RAPP insider transactions

Large owner Third Rock Ventures V, L.P. sold $743,753 worth of shares (18,572 units at $40.05) as part of a pre-agreed trading plan (SEC Form 4)

Large owner Third Rock Ventures V, L.P. sold $5,377,323 worth of shares (133,618 units at $40.24) as part of a pre-agreed trading plan (SEC Form 4)

Large owner Third Rock Ventures V, L.P. sold $11,094,906 worth of shares (276,513 units at $40.12) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Third Rock Ventures V, L.P.

SEC Form 4 filed by Yeleswaram Krishnaswamy

SEC Form 4 filed by Yeleswaram Krishnaswamy

SEC Form 4 filed by Yeleswaram Krishnaswamy

SEC Form 4 filed by Gault Cheryl

SEC Form 4 filed by Yeleswaram Krishnaswamy

Chief Operating Officer Gault Cheryl sold $58,265 worth of shares (2,014 units at $28.93), decreasing direct ownership by 1% to 169,914 units (SEC Form 4)

Chief Executive Officer Ceesay Abraham sold $320,373 worth of shares (10,916 units at $29.35), decreasing direct ownership by 1% to 556,247 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $246,655 worth of shares (8,500 units at $29.02) and exercised 6,000 shares at a strike of $1.80, decreasing direct ownership by 0.63% to 393,075 units (SEC Form 4)

SEC Form 4 filed by Chief Medical Officer Sevigny Jeffrey

SEC Form 4 filed by Chief Executive Officer Ceesay Abraham

SEC Form 4 filed by Chief Financial Officer Ignelzi Troy A.

SEC Form 4 filed by Chief Development Officer Yeleswaram Krishnaswamy

SEC Form 4 filed by Chief Scientific Officer Bredt David

SEC Form 4 filed by Chief Operating Officer Gault Cheryl

Chief Executive Officer Ceesay Abraham sold $285,071 worth of shares (10,916 units at $26.11), decreasing direct ownership by 1% to 562,080 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $228,132 worth of shares (8,500 units at $26.84), decreasing direct ownership by 2% to 395,575 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $197,338 worth of shares (6,567 units at $30.05) and gave a grant of 18,000 shares, decreasing direct ownership by 6% to 404,075 units (SEC Form 4)

Chief Development Officer Yeleswaram Krishnaswamy was granted 9,000 shares and sold $85,342 worth of shares (2,840 units at $30.05), increasing direct ownership by 2% to 296,991 units (SEC Form 4)

Chief Executive Officer Ceesay Abraham sold $323,508 worth of shares (10,916 units at $29.64), decreasing direct ownership by 1% to 567,913 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $255,130 worth of shares (8,500 units at $30.02), decreasing direct ownership by 2% to 392,642 units (SEC Form 4)

Chief Operating Officer Gault Cheryl exercised 5,000 shares at a strike of $1.80 and sold $150,486 worth of shares (5,000 units at $30.10) (SEC Form 4)

Chief Executive Officer Ceesay Abraham sold $275,047 worth of shares (10,916 units at $25.20), decreasing direct ownership by 1% to 573,746 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $214,091 worth of shares (8,500 units at $25.19), decreasing direct ownership by 2% to 401,142 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $219,196 worth of shares (8,500 units at $25.79), decreasing direct ownership by 2% to 409,642 units (SEC Form 4)

Chief Executive Officer Ceesay Abraham sold $281,729 worth of shares (10,916 units at $25.81), decreasing direct ownership by 1.00% to 579,579 units (SEC Form 4)

Chief Executive Officer Ceesay Abraham sold $2,011,197 worth of shares (76,420 units at $26.32), decreasing direct ownership by 7% to 585,412 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $205,649 worth of shares (8,500 units at $24.19), decreasing direct ownership by 2% to 418,142 units (SEC Form 4)

Director Huber Reid M bought $499,374 worth of shares (20,400 units at $24.48) (SEC Form 4)

Director Paul Steven M bought $1,027,111 worth of shares (41,666 units at $24.65) (SEC Form 4)

Director Young Wendy B. bought $79,100 worth of shares (3,500 units at $22.60), increasing direct ownership by 58% to 9,500 units (SEC Form 4)

Chief Operating Officer Gault Cheryl sold $191,650 worth of shares (5,000 units at $38.33) and exercised 5,000 shares at a strike of $1.80 (SEC Form 4)

Chief Scientific Officer Bredt David sold $127,466 worth of shares (8,500 units at $15.00), decreasing direct ownership by 2% to 426,642 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $118,962 worth of shares (8,500 units at $14.00), decreasing direct ownership by 2% to 435,142 units (SEC Form 4)

SEC Form 4 filed by Director Young Wendy B.

SEC Form 4 filed by Director Sanchez Ramiro

SEC Form 4 filed by Director Maraganore John

SEC Form 4 filed by Director Healy James

SEC Form 4 filed by Director Perez Robert J

SEC Form 4 filed by Director Silva Paul M

Chief Scientific Officer Bredt David sold $93,522 worth of shares (8,500 units at $11.00), decreasing direct ownership by 2% to 443,642 units (SEC Form 4)

SEC Form 4 filed by Director Huber Reid M

SEC Form 4 filed by Director Paul Steven M

Chief Scientific Officer Bredt David sold $81,262 worth of shares (8,500 units at $9.56), decreasing direct ownership by 2% to 452,142 units (SEC Form 4)

Chief Scientific Officer Bredt David sold $81,310 worth of shares (8,500 units at $9.57), decreasing direct ownership by 2% to 460,642 units (SEC Form 4)

SEC Form 4 filed by Chief Medical Officer Sevigny Jeffrey

Chief Scientific Officer Bredt David sold $92,205 worth of shares (8,500 units at $10.85), decreasing direct ownership by 2% to 469,142 units (SEC Form 4)

Chief Financial Officer Ignelzi Troy A. bought $100,988 worth of shares (10,000 units at $10.10) (SEC Form 4)

Director Young Wendy B. bought $61,250 worth of shares (6,000 units at $10.21) (SEC Form 4)

Chief Operating Officer Gault Cheryl was granted 13,987 shares, increasing direct ownership by 9% to 171,928 units (SEC Form 4)

SEC Form 3 filed by new insider Sevigny Jeffrey

SEC Form 4 filed by Chief Financial Officer Ignelzi Troy A.

SEC Form 4 filed by Chief Scientific Officer Bredt David

SEC Form 4 filed by Chief Executive Officer Ceesay Abraham

SEC Form 4 filed by Chief Development Officer Yeleswaram Krishnaswamy

SEC Form 4 filed by Chief Operating Officer Gault Cheryl

SEC Form 4 filed by Director Young Wendy B.