ADCT - SEC Form 4 insider transactions

Director Azelby Robert was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 40% to 112,805 units (SEC Form 4) to cover withholding tax

Director Squarer Ron was granted 45,000 shares and covered exercise/tax liability with 15,196 shares, increasing direct ownership by 32% to 123,431 units (SEC Form 4) to satisfy withholding obligation

Director Sandor Victor was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 30% to 140,686 units (SEC Form 4) (tax withholding)

Director Monges Viviane was granted 45,000 shares and covered exercise/tax liability with 2,596 shares, increasing direct ownership by 29% to 186,447 units (SEC Form 4) to cover withholding tax

Director Hug Peter was granted 45,000 shares and covered exercise/tax liability with 2,156 shares, increasing direct ownership by 19% to 263,344 units (SEC Form 4) to cover withholding tax

Director Bizzari Jean-Pierre was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 30% to 139,302 units (SEC Form 4) to satisfy withholding tax

Director Coughlin Timothy was granted 45,000 shares and covered exercise/tax liability with 12,600 shares, increasing direct ownership by 81% to 72,400 units (SEC Form 4) (tax withholding)

SEC Form 4 filed by Redmile Group, Llc

Chief Accounting Officer Kallebo Lisa Michelle was granted 62,900 shares and covered exercise/tax liability with 5,433 shares, increasing direct ownership by 81% to 128,224 units (SEC Form 4)

Chief Medical Officer Zaki Mohamed was granted 285,200 shares and covered exercise/tax liability with 24,603 shares, increasing direct ownership by 62% to 682,417 units (SEC Form 4)

Chief Legal Officer Graham Peter J was granted 294,800 shares and covered exercise/tax liability with 33,294 shares, increasing direct ownership by 73% to 620,540 units (SEC Form 4)

Chief Financial Officer Carmona Jose was granted 271,600 shares and covered exercise/tax liability with 25,880 shares, increasing direct ownership by 50% to 734,376 units (SEC Form 4)

Chief Executive Officer Mallik Ameet was granted 900,000 shares and covered exercise/tax liability with 103,231 shares, increasing direct ownership by 123% to 1,446,769 units (SEC Form 4)

Chief Executive Officer Mallik Ameet covered exercise/tax liability with 233,146 shares, decreasing direct ownership by 15% to 1,319,101 units (SEC Form 4)

Chief Medical Officer Zaki Mohamed covered exercise/tax liability with 41,068 shares, decreasing direct ownership by 9% to 421,820 units (SEC Form 4)

Chief Accounting Officer Kallebo Lisa Michelle covered exercise/tax liability with 7,140 shares, decreasing direct ownership by 9% to 70,757 units (SEC Form 4)

Chief Legal Officer Graham Peter J covered exercise/tax liability with 49,508 shares, decreasing direct ownership by 12% to 359,034 units (SEC Form 4)

Chief Financial Officer Carmona Jose covered exercise/tax liability with 53,236 shares, decreasing direct ownership by 10% to 488,656 units (SEC Form 4)

SEC Form 4 filed by Large owner Redmile Group, Llc

Director Squarer Ron covered exercise/tax liability with 15,184 shares, decreasing direct ownership by 14% to 93,627 units (SEC Form 4)

Director Sandor Victor covered exercise/tax liability with 12,600 shares, decreasing direct ownership by 10% to 108,286 units (SEC Form 4)

Director Monges Viviane covered exercise/tax liability with 2,584 shares, decreasing direct ownership by 2% to 144,043 units (SEC Form 4)

Director Hug Peter covered exercise/tax liability with 2,144 shares, decreasing direct ownership by 0.96% to 220,500 units (SEC Form 4)

Director Bizzari Jean-Pierre covered exercise/tax liability with 12,600 shares, decreasing direct ownership by 11% to 106,902 units (SEC Form 4)

Director Azelby Robert covered exercise/tax liability with 12,600 shares, decreasing direct ownership by 14% to 80,405 units (SEC Form 4)

SEC Form 4 filed by Large owner Redmile Group, Llc

Director Coughlin Timothy was granted 40,000 shares (SEC Form 4)

Director Sandor Victor was granted 40,000 shares, increasing direct ownership by 49% to 120,886 units (SEC Form 4)

Director Azelby Robert was granted 40,000 shares, increasing direct ownership by 75% to 93,005 units (SEC Form 4)

Director Bizzari Jean-Pierre was granted 40,000 shares, increasing direct ownership by 50% to 119,502 units (SEC Form 4)

Director Hug Peter was granted 40,000 shares, increasing direct ownership by 22% to 222,644 units (SEC Form 4)

Director Monges Viviane was granted 40,000 shares, increasing direct ownership by 38% to 146,627 units (SEC Form 4)

Director Squarer Ron was granted 40,000 shares, increasing direct ownership by 58% to 108,811 units (SEC Form 4)

Large owner Wild Hans Peter acquired 9,788,944 shares (SEC Form 4)

See Explanations Pfisterer Thomas disposed of 451,856 shares, decreasing direct ownership by 72% to 173,899 units (SEC Form 4)

Chief Executive Officer Mallik Ameet covered exercise/tax liability with 26,758 shares, decreasing direct ownership by 2% to 1,552,247 units (SEC Form 4)

Chief Legal Officer Graham Peter J was granted 220,000 shares, increasing direct ownership by 117% to 408,542 units (SEC Form 4)

Chief Medical Officer Zaki Mohamed was granted 230,000 shares, increasing direct ownership by 99% to 462,888 units (SEC Form 4)

Chief Accounting Officer Kallebo Lisa Michelle was granted 41,900 shares, increasing direct ownership by 116% to 77,897 units (SEC Form 4)

Chief Financial Officer Carmona Jose was granted 240,000 shares, increasing direct ownership by 79% to 541,892 units (SEC Form 4)

Chief Executive Officer Mallik Ameet was granted 650,000 shares, increasing direct ownership by 70% to 1,579,005 units (SEC Form 4)

Chief Medical Officer Zaki Mohamed covered exercise/tax liability with 37,112 shares, decreasing direct ownership by 14% to 232,888 units (SEC Form 4)

Chief Accounting Officer Kallebo Lisa Michelle covered exercise/tax liability with 6,503 shares, decreasing direct ownership by 15% to 35,997 units (SEC Form 4)

Chief Financial Officer Carmona Jose covered exercise/tax liability with 48,108 shares, decreasing direct ownership by 14% to 301,892 units (SEC Form 4)

Chief Legal Officer Graham Peter J covered exercise/tax liability with 41,458 shares, decreasing direct ownership by 18% to 188,542 units (SEC Form 4)

Chief Executive Officer Mallik Ameet covered exercise/tax liability with 238,343 shares, decreasing direct ownership by 20% to 929,005 units (SEC Form 4)

Large owner Redmile Group, Llc acquired $209,782 worth of shares (101,344 units at $2.07), sold $52,479 worth of shares (25,352 units at $2.07) and disposed of $104,891 worth of shares (50,672 units at $2.07) (SEC Form 4)

Director Azelby Robert sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 12% to 53,005 units (SEC Form 4)

Director Bizzari Jean-Pierre sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 8% to 79,502 units (SEC Form 4)

Director Hug Peter sold $3,448 worth of shares (1,193 units at $2.89), decreasing direct ownership by 0.65% to 182,644 units (SEC Form 4)

Director Monges Viviane sold $4,153 worth of shares (1,437 units at $2.89), decreasing direct ownership by 1% to 106,627 units (SEC Form 4)

Director Pfisterer Thomas sold $4,153 worth of shares (1,437 units at $2.89), decreasing direct ownership by 0.67% to 213,900 units (SEC Form 4)

Director Sandor Victor sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 8% to 80,886 units (SEC Form 4)

Director Squarer Ron sold $20,216 worth of shares (6,995 units at $2.89), decreasing direct ownership by 8% to 80,663 units (SEC Form 4)

Director Azelby Robert was granted 40,000 shares, increasing direct ownership by 200% to 60,000 units (SEC Form 4)

Director Bizzari Jean-Pierre was granted 40,000 shares, increasing direct ownership by 86% to 86,497 units (SEC Form 4)

Director Hug Peter was granted 40,000 shares, increasing direct ownership by 28% to 183,837 units (SEC Form 4)

Director Pfisterer Thomas was granted 40,000 shares, increasing direct ownership by 23% to 215,337 units (SEC Form 4)

Director Sandor Victor was granted 40,000 shares, increasing direct ownership by 84% to 87,881 units (SEC Form 4)

Director Squarer Ron was granted 40,000 shares, increasing direct ownership by 84% to 87,658 units (SEC Form 4)