FATE insider transactions

Officer Tahl Cindy sold $48,084 worth of shares (25,590 units at $1.88), decreasing direct ownership by 4% to 628,155 units (SEC Form 4) (withholding obligation)

President and CEO Valamehr Bahram sold $54,482 worth of shares (28,946 units at $1.88), decreasing direct ownership by 4% to 635,762 units (SEC Form 4) to satisfy withholding tax

Officer Tahl Cindy exercised 166,664 shares at a strike of $1.25, increasing direct ownership by 34% to 653,745 units (SEC Form 4)

Director Epstein Robert S exercised 25,000 shares at a strike of $1.69, increasing direct ownership by 221% to 36,331 units (SEC Form 4)

Director Rastetter William H exercised 25,000 shares at a strike of $1.69, increasing direct ownership by 221% to 36,331 units (SEC Form 4)

Amendment: SEC Form 4 filed by Director Redmile Group, Llc

SEC Form 4 filed by Redmile Group, Llc

Officer Tahl Cindy was granted 100,000 shares, increasing direct ownership by 26% to 487,081 units (SEC Form 4)

Chief Financial Officer Adawi Kamal was granted 25,000 shares, increasing direct ownership by 33% to 100,000 units (SEC Form 4)

President and CEO Valamehr Bahram was granted 335,000 shares, increasing direct ownership by 102% to 664,708 units (SEC Form 4)

Officer Tahl Cindy sold $11,275 worth of shares (10,589 units at $1.06), decreasing direct ownership by 3% to 387,081 units (SEC Form 4)

President and CEO Valamehr Bahram sold $5,557 worth of shares (5,190 units at $1.07), decreasing direct ownership by 2% to 329,708 units (SEC Form 4)

Chief Financial Officer Adawi Kamal was granted 75,000 shares (SEC Form 4)

SEC Form 3 filed by new insider Adawi Kamal

Officer Tahl Cindy sold $9,573 worth of shares (9,037 units at $1.06), decreasing direct ownership by 2% to 397,670 units (SEC Form 4)

President and CEO Valamehr Bahram sold $15,396 worth of shares (14,466 units at $1.06), decreasing direct ownership by 4% to 334,898 units (SEC Form 4)

New insider Redco Ii Master Fund, L.P. claimed ownership of 8,977,624 shares (SEC Form 3)

SEC Form 4 filed by Director Lee Michael Stewart

SEC Form 4 filed by Director Redmile Group, Llc

SEC Form 4 filed by Director Xu Yuan

SEC Form 4 filed by Director Mozaffarian Neelufar

SEC Form 4 filed by Director Rastetter William H

SEC Form 4 filed by Director Mendlein John

SEC Form 4 filed by Director Jooss Karin

SEC Form 4 filed by Director Epstein Robert S

SEC Form 4 filed by Director Abernethy Matt

SEC Form 4 filed by Director Agarwal Shefali

SEC Form 3 filed by new insider Abernethy Matt

SEC Form 4 filed by President and CEO Valamehr Bahram

Officer Tahl Cindy was granted 70,000 shares, increasing direct ownership by 21% to 406,707 units (SEC Form 4)

Officer Bressi Jerome Charles was granted 65,000 shares, increasing direct ownership by 24% to 335,203 units (SEC Form 4)

Officer Bressi Jerome Charles sold $9,269 worth of shares (5,980 units at $1.55), decreasing direct ownership by 2% to 270,203 units (SEC Form 4)

Officer Tahl Cindy sold $8,764 worth of shares (5,654 units at $1.55), decreasing direct ownership by 2% to 336,707 units (SEC Form 4)

President and CEO Valamehr Bahram sold $13,406 worth of shares (8,705 units at $1.54), decreasing direct ownership by 2% to 349,364 units (SEC Form 4)

Director Redmile Group, Llc sold $573,943 worth of shares (341,633 units at $1.68), bought $668,580 worth of shares (397,964 units at $1.68), disposed of $1,822,692 worth of shares (1,084,936 units at $1.68) and acquired $1,822,692 worth of shares (1,084,936 units at $1.68) (SEC Form 4)

Director Redmile Group, Llc converted options into 30,110 shares (SEC Form 4)

New insider Bressi Jerome Charles claimed ownership of 276,183 shares (SEC Form 3)

Director Xu Yuan sold $2,678 worth of shares (633 units at $4.23), decreasing direct ownership by 7% to 8,669 units (SEC Form 4)

Chief R&D Officer Valamehr Bahram was granted 200,000 shares, increasing direct ownership by 127% to 358,069 units (SEC Form 4)

SEC Form 4 filed by Director Mozaffarian Neelufar

General Counsel and Secretary Tahl Cindy was granted 200,000 shares, increasing direct ownership by 140% to 342,361 units (SEC Form 4)

SEC Form 3 filed by new insider Mozaffarian Neelufar

SEC Form 4 filed by Director Lee Michael Stewart

SEC Form 4 filed by Director Redmile Group, Llc

SEC Form 4 filed by Director Rastetter William H

SEC Form 4 filed by Director Jooss Karin

SEC Form 4 filed by Director Coughlin Timothy

SEC Form 4 filed by Director Agarwal Shefali

SEC Form 4 filed by Director Xu Yuan

SEC Form 4 filed by Director Epstein Robert S

SEC Form 4 filed by Director Mendlein John

SEC Form 4 filed by Redmile Group, Llc

SEC Form 4 filed by Wolchko J Scott

SEC Form 4 filed by Tahl Cindy

SEC Form 4 filed by Dulac Edward J Iii

SEC Form 4 filed by Valamehr Bahram

Dulac Edward J Iii sold $9,245 worth of shares (1,849 units at $5.00), decreasing direct ownership by 2% to 103,926 units (SEC Form 4)

Tahl Cindy sold $47,519 worth of shares (10,874 units at $4.37), decreasing direct ownership by 7% to 142,361 units (SEC Form 4)

Valamehr Bahram sold $49,367 worth of shares (11,271 units at $4.38), decreasing direct ownership by 7% to 158,069 units (SEC Form 4)

Wolchko J Scott sold $62,889 worth of shares (14,391 units at $4.37), decreasing direct ownership by 4% to 371,248 units (SEC Form 4)