ACLX insider transactions

SEC Form 4 filed by Director Carroll Jill to satisfy tax liability

Director Behbahani Ali closing all direct ownership in the company (SEC Form 4) to satisfy tax liability

SEC Form 4 filed by Director Ware Olivia C

SEC Form 4 filed by Director Patel Kavita

SEC Form 4 filed by Director Myers Kristin

Director Lubner David Charles closing all direct ownership in the company (SEC Form 4) (withholding obligation)

SEC Form 4 filed by Director Galligan Andrew H (tax withholding)

CHIEF FINANCIAL OFFICER Gilson Michelle closing all direct ownership in the company (SEC Form 4) (tax withholding)

CHIEF MEDICAL OFFICER Heery Christopher closing all direct ownership in the company (SEC Form 4) (withholding obligation)

Officer Elghandour Rami closing all direct ownership in the company (SEC Form 4) (tax liability)

SEC Form 4 filed by Gilson Michelle

SEC Form 4 filed by Gilson Michelle

Officer Elghandour Rami gifted 101,164 shares (SEC Form 4)

Officer Elghandour Rami converted options into 164,548 shares and sold $10,243,267 worth of shares (89,916 units at $113.92), decreasing direct ownership by 55% to 276,051 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gilson Michelle sold $1,276,954 worth of shares (11,219 units at $113.82) and converted options into 20,530 shares, decreasing direct ownership by 23% to 33,938 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gilson Michelle converted options into 15,340 shares and sold $572,568 worth of shares (8,384 units at $68.29), increasing direct ownership by 56% to 45,157 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gilson Michelle converted options into 20,496 shares and sold $784,783 worth of shares (11,291 units at $69.51), increasing direct ownership by 532% to 53,541 units (SEC Form 4)

Officer Elghandour Rami gifted 198,000 shares (SEC Form 4)

Officer Elghandour Rami gifted 218,500 shares (SEC Form 4)

Director Lubner David Charles exercised 6,000 shares at a strike of $6.28 and sold $450,000 worth of shares (6,000 units at $75.00) (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher converted options into 13,064 shares and sold $402,997 worth of shares (5,882 units at $68.51), decreasing direct ownership by 21% to 23,749 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher converted options into 16,520 shares and sold $487,213 worth of shares (7,437 units at $65.51), increasing direct ownership by 118% to 29,631 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher converted options into 13,021 shares and sold $393,286 worth of shares (6,131 units at $64.15), increasing direct ownership by 6,140% to 37,068 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher converted options into 42,605 shares, increasing direct ownership by 7,173% to 43,199 units (SEC Form 4)

Officer Elghandour Rami converted options into 164,548 shares, increasing direct ownership by 27% to 782,467 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gilson Michelle converted options into 56,366 shares, increasing direct ownership by 666% to 64,832 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher sold $30,600 worth of shares (340 units at $90.00), decreasing direct ownership by 54% to 284 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gilson Michelle sold $488,315 worth of shares (5,364 units at $91.04), decreasing direct ownership by 39% to 8,466 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gilson Michelle sold $511,603 worth of shares (5,946 units at $86.04), decreasing direct ownership by 30% to 13,830 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher sold $1,709,723 worth of shares (21,034 units at $81.28), decreasing direct ownership by 97% to 624 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher sold $5,852 worth of shares (73 units at $80.16), decreasing direct ownership by 0.34% to 21,658 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher sold $993,155 worth of shares (12,396 units at $80.12), decreasing direct ownership by 36% to 21,731 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher sold $291,468 worth of shares (3,643 units at $80.01), decreasing direct ownership by 10% to 34,127 units (SEC Form 4)

Officer Elghandour Rami covered exercise/tax liability with 546,938 shares, decreasing direct ownership by 47% to 617,919 units (SEC Form 4)

Director Behbahani Ali acquired 4,207 shares, increasing direct ownership by 468% to 1,925 units (SEC Form 4)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $101,040 worth of shares (1,500 units at $67.36) (SEC Form 4)

SEC Form 4 filed by Director Behbahani Ali

SEC Form 4 filed by Director Galligan Andrew H

SEC Form 4 filed by Director Patel Kavita

SEC Form 4 filed by Director Myers Kristin

SEC Form 4 filed by Director Ware Olivia C

SEC Form 4 filed by Director Carroll Jill

SEC Form 4 filed by Director Lubner David Charles

CHIEF FINANCIAL OFFICER Gilson Michelle converted options into 22,429 shares and sold $784,777 worth of shares (12,235 units at $64.14), increasing direct ownership by 106% to 19,776 units (SEC Form 4)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $87,645 worth of shares (1,500 units at $58.43) (SEC Form 4)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $96,300 worth of shares (1,500 units at $64.20) (SEC Form 4)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $86,250 worth of shares (1,500 units at $57.50) (SEC Form 4)

SEC Form 4 filed by Director Myers Kristin

SEC Form 4 filed by Director Galligan Andrew H

SEC Form 3 filed by new insider Myers Kristin

New insider Galligan Andrew H claimed ownership of 5,000 shares (SEC Form 3)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $107,460 worth of shares (1,500 units at $71.64) (SEC Form 4)

Officer Elghandour Rami was granted 1,015,671 shares, increasing direct ownership by 681% to 1,164,857 units (SEC Form 4)

Officer Elghandour Rami converted options into 70,211 shares and sold $2,375,517 worth of shares (38,300 units at $62.02), increasing direct ownership by 27% to 149,186 units (SEC Form 4)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $94,740 worth of shares (1,500 units at $63.16) (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher converted options into 22,556 shares and sold $647,773 worth of shares (10,155 units at $63.79), increasing direct ownership by 49% to 37,486 units (SEC Form 4)

CHIEF MEDICAL OFFICER Heery Christopher converted options into 22,556 shares, increasing direct ownership by 90% to 47,641 units (SEC Form 4)

Officer Elghandour Rami converted options into 70,211 shares, increasing direct ownership by 60% to 187,486 units (SEC Form 4)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $96,855 worth of shares (1,500 units at $64.57) (SEC Form 4)

Director Patel Kavita exercised 1,500 shares at a strike of $6.66 and sold $98,801 worth of shares (1,500 units at $65.87) (SEC Form 4)