APGE insider transactions

Chief Medical Officer Dambkowski Carl exercised 4,125 shares at a strike of $22.86 and sold $432,905 worth of shares (5,500 units at $78.71) as part of a pre-agreed trading plan, decreasing direct ownership by 0.66% to 205,648 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $1,641,711 worth of shares (20,000 units at $82.09) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 1,115,987 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 4,125 shares at a strike of $22.86 and sold $462,784 worth of shares (5,500 units at $84.14) as part of a pre-agreed trading plan, decreasing direct ownership by 0.66% to 207,023 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $164,080 worth of shares (2,000 units at $82.04) as part of a pre-agreed trading plan, decreasing direct ownership by 1% to 173,371 units (SEC Form 4)

SEC Form 4 filed by Henderson Michael Thomas

SEC Form 4 filed by Henderson Jane

SEC Form 4 filed by Henderson Michael Thomas

SEC Form 4 filed by Dambkowski Carl

SEC Form 4 filed by Henderson Jane

SEC Form 4 filed by Henderson Jane

Chief Executive Officer Henderson Michael Thomas sold $1,495,605 worth of shares (20,000 units at $74.78), decreasing direct ownership by 2% to 1,152,987 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 4,125 shares at a strike of $22.86 and sold $390,825 worth of shares (5,500 units at $71.06), decreasing direct ownership by 0.65% to 209,773 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $140,431 worth of shares (2,000 units at $70.22), decreasing direct ownership by 1% to 181,371 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $1,266,953 worth of shares (20,000 units at $63.35), decreasing direct ownership by 2% to 1,172,987 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 4,125 shares at a strike of $22.86 and sold $361,860 worth of shares (5,500 units at $65.79), decreasing direct ownership by 0.65% to 211,148 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $131,630 worth of shares (2,000 units at $65.81), decreasing direct ownership by 1% to 183,371 units (SEC Form 4)

Director Fairmount Funds Management Llc sold $133,525,000 worth of shares (1,750,000 units at $76.30) (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $1,622,159 worth of shares (20,000 units at $81.11), decreasing direct ownership by 2% to 1,192,987 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 14,025 shares at a strike of $22.86 and sold $1,455,613 worth of shares (18,700 units at $77.84), decreasing direct ownership by 2% to 212,523 units (SEC Form 4)

SEC Form 4 filed by Chief Medical Officer Dambkowski Carl

SEC Form 4 filed by Chief Executive Officer Henderson Michael Thomas

Chief Financial Officer Henderson Jane sold $609,146 worth of shares (8,000 units at $76.14), decreasing direct ownership by 4% to 185,371 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $120,000 worth of shares (1,500 units at $80.00), decreasing direct ownership by 0.77% to 193,371 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $1,507,657 worth of shares (20,000 units at $75.38), decreasing direct ownership by 2% to 1,212,987 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl sold $817,500 worth of shares (10,900 units at $75.00), decreasing direct ownership by 4% to 271,108 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $112,500 worth of shares (1,500 units at $75.00), decreasing direct ownership by 0.76% to 194,871 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $3,000,400 worth of shares (40,000 units at $75.01), decreasing direct ownership by 3% to 1,232,987 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $105,000 worth of shares (1,500 units at $70.00), decreasing direct ownership by 0.76% to 196,371 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $130,000 worth of shares (2,000 units at $65.00), decreasing direct ownership by 1% to 197,871 units (SEC Form 4)

Chief Financial Officer Henderson Jane sold $60,000 worth of shares (1,000 units at $60.00), decreasing direct ownership by 0.50% to 199,871 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $1,260,236 worth of shares (20,000 units at $63.01), decreasing direct ownership by 2% to 1,272,987 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 8,060 shares at a strike of $22.86 and sold $593,903 worth of shares (10,785 units at $55.07), decreasing direct ownership by 0.96% to 282,008 units (SEC Form 4)

SEC Form 4 filed by Director Shah Nimish P

Chief Medical Officer Dambkowski Carl exercised 2,385 shares at a strike of $22.86 and sold $203,378 worth of shares (5,110 units at $39.80), decreasing direct ownership by 0.95% to 284,733 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl sold $103,198 worth of shares (2,725 units at $37.87), decreasing direct ownership by 1% to 233,548 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl sold $102,950 worth of shares (2,725 units at $37.78), decreasing direct ownership by 1% to 236,273 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 7,365 shares at a strike of $22.86 and sold $454,954 worth of shares (10,090 units at $45.09), decreasing direct ownership by 1% to 238,998 units (SEC Form 4)

SEC Form 4 filed by Director Fairmount Funds Management Llc

SEC Form 4 filed by Director Shah Nimish P

SEC Form 4 filed by Director Mckenna Mark C.

SEC Form 4 filed by Director Jones William A Jr

SEC Form 4 filed by Director Gottesdiener Andrew

SEC Form 4 filed by Director Fox Jennifer A.

SEC Form 4 filed by Director Bollinger Lisa

Chief Medical Officer Dambkowski Carl sold $100,716 worth of shares (2,725 units at $36.96), decreasing direct ownership by 1% to 241,723 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl sold $97,419 worth of shares (2,725 units at $35.75), decreasing direct ownership by 1% to 244,448 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl sold $139,801 worth of shares (3,860 units at $36.22), decreasing direct ownership by 2% to 247,173 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl sold $48,463 worth of shares (1,590 units at $30.48), decreasing direct ownership by 0.63% to 251,033 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $301,511 worth of shares (10,000 units at $30.15), decreasing direct ownership by 0.77% to 1,292,987 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 795 shares at a strike of $22.86 and sold $143,229 worth of shares (3,520 units at $40.69), decreasing direct ownership by 1% to 252,623 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $608,700 worth of shares (15,000 units at $40.58), decreasing direct ownership by 1% to 1,302,987 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas exercised 8,500 shares at a strike of $22.86, increasing direct ownership by 0.65% to 1,317,987 units (SEC Form 4)

Chief Executive Officer Henderson Michael Thomas sold $732,693 worth of shares (15,000 units at $48.85), decreasing direct ownership by 1% to 1,309,487 units (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 1,360 shares at a strike of $22.86 and sold $191,740 worth of shares (4,085 units at $46.94), decreasing direct ownership by 1% to 255,348 units (SEC Form 4)

Director Mckenna Mark C. bought $990,775 worth of shares (20,000 units at $49.54) (SEC Form 4)

Chief Medical Officer Dambkowski Carl exercised 1,815 shares at a strike of $22.86 and sold $221,363 worth of shares (4,540 units at $48.76), decreasing direct ownership by 1% to 258,073 units (SEC Form 4)

SEC Form 4 filed by Chief Executive Officer Henderson Michael Thomas

SEC Form 4 filed by Chief Financial Officer Henderson Jane

SEC Form 4 filed by Chief Medical Officer Dambkowski Carl

Chief Medical Officer Dambkowski Carl sold $307,057 worth of shares (6,665 units at $46.07), decreasing direct ownership by 2% to 260,798 units (SEC Form 4)