EXEL insider transactions

Director Wyszomierski Jack L sold $198,409 worth of shares (3,925 units at $50.55) as part of a pre-agreed trading plan, decreasing direct ownership by 1% to 284,384 units (SEC Form 4)

Director Eckhardt Sue Gail sold $491,974 worth of shares (9,812 units at $50.14) as part of a pre-agreed trading plan, decreasing direct ownership by 38% to 16,079 units (SEC Form 4)

Director Papadopoulos Stelios was granted 8,367 shares, increasing direct ownership by 0.70% to 1,197,595 units (SEC Form 4)

Director Eckhardt Sue Gail was granted 8,367 shares, increasing direct ownership by 48% to 25,891 units (SEC Form 4)

Director Heyman Tomas J. was granted 8,367 shares, increasing direct ownership by 20% to 50,649 units (SEC Form 4)

Director Smith Julie was granted 8,367 shares, increasing direct ownership by 41% to 28,957 units (SEC Form 4)

Director Freire Maria C was granted 8,367 shares, increasing direct ownership by 8% to 109,186 units (SEC Form 4)

Director Beckerle Mary C was granted 8,367 shares, increasing direct ownership by 48% to 25,891 units (SEC Form 4)

Director Oliver Bob was granted 8,367 shares, increasing direct ownership by 40% to 29,487 units (SEC Form 4)

Director Wyszomierski Jack L was granted 8,367 shares, increasing direct ownership by 3% to 288,309 units (SEC Form 4)

Director Poste George was granted 8,367 shares, increasing direct ownership by 7% to 127,199 units (SEC Form 4)

SEC Form 4 filed by Director Johnson David Edward

EVP, Research and Development Aftab Dana sold $2,187,758 worth of shares (43,451 units at $50.35), decreasing direct ownership by 7% to 594,741 units (SEC Form 4)

EVP, Commercial Haley Patrick J. sold $1,599,399 worth of shares (32,110 units at $49.81), decreasing direct ownership by 8% to 357,638 units (SEC Form 4)

President and CEO Morrissey Michael covered exercise/tax liability with 128,497 shares, gifted 124,047 shares and received a gift of 124,047 shares, decreasing direct ownership by 16% to 1,362,008 units (SEC Form 4)

EVP and CFO Senner Christopher J. covered exercise/tax liability with 40,892 shares and sold $1,745,050 worth of shares (34,901 units at $50.00), decreasing direct ownership by 7% to 952,317 units (SEC Form 4)

EVP, Commercial Haley Patrick J. covered exercise/tax liability with 33,265 shares, decreasing direct ownership by 8% to 389,748 units (SEC Form 4)

SVP and General Counsel Hefti Brenda covered exercise/tax liability with 6,411 shares and sold $332,641 worth of shares (6,625 units at $50.21) as part of a pre-agreed trading plan, decreasing direct ownership by 11% to 106,762 units (SEC Form 4)

EVP, Research and Development Aftab Dana covered exercise/tax liability with 30,578 shares, decreasing direct ownership by 5% to 638,192 units (SEC Form 4)

Director Freire Maria C exercised 20,634 shares at a strike of $19.77 and sold $949,164 worth of shares (20,634 units at $46.00) (SEC Form 4)

Director Beckerle Mary C exercised 3,856 shares at a strike of $23.24 and sold $373,646 worth of shares (7,712 units at $48.45), decreasing direct ownership by 18% to 17,524 units (SEC Form 4)

Director Poste George sold $2,742,600 worth of shares (60,000 units at $45.71), decreasing direct ownership by 34% to 118,832 units (SEC Form 4)

President and CEO Morrissey Michael gifted 109,676 shares (SEC Form 4)

EVP, Research and Development Aftab Dana was granted 52,018 shares, increasing direct ownership by 8% to 668,124 units (SEC Form 4)

SVP and General Counsel Hefti Brenda was granted 23,119 shares, increasing direct ownership by 24% to 119,631 units (SEC Form 4)

EVP and CFO Senner Christopher J. was granted 52,018 shares, increasing direct ownership by 5% to 1,028,110 units (SEC Form 4)

EVP, Commercial Haley Patrick J. was granted 40,459 shares, increasing direct ownership by 11% to 422,367 units (SEC Form 4)

President and CEO Morrissey Michael gifted 100,278 shares and was granted 160,437 shares, increasing direct ownership by 11% to 1,614,552 units (SEC Form 4)

EVP, Research and Development Aftab Dana sold $2,132,351 worth of shares (47,918 units at $44.50), decreasing direct ownership by 7% to 616,106 units (SEC Form 4)

EVP, Research and Development Aftab Dana sold $1,324,868 worth of shares (29,873 units at $44.35), decreasing direct ownership by 4% to 664,024 units (SEC Form 4)

Director Wyszomierski Jack L exercised 20,634 shares at a strike of $19.77 and sold $4,382,252 worth of shares (99,574 units at $44.01), decreasing direct ownership by 22% to 279,942 units (SEC Form 4)

Director Smith Julie sold $4,687,346 worth of shares (106,539 units at $44.00) and exercised 106,539 shares at a strike of $19.34 (SEC Form 4)

EVP and CFO Senner Christopher J. sold $2,810,998 worth of shares (64,895 units at $43.32) and covered exercise/tax liability with 35,870 shares, decreasing direct ownership by 9% to 976,092 units (SEC Form 4)

EVP, Commercial Haley Patrick J. covered exercise/tax liability with 31,483 shares and sold $2,950,941 worth of shares (67,814 units at $43.52), decreasing direct ownership by 21% to 381,908 units (SEC Form 4)

President and CEO Morrissey Michael covered exercise/tax liability with 489,996 shares, gifted 375,830 shares, received a gift of 375,830 shares and exercised 494,700 shares at a strike of $21.31, decreasing direct ownership by 20% to 1,454,115 units (SEC Form 4)

EVP, Research and Development Aftab Dana covered exercise/tax liability with 39,205 shares, decreasing direct ownership by 5% to 693,897 units (SEC Form 4)

Director Eckhardt Sue Gail sold $168,854 worth of shares (3,856 units at $43.79), decreasing direct ownership by 18% to 17,524 units (SEC Form 4)

Director Oliver Bob exercised 9,088 shares at a strike of $19.28 and sold $1,325,339 worth of shares (30,250 units at $43.81), decreasing direct ownership by 50% to 21,120 units (SEC Form 4)

SVP and General Counsel Hefti Brenda covered exercise/tax liability with 5,430 shares and sold $821,623 worth of shares (18,669 units at $44.01), decreasing direct ownership by 20% to 96,512 units (SEC Form 4)

President and CEO Morrissey Michael covered exercise/tax liability with 139,524 shares and was granted 548,073 shares, increasing direct ownership by 29% to 1,825,241 units (SEC Form 4)

EVP, Research and Development Aftab Dana covered exercise/tax liability with 27,254 shares and was granted 119,578 shares, increasing direct ownership by 14% to 733,102 units (SEC Form 4)

EVP, Commercial Haley Patrick J. was granted 139,508 shares and covered exercise/tax liability with 32,332 shares, increasing direct ownership by 29% to 481,205 units (SEC Form 4)

EVP and CFO Senner Christopher J. was granted 149,474 shares and covered exercise/tax liability with 40,459 shares, increasing direct ownership by 11% to 1,076,857 units (SEC Form 4)

SVP and General Counsel Hefti Brenda was granted 30,170 shares, increasing direct ownership by 33% to 120,611 units (SEC Form 4)

Director Johnson David Edward bought $1,187,235 worth of shares (27,532 units at $43.12) (SEC Form 4)

EVP, Research and Development Aftab Dana gifted 24,000 shares, decreasing direct ownership by 4% to 640,778 units (SEC Form 4)

EVP, Commercial Haley Patrick J. sold $3,046,928 worth of shares (72,230 units at $42.18), decreasing direct ownership by 9% to 374,029 units (SEC Form 4)

New insider Hefti Brenda claimed ownership of 95,968 shares (SEC Form 3)

Director Oliver Bob gifted 1,044 shares, decreasing direct ownership by 2% to 42,282 units (SEC Form 4)

Director Papadopoulos Stelios sold $4,355,000 worth of shares (100,000 units at $43.55), decreasing direct ownership by 8% to 1,189,228 units (SEC Form 4)

Director Beckerle Mary C exercised 5,784 shares at a strike of $23.24 and sold $1,032,414 worth of shares (24,622 units at $41.93), decreasing direct ownership by 47% to 21,380 units (SEC Form 4)

EVP, Research and Development Aftab Dana sold $2,056,278 worth of shares (48,383 units at $42.50), decreasing direct ownership by 7% to 664,778 units (SEC Form 4)

President and CEO Morrissey Michael gifted 341,548 shares and received a gift of 101,548 shares, decreasing direct ownership by 7% to 1,416,692 units (SEC Form 4)

EVP, Research & Development Aftab Dana was granted 50,673 shares, increasing direct ownership by 8% to 713,161 units (SEC Form 4)

Director Eckhardt Sue Gail sold $805,140 worth of shares (18,838 units at $42.74), decreasing direct ownership by 47% to 21,380 units (SEC Form 4)

Director Wyszomierski Jack L sold $324,683 worth of shares (7,535 units at $43.09), decreasing direct ownership by 2% to 358,882 units (SEC Form 4)

SEC Form 4 filed by Director Johnson David Edward

Director Beckerle Mary C was granted 9,812 shares, increasing direct ownership by 32% to 40,218 units (SEC Form 4)

Director Oliver Bob was granted 9,812 shares, increasing direct ownership by 29% to 43,326 units (SEC Form 4)

Director Heyman Tomas J. was granted 9,812 shares, increasing direct ownership by 30% to 42,282 units (SEC Form 4)