INCY insider transactions

President, Global Head of R&D Cagnoni Pablo J sold $1,356,174 worth of shares (10,801 units at $125.56), decreasing direct ownership by 6% to 183,200 units (SEC Form 4)

President, Global Head of R&D Cagnoni Pablo J sold $1,305,422 worth of shares (10,640 units at $122.69), decreasing direct ownership by 5% to 204,804 units (SEC Form 4)

EVP & Chief Scientific Officer Mayes Patrick A exercised 2,207 shares at a strike of $106.47 and sold $273,646 worth of shares (2,207 units at $123.99) (SEC Form 4)

President, Global Head of R&D Cagnoni Pablo J sold $1,901,794 worth of shares (15,888 units at $119.70), decreasing direct ownership by 7% to 215,444 units (SEC Form 4)

EVP & Chief Scientific Officer Mayes Patrick A exercised 45,767 shares at a strike of $78.48 and sold $5,734,376 worth of shares (47,954 units at $119.58), decreasing direct ownership by 3% to 61,441 units (SEC Form 4)

SEC Form 4 filed by EVP, Head of Tech. Operations Morrissey Michael James

SEC Form 4 filed by EVP, Head of Incyte Intl Heeson Lee

Principal Accounting Officer Tray Thomas was granted 2,834 shares, increasing direct ownership by 15% to 21,699 units (SEC Form 4)

CMO & Head of Late-Stage Dev. Stein Steven H sold $215,348 worth of shares (1,877 units at $114.73) and was granted 9,798 shares, increasing direct ownership by 34% to 30,916 units (SEC Form 4)

EVP & Chief Scientific Officer Mayes Patrick A was granted 5,916 shares, increasing direct ownership by 10% to 63,628 units (SEC Form 4)

President, Global Head of R&D Cagnoni Pablo J was granted 13,403 shares, increasing direct ownership by 6% to 231,332 units (SEC Form 4)

EVP, Head of U.S. Commercial Issa Mohamed Khairie sold $125,706 worth of shares (1,093 units at $115.01) and was granted 7,857 shares, increasing direct ownership by 10% to 71,797 units (SEC Form 4)

EVP, Human Resources Basi Ramitpal K was granted 4,991 shares, increasing direct ownership by 77% to 11,497 units (SEC Form 4)

EVP, Chief Strategy Officer Gardner David H was granted 7,395 shares, increasing direct ownership by 78% to 16,824 units (SEC Form 4)

EVP & General Counsel Hoffman Richard A. was granted 7,395 shares, increasing direct ownership by 78% to 16,861 units (SEC Form 4)

Chief Executive Officer Meury William was granted 26,807 shares, increasing direct ownership by 17% to 183,129 units (SEC Form 4)

President, Global Head of R&D Cagnoni Pablo J covered exercise/tax liability with 22,919 shares, decreasing direct ownership by 10% to 217,929 units (SEC Form 4) (tax withholding)

EVP & Chief Scientific Officer Mayes Patrick A covered exercise/tax liability with 1,949 shares, decreasing direct ownership by 3% to 57,712 units (SEC Form 4) (tax liability)

Principal Accounting Officer Tray Thomas covered exercise/tax liability with 1,790 shares, decreasing direct ownership by 9% to 18,865 units (SEC Form 4) to cover withholding tax

CMO & Head of Late-Stage Dev. Stein Steven H sold $3,192,193 worth of shares (28,237 units at $113.05) and covered exercise/tax liability with 24,918 shares, decreasing direct ownership by 70% to 22,995 units (SEC Form 4) (for tax liability)

EVP, Head of U.S. Commercial Issa Mohamed Khairie covered exercise/tax liability with 1,099 shares, decreasing direct ownership by 2% to 65,033 units (SEC Form 4) to satisfy withholding tax

Chief Executive Officer Meury William covered exercise/tax liability with 4,779 shares, decreasing direct ownership by 3% to 156,322 units (SEC Form 4) (withholding tax)

EVP & Chief Scientific Officer Mayes Patrick A covered exercise/tax liability with 350 shares, decreasing direct ownership by 0.58% to 59,661 units (SEC Form 4) to cover taxes

Principal Accounting Officer Tray Thomas covered exercise/tax liability with 477 shares, decreasing direct ownership by 2% to 20,655 units (SEC Form 4) to satisfy withholding obligation

CMO & Head of Late-Stage Dev. Stein Steven H covered exercise/tax liability with 2,177 shares, decreasing direct ownership by 3% to 76,150 units (SEC Form 4) to cover withholding tax

Director Baker Bros. Advisors Lp was granted 800 shares (SEC Form 4)

Director Clancy Paul J was granted 252 shares, increasing direct ownership by 0.99% to 25,635 units (SEC Form 4)

Director Harrigan Edmund was granted 255 shares, increasing direct ownership by 1% to 23,019 units (SEC Form 4)

Director Baker Bros. Advisors Lp was granted 3,284 shares (SEC Form 4)

Director Harrigan Edmund was granted 1,642 shares, increasing direct ownership by 8% to 22,764 units (SEC Form 4)

Director Clancy Paul J was granted 1,642 shares, increasing direct ownership by 7% to 25,383 units (SEC Form 4)

Director Fouse Jacqualyn A was granted 1,642 shares, increasing direct ownership by 8% to 20,968 units (SEC Form 4)

Director Bienaime Jean Jacques was granted 1,642 shares, increasing direct ownership by 7% to 24,424 units (SEC Form 4)

Director High Katherine A was granted 1,642 shares, increasing direct ownership by 12% to 14,983 units (SEC Form 4)

Director Brawley Otis W was granted 1,642 shares, increasing direct ownership by 15% to 12,894 units (SEC Form 4)

Principal Accounting Officer Tray Thomas sold $263,900 worth of shares (2,639 units at $100.00) and exercised 2,639 shares at a strike of $83.83 (SEC Form 4)

President, Global Head of R&D Cagnoni Pablo J covered exercise/tax liability with 25,469 shares, decreasing direct ownership by 10% to 240,848 units (SEC Form 4) to cover taxes

Principal Accounting Officer Tray Thomas sold $199,665 worth of shares (2,051 units at $97.35), decreasing direct ownership by 9% to 21,132 units (SEC Form 4)

Director Bienaime Jean Jacques exercised 15,000 shares at a strike of $84.53 and covered exercise/tax liability with 13,059 shares, increasing direct ownership by 9% to 22,782 units (SEC Form 4)

Director Clancy Paul J exercised 15,000 shares at a strike of $84.53 and sold $1,423,950 worth of shares (15,000 units at $94.93) (SEC Form 4)

Amendment: CMO & Head of Late-Stage Dev. Stein Steven H was granted 44,124 shares, increasing direct ownership by 129% to 78,327 units (SEC Form 4)

Amendment: President, Global Head of R&D Cagnoni Pablo J was granted 31,517 shares, increasing direct ownership by 13% to 266,317 units (SEC Form 4)

Director Baker Bros. Advisors Lp exercised 30,000 shares at a strike of $84.53 (SEC Form 4)

EVP & Chief Financial Officer Upadhyay Suketu was granted 26,343 shares (SEC Form 4)

SEC Form 3 filed by new insider Upadhyay Suketu

SEC Form 4 filed by Cagnoni Pablo J

SEC Form 4 filed by Meury William

SEC Form 4 filed by Cagnoni Pablo J

SEC Form 4 filed by Stein Steven H

SEC Form 4 filed by Harrigan Edmund

SEC Form 4 filed by Baker Bros. Advisors Lp

SEC Form 4 filed by Clancy Paul J

SEC Form 4 filed by Trotta Matteo

SEC Form 4 filed by Cagnoni Pablo J

President, R&D Cagnoni Pablo J exercised 18,668 shares at a strike of $61.59 and sold $1,883,788 worth of shares (18,668 units at $100.91) (SEC Form 4)

EVP, Head of Tech. Operations Morrissey Michael James covered exercise/tax liability with 185 shares, decreasing direct ownership by 0.54% to 34,065 units (SEC Form 4)

EVP, Head of Incyte Intl Heeson Lee covered exercise/tax liability with 111 shares, decreasing direct ownership by 0.29% to 38,041 units (SEC Form 4)

SEC Form 4 filed by President, R&D Cagnoni Pablo J

EVP, Head of Incyte Intl Heeson Lee was granted 8,911 shares, increasing direct ownership by 30% to 38,152 units (SEC Form 4)

SEC Form 4 filed by EVP & Chief Medical Officer Stein Steven H