MIRM insider transactions

Director Cardon Lon converted options into 3,977 shares, increasing direct ownership by 70% to 9,680 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher exercised 30,000 shares at a strike of $2.94 and sold $2,875,103 worth of shares (30,000 units at $95.84) as part of a pre-agreed trading plan (SEC Form 4)

Director Walbert Timothy P converted options into 3,977 shares, increasing direct ownership by 70% to 9,680 units (SEC Form 4)

Director Fischer Laurent converted options into 3,977 shares, increasing direct ownership by 59% to 10,727 units (SEC Form 4)

Director Ramasastry Saira converted options into 3,977 shares and sold $397,700 worth of shares (3,977 units at $100.00) as part of a pre-agreed trading plan (SEC Form 4)

Director Ramasastry Saira exercised 2,000 shares at a strike of $23.51 and sold $218,940 worth of shares (2,000 units at $109.47) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Ramasastry Saira

PRESIDENT AND COO Radovich Peter converted options into 30,220 shares and sold $1,519,015 worth of shares (16,515 units at $91.98), increasing direct ownership by 52% to 40,272 units (SEC Form 4)

CHIEF MEDICAL OFFICER Quan Joanne converted options into 13,334 shares and sold $670,243 worth of shares (7,287 units at $91.98), increasing direct ownership by 47% to 18,864 units (SEC Form 4)

Director Ramasastry Saira exercised 2,000 shares at a strike of $23.51 and sold $181,520 worth of shares (2,000 units at $90.76) (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher converted options into 75,000 shares and sold $3,769,714 worth of shares (40,985 units at $91.98), increasing direct ownership by 21% to 194,309 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Bjerkholt Eric converted options into 13,334 shares and sold $670,243 worth of shares (7,287 units at $91.98), increasing direct ownership by 14% to 49,788 units (SEC Form 4)

SVP, GLOBAL CONTROLLER Howe Jolanda converted options into 8,658 shares and sold $435,239 worth of shares (4,732 units at $91.98), increasing direct ownership by 87% to 8,429 units (SEC Form 4)

PRESIDENT AND COO Radovich Peter exercised 5,912 shares at a strike of $15.87, increasing direct ownership by 29% to 26,567 units (SEC Form 4)

Director Ramasastry Saira exercised 2,000 shares at a strike of $23.51 and sold $204,180 worth of shares (2,000 units at $102.09) (SEC Form 4)

PRESIDENT AND COO Radovich Peter sold $271,792 worth of shares (2,631 units at $103.30), decreasing direct ownership by 11% to 20,655 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher sold $940,888 worth of shares (9,108 units at $103.30), decreasing direct ownership by 5% to 160,294 units (SEC Form 4)

SVP, GLOBAL CONTROLLER Howe Jolanda converted options into 1,771 shares and sold $99,998 worth of shares (968 units at $103.30), increasing direct ownership by 22% to 4,503 units (SEC Form 4)

SEC Form 4 filed by CHIEF FINANCIAL OFFICER Bjerkholt Eric

SEC Form 4 filed by CHIEF EXECUTIVE OFFICER Peetz Christopher

SEC Form 4 filed by PRESIDENT AND COO Radovich Peter

SEC Form 4 filed by SVP, GLOBAL CONTROLLER Howe Jolanda

SEC Form 4 filed by CHIEF MEDICAL OFFICER Quan Joanne

CHIEF FINANCIAL OFFICER Bjerkholt Eric converted options into 2,667 shares and sold $101,290 worth of shares (1,053 units at $96.19), increasing direct ownership by 4% to 43,741 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher converted options into 12,500 shares and sold $657,088 worth of shares (6,831 units at $96.19), increasing direct ownership by 3% to 169,402 units (SEC Form 4)

PRESIDENT AND COO Radovich Peter converted options into 5,750 shares and sold $302,331 worth of shares (3,143 units at $96.19), increasing direct ownership by 13% to 23,286 units (SEC Form 4)

SVP, GLOBAL CONTROLLER Howe Jolanda converted options into 1,500 shares and sold $80,994 worth of shares (842 units at $96.19), increasing direct ownership by 22% to 3,700 units (SEC Form 4)

Director Heron Patrick J acquired 159,277 shares and bought $8,999,984 worth of shares (131,425 units at $68.48) (SEC Form 4)

SVP, GLOBAL CONTROLLER Howe Jolanda converted options into 1,542 shares and sold $86,419 worth of shares (926 units at $93.33), increasing direct ownership by 25% to 3,042 units (SEC Form 4)

CHIEF MEDICAL OFFICER Quan Joanne converted options into 3,334 shares and sold $170,039 worth of shares (1,822 units at $93.33), increasing direct ownership by 13% to 12,817 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher converted options into 12,797 shares and sold $662,422 worth of shares (7,098 units at $93.33), increasing direct ownership by 4% to 163,733 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Bjerkholt Eric converted options into 3,334 shares and sold $132,615 worth of shares (1,421 units at $93.33), increasing direct ownership by 5% to 42,127 units (SEC Form 4)

PRESIDENT AND COO Radovich Peter converted options into 4,167 shares and sold $222,301 worth of shares (2,382 units at $93.33), increasing direct ownership by 9% to 20,679 units (SEC Form 4)

CHIEF MEDICAL OFFICER Quan Joanne sold $623,853 worth of shares (6,911 units at $90.27) and converted options into 12,500 shares, increasing direct ownership by 98% to 11,305 units (SEC Form 4)

Director Ramasastry Saira exercised 2,000 shares at a strike of $23.51 and sold $181,980 worth of shares (2,000 units at $90.99) (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher gifted 21,070 shares (SEC Form 4)

Director Ramasastry Saira exercised 5,000 shares at a strike of $23.51 and sold $400,000 worth of shares (5,000 units at $80.00) (SEC Form 4)

Director Grey Michael G exercised 50,000 shares at a strike of $2.94 and sold $3,900,000 worth of shares (50,000 units at $78.00) (SEC Form 4)

Director Ramasastry Saira exercised 2,000 shares at a strike of $23.51 and sold $139,460 worth of shares (2,000 units at $69.73) (SEC Form 4)

Director Grey Michael G exercised 50,000 shares at a strike of $2.94 and sold $3,700,000 worth of shares (50,000 units at $74.00) (SEC Form 4)

Director Grey Michael G exercised 50,000 shares at a strike of $2.94 and sold $3,500,000 worth of shares (50,000 units at $70.00) (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher exercised 19,133 shares at a strike of $19.24, increasing direct ownership by 14% to 158,034 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Bjerkholt Eric converted options into 18,333 shares and sold $728,024 worth of shares (9,578 units at $76.01), increasing direct ownership by 28% to 39,945 units (SEC Form 4)

Director Brege Laura sold $1,264,868 worth of shares (17,000 units at $74.40) and exercised 17,000 shares at a strike of $15.00 (SEC Form 4)

Director Ramasastry Saira exercised 17,000 shares at a strike of $23.51 and sold 17,000 shares (SEC Form 4)

CHIEF FINANCIAL OFFICER Bjerkholt Eric sold 8,000 shares and exercised 2,954 shares at a strike of $26.49, decreasing direct ownership by 14% to 31,190 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher exercised 40,000 shares at a strike of $2.94 and sold $2,480,000 worth of shares (40,000 units at $62.00) (SEC Form 4)

SVP, GLOBAL CONTROLLER Howe Jolanda sold $580,000 worth of shares (10,000 units at $58.00) and exercised 10,000 shares at a strike of $6.27 (SEC Form 4)

CHIEF EXECUTIVE OFFICER Peetz Christopher exercised 40,000 shares at a strike of $2.94 and sold $2,210,040 worth of shares (40,000 units at $55.25) (SEC Form 4)

SVP, GLOBAL CONTROLLER Howe Jolanda converted options into 1,041 shares and sold $50,624 worth of shares (1,041 units at $48.63) (SEC Form 4)

Director Fairey William sold $155,091 worth of shares (3,203 units at $48.42), decreasing direct ownership by 56% to 2,500 units (SEC Form 4)

Director Ramasastry Saira sold $377,843 worth of shares (8,203 units at $46.06) and exercised 2,500 shares at a strike of $14.12, closing all direct ownership in the company (SEC Form 4)

Director Ramasastry Saira converted options into 5,703 shares (SEC Form 4)

Director Heron Patrick J converted options into 5,703 shares (SEC Form 4)

SEC Form 4 filed by Director Grey Michael G

Director Brege Laura converted options into 5,703 shares, increasing direct ownership by 57% to 15,703 units (SEC Form 4)

Director Fairey William converted options into 5,703 shares (SEC Form 4)

Director Cardon Lon converted options into 5,703 shares (SEC Form 4)

SEC Form 4 filed by Director Fischer Laurent

Director Walbert Timothy P converted options into 5,703 shares (SEC Form 4)