Director Dhingra Kapil

SEC Form 4 filed by Director Slattery Joseph P

Chief Financial Officer Hill Emily Luisa was granted 45,000 shares, increasing direct ownership by 45% to 146,057 units (SEC Form 4)

SEC Form 4 filed by Director Weinand Dieter

Chief Commercial Officer Sarchi Christopher was granted 45,000 shares, increasing direct ownership by 52% to 132,045 units (SEC Form 4)

SEC Form 4 filed by Director Oliger Christy J.

Chief Accounting Officer Schwendenman Andrew gave a grant of 33,333 shares, decreasing direct ownership by 32% to 71,571 units (SEC Form 4)

SEC Form 3 filed by new insider Goller Michael

SEC Form 4 filed by Director Baker Bros. Advisors Lp

New insider Baker Bros. Advisors Lp claimed ownership of 11,045,336 shares (SEC Form 3)

Chief Executive Officer Patel Sushil sold $124,200 worth of shares (10,000 units at $12.42), decreasing direct ownership by 5% to 202,014 units (SEC Form 4)

Chief Medical Officer Xynos Konstantinos sold $78,112 worth of shares (7,246 units at $10.78), decreasing direct ownership by 6% to 109,885 units (SEC Form 4)

Chief Commercial Officer Sarchi Christopher sold $56,131 worth of shares (5,207 units at $10.78), decreasing direct ownership by 6% to 87,045 units (SEC Form 4)

SEC Form 4 filed by Director Balachandran Madhavan

SEC Form 3 filed by new insider Balachandran Madhavan

Executive Chairman Astley-Sparke Philip gifted 50,000 shares, decreasing direct ownership by 3% to 1,437,350 units (SEC Form 4)