MDGL insider transactions

Chief Medical Officer Soergel David sold $516,561 worth of shares (1,042 units at $495.74) as part of a pre-agreed trading plan, decreasing direct ownership by 9% to 10,033 units (SEC Form 4)

Director Levy Richard S sold $2,928,716 worth of shares (5,682 units at $515.44) as part of a pre-agreed trading plan, decreasing direct ownership by 21% to 22,015 units (SEC Form 4)

Chief Medical Officer Soergel David sold $435,420 worth of shares (844 units at $515.90), decreasing direct ownership by 7% to 11,075 units (SEC Form 4) to satisfy tax liability

EVP and CFO Dier Mardi was granted 5,215 shares and sold $853,993 worth of shares (1,982 units at $430.87), increasing direct ownership by 35% to 12,490 units (SEC Form 4)

President and CEO Sibold William John was granted 14,995 shares and sold $718,316 worth of shares (1,663 units at $431.94), increasing direct ownership by 9% to 161,829 units (SEC Form 4)

General Counsel Kelley Shannon T was granted 4,017 shares and sold $155,498 worth of shares (360 units at $431.94), increasing direct ownership by 43% to 12,138 units (SEC Form 4)

Chief Commercial Officer Huntsman Carole was granted 3,989 shares and sold $180,983 worth of shares (419 units at $431.94), increasing direct ownership by 39% to 12,692 units (SEC Form 4)

Director Taub Rebecca sold $212,083 worth of shares (491 units at $431.94), decreasing direct ownership by 0.11% to 452,213 units (SEC Form 4)

Chief Medical Officer Soergel David was granted 4,374 shares, increasing direct ownership by 58% to 11,919 units (SEC Form 4)

EVP and CFO Dier Mardi sold $505,389 worth of shares (1,183 units at $427.21), decreasing direct ownership by 11% to 9,257 units (SEC Form 4)

Director Levy Richard S exercised 2,500 shares at a strike of $7.36, increasing direct ownership by 10% to 27,697 units (SEC Form 4)

Director Levy Richard S exercised 4,000 shares at a strike of $16.46, increasing direct ownership by 19% to 25,197 units (SEC Form 4)

Chief Commercial Officer Huntsman Carole sold $449,339 worth of shares (910 units at $493.78), decreasing direct ownership by 9% to 9,122 units (SEC Form 4)

President and CEO Sibold William John sold $776,546 worth of shares (1,577 units at $492.42), decreasing direct ownership by 1% to 148,497 units (SEC Form 4)

Director Taub Rebecca sold $318,596 worth of shares (647 units at $492.42), decreasing direct ownership by 0.14% to 452,704 units (SEC Form 4)

General Counsel Kelley Shannon T sold $344,173 worth of shares (692 units at $497.36), decreasing direct ownership by 8% to 8,481 units (SEC Form 4)

Director Taub Rebecca sold $1,098,343 worth of shares (2,238 units at $490.77), decreasing direct ownership by 0.49% to 453,351 units (SEC Form 4)

Chief Accounting Officer Thakkar Rita was granted 2,398 shares (SEC Form 4)

SEC Form 3 filed by new insider Thakkar Rita

Director Friedman Paul A exercised 280 shares at a strike of $15.80 and sold $154,348 worth of shares (280 units at $551.24) (SEC Form 4)

Director Friedman Paul A exercised 24,520 shares at a strike of $15.80 and sold $12,808,957 worth of shares (24,520 units at $522.39) (SEC Form 4)

Director Taub Rebecca exercised 240 shares at a strike of $15.80 and sold $132,080 worth of shares (240 units at $550.33) (SEC Form 4)

Director Taub Rebecca exercised 18,410 shares at a strike of $15.80 and sold $9,617,312 worth of shares (18,410 units at $522.40) (SEC Form 4)

Director Friedman Paul A exercised 24,800 shares at a strike of $15.80 and sold $13,694,158 worth of shares (24,800 units at $552.18) (SEC Form 4)

Director Taub Rebecca exercised 18,650 shares at a strike of $15.80, sold $10,297,573 worth of shares (18,650 units at $552.15) and gifted 5,455 shares, decreasing direct ownership by 1% to 455,589 units (SEC Form 4)

President and CEO Sibold William John converted options into 50,000 shares and sold $1,380,816 worth of shares (2,400 units at $575.34), increasing direct ownership by 46% to 150,074 units (SEC Form 4)

EVP and CFO Dier Mardi exercised 4,173 shares at a strike of $251.63 and sold $2,413,416 worth of shares (4,173 units at $578.34) (SEC Form 4)

Chief Commercial Officer Huntsman Carole sold $1,082,986 worth of shares (1,958 units at $553.11), decreasing direct ownership by 16% to 10,032 units (SEC Form 4)

Director Levy Richard S exercised 8,500 shares at a strike of $13.78 and sold $4,428,198 worth of shares (8,500 units at $520.96) (SEC Form 4)

Director Bate Kenneth exercised 16,575 shares at a strike of $205.07 and sold $8,027,354 worth of shares (16,575 units at $484.30) (SEC Form 4)

President and CEO Sibold William John sold $3,243,741 worth of shares (7,279 units at $445.63), decreasing direct ownership by 7% to 102,474 units (SEC Form 4)

President and CEO Sibold William John sold $3,047,756 worth of shares (7,616 units at $400.18), decreasing direct ownership by 6% to 109,753 units (SEC Form 4)

Director Baker Bros. Advisors Lp bought $36,941,197 worth of shares (97,065 units at $380.58) (SEC Form 4)

Director Baker Bros. Advisors Lp bought $24,979,827 worth of shares (68,618 units at $364.04) (SEC Form 4)

General Counsel Kelley Shannon T sold $479,627 worth of shares (1,304 units at $367.81), decreasing direct ownership by 12% to 9,173 units (SEC Form 4)

Director Bate Kenneth exercised 10,000 shares at a strike of $16.46 and sold $3,652,009 worth of shares (10,000 units at $365.20) (SEC Form 4)

Director Friedman Paul A exercised 129,172 shares at a strike of $9.45 and sold $47,825,149 worth of shares (129,172 units at $370.24) (SEC Form 4)

Director Friedman Paul A exercised 46,808 shares at a strike of $9.45 and sold $16,631,386 worth of shares (46,808 units at $355.31) (SEC Form 4)

Director Taub Rebecca exercised 46,463 shares at a strike of $9.45 and sold $16,509,032 worth of shares (46,463 units at $355.32) (SEC Form 4)

Director Brennan Daniel J. was granted 967 shares (SEC Form 4)

SEC Form 3 filed by new insider Brennan Daniel J.

Director Taub Rebecca exercised 1,000 shares at a strike of $9.45 and sold $350,005 worth of shares (1,000 units at $350.00) (SEC Form 4)

Director Friedman Paul A exercised 1,400 shares at a strike of $9.45 and sold $490,044 worth of shares (1,400 units at $350.03) (SEC Form 4)

Director Friedman Paul A sold $10,198,844 worth of shares (28,876 units at $353.19) and exercised 28,876 shares at a strike of $9.45 (SEC Form 4)

Director Taub Rebecca exercised 29,101 shares at a strike of $9.45 and sold $10,278,098 worth of shares (29,101 units at $353.19) (SEC Form 4)

Director Bate Kenneth was granted 715 shares, increasing direct ownership by 37% to 2,627 units (SEC Form 4)

Director Levy Richard S was granted 715 shares, increasing direct ownership by 3% to 21,197 units (SEC Form 4)

Director Fouse Jacqualyn A was granted 203 shares, increasing direct ownership by 23% to 1,097 units (SEC Form 4)

Director Baker Bros. Advisors Lp was granted 2,860 shares (SEC Form 4)

Director Daly James M was granted 715 shares, increasing direct ownership by 37% to 2,627 units (SEC Form 4)

Director Friedman Paul A was granted 715 shares, increasing direct ownership by 0.38% to 187,164 units (SEC Form 4)

Chief Medical Officer Soergel David was granted 7,545 shares (SEC Form 4)

SEC Form 3 filed by new insider Soergel David

Director Craves Fred B exercised 15,470 shares at a strike of $82.90 and sold $5,082,480 worth of shares (15,470 units at $328.54) (SEC Form 4)

SVP and CFO Dier Mardi sold $83,344 worth of shares (258 units at $323.04), decreasing direct ownership by 2% to 10,440 units (SEC Form 4)

Director Fouse Jacqualyn A was granted 894 shares (SEC Form 4)

SEC Form 3 filed by new insider Fouse Jacqualyn A

President and CEO Sibold William John was granted 13,066 shares, increasing direct ownership by 13% to 117,369 units (SEC Form 4)

SVP and CFO Dier Mardi was granted 3,784 shares, increasing direct ownership by 55% to 10,698 units (SEC Form 4)

Senior VP, Chief Pharma Dev. Waltermire Robert E. exercised 14,113 shares at a strike of $87.49, sold $4,817,104 worth of shares (14,113 units at $341.32) and was granted 2,061 shares, increasing direct ownership by 55% to 5,789 units (SEC Form 4)