TAK - SEC Form 4 insider transactions

President, R&D Plump Andrew Stewart sold $363,347 worth of American Depositary Shares (19,651 units at $18.49) as part of a pre-agreed trading plan (SEC Form 4)

Chief Human Resources Officer Greenway Nicola Deidre Petal sold $235,118 worth of American Depositary Shares (12,980 units at $18.11), decreasing direct ownership by 24% to 40,049 units (SEC Form 4)

Chief Medical Officer Farajallah Awny Samaan Botros sold $239,503 worth of American Depositary Shares (14,006 units at $17.10), decreasing direct ownership by 11% to 116,177 units (SEC Form 4)

President, PDT BU Ibrahim Ramy Riad Ahmed sold $124,437 worth of American Depositary Shares (7,277 units at $17.10), decreasing direct ownership by 7% to 102,588 units (SEC Form 4)

President, U.S. Business Unit Pacheco Rhonda Janice sold $289,007 worth of American Depositary Shares (16,901 units at $17.10), decreasing direct ownership by 8% to 182,507 units (SEC Form 4)

Chief Transformation Officer Duprey Lauren Rusckowski sold $813,721 worth of American Depositary Shares (47,586 units at $17.10), decreasing direct ownership by 17% to 226,057 units (SEC Form 4)

President, R&D Plump Andrew Stewart sold $2,828,220 worth of American Depositary Shares (165,393 units at $17.10), decreasing direct ownership by 18% to 766,569 units (SEC Form 4)

Head, Strat. & Port. Dev Pignagnoli Agosti Marcello sold $392,565 worth of American Depositary Shares (22,957 units at $17.10), decreasing direct ownership by 11% to 176,977 units (SEC Form 4)

President, OBU Bitetti Teresa Marie sold $855,205 worth of American Depositary Shares (50,012 units at $17.10), decreasing direct ownership by 17% to 252,010 units (SEC Form 4)

Pres., Global Supply & Quality Shannon Elaine Mary sold $68,024 worth of American Depositary Shares (3,978 units at $17.10), decreasing direct ownership by 6% to 63,333 units (SEC Form 4)

Chief Data & Tech. Officer Ricci Gabriele sold $429,005 worth of American Depositary Shares (25,088 units at $17.10), decreasing direct ownership by 13% to 171,654 units (SEC Form 4)

Chief Human Resources Officer Greenway Nicola Deidre Petal sold $115,835 worth of American Depositary Shares (6,774 units at $17.10), decreasing direct ownership by 11% to 53,029 units (SEC Form 4)

President and CEO Kim Julie So-Young sold $1,523,439 worth of American Depositary Shares (89,090 units at $17.10), decreasing direct ownership by 19% to 391,489 units (SEC Form 4)

President, IBU Platford Giles Richard sold $531,519 worth of American Depositary Shares (31,083 units at $17.10), decreasing direct ownership by 9% to 315,838 units (SEC Form 4)

Global General Counsel Furney Natalie Anne Marie sold $527,843 worth of American Depositary Shares (30,868 units at $17.10), decreasing direct ownership by 13% to 204,298 units (SEC Form 4)

Chief Human Resources Officer Greenway Nicola Deidre Petal sold $605,778 worth of American Depositary Shares (34,603 units at $17.51), decreasing direct ownership by 37% to 59,803 units (SEC Form 4)

Pres., Global Supply & Quality Shannon Elaine Mary sold $357,371 worth of American Depositary Shares (20,363 units at $17.55), decreasing direct ownership by 23% to 67,311 units (SEC Form 4)

Director Gillis Steven was granted 3,800 units of Ordinary Shares, increasing direct ownership by 58% to 10,400 units (SEC Form 4) to satisfy withholding obligation

Director Maraganore John was granted 3,800 units of Ordinary Shares, increasing direct ownership by 58% to 10,400 units (SEC Form 4) (for withholding tax)

Director Reed Kimberly A. was granted 3,800 units of Ordinary Shares, increasing direct ownership by 58% to 10,400 units (SEC Form 4) (tax withholding)

Director Iijima Masami was granted 1,800 units of Ordinary Shares, increasing direct ownership by 14% to 14,601 units (SEC Form 4) to satisfy withholding tax

Director Broussard Bruce D was granted 3,800 units of American Depositary Shares, increasing direct ownership by 478% to 4,595 units (SEC Form 4) (withholding obligation)

Director Stoffels Paulus was granted 3,800 units of Ordinary Shares (SEC Form 4) to cover withholding tax

Director Kimura Koichiro was granted 1,800 units of Ordinary Shares (SEC Form 4) (tax liability)

Director Tsusaka Miki was granted 1,800 units of Ordinary Shares, increasing direct ownership by 28% to 8,200 units (SEC Form 4) (withholding obligation)

President, Japan Pharma B.U. Miyabashira Asuka was granted 1,500 units of Ordinary Shares, increasing direct ownership by 50% to 4,500 units (SEC Form 4) (tax liability)

Chief Financial Officer Furuta Milano was granted 12,300 units of Ordinary Shares, increasing direct ownership by 21% to 70,200 units (SEC Form 4) (tax withholding)

President, IBU Platford Giles Richard was granted 49,558 units of American Depositary Shares, increasing direct ownership by 17% to 346,921 units (SEC Form 4)

Chief Comm. & Gov. Officer Smoter Jennifer Marie was granted 18,808 units of American Depositary Shares (SEC Form 4)

President, PDT BU Ibrahim Ramy Riad Ahmed was granted 25,078 units of American Depositary Shares, increasing direct ownership by 30% to 109,865 units (SEC Form 4)

Chief Human Resources Officer Greenway Nicola Deidre Petal was granted 22,570 units of American Depositary Shares, increasing direct ownership by 31% to 94,406 units (SEC Form 4)

Chief Medical Officer Farajallah Awny Samaan Botros was granted 17,554 units of American Depositary Shares, increasing direct ownership by 16% to 130,183 units (SEC Form 4)

Global General Counsel Furney Natalie Anne Marie was granted 43,886 units of American Depositary Shares, increasing direct ownership by 23% to 235,166 units (SEC Form 4)

President, U.S. Business Unit Pacheco Rhonda Janice was granted 50,156 units of American Depositary Shares, increasing direct ownership by 34% to 199,408 units (SEC Form 4)

Head, Strat. & Port. Dev. Pignagnoli Agosti Marcello was granted 27,586 units of American Depositary Shares, increasing direct ownership by 16% to 199,934 units (SEC Form 4)

Chief Data & Tech. Officer Ricci Gabriele was granted 37,616 units of American Depositary Shares, increasing direct ownership by 24% to 196,742 units (SEC Form 4)

Pres., Global Supply & Quality Shannon Elaine Mary was granted 30,094 units of American Depositary Shares, increasing direct ownership by 52% to 87,674 units (SEC Form 4)

Chief Transformation Officer Duprey Lauren Rusckowski was granted 45,140 units of American Depositary Shares, increasing direct ownership by 20% to 273,643 units (SEC Form 4)

President, OBU Bitetti Teresa Marie was granted 43,886 units of American Depositary Shares, increasing direct ownership by 17% to 302,022 units (SEC Form 4)

President and CEO Kim Julie So-Young was granted 50,434 units of American Depositary Shares and was granted 22,800 units of Ordinary Shares, decreasing direct ownership by 95% to 22,800 units (SEC Form 4) to satisfy withholding obligation

President, R&D Plump Andrew Stewart was granted 125,390 units of American Depositary Shares, increasing direct ownership by 16% to 931,962 units (SEC Form 4)

President and CEO Weber Christophe Pierre was granted 78,900 units of Ordinary Shares and was granted 165,370 units of American Depositary Shares, decreasing direct ownership by 55% to 418,803 units (SEC Form 4) to cover taxes

President, R&D Plump Andrew Stewart was granted 212,470 units of American Depositary Shares, increasing direct ownership by 36% to 806,572 units (SEC Form 4)

Head, Strat. & Port. Dev. Pignagnoli Agosti Marcello was granted 27,740 units of American Depositary Shares, increasing direct ownership by 19% to 172,348 units (SEC Form 4)

Chief Transformation Officer Duprey Lauren Rusckowski was granted 59,990 units of American Depositary Shares, increasing direct ownership by 36% to 228,503 units (SEC Form 4)

CEO - Elect Kim Julie So-Young was granted 105,416 units of American Depositary Shares, increasing direct ownership by 32% to 430,145 units (SEC Form 4)

Chief Data & Tech. Officer Ricci Gabriele was granted 34,994 units of American Depositary Shares, increasing direct ownership by 28% to 159,126 units (SEC Form 4)

Chief Financial Officer Furuta Milano was granted 7,800 units of Ordinary Shares, increasing direct ownership by 16% to 57,900 units (SEC Form 4) (withholding obligation)

President, OBU Bitetti Teresa Marie was granted 64,988 units of American Depositary Shares, increasing direct ownership by 34% to 258,136 units (SEC Form 4)

President, IBU Platford Giles Richard was granted 72,124 units of American Depositary Shares, increasing direct ownership by 32% to 297,363 units (SEC Form 4)

Large owner Takeda Pharmaceutical Co Ltd converted options into 1,250,000 shares (SEC Form 4)

SEC Form 4: Takeda Pharmaceutical Co Ltd converted options into 1,615,427 shares