INCY insider transactions

President, Global Head of R&D Cagnoni Pablo J covered exercise/tax liability with 25,469 shares, decreasing direct ownership by 10% to 240,848 units (SEC Form 4) to cover taxes

Principal Accounting Officer Tray Thomas sold $199,665 worth of shares (2,051 units at $97.35), decreasing direct ownership by 9% to 21,132 units (SEC Form 4)

Director Bienaime Jean Jacques exercised 15,000 shares at a strike of $84.53 and covered exercise/tax liability with 13,059 shares, increasing direct ownership by 9% to 22,782 units (SEC Form 4)

Director Clancy Paul J exercised 15,000 shares at a strike of $84.53 and sold $1,423,950 worth of shares (15,000 units at $94.93) (SEC Form 4)

Amendment: CMO & Head of Late-Stage Dev. Stein Steven H was granted 44,124 shares, increasing direct ownership by 129% to 78,327 units (SEC Form 4)

Amendment: President, Global Head of R&D Cagnoni Pablo J was granted 31,517 shares, increasing direct ownership by 13% to 266,317 units (SEC Form 4)

Director Baker Bros. Advisors Lp exercised 30,000 shares at a strike of $84.53 (SEC Form 4)

EVP & Chief Financial Officer Upadhyay Suketu was granted 26,343 shares (SEC Form 4)

SEC Form 3 filed by new insider Upadhyay Suketu

SEC Form 4 filed by Cagnoni Pablo J

SEC Form 4 filed by Meury William

SEC Form 4 filed by Cagnoni Pablo J

SEC Form 4 filed by Stein Steven H

SEC Form 4 filed by Harrigan Edmund

SEC Form 4 filed by Baker Bros. Advisors Lp

SEC Form 4 filed by Clancy Paul J

SEC Form 4 filed by Trotta Matteo

SEC Form 4 filed by Cagnoni Pablo J

President, R&D Cagnoni Pablo J exercised 18,668 shares at a strike of $61.59 and sold $1,883,788 worth of shares (18,668 units at $100.91) (SEC Form 4)

EVP, Head of Tech. Operations Morrissey Michael James covered exercise/tax liability with 185 shares, decreasing direct ownership by 0.54% to 34,065 units (SEC Form 4)

EVP, Head of Incyte Intl Heeson Lee covered exercise/tax liability with 111 shares, decreasing direct ownership by 0.29% to 38,041 units (SEC Form 4)

SEC Form 4 filed by President, R&D Cagnoni Pablo J

EVP, Head of Incyte Intl Heeson Lee was granted 8,911 shares, increasing direct ownership by 30% to 38,152 units (SEC Form 4)

SEC Form 4 filed by EVP & Chief Medical Officer Stein Steven H

SEC Form 4 filed by EVP, Head of US Oncology Issa Mohamed Khairie

SEC Form 4 filed by EVP, GM, Dermatology US Trotta Matteo

SEC Form 4 filed by Principal Accounting Officer Tray Thomas

SEC Form 4 filed by EVP & Chief Scientific Officer Mayes Patrick A

EVP, Head of Tech. Operations Morrissey Michael James was granted 7,426 shares and covered exercise/tax liability with 429 shares, increasing direct ownership by 26% to 34,250 units (SEC Form 4)

EVP, Head of US Oncology Issa Mohamed Khairie covered exercise/tax liability with 8,264 shares and sold $1,184,064 worth of shares (10,856 units at $109.07), decreasing direct ownership by 22% to 66,132 units (SEC Form 4)

EVP & Chief Medical Officer Stein Steven H sold $1,589,978 worth of shares (15,634 units at $101.70), decreasing direct ownership by 31% to 34,203 units (SEC Form 4)

Director Clancy Paul J was granted 241 shares, increasing direct ownership by 1% to 23,476 units (SEC Form 4)

Director Harrigan Edmund was granted 245 shares, increasing direct ownership by 1% to 20,853 units (SEC Form 4)

EVP & Chief Medical Officer Stein Steven H covered exercise/tax liability with 13,292 shares, decreasing direct ownership by 21% to 49,837 units (SEC Form 4)

EVP, Head of Tech. Operations Morrissey Michael James covered exercise/tax liability with 254 shares, decreasing direct ownership by 0.92% to 27,253 units (SEC Form 4)

Director Baker Bros. Advisors Lp was granted 656 shares (SEC Form 4)

Principal Accounting Officer Tray Thomas sold $336,350 worth of shares (3,374 units at $99.69) and exercised 2,774 shares at a strike of $95.76, decreasing direct ownership by 3% to 22,973 units (SEC Form 4)

EVP, Head of Tech. Operations Morrissey Michael James sold $5,675,002 worth of shares (58,331 units at $97.29), decreasing direct ownership by 68% to 27,507 units (SEC Form 4)

EVP & Chief Scientific Officer Mayes Patrick A sold $554,965 worth of shares (5,808 units at $95.55), decreasing direct ownership by 9% to 60,011 units (SEC Form 4)

Director Hoppenot Herve covered exercise/tax liability with 2,843 shares, decreasing direct ownership by 0.86% to 326,803 units (SEC Form 4)

EVP & Chief Medical Officer Stein Steven H covered exercise/tax liability with 17,093 shares and sold $2,324,438 worth of shares (22,664 units at $102.56), decreasing direct ownership by 39% to 63,129 units (SEC Form 4)

EVP, Head of Tech. Operations Morrissey Michael James covered exercise/tax liability with 326 shares, decreasing direct ownership by 0.38% to 85,838 units (SEC Form 4)

EVP & General Counsel Hoffman Richard A. was granted 9,466 shares (SEC Form 4)

SEC Form 3 filed by new insider Hoffman Richard A.

Principal Accounting Officer Tray Thomas sold $79,038 worth of shares (769 units at $102.78), decreasing direct ownership by 3% to 23,573 units (SEC Form 4)

EVP & General Counsel Denton Sheila A. exercised 278 shares at a strike of $64.25 and sold $29,012 worth of shares (278 units at $104.36) (SEC Form 4)

Director Hoppenot Herve sold $19,773,750 worth of shares (187,500 units at $105.46), decreasing direct ownership by 36% to 329,646 units (SEC Form 4)

EVP & Chief Medical Officer Stein Steven H exercised 5,233 shares at a strike of $93.04 and sold $534,813 worth of shares (5,233 units at $102.20) (SEC Form 4)

EVP & General Counsel Denton Sheila A. exercised 598 shares at a strike of $58.06 and sold $60,613 worth of shares (598 units at $101.36) (SEC Form 4)

EVP, Head of Incyte Intl Heeson Lee sold $289,017 worth of shares (3,074 units at $94.02), decreasing direct ownership by 10% to 29,241 units (SEC Form 4)

EVP & General Counsel Denton Sheila A. exercised 277 shares at a strike of $64.25 and sold $23,581 worth of shares (277 units at $85.13) (SEC Form 4)

EVP & General Counsel Denton Sheila A. exercised 599 shares at a strike of $58.06, sold $351,978 worth of shares (4,100 units at $85.85) and covered exercise/tax liability with 3,130 shares, decreasing direct ownership by 20% to 26,569 units (SEC Form 4)

EVP & Chief Scientific Officer Mayes Patrick A covered exercise/tax liability with 1,569 shares, decreasing direct ownership by 2% to 65,819 units (SEC Form 4)

EVP, Head of Incyte Intl Heeson Lee covered exercise/tax liability with 463 shares, decreasing direct ownership by 1% to 32,315 units (SEC Form 4)

Director Baker Bros. Advisors Lp was granted 776 shares (SEC Form 4)

Director Clancy Paul J was granted 285 shares, increasing direct ownership by 1% to 23,235 units (SEC Form 4)

Director Harrigan Edmund was granted 289 shares, increasing direct ownership by 1% to 20,608 units (SEC Form 4)

EVP, Chief Strategy Officer Gardner David H was granted 9,429 shares (SEC Form 4)

SEC Form 3 filed by new insider Gardner David H

EVP & General Counsel Denton Sheila A. exercised 278 shares at a strike of $64.25 and sold $23,116 worth of shares (278 units at $83.15) (SEC Form 4)