INSM insider transactions

Chief Operating Officer Adsett Roger sold $242,380 worth of shares (2,370 units at $102.27), decreasing direct ownership by 2% to 98,603 units (SEC Form 4) (tax liability)

Chief Financial Officer Bonstein Sara sold $245,857 worth of shares (2,404 units at $102.27), decreasing direct ownership by 3% to 69,082 units (SEC Form 4) (tax withholding)

Chief Legal Officer Smith Michael Alexander sold $220,801 worth of shares (2,159 units at $102.27), decreasing direct ownership by 5% to 39,454 units (SEC Form 4) (tax liability)

Chief Medical Officer Flammer Martina M.D. sold $455,248 worth of shares (4,424 units at $102.90) as part of a pre-agreed trading plan, decreasing direct ownership by 7% to 60,486 units (SEC Form 4) to satisfy withholding obligation

Chair and CEO Lewis William sold $777,763 worth of shares (7,605 units at $102.27), decreasing direct ownership by 3% to 265,432 units (SEC Form 4) (for tax liability)

Chief Legal Officer Smith Michael Alexander sold $666,982 worth of shares (6,149 units at $108.47) as part of a pre-agreed trading plan, decreasing direct ownership by 13% to 41,613 units (SEC Form 4)

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $2,718,224 worth of shares (25,564 units at $106.33) as part of a pre-agreed trading plan, decreasing direct ownership by 5% to 273,037 units (SEC Form 4)

Chief Financial Officer Bonstein Sara sold $961,041 worth of shares (8,272 units at $116.18), decreasing direct ownership by 10% to 71,486 units (SEC Form 4) (withholding obligation)

Director Schafer Carol was granted 3,305 shares, increasing direct ownership by 5% to 66,622 units (SEC Form 4)

Chief Legal Officer Smith Michael Alexander sold $477,384 worth of shares (4,109 units at $116.18), decreasing direct ownership by 8% to 47,762 units (SEC Form 4) to satisfy tax liability

Chief Medical Officer Flammer Martina M.D. sold $2,128,892 worth of shares (18,333 units at $116.12) as part of a pre-agreed trading plan, decreasing direct ownership by 22% to 64,910 units (SEC Form 4) (tax liability)

Chief Operating Officer Adsett Roger sold $678,143 worth of shares (5,837 units at $116.18), decreasing direct ownership by 5% to 100,973 units (SEC Form 4) (for withholding tax)

Director Anderson Elizabeth M was granted 3,305 shares, increasing direct ownership by 6% to 62,034 units (SEC Form 4)

SEC Form 4 filed by Insmed Incorporated

Director Brennan David R was granted 3,305 shares, increasing direct ownership by 5% to 64,238 units (SEC Form 4)

Director Lee Leo was granted 3,305 shares, increasing direct ownership by 6% to 57,971 units (SEC Form 4)

Director Desjardins Clarissa was granted 3,305 shares, increasing direct ownership by 5% to 70,312 units (SEC Form 4)

Chair and CEO Lewis William sold $1,543,219 worth of shares (13,283 units at $116.18), decreasing direct ownership by 4% to 287,902 units (SEC Form 4) (withholding obligation)

Chief Medical Officer Flammer Martina M.D. exercised 12,949 shares at a strike of $17.07 and sold $1,300,121 worth of shares (12,949 units at $100.40) as part of a pre-agreed trading plan (SEC Form 4)

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $1,469,442 worth of shares (10,699 units at $137.34) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Lewis William

SEC Form 4 filed by Lewis William

SEC Form 4 filed by Adsett Roger

SEC Form 4 filed by Smith Michael Alexander

SEC Form 4 filed by Lewis William

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $1,562,328 worth of shares (10,699 units at $146.03) (SEC Form 4)

Director Sharoky Melvin Md gifted 100 shares, decreasing direct ownership by 0.04% to 242,776 units (SEC Form 4)

Director Sharoky Melvin Md gifted 1,072 shares and received a gift of 972 shares, decreasing direct ownership by 0.44% to 242,876 units (SEC Form 4)

Chief Legal Officer Smith Michael Alexander exercised 20,248 shares at a strike of $17.07 and sold $3,859,157 worth of shares (24,774 units at $155.77), decreasing direct ownership by 8% to 51,871 units (SEC Form 4)

Director Brennan David R gifted 6,000 shares, decreasing direct ownership by 9% to 60,933 units (SEC Form 4)

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $1,615,257 worth of shares (10,699 units at $150.97) (SEC Form 4)

Director Mcgirr David W J gifted 53,400 shares and received a gift of 53,400 shares, decreasing direct ownership by 55% to 44,323 units (SEC Form 4)

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $1,979,764 worth of shares (13,396 units at $147.79), decreasing direct ownership by 0.89% to 301,185 units (SEC Form 4)

Chief Medical Officer Flammer Martina M.D. sold $132,470 worth of shares (869 units at $152.44), decreasing direct ownership by 1% to 83,243 units (SEC Form 4)

Chief Operating Officer Adsett Roger sold $123,530 worth of shares (791 units at $156.17), decreasing direct ownership by 0.74% to 106,810 units (SEC Form 4)

Chief Financial Officer Bonstein Sara sold $116,942 worth of shares (748 units at $156.34), decreasing direct ownership by 0.93% to 79,758 units (SEC Form 4)

Chair and CEO Lewis William sold $470,427 worth of shares (3,009 units at $156.34), decreasing direct ownership by 0.98% to 303,882 units (SEC Form 4)

Chief Legal Officer Smith Michael Alexander sold $100,013 worth of shares (640 units at $156.27), decreasing direct ownership by 1% to 56,397 units (SEC Form 4)

Chief Medical Officer Flammer Martina M.D. exercised 7,982 shares at a strike of $65.72 and sold $1,357,796 worth of shares (8,777 units at $154.70), decreasing direct ownership by 0.94% to 84,112 units (SEC Form 4)

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $1,700,411 worth of shares (10,699 units at $158.93) (SEC Form 4)

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $3,247,349 worth of shares (19,215 units at $169.00), decreasing direct ownership by 3% to 306,891 units (SEC Form 4)

Chief Medical Officer Flammer Martina M.D. sold $351,341 worth of shares (1,887 units at $186.19), decreasing direct ownership by 2% to 84,907 units (SEC Form 4)

Chief Operating Officer Adsett Roger sold $746,711 worth of shares (4,290 units at $174.06), decreasing direct ownership by 4% to 107,601 units (SEC Form 4)

Chief Financial Officer Bonstein Sara sold $808,733 worth of shares (4,642 units at $174.22), decreasing direct ownership by 5% to 80,506 units (SEC Form 4)

Chief Medical Officer Flammer Martina M.D. exercised 8,570 shares at a strike of $26.43 and sold $2,877,139 worth of shares (16,530 units at $174.06), decreasing direct ownership by 8% to 86,794 units (SEC Form 4)

Chair and CEO Lewis William sold $1,683,950 worth of shares (9,676 units at $174.03), decreasing direct ownership by 3% to 315,407 units (SEC Form 4)

Chief Legal Officer Smith Michael Alexander sold $549,494 worth of shares (3,158 units at $174.00), decreasing direct ownership by 5% to 57,037 units (SEC Form 4)

Chief Financial Officer Bonstein Sara was granted 11,643 shares, increasing direct ownership by 16% to 85,148 units (SEC Form 4)

Chair and CEO Lewis William was granted 21,172 shares, increasing direct ownership by 7% to 325,083 units (SEC Form 4)

Chief Medical Officer Flammer Martina M.D. was granted 11,643 shares, exercised 12,303 shares at a strike of $25.80 and sold $2,108,507 worth of shares (12,303 units at $171.38), increasing direct ownership by 14% to 94,754 units (SEC Form 4)

Chief Operating Officer Adsett Roger was granted 5,998 shares, increasing direct ownership by 6% to 111,891 units (SEC Form 4)

Chief Legal Officer Smith Michael Alexander was granted 5,293 shares, increasing direct ownership by 10% to 60,195 units (SEC Form 4)

Chief People Strategy Officer Schaeffer Orlov S Nicole was granted 5,293 shares, exercised 87,290 shares at a strike of $13.91 and sold $15,293,422 worth of shares (87,290 units at $175.20), increasing direct ownership by 15% to 41,754 units (SEC Form 4)

Chair and CEO Lewis William exercised 10,699 shares at a strike of $24.94 and sold $1,786,457 worth of shares (10,699 units at $166.97) (SEC Form 4)

Director Sharoky Melvin Md sold $4,100,200 worth of shares (20,000 units at $205.01), decreasing direct ownership by 8% to 243,948 units (SEC Form 4)

Chair and CEO Lewis William sold $2,199,915 worth of shares (10,699 units at $205.62) and exercised 10,699 shares at a strike of $24.94 (SEC Form 4)

Chief Medical Officer Flammer Martina M.D. exercised 8,895 shares at a strike of $25.83 and sold $1,841,101 worth of shares (8,895 units at $206.98) (SEC Form 4)

Director Anderson Elizabeth M sold $1,022,900 worth of shares (5,000 units at $204.58), decreasing direct ownership by 8% to 58,729 units (SEC Form 4)

Director Lee Leo sold $14,692,249 worth of shares (75,000 units at $195.90), decreasing direct ownership by 58% to 54,677 units (SEC Form 4)

Director Anderson Elizabeth M sold $1,958,700 worth of shares (10,000 units at $195.87), decreasing direct ownership by 14% to 63,729 units (SEC Form 4)