PTGX insider transactions

Director Waddill William D. exercised 9,000 shares at a strike of $11.80 and sold $896,760 worth of shares (9,000 units at $99.64) as part of a pre-agreed trading plan (SEC Form 4)

Amendment: President and CEO Patel Dinesh V Ph D exercised 75,000 shares at a strike of $21.58 and sold $7,509,000 worth of shares (75,000 units at $100.12) as part of a pre-agreed trading plan (SEC Form 4)

President and CEO Patel Dinesh V Ph D sold $7,509,000 worth of shares (75,000 units at $100.12) and exercised 75,000 shares at a strike of $21.58 (SEC Form 4)

Director Giraudo Bryan exercised 36,000 shares at a strike of $6.63 and sold $5,918,880 worth of shares (59,130 units at $100.10), increasing direct ownership by 62% to 12,695 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 1,460 shares, decreasing direct ownership by 0.28% to 523,478 units (SEC Form 4)

SEC Form 4 filed by Ali Asif

SEC Form 4 filed by Molina Arturo Md

SEC Form 4 filed by Selick Harold E

SEC Form 4 filed by Ali Asif

SEC Form 4 filed by Patel Dinesh V Ph D

Director Williams Lewis T exercised 18,000 shares at a strike of $10.84 and sold $1,483,560 worth of shares (18,000 units at $82.42) (SEC Form 4)

Director Waddill William D. exercised 20,000 shares at a strike of $8.31 and sold $1,673,600 worth of shares (20,000 units at $83.68) (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 6,000 shares, exercised 48,273 shares at a strike of $10.79 and sold $4,063,743 worth of shares (48,273 units at $84.18), decreasing direct ownership by 1% to 574,505 units (SEC Form 4)

Chief Financial Officer Ali Asif exercised 28,000 shares at a strike of $16.18 and sold $3,841,037 worth of shares (46,203 units at $83.13), decreasing direct ownership by 23% to 60,320 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md sold $1,905,305 worth of shares (23,151 units at $82.30) and exercised 10,000 shares at a strike of $8.04, decreasing direct ownership by 14% to 84,115 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md sold $784,715 worth of shares (9,514 units at $82.48), decreasing direct ownership by 9% to 97,266 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D sold $2,840,446 worth of shares (34,438 units at $82.48), decreasing direct ownership by 6% to 580,505 units (SEC Form 4)

Chief Financial Officer Ali Asif sold $708,338 worth of shares (8,588 units at $82.48), decreasing direct ownership by 10% to 78,077 units (SEC Form 4)

Director Selick Harold E exercised 14,299 shares at a strike of $4.21, increasing direct ownership by 31% to 60,845 units (SEC Form 4)

Director Selick Harold E was granted 2,695 shares, increasing direct ownership by 6% to 46,546 units (SEC Form 4)

Director Waddill William D. was granted 2,695 shares, increasing direct ownership by 53% to 7,825 units (SEC Form 4)

Director Giraudo Bryan was granted 2,695 shares, increasing direct ownership by 18% to 17,825 units (SEC Form 4)

Director Williams Lewis T was granted 2,695 shares, increasing direct ownership by 53% to 7,825 units (SEC Form 4)

Director O'Dowd Sarah A was granted 2,695 shares, increasing direct ownership by 53% to 7,825 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D was granted 95,400 shares, increasing direct ownership by 18% to 614,943 units (SEC Form 4)

Chief Financial Officer Ali Asif was granted 25,600 shares, increasing direct ownership by 42% to 86,665 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md was granted 25,600 shares, increasing direct ownership by 32% to 106,780 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 440 shares, decreasing direct ownership by 0.08% to 519,543 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md sold $229,896 worth of shares (2,712 units at $84.77), decreasing direct ownership by 3% to 81,180 units (SEC Form 4)

Director Waddill William D. exercised 12,000 shares at a strike of $6.98 and sold $979,480 worth of shares (12,000 units at $81.62) (SEC Form 4)

Director Waddill William D. sold $257,000 worth of shares (4,000 units at $64.25), decreasing direct ownership by 44% to 5,130 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 620 shares, decreasing direct ownership by 0.12% to 519,983 units (SEC Form 4)

Director Waddill William D. sold $237,000 worth of shares (4,000 units at $59.25), decreasing direct ownership by 30% to 9,130 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D sold $570,534 worth of shares (10,415 units at $54.78), decreasing direct ownership by 2% to 520,603 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D was granted 25,000 shares and sold $2,880,044 worth of shares (52,444 units at $54.92), decreasing direct ownership by 5% to 531,018 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 5,000 shares, decreasing direct ownership by 0.89% to 558,462 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 1,355 shares, decreasing direct ownership by 0.24% to 562,905 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md exercised 20,000 shares at a strike of $8.04 and sold $1,125,400 worth of shares (20,000 units at $56.27) (SEC Form 4)

Director Selick Harold E exercised 10,725 shares at a strike of $1.16, increasing direct ownership by 32% to 43,851 units (SEC Form 4)

Chief Financial Officer Ali Asif sold $80,776 worth of shares (1,756 units at $46.00), decreasing direct ownership by 3% to 61,065 units (SEC Form 4)

Director Waddill William D. sold $217,000 worth of shares (4,000 units at $54.25), decreasing direct ownership by 23% to 13,130 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md exercised 30,514 shares at a strike of $24.48 and sold $1,700,850 worth of shares (30,514 units at $55.74) (SEC Form 4)

Chief Financial Officer Ali Asif exercised 24,903 shares at a strike of $14.90 and sold $1,462,553 worth of shares (24,903 units at $58.73) (SEC Form 4)

President and CEO Patel Dinesh V Ph D exercised 24,000 shares at a strike of $4.21, increasing direct ownership by 4% to 564,260 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D sold $204,607 worth of shares (5,359 units at $38.18), decreasing direct ownership by 0.98% to 540,260 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md sold 3,640 shares, decreasing direct ownership by 4% to 83,892 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D covered exercise/tax liability with 12,636 shares, decreasing direct ownership by 2% to 545,619 units (SEC Form 4)

Chief Financial Officer Ali Asif sold 3,918 shares, decreasing direct ownership by 6% to 62,821 units (SEC Form 4)

Director Waddill William D. was granted 5,130 shares, increasing direct ownership by 43% to 17,130 units (SEC Form 4)

Director O'Dowd Sarah A was granted 5,130 shares (SEC Form 4)

Director Williams Lewis T was granted 5,130 shares (SEC Form 4)

Director Selick Harold E was granted 5,130 shares, increasing direct ownership by 18% to 33,126 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D was granted 149,800 shares, increasing direct ownership by 37% to 558,255 units (SEC Form 4)

Director Giraudo Bryan was granted 5,130 shares, increasing direct ownership by 51% to 15,130 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md was granted 41,088 shares, increasing direct ownership by 88% to 87,532 units (SEC Form 4)

Chief Financial Officer Ali Asif was granted 31,779 shares, increasing direct ownership by 91% to 66,739 units (SEC Form 4)

Chief Medical Officer Molina Arturo Md exercised 31,529 shares at a strike of $8.04 and sold $1,414,402 worth of shares (31,529 units at $44.86) (SEC Form 4)

Chief Development Officer Gupta Suneel exercised 205,450 shares at a strike of $8.40 and sold $5,635,430 worth of shares (122,628 units at $45.96), increasing direct ownership by 45% to 267,433 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 7,000 shares, exercised 1,727 shares at a strike of $21.58 and sold $4,680,749 worth of shares (100,000 units at $46.81), decreasing direct ownership by 20% to 408,455 units (SEC Form 4)

President and CEO Patel Dinesh V Ph D gifted 1,000 shares, decreasing direct ownership by 0.19% to 513,415 units (SEC Form 4)