ADCT insider transactions

Director Azelby Robert was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 40% to 112,805 units (SEC Form 4) to cover withholding tax

Director Squarer Ron was granted 45,000 shares and covered exercise/tax liability with 15,196 shares, increasing direct ownership by 32% to 123,431 units (SEC Form 4) to satisfy withholding obligation

Director Sandor Victor was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 30% to 140,686 units (SEC Form 4) (tax withholding)

Director Monges Viviane was granted 45,000 shares and covered exercise/tax liability with 2,596 shares, increasing direct ownership by 29% to 186,447 units (SEC Form 4) to cover withholding tax

Director Hug Peter was granted 45,000 shares and covered exercise/tax liability with 2,156 shares, increasing direct ownership by 19% to 263,344 units (SEC Form 4) to cover withholding tax

Director Bizzari Jean-Pierre was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 30% to 139,302 units (SEC Form 4) to satisfy withholding tax

Director Coughlin Timothy was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 81% to 72,400 units (SEC Form 4) (tax withholding)

SEC Form 4 filed by Redmile Group, Llc

Chief Accounting Officer Kallebo Lisa Michelle was granted 62,900 shares and covered exercise/tax liability with 5,433 shares, increasing direct ownership by 81% to 128,224 units (SEC Form 4)

Chief Medical Officer Zaki Mohamed was granted 285,200 shares and covered exercise/tax liability with 24,603 shares, increasing direct ownership by 62% to 682,417 units (SEC Form 4)

Chief Legal Officer Graham Peter J was granted 294,800 shares and covered exercise/tax liability with 33,294 shares, increasing direct ownership by 73% to 620,540 units (SEC Form 4)

Chief Financial Officer Carmona Jose was granted 271,600 shares and covered exercise/tax liability with 25,880 shares, increasing direct ownership by 50% to 734,376 units (SEC Form 4)

Chief Executive Officer Mallik Ameet was granted 900,000 shares and covered exercise/tax liability with 103,231 shares, increasing direct ownership by 123% to 1,446,769 units (SEC Form 4)

Chief Executive Officer Mallik Ameet covered exercise/tax liability with 233,146 shares, decreasing direct ownership by 15% to 1,319,101 units (SEC Form 4)

Chief Medical Officer Zaki Mohamed covered exercise/tax liability with 41,068 shares, decreasing direct ownership by 9% to 421,820 units (SEC Form 4)

Chief Accounting Officer Kallebo Lisa Michelle covered exercise/tax liability with 7,140 shares, decreasing direct ownership by 9% to 70,757 units (SEC Form 4)

Chief Legal Officer Graham Peter J covered exercise/tax liability with 49,508 shares, decreasing direct ownership by 12% to 359,034 units (SEC Form 4)

Chief Financial Officer Carmona Jose covered exercise/tax liability with 53,236 shares, decreasing direct ownership by 10% to 488,656 units (SEC Form 4)

SEC Form 4 filed by Large owner Redmile Group, Llc

Director Squarer Ron covered exercise/tax liability with 15,184 shares, decreasing direct ownership by 14% to 93,627 units (SEC Form 4)

Director Sandor Victor covered exercise/tax liability with 12,600 shares, decreasing direct ownership by 10% to 108,286 units (SEC Form 4)

Director Monges Viviane covered exercise/tax liability with 2,584 shares, decreasing direct ownership by 2% to 144,043 units (SEC Form 4)

Director Hug Peter covered exercise/tax liability with 2,144 shares, decreasing direct ownership by 0.96% to 220,500 units (SEC Form 4)

Director Bizzari Jean-Pierre covered exercise/tax liability with 12,600 shares, decreasing direct ownership by 11% to 106,902 units (SEC Form 4)

Director Azelby Robert covered exercise/tax liability with 12,600 shares, decreasing direct ownership by 14% to 80,405 units (SEC Form 4)

SEC Form 4 filed by Large owner Redmile Group, Llc

Director Coughlin Timothy was granted 40,000 shares (SEC Form 4)

Director Sandor Victor was granted 40,000 shares, increasing direct ownership by 49% to 120,886 units (SEC Form 4)

Director Azelby Robert was granted 40,000 shares, increasing direct ownership by 75% to 93,005 units (SEC Form 4)

Director Bizzari Jean-Pierre was granted 40,000 shares, increasing direct ownership by 50% to 119,502 units (SEC Form 4)

Director Hug Peter was granted 40,000 shares, increasing direct ownership by 22% to 222,644 units (SEC Form 4)

Director Monges Viviane was granted 40,000 shares, increasing direct ownership by 38% to 146,627 units (SEC Form 4)

Director Squarer Ron was granted 40,000 shares, increasing direct ownership by 58% to 108,811 units (SEC Form 4)

SEC Form 3 filed by new insider Coughlin Timothy

Amendment: New insider Squarer Ron claimed ownership of 35,806 shares (SEC Form 3)

Large owner Wild Hans Peter acquired 9,788,944 shares (SEC Form 4)

See Explanations Pfisterer Thomas disposed of 451,856 shares, decreasing direct ownership by 72% to 173,899 units (SEC Form 4)

Chief Executive Officer Mallik Ameet covered exercise/tax liability with 26,758 shares, decreasing direct ownership by 2% to 1,552,247 units (SEC Form 4)

Chief Legal Officer Graham Peter J was granted 220,000 shares, increasing direct ownership by 117% to 408,542 units (SEC Form 4)

Chief Medical Officer Zaki Mohamed was granted 230,000 shares, increasing direct ownership by 99% to 462,888 units (SEC Form 4)

Chief Accounting Officer Kallebo Lisa Michelle was granted 41,900 shares, increasing direct ownership by 116% to 77,897 units (SEC Form 4)

Chief Financial Officer Carmona Jose was granted 240,000 shares, increasing direct ownership by 79% to 541,892 units (SEC Form 4)

Chief Executive Officer Mallik Ameet was granted 650,000 shares, increasing direct ownership by 70% to 1,579,005 units (SEC Form 4)

Large owner Redmile Group, Llc bought $609,000 worth of shares (200,000 units at $3.04) (SEC Form 4)

Chief Medical Officer Zaki Mohamed covered exercise/tax liability with 37,112 shares, decreasing direct ownership by 14% to 232,888 units (SEC Form 4)

Chief Accounting Officer Kallebo Lisa Michelle covered exercise/tax liability with 6,503 shares, decreasing direct ownership by 15% to 35,997 units (SEC Form 4)

Chief Financial Officer Carmona Jose covered exercise/tax liability with 48,108 shares, decreasing direct ownership by 14% to 301,892 units (SEC Form 4)

Chief Legal Officer Graham Peter J covered exercise/tax liability with 41,458 shares, decreasing direct ownership by 18% to 188,542 units (SEC Form 4)

Chief Executive Officer Mallik Ameet covered exercise/tax liability with 238,343 shares, decreasing direct ownership by 20% to 929,005 units (SEC Form 4)

Large owner Redmile Group, Llc acquired $209,782 worth of shares (101,344 units at $2.07), sold $52,479 worth of shares (25,352 units at $2.07) and disposed of $104,891 worth of shares (50,672 units at $2.07) (SEC Form 4)

Large owner Redmile Group, Llc bought $2,248,000 worth of shares (800,000 units at $2.81) (SEC Form 4)

Director Azelby Robert sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 12% to 53,005 units (SEC Form 4)

Director Bizzari Jean-Pierre sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 8% to 79,502 units (SEC Form 4)

Director Hug Peter sold $3,448 worth of shares (1,193 units at $2.89), decreasing direct ownership by 0.65% to 182,644 units (SEC Form 4)

Director Monges Viviane sold $4,153 worth of shares (1,437 units at $2.89), decreasing direct ownership by 1% to 106,627 units (SEC Form 4)

Director Pfisterer Thomas sold $4,153 worth of shares (1,437 units at $2.89), decreasing direct ownership by 0.67% to 213,900 units (SEC Form 4)

Director Sandor Victor sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 8% to 80,886 units (SEC Form 4)

Director Squarer Ron sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 8% to 80,663 units (SEC Form 4)

Director Azelby Robert was granted 40,000 shares, increasing direct ownership by 200% to 60,000 units (SEC Form 4)

Director Bizzari Jean-Pierre was granted 40,000 shares, increasing direct ownership by 86% to 86,497 units (SEC Form 4)