STE - SEC Form 4 insider transactions

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 401 units of Ordinary Shares, decreasing direct ownership by 1% to 36,678 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 65 units of Ordinary Shares, decreasing direct ownership by 1% to 6,194 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 195 units of Ordinary Shares, decreasing direct ownership by 2% to 12,257 units (SEC Form 4)

SVP & GM, AST Kohler Kenneth E covered exercise/tax liability with 150 units of Ordinary Shares, decreasing direct ownership by 1% to 11,332 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare covered exercise/tax liability with 600 units of Ordinary Shares, decreasing direct ownership by 4% to 13,716 units (SEC Form 4)

President and CEO Carestio Daniel A covered exercise/tax liability with 1,889 units of Ordinary Shares and sold $946,799 worth of Ordinary Shares (4,428 units at $213.82), decreasing direct ownership by 9% to 63,647 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L covered exercise/tax liability with 90 units of Ordinary Shares, decreasing direct ownership by 0.68% to 13,184 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 365 units of Ordinary Shares, decreasing direct ownership by 0.97% to 37,079 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 64 units of Ordinary Shares, decreasing direct ownership by 1% to 6,259 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 239 units of Ordinary Shares, decreasing direct ownership by 2% to 12,452 units (SEC Form 4)

SVP & GM, AST Kohler Kenneth E covered exercise/tax liability with 184 units of Ordinary Shares, decreasing direct ownership by 2% to 11,482 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare covered exercise/tax liability with 311 units of Ordinary Shares, decreasing direct ownership by 2% to 14,316 units (SEC Form 4)

President and CEO Carestio Daniel A covered exercise/tax liability with 2,619 units of Ordinary Shares, decreasing direct ownership by 4% to 69,964 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L covered exercise/tax liability with 190 units of Ordinary Shares, decreasing direct ownership by 1% to 13,274 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam was granted 4,359 units of Ordinary Shares and covered exercise/tax liability with 247 units of Ordinary Shares, increasing direct ownership by 12% to 37,444 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato was granted 750 units of Ordinary Shares and covered exercise/tax liability with 41 units of Ordinary Shares, increasing direct ownership by 13% to 6,323 units (SEC Form 4)

SVP and President, Healthcare Majors Cary L was granted 4,746 units of Ordinary Shares and covered exercise/tax liability with 67 units of Ordinary Shares, increasing direct ownership by 37% to 17,338 units (SEC Form 4)

VP, Chf. Comp. & Quality Offc. Mcgowan Lindsey covered exercise/tax liability with 329 units of Ordinary Shares and was granted 1,155 units of Ordinary Shares, increasing direct ownership by 17% to 5,656 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia was granted 2,316 units of Ordinary Shares and covered exercise/tax liability with 127 units of Ordinary Shares, increasing direct ownership by 21% to 12,691 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare was granted 3,009 units of Ordinary Shares and covered exercise/tax liability with 591 units of Ordinary Shares, increasing direct ownership by 20% to 14,627 units (SEC Form 4)

SVP & GM, AST Kohler Kenneth E was granted 2,199 units of Ordinary Shares and covered exercise/tax liability with 66 units of Ordinary Shares, increasing direct ownership by 22% to 11,666 units (SEC Form 4)

President and CEO Carestio Daniel A was granted 23,736 units of Ordinary Shares and covered exercise/tax liability with 995 units of Ordinary Shares, increasing direct ownership by 46% to 72,583 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L was granted 5,325 units of Ordinary Shares, increasing direct ownership by 64% to 13,464 units (SEC Form 4)

SEC Form 4 filed by Director Boulud Pierre

Director Breeden Richard C exercised 3,781 units of Ordinary Shares at a strike of $71.40 and sold $310,284 worth of Ordinary Shares (1,481 units at $209.51), increasing direct ownership by 6% to 38,964 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 337 units of Ordinary Shares, decreasing direct ownership by 1% to 33,332 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 81 units of Ordinary Shares, decreasing direct ownership by 1% to 5,614 units (SEC Form 4)

VP, Chf. Comp. & Quality Offc. Mcgowan Lindsey covered exercise/tax liability with 198 units of Ordinary Shares, decreasing direct ownership by 4% to 4,830 units (SEC Form 4)

SVP and President, Healthcare Majors Cary L covered exercise/tax liability with 768 units of Ordinary Shares, decreasing direct ownership by 6% to 12,659 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 208 units of Ordinary Shares, decreasing direct ownership by 2% to 10,502 units (SEC Form 4)

SVP & GM, AST Kohler Kenneth E covered exercise/tax liability with 109 units of Ordinary Shares, decreasing direct ownership by 1% to 9,533 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare covered exercise/tax liability with 673 units of Ordinary Shares, decreasing direct ownership by 5% to 12,209 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L covered exercise/tax liability with 99 units of Ordinary Shares, decreasing direct ownership by 1% to 8,205 units (SEC Form 4)

President and CEO Carestio Daniel A covered exercise/tax liability with 1,254 units of Ordinary Shares, decreasing direct ownership by 2% to 49,842 units (SEC Form 4)

Director Feldmann Cynthia L exercised 3,098 units of Ordinary Shares at a strike of $152.32 and sold $734,877 worth of Ordinary Shares (3,098 units at $237.21) (SEC Form 4)

VP, Chf. Comp. & Quality Offc. Mcgowan Lindsey was granted 798 units of Ordinary Shares, increasing direct ownership by 19% to 5,028 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia exercised 5,008 units of Ordinary Shares at a strike of $128.22 and sold $1,312,096 worth of Ordinary Shares (5,008 units at $262.00) (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato exercised 3,536 units of Ordinary Shares at a strike of $182.22 and sold $1,297,040 worth of Ordinary Shares (5,036 units at $257.55), decreasing direct ownership by 21% to 5,695 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam exercised 15,000 units of Ordinary Shares at a strike of $69.72 and sold $3,977,100 worth of Ordinary Shares (15,000 units at $265.14) (SEC Form 4)

President and CEO Carestio Daniel A sold $38,449 worth of Ordinary Shares (159 units at $241.82), decreasing direct ownership by 0.31% to 51,096 units (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam covered exercise/tax liability with 91 units of Ordinary Shares, decreasing direct ownership by 0.27% to 33,669 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato covered exercise/tax liability with 26 units of Ordinary Shares, decreasing direct ownership by 0.36% to 7,195 units (SEC Form 4)

SVP and President, Healthcare Majors Cary L covered exercise/tax liability with 303 units of Ordinary Shares, decreasing direct ownership by 2% to 13,427 units (SEC Form 4)

Sr. VP and GM, Life Sciences Madsen Julia covered exercise/tax liability with 52 units of Ordinary Shares, decreasing direct ownership by 0.48% to 10,710 units (SEC Form 4)

SVP & Chief HRO Fraser Mary Clare covered exercise/tax liability with 207 units of Ordinary Shares, decreasing direct ownership by 2% to 12,882 units (SEC Form 4)

Sr. Vice Pres., CFO Burton Karen L covered exercise/tax liability with 39 units of Ordinary Shares and was granted 2,349 units of Ordinary Shares, increasing direct ownership by 39% to 8,304 units (SEC Form 4)

President and CEO Carestio Daniel A covered exercise/tax liability with 130 units of Ordinary Shares, decreasing direct ownership by 0.25% to 51,255 units (SEC Form 4)

V.P. & Corporate Treasurer Tamaro Renato exercised 3,204 units of Ordinary Shares at a strike of $147.05 and sold $798,565 worth of Ordinary Shares (3,204 units at $249.24) (SEC Form 4)

Director Breeden Richard C exercised 4,110 units of Ordinary Shares at a strike of $64.05, increasing direct ownership by 13% to 36,664 units (SEC Form 4)

Director Sohi Mohsen exercised 4,110 units of Ordinary Shares at a strike of $64.05 and sold $994,456 worth of Ordinary Shares (4,110 units at $241.96) (SEC Form 4)

SEC Form 4 filed by Director Shapiro Louis

SEC Form 4 filed by Director Shah Nirav R

SEC Form 4 filed by Director Martin Paul Edward

SEC Form 4 filed by Director Holland Christopher S

Director Feldmann Cynthia L converted options into 3,495 units of Ordinary Shares and sold $844,252 worth of Ordinary Shares (3,495 units at $241.56) (SEC Form 4)

SEC Form 4 filed by Director Breeden Richard C

SEC Form 4 filed by Director Alegria Esther M.

VP & CAO Burton Karen L exercised 7,900 units of Ordinary Shares at a strike of $114.22 and sold $1,909,667 worth of Ordinary Shares (7,900 units at $241.73) (SEC Form 4)

Sr. VP, Gen Counsel, and Sec. Zangerle John Adam sold $477,581 worth of Ordinary Shares (1,978 units at $241.45), decreasing direct ownership by 6% to 33,760 units (SEC Form 4)

Sr. Vice Pres., CFO Tokich Michael J covered exercise/tax liability with 341 units of Ordinary Shares, decreasing direct ownership by 0.77% to 43,891 units (SEC Form 4)