PRTA - SEC Form 4 insider transactions

Large owner Scully William P received a gift of 336,000 units of Ordinary Shares and gifted 627,553 units of Ordinary Shares, decreasing direct ownership by 28% to 750,000 units (SEC Form 4)

Large owner Scully William P received a gift of 251,553 units of Ordinary Shares, increasing direct ownership by 32% to 1,041,553 units (SEC Form 4)

Chief Scientific Officer Zago Wagner M. converted options into 51,000 units of Ordinary Shares and returned $436,560 worth of Ordinary Shares to the company (51,000 units at $8.56) (SEC Form 4)

Chief Accounting Officer Walker Karin L converted options into 15,000 units of Ordinary Shares and returned $128,400 worth of Ordinary Shares to the company (15,000 units at $8.56) (SEC Form 4)

Chief Development Officer Swanson Chad J. converted options into 51,000 units of Ordinary Shares, returned $349,248 worth of Ordinary Shares to the company (40,800 units at $8.56) and covered exercise/tax liability with 3,467 units of Ordinary Shares, increasing direct ownership by 20% to 40,733 units (SEC Form 4)

Chief Operating Officer Smith Brandon S. converted options into 78,000 units of Ordinary Shares and returned $667,680 worth of Ordinary Shares to the company (78,000 units at $8.56) (SEC Form 4)

Chief Strategy Officer and CFO Nguyen Tran converted options into 57,000 units of Ordinary Shares and returned $487,920 worth of Ordinary Shares to the company (57,000 units at $8.56) (SEC Form 4)

President and CEO Kinney Gene G. converted options into 84,000 units of Ordinary Shares and returned $719,040 worth of Ordinary Shares to the company (84,000 units at $8.56) (SEC Form 4)

Chief Strategy Officer Kingston Anne Evans covered exercise/tax liability with 3,498 units of Ordinary Shares and sold $64,919 worth of Ordinary Shares (7,662 units at $8.47) as part of a pre-agreed trading plan, decreasing direct ownership by 17% to 55,782 units (SEC Form 4)

General Counsel & Company Sec. Isaacs Michael John covered exercise/tax liability with 4,694 units of Ordinary Shares and sold $71,055 worth of Ordinary Shares (8,386 units at $8.47) as part of a pre-agreed trading plan, decreasing direct ownership by 27% to 35,745 units (SEC Form 4)

Large owner Scully William P gifted 325,000 units of Ordinary Shares, decreasing direct ownership by 31% to 736,000 units (SEC Form 4)

SEC Form 4 filed by Director Welch Daniel G

SEC Form 4 filed by Director Selkoe Dennis J.

SEC Form 4 filed by Director Ekman Lars

SEC Form 4 filed by Director Dunn William H. Jr.

SEC Form 4 filed by Director Cooke Shane

SEC Form 4 filed by Director Collier Richard T

SEC Form 4 filed by Kingston Anne Evans

SEC Form 4 filed by Chief Scientific Officer Zago Wagner M.

SEC Form 4 filed by Chief Accounting Officer Walker Karin L

SEC Form 4 filed by Chief Development Officer Swanson Chad J.

SEC Form 4 filed by Chief Operating Officer Smith Brandon S.

SEC Form 4 filed by Chief Strategy Officer and CFO Nguyen Tran

SEC Form 4 filed by Chief Legal Officer Malecek Michael J

SEC Form 4 filed by President and CEO Kinney Gene G.

Chief Scientific Officer Zago Wagner M. was granted 85,000 units of Ordinary Shares (SEC Form 4)

Chief Accounting Officer Walker Karin L was granted 25,000 units of Ordinary Shares (SEC Form 4)

Chief Development Officer Swanson Chad J. was granted 85,000 units of Ordinary Shares (SEC Form 4)

Chief Operating Officer Smith Brandon S. was granted 130,000 units of Ordinary Shares (SEC Form 4)

Chief Strategy Officer and CFO Nguyen Tran was granted 95,000 units of Ordinary Shares, increasing direct ownership by 4,308% to 97,205 units (SEC Form 4)

Chief Legal Officer Malecek Michael J was granted 80,000 units of Ordinary Shares (SEC Form 4)

President and CEO Kinney Gene G. was granted 140,000 units of Ordinary Shares, increasing direct ownership by 1,094% to 152,793 units (SEC Form 4)

SEC Form 4 filed by Director Welch Daniel G

SEC Form 4 filed by Director Selkoe Dennis J.

SEC Form 4 filed by Director Kim Helen Susan

SEC Form 4 filed by Director Ekman Lars

SEC Form 4 filed by Director Dunn William H. Jr.

SEC Form 4 filed by Director Cooke Shane

SEC Form 4 filed by Director Collier Richard T

SEC Form 4 filed by Director Cobb Paula K

Large owner Ecor1 Capital, Llc sold $50,839,807 worth of Ordinary Shares (6,279,684 units at $8.10) (SEC Form 4)

SEC Form 4 filed by Chief Scientific Officer Zago Wagner M.

SEC Form 4 filed by Chief Accounting Officer Walker Karin L

SEC Form 4 filed by Chief Development Officer Swanson Chad J.

SEC Form 4 filed by Chief Operating Officer Smith Brandon S.

SEC Form 4 filed by Chief Strategy Officer and CFO Nguyen Tran

SEC Form 4 filed by Chief Legal Officer Malecek Michael J

SEC Form 4 filed by President and CEO Kinney Gene G.

SEC Form 4 filed by Chief Regulatory Officer Karp Carol D.

SEC Form 4 filed by Chief People Officer Ford David A

Chief Strategy Officer and CFO Nguyen Tran disposed of 995 units of Ordinary Shares, decreasing direct ownership by 31% to 2,205 units (SEC Form 4)

SEC Form 4 filed by Chief Development Officer Swanson Chad J.

SEC Form 4 filed by Welch Daniel G

SEC Form 4 filed by Selkoe Dennis J.

SEC Form 4 filed by Kim Helen Susan

SEC Form 4 filed by Ekman Lars

SEC Form 4 filed by Dunn William H. Jr.

SEC Form 4 filed by Cooke Shane

SEC Form 4 filed by Collier Richard T

SEC Form 4 filed by Cobb Paula K