PEPG insider transactions

Chief Technical Officer Kasraian Kasra sold $1,739 worth of shares (1,233 units at $1.41) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 50,074 units (SEC Form 4) (withholding tax)

EVP, Head of R&D Streck Paul sold $11,709 worth of shares (1,879 units at $6.23), decreasing direct ownership by 2% to 76,226 units (SEC Form 4)

Chief Financial Officer Donnelly Noel sold $12,988 worth of shares (2,084 units at $6.23), decreasing direct ownership by 2% to 111,603 units (SEC Form 4)

President and CEO Mcarthur James G sold $32,876 worth of shares (5,275 units at $6.23), decreasing direct ownership by 2% to 296,326 units (SEC Form 4)

Chief Business & Legal Officer Vittiglio Joseph was granted 30,717 shares, increasing direct ownership by 88% to 65,717 units (SEC Form 4)

Chief Technical Officer Kasraian Kasra was granted 34,557 shares, increasing direct ownership by 206% to 51,307 units (SEC Form 4)

EVP, Head of R&D Streck Paul was granted 50,300 shares, increasing direct ownership by 181% to 78,105 units (SEC Form 4)

Chief Financial Officer Donnelly Noel was granted 76,793 shares, increasing direct ownership by 208% to 113,687 units (SEC Form 4)

President and CEO Mcarthur James G was granted 187,688 shares, increasing direct ownership by 165% to 301,601 units (SEC Form 4)

SEC Form 4 filed by EVP, Head of R&D Streck Paul

SEC Form 4 filed by President and CEO Mcarthur James G

SEC Form 4 filed by Chief Financial Officer Donnelly Noel

Chief Business & Legal Officer Vittiglio Joseph was granted 35,000 shares (SEC Form 4)

SEC Form 3 filed by new insider Vittiglio Joseph

Former 10% Owner Oxford Science Enterprises Plc bought $640,000 worth of shares (200,000 units at $3.20), increasing direct ownership by 4% to 4,955,388 units (SEC Form 4)

Director Ra Capital Management, L.P. bought $30,000,000 worth of shares (9,375,000 units at $3.20) (SEC Form 4)

SEC Form 4 filed by Director Ra Capital Management, L.P.

SEC Form 4 filed by Director Mayer Howard

SEC Form 4 filed by Director Henson Heidi

SEC Form 4 filed by Director Keating Laurie

SEC Form 4 filed by Director Dable Habib J

SEC Form 4 filed by Director Resnick Joshua

EVP, Head of R&D Streck Paul bought $10,393 worth of shares (8,375 units at $1.24), increasing direct ownership by 43% to 27,805 units (SEC Form 4)

Chief Technical Officer Kasraian Kasra was granted 16,750 shares (SEC Form 4)

SEC Form 3 filed by new insider Kasraian Kasra

President and CEO Mcarthur James G bought $13,550 worth of shares (10,000 units at $1.35), increasing direct ownership by 10% to 113,913 units (SEC Form 4)

President and CEO Mcarthur James G bought $47,725 worth of shares (41,500 units at $1.15), increasing direct ownership by 66% to 103,913 units (SEC Form 4)

SEC Form 4 filed by Director Finer Mitchell H.

SEC Form 4 filed by Director Wyman Lisa

SEC Form 3 filed by new insider Finer Mitchell H.

SEC Form 3 filed by new insider Wyman Lisa

General Counsel Delena Mary Beth was granted 13,400 shares, increasing direct ownership by 855% to 14,968 units (SEC Form 4)

Chief Financial Officer Donnelly Noel was granted 23,283 shares, increasing direct ownership by 1,392% to 24,956 units (SEC Form 4)

EVP, Head of R&D Streck Paul was granted 19,430 shares (SEC Form 4)

President and CEO Mcarthur James G was granted 60,719 shares, increasing direct ownership by 3,584% to 62,413 units (SEC Form 4)

General Counsel Delena Mary Beth was granted 3,000 shares and sold $2,406 worth of shares (1,432 units at $1.68) (SEC Form 4)

Chief Financial Officer Donnelly Noel was granted 3,200 shares and sold $2,565 worth of shares (1,527 units at $1.68) (SEC Form 4)

SEC Form 4 filed by EVP, Head of R&D Streck Paul

SEC Form 3 filed by new insider Streck Paul

Chief Medical Officer Mellion Michelle L exercised 7,772 shares at a strike of $10.21 and sold $140,360 worth of shares (7,772 units at $18.06) (SEC Form 4)

Chief Medical Officer Mellion Michelle L sold $229,804 worth of shares (12,625 units at $18.20) and exercised 12,625 shares at a strike of $10.21 (SEC Form 4)

Chief Medical Officer Mellion Michelle L exercised 9,189 shares at a strike of $10.21 and sold $165,578 worth of shares (9,189 units at $18.02) (SEC Form 4)

Chief Medical Officer Mellion Michelle L sold $16,428 worth of shares (912 units at $18.01) and exercised 912 shares at a strike of $10.21 (SEC Form 4)

Chief Medical Officer Mellion Michelle L sold $168,427 worth of shares (9,260 units at $18.19) and exercised 9,260 shares at a strike of $10.21 (SEC Form 4)

SEC Form 4 filed by Director Ra Capital Management, L.P.

SEC Form 4 filed by Director Henson Heidi

SEC Form 4 filed by Director Keating Laurie

SEC Form 4 filed by Director Resnick Joshua

SEC Form 4 filed by Director Ashton Christopher

SEC Form 4 filed by Director Mayer Howard

SEC Form 4 filed by Director Dable Habib J

Chief Medical Officer Mellion Michelle L exercised 1,586 shares at a strike of $10.21 and sold $28,637 worth of shares (1,586 units at $18.06) (SEC Form 4)

Mellion Michelle L exercised 8,656 shares at a strike of $10.21 and sold $156,460 worth of shares (8,656 units at $18.08) (SEC Form 4)

Svenstrup Niels sold $134,100 worth of shares (10,000 units at $13.41), closing all direct ownership in the company (SEC Form 4)

Oxford Science Enterprises Plc bought $10,559,640 worth of shares (879,970 units at $12.00), increasing direct ownership by 23% to 4,755,388 units (SEC Form 4) (Amendment)

SEC Form 4 filed by Svenstrup Niels

SEC Form 4 filed by Mcarthur James G

SEC Form 4 filed by Donnelly Noel

SEC Form 4 filed by Mellion Michelle L

Ra Capital Management, L.P. bought $27,212,790 worth of shares (2,557,593 units at $10.64) (SEC Form 4)