ADVM insider transactions

CEO, PRESIDENT AND DIRECTOR Fischer Laurent exercised 150,000 shares at a strike of $4.20 and was granted 500,000 units of Common Stock - Performance Stock Units, closing all direct ownership in the company (SEC Form 4)

CHIEF OPERATING OFFICER Soparkar Peter was granted 150,000 units of Common Stock - Performance Stock Units, closing all direct ownership in the company (SEC Form 4)

Chief Medical Officer Ozden Rabia Gurses was granted 85,000 units of Common Stock - Performance Stock Units, closing all direct ownership in the company (SEC Form 4)

CHIEF DEVELOPMENT OFFICER Seyedkazemi Setareh was granted 85,000 units of Common Stock - Performance Stock Units, closing all direct ownership in the company (SEC Form 4)

CHIEF FINANCIAL OFFICER Rubinstein Linda M was granted 42,000 units of Common Stock - Performance Stock Units and exercised 48,750 shares at a strike of $4.20, closing all direct ownership in the company (SEC Form 4)

SEC Form 4 filed by Director Hong Soo

SEC Form 4 filed by Director Whitcup Scott M

SEC Form 4 filed by Director Tuckson Reed Vaughn

Director Svoronos Dawn closing all direct ownership in the company (SEC Form 4)

Director Scopa James Paul closing all direct ownership in the company (SEC Form 4)

SEC Form 4 filed by Director Nicholson, C. David

Director Lupher, Jr. Mark L. closing all direct ownership in the company (SEC Form 4)

Director Machado Patrick closing all direct ownership in the company (SEC Form 4)

SEC Form 4 filed by Director Kiss Szilard

SEC Form 4 filed by Large owner Frazier Life Sciences Public Fund, L.P.

CEO, PRESIDENT AND DIRECTOR Fischer Laurent bought $553,917 worth of shares (128,699 units at $4.30), increasing direct ownership by 177% to 201,513 units (SEC Form 4)

CHIEF OPERATING OFFICER Soparkar Peter bought $211,000 worth of shares (50,000 units at $4.22), increasing direct ownership by 166% to 80,189 units (SEC Form 4)

Large owner Leonard Braden Michael sold $2,200,372 worth of shares (524,560 units at $4.19) (SEC Form 4)

New insider Frazier Life Sciences Public Fund, L.P. claimed ownership of 4,288,949 shares (SEC Form 3)

Large owner Leonard Braden Michael sold $2,407,833 worth of shares (574,886 units at $4.19) (SEC Form 4)

SEC Form 4 filed by CHIEF OPERATING OFFICER Soparkar Peter

SEC Form 4 filed by CHIEF DEVELOPMENT OFFICER Seyedkazemi Setareh

SEC Form 4 filed by CHIEF FINANCIAL OFFICER Rubinstein Linda M

SEC Form 4 filed by Chief Medical Officer Ozden Rabia Gurses

SEC Form 4 filed by CEO, PRESIDENT AND DIRECTOR Fischer Laurent

SEC Form 4 filed by Director Kiss Szilard

SEC Form 4 filed by Director Scopa James Paul

SEC Form 4 filed by Director Whitcup Scott M

SEC Form 4 filed by Director Tuckson Reed Vaughn

SEC Form 4 filed by Director Svoronos Dawn

SEC Form 4 filed by Director Lupher, Jr. Mark L.

SEC Form 4 filed by Director Hong Soo

SEC Form 4 filed by Director Nicholson, C. David

SEC Form 4 filed by Director Machado Patrick

CHIEF OPERATING OFFICER Soparkar Peter sold $5,920 worth of shares (2,960 units at $2.00), decreasing direct ownership by 7% to 39,154 units (SEC Form 4)

CHIEF DEVELOPMENT OFFICER Seyedkazemi Setareh sold $1,848 worth of shares (924 units at $2.00), decreasing direct ownership by 6% to 13,768 units (SEC Form 4)

CEO, PRESIDENT AND DIRECTOR Fischer Laurent sold $18,252 worth of shares (9,126 units at $2.00), decreasing direct ownership by 9% to 87,488 units (SEC Form 4)

Amendment: Large owner Leonard Braden Michael bought $188,931 worth of shares (37,000 units at $5.11), increasing direct ownership by 35% to 141,800 units (SEC Form 4)

Large owner Leonard Braden Michael bought $188,931 worth of shares (37,000 units at $5.11), increasing direct ownership by 35% to 141,800 units (SEC Form 4)

Large owner Leonard Braden Michael bought $1,048,950 worth of shares (350,000 units at $3.00), increasing direct ownership by 35% to 191,800 units (SEC Form 4)

Large owner Leonard Braden Michael bought $147,076 worth of shares (34,775 units at $4.23) (SEC Form 4)

Large owner Leonard Braden Michael bought $102,841 worth of shares (20,407 units at $5.04), increasing direct ownership by 35% to 141,800 units (SEC Form 4)

Large owner Leonard Braden Michael bought $415,808 worth of shares (87,341 units at $4.76) and bought $171,767 worth of Common Stovk (30,600 units at $5.61) (SEC Form 4)

Large owner Leonard Braden Michael bought $1,439,087 worth of shares (336,756 units at $4.27) (SEC Form 4)

CHIEF OPERATING OFFICER Soparkar Peter was granted 13,125 shares, increasing direct ownership by 45% to 42,114 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Rubinstein Linda M was granted 8,125 shares, increasing direct ownership by 73% to 19,325 units (SEC Form 4)

CHIEF DEVELOPMENT OFFICER Seyedkazemi Setareh was granted 8,125 shares, increasing direct ownership by 124% to 14,692 units (SEC Form 4)

Chief Medical Officer Ozden Rabia Gurses was granted 8,125 shares (SEC Form 4)

CEO, PRESIDENT AND DIRECTOR Fischer Laurent was granted 25,000 shares, increasing direct ownership by 35% to 96,614 units (SEC Form 4)

SEC Form 4 filed by Chief Medical Officer Ozden Rabia Gurses

SEC Form 4 filed by CHIEF FINANCIAL OFFICER Rubinstein Linda M

SEC Form 4 filed by CHIEF DEVELOPMENT OFFICER Seyedkazemi Setareh

SEC Form 4 filed by CHIEF OPERATING OFFICER Soparkar Peter

SEC Form 4 filed by CEO, PRESIDENT AND DIRECTOR Fischer Laurent

Large owner Leonard Braden Michael bought $613,470 worth of shares (85,800 units at $7.15) (SEC Form 4)

New insider Leonard Braden Michael claimed ownership of 2,207,976 shares (SEC Form 3)

Large owner Leonard Braden Michael bought $1,785,662 worth of shares (216,264 units at $8.26) (SEC Form 4)

SEC Form 4 filed by Chief Medical Officer Ozden Rabia Gurses

SEC Form 4 filed by Director Nicholson, C. David

SEC Form 4 filed by Director Hong Soo